Severe Accident Simulation of the Laguna Verde Nuclear Power Plant by Gilberto Espinosa-Paredes, Raúl Camargo-Camargo, Alejandro Nuñez-Carrera

“…Faced with a severe accident, the first response is to maintain the reactor core cooling by any means available, but in order to carry out such an attempt is necessary to understand fully the progression of core damage, since such action has effects that may be decisive in accident progression. …”
Get full text

Increased serum soluble PD-l1 levels in patients with advanced stages of chronic kidney disease by Ayaka Hayashi, Ayaka Hayashi, Hiroto Ishihara, Mayuko Kawabe, Kazuhiko Kato, Kazuhiko Kato, Akio Nakashima, Akio Nakashima, Izumi Yamamoto, Teppei Sakano, Teppei Sakano, Hiroe Kobashi, Makoto Morita, Makoto Morita, Takashi Yokoo, Mitsuyoshi Urashima

“…In the Vaccine Cohort, elevated median sPD-L1 levels (pg/mL) were significantly associated with CKD stage progression (P < 0.001), showing exponentially higher levels with CKD progression. …”
Get full text

TERT promoter mutations in thyroid cancer by Michiko Matsuse, Norisato Mitsutake

“…TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also involved in tumor progression and aggressiveness. …”
Get full text

Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review by Adelina Gama, Fernando Schmitt

“…This paper highlights the need for further research studies in this setting in order to elucidate the role of these adhesion molecules during tumour progression and metastasis.…”
Get full text

Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…These drugs reduce inflammation and regulate key biological pathways involved in cancer progression, offering new avenues for prevention and therapy. …”
Get full text

Pretransplant Evaluation and Liver Transplantation Outcome in PBC Patients by Maja Mijic, Ivona Saric, Bozena Delija, Milos Lalovac, Nikola Sobocan, Eva Radetic, Dora Martincevic, Tajana Filipec Kanizaj

“…Primary biliary cholangitis (PBC) is an autoimmune chronic cholestatic liver disease characterized by progressive cholangiocyte and bile duct destruction leading to fibrosis and finally to liver cirrhosis. …”
Get full text

Subjective social status and trajectories of frailty: findings from the English Longitudinal Study of Ageing by Patrick Präg, Lindsay Richards, Asri Maharani

“…Controls were included for confounding factors, including a range of socioeconomic indicators and health behaviours.Results Four trajectories of the frailty index were retained: low frailty (53% of participants), progressive mild frailty (25%), progressive moderate frailty (15%) and high frailty (6%). …”
Get full text

Development of animal models to study aggressive thyroid cancers by Shovan Dutta, Jeffrey A Knauf

“…While driver mutations can initiate tumorigenesis, they are often insufficient to sustain cancer progression and invasion, which significantly limits their usefulness in studying advanced thyroid cancers. …”
Get full text

MicroRNAs in Diabetic Kidney Disease by Rong Li, Arthur C. K. Chung, Xueqing Yu, Hui Y. Lan

“…Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantation. …”
Get full text

Gadospin F—Enhanced Magnetic Resonance Imaging for Diagnosis and Monitoring of Atherosclerosis: Validation with Transmission Electron Microscopy and X-Ray Fluorescence Imaging in t... by Caroline Jung, Tanja Dučić, Rudolph Reimer, Eva Koziolek, Fabian Kording, Markus Heine, Gerhard Adam, Harald Ittrich, Michael G. Kaul

“…GDF-enhanced MRI allows noninvasive and reliable estimation of plaque burden and monitoring of atherosclerotic progression in vivo.…”
Get full text

Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies by Androulla N. Miliotou, Andria Kotsoni, Lefteris C. Zacharia

“…It is the most common cause of progressive memory loss (dementia) in the elderly, and to date, there is no effective treatment to cure or slow disease progression substantially. …”
Get full text

Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…These drugs reduce inflammation and regulate key biological pathways involved in cancer progression, offering new avenues for prevention and therapy. …”
Get full text

Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer by Xiao Li, Yanghao Tai, Shuying Liu, Yating Gao, Kaining Zhang, Jierong Yin, Huijuan Zhang, Xia Wang, Xiaofei Li, Dongfeng Zhang

“…Although treatment has made progress, the prospect of gastric cancer patients is bleak. …”
Get full text

Incorporating Internal and External Training Load Measurements in Clinical Decision Making After ACL Reconstruction: A Clinical Commentary by Jeffrey B Taylor, Kevin R Ford, Robin M Queen, Elizabeth C Owen, Angela Spontelli Gisselman

“…Additionally, clinicians can use internal load measures to objectively monitor patient’s physiological responses to rehabilitation progressions and recovery rather than relying on subjective patient-reported data…”
Get full text

Integrals at secondary school by Antanas Anynis, Juozas Šinkūnas

“… Teaching of integrals in Lithuania, Denmark and France is presented. It is suggested to progress to three levels teaching of mathematics. …”
Get full text

Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis by Min-Na Zhang, Ran Duan, Gui-Hong Chen, Mei-Jun Chen, Chun-Gu Hong, Xin Wang, Zhi-Lin Pang, Chun-Yuan Chen, Hua-Feng Liu, Da Zhong, Hui Xie, Wen-Bao Hu, Zheng-Zhao Liu

“…Furthermore, fasting prevented OA progression by activating OPTN-mediated mitophagy and maintaining mitochondrial homeostasis in mice. …”
Get full text

Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer by Jarupa Soongsathitanon, Pranisa Jamjuntra, Nuttavut Sumransub, Supaporn Yangngam, Marjorie De la Fuente, Glauben Landskron, Peti Thuwajit, Marcela A. Hermoso, Chanitra Thuwajit

“…Signals from the tumor microenvironment (TME) have a profound influence on the maintenance and progression of cancers. Chronic inflammation and the infiltration of immune cells in breast cancer (BC) have been strongly associated with early carcinogenic events and a switch to a more immunosuppressive response. …”
Get full text

Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy by Xiuhong Lu, Bin Ji, Gang Huang, Hong Ding

“…Many studies have reviewed the progress of synaptic density imaging; however, to our knowledge, there is no article yet that summarizes the research progress of multimodal imaging of synaptic density tracers combined with other dementia biomarkers. …”
Get full text

Propensity score matched comparison of lymph node upstaging in early-stage lung cancer: open versus minimally invasive surgery with standardized lymphadenectomy by Julia Zimmermann, Julia Walter, Valentina Pfeiffer, Julia Kovács, Gökçe Yavuz, Johannes Schön, Mircea Gabriel Stoleriu, Christian Ketscher, Niels Reinmuth, Rudolf A. Hatz, Amanda Tufman, Christian P. Schneider

“…Multivariate Cox regression analysis showed that overall survival and progression free survival were also independent of the surgical approach. …”
Get full text