The Self-Perception and Political Biases of ChatGPT by Jérôme Rutinowski, Sven Franke, Jan Endendyk, Ina Dormuth, Moritz Roidl, Markus Pauly

“…These eight tests were repeated ten times each and indicate that ChatGPT seems to hold a bias towards progressive views. The political compass test revealed a bias towards progressive and libertarian views, supporting the claims of prior research. …”
Get full text

PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

“…Here, we find that PAX6 overexpression promotes SCLC cell proliferation and cell cycle progression, while downregulation of PAX6 expression suppresses SCLC cell proliferation and cell cycle progression. …”
Get full text

The Effect of Steep Trendelenburg Positioning on Retinal Structure and Function during Robotic-Assisted Laparoscopic Procedures by Kazuyuki Hirooka, Kaori Ukegawa, Eri Nitta, Nobufumi Ueda, Yushi Hayashida, Hiromi Hirama, Rikiya Taoka, Yuma Sakura, Mari Yamasaki, Hiroyuki Tsunemori, Mikio Sugimoto, Yoshiyuki Kakehi

“…RNFL thickness progression and visual field progression were evaluated by event analysis. …”
Get full text

Astigmatism and maternal myopia as important factors affecting success rate of DIMS lens treatment by Christof Meigen, Adrienne Csutak, Patricia Domsa, Éva M Bankó, Judit Körtvélyes, Rita Széchey, Krisztina Lantos, Zoltán Zsolt Nagy

“…Additionally, parental myopic dioptre was recorded when applicable.Results At the 12-month mark, myopia progression in patients (mean±SE: −0.40±0.05) mirrored findings from prior European DIMS studies, but with 50% of patients showing no progression. …”
Get full text

Complete metabolic response as early predictor of long-term efficacy after adoptive T cell therapy using tumor-infiltrating lymphocytes by Rikke Andersen, Troels Holz Borch, Eva Ellebaek, Inge Marie Svane, Helle Westergren Hendel, Kasper Madsen

“…These patients might benefit from additional consolidating treatment before clinical progression, but thus far, it is not possible to identify this subgroup of patients prone to progress. …”
Get full text

Treatment of Advanced Hepatocellular Carcinoma after Failure of Sorafenib Treatment: Subsequent or Additional Treatment Interventions Contribute to Prolonged Survival Postprogressi... by Masaaki Kondo, Kazushi Numata, Koji Hara, Akito Nozaki, Hiroyuki Fukuda, Makoto Chuma, Shin Maeda, Katsuaki Tanaka

“…Furthermore, interventions consisting of other treatment options upon the appearance of progression might prolong OS.…”
Get full text

Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Abstract To better understand drug resistance mechanisms to CDK4/6 inhibitors and inform precision medicine, we analyze real-world multi-omics data from 400 HR+/HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapies, including 200 pre-treatment and 227 post-progression samples. The prevalences of ESR1 and RB1 alterations significantly increase in post-progression samples. …”
Get full text

Case report: A rare case of a long-term survivor of glioblastoma who underwent two courses of hypofractionated radiotherapy as part of her care by Midhad Mrvoljak, Midhad Mrvoljak, Shubhendu Mishra, Liam Chen, Liam Chen, Elizabeth Neil, Elizabeth Neil, Eric Ehler, Stephanie Terezakis, Stephanie Terezakis, Lindsey Sloan, Lindsey Sloan

“…After recurrence, another HFRT (35 Gy in 10 fractions) was employed. She was progression-free on imaging for 8 months until a recent follow-up scan showed potential progression versus radiation-related change. …”
Get full text

Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice by Kenichi Nakajima, Tomoya Mita, Yusuke Osonoi, Kosuke Azuma, Toshiyuki Takasu, Yoshio Fujitani, Hirotaka Watada

“…However, the effects of repetitive postprandial glucose spikes, repetitive hypoglycaemia, and their combination on the progression of atherosclerosis remain largely unknown. …”
Get full text

Evolutionary Algorithms and Quantum Computing: Recent Advances, Opportunities, and Challenges by Junaid Ur Rehman, Muhammad Shohibul Ulum, Abdurrahman Wachid Shaffar, Amirul Adlil Hakim, Mujirin, Zaid Abdullah, Hayder Al-Hraishawi, Symeon Chatzinotas, Hyundong Shin

“…Quantum computers have made significant progress in the last two decades showing great potential in tackling some of the most challenging problems in computing. …”
Get full text

Rasmussen’s Encephalitis: A Report of a Tunisian Pediatric Case and Literature Review by Hedia Klaa, Thouraya Ben Younes, Hanene Benrhouma, Sonia Nagi, Aida Rouissi, Ichraf Kraoua, Ilhem Ben Youssef-Turki

“…Rasmussen’s encephalitis (RE) is a rare progressive inflammatory disease of the central nervous system. …”
Get full text

A Severe Complication of Crack Cocaine Use by Gokul Vidyasankar, Carolina Souza, Chi Lai, Sunita Mulpuru

“…The present report describes a 48-year-old woman with a history of recurrent ‘crack’ cocaine use, who developed progressive shortness of breath over a period of years. …”
Get full text

Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas by Matilde Cacciatore, Carla Guarnotta, Marco Calvaruso, Sabina Sangaletti, Ada Maria Florena, Vito Franco, Mario Paolo Colombo, Claudio Tripodo

“…In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. …”
Get full text

Detrusor Arreflexia as an End Stage of Neurogenic Bladder in HAM/TSP? by Matheus Tannus, Davi Tanajura, Michael A. Sundberg, Paulo Oliveira, Neviton Castro, André Muniz Santos

“…Further cohort or case-series studies, with particular emphasis on the progression of neurogenic bladder, are needed to evaluate the significance of this described case in relation to typical disease progression patterns.…”
Get full text

Application of immunohistochemical markers in mycosis fungoides by SHAO Kaixin, LIU Xiangjun, TANG Zhenzhen

“…Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphomas. Most cases of MF progress slowly with a good prognosis. However, some early-stage patients may still experience disease progression with a poor prognosis. …”
Get full text

Magnetic Resonance Spectroscopy (MRS) transforming multiple sclerosis (MS) diagnosis by Landoline Bonnin, Pascal Bourdon, Carole Guillevin, Remy Guillevin, Clement Giraud, Christine Fernandez-Maloigne

“…Anna is one of the 1.8 million people worldwide with multiple sclerosis who live with the uncertainty of disease progression every day [1]. Traditional Magnetic Resonance Imaging scans every six months reveal brain lesions but can't predict how the disease will progress [2]. …”
Get full text

Cyclic and Explosive Evaluation of New Proposed Steel Joint by Iman Faridmehr, Yusof Ahmad, Mahmood Md. Tahir, Mohd Hanim Osman

“…The behaviour of a novel steel beam-to-column connection, the saddlebag, subjected to cyclic and progressive collapse, was evaluated in this paper. The cyclic behaviour considered the interstory drift angle and flexural strength in accordance with 2010 AISC Seismic Provisions, while progressive collapse assessment was evaluated through the plastic hinge rotation angle based on acceptance criteria provided in the UFC 4-023-03 guideline. …”
Get full text

Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities by Filippa Lo Cascio, Suhyeorn Park, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Nikita Shchankin, Cynthia Jerez, Naomi Moreno, Alice Bittar, Rhea Xavier, Yingxin Zhao, Cankun Wang, Hongjun Fu, Qin Ma, Mauro Montalbano, Rakez Kayed

“…Our results indicate that the aBDTOs possess different structural and morphological features that impact neuronal function, gene regulation, and ultimately disease progression. The distinct tau oligomeric polymorphs may thus contribute to the development of clinical phenotypes and shape the progression of diseases. …”
Get full text

Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches by Yifan Lu, Yifan Lu, Tiao Li, Yang Shu, Yang Shu, Chengyin Lu, Chengyin Lu, Zhiqiang Luo, Zhiqiang Luo, Jingrui Wang, Jingrui Wang, Hui Xiong, Wangyang Li, Wangyang Li

“…Sarcopenia is an age-related condition characterized by the progressive loss of skeletal muscle mass and strength. …”
Get full text

The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana by Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen

“…Conserved histone methyltransferases of the DOT1 family are involved in replication regulation, cell cycle progression, stage differentiation, and gene regulation in trypanosomatids. …”
Get full text