CHARACTERISTICS OF CYTOPROTECTIVE EFFECT ON THE GASTRIC MUCOSA OF CRYOPRESERVED PLACENTA EXTRACT UNDER WATER-IMMOBILIZATION STRESS by Illia Koshurba, Fedir Hladkykh, Mykola Chyzh

“…Along with psycho-emotional stressing experiences, the causes of formation of stress ulcers include major surgical interventions, thermal or mechanical injuries, severe blood loss, progressive syndrome of endogenous intoxication and more. …”
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Genome-Wide Profiling of Human Papillomavirus DNA Integration into Human Genome and Its Influence on PD-L1 Expression in Chinese Uygur Cervical Cancer Women by Feng Yang-chun, Wang Sen-yu, Zhang Yuan, Huang Yan-chun

“…Most high-frequency sites of HPV integration in Chinese Uygur cervical cancer are related to cancer progression, and the gene integration hotspots may be potential HPV carcinogenic targets. …”
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Effects of Local Heating and Whole-Body Hyperthermia on Neuromuscular and Cognitive Function in Young and Old Healthy Adults by Junli Wang

“… Background and objectives: Aging population is growing fast in European Union and worldwide (Shimizu et al., 2020). A progressive decline in neuromuscular function (Lexell et al., 1983), structural changes in the brain ( Smith et al., 2010; Zahra et al., 2019)aged 30 to 99 years, were studied with MRI. …”
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Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…MIA offers 7 features: personalized tips, PA literacy, guided peer workouts, a community calendar, a personal activity diary, a progression monitor, and a chatbot. MethodsOur study used a mixed methods approach to evaluate the MIA app’s acceptability, feasibility, and usability. …”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Nonetheless, myrrh’s precise rudimentary mechanisms of action in regulating genes involved in breast cancer evolution and progression remain elusive. Purpose: Herein, we use a network pharmacology platform to identify the potential genes targeted by myrrh-active molecules in breast cancer. …”
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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…The diagnostic model constructed based on these Hub PCD-DEGs demonstrated diagnostic efficiency in distinguishing OA tissues as well as progression of OA. Additionally, a correlation was observed between the expression levels of Hub PCD-DEGs, immune cell infiltration, and inflammatory cytokine levels. …”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…EVs transport transforming growth factor-β (TGF-β), which is commonly activated under late stages of cancer progression. Nevertheless, whether TGF-β signaling coordinates EV biogenesis is a relevant topic that remains minimally explored. …”
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Lenvatinib Therapy in Patients with Unresectable Hepatocellular Carcinoma in Real Clinical Practice by V. V. Petkau, A. V. Sultanbaev, K. V. Menshikov, A. S. Antipin, M. V. Volkonsky, V. M. Filippova, Yu. V. Vasilyeva, A. A. Tarkhanov, M. R. Mukhitova, M. Zh. Murzalina, A. R. Safarova

“…The objective response rate (ORR), disease control rate (DCR), median overall survival (OS) and median progression-free survival (PFS) rates were assessed. …”
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Building resilient cattle through better management of buffalo health by Alfredo Sánchez, Merilio Montero

“…In particular, the immune system’s effectiveness in recognizing the progression and pathogenic action of some agents, from which the buffalo is not exempt from becoming infected, but which do not thrive or induce clinical manifestations or functionality variations. …”
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Feasibility and Acceptability of Antenatal Hepatitis C Screening: A Pilot Study by Joseph Valamparampil, Jaswant Sira, Maxine Brown, Saket Singhal, Deirdre Kelly

“…Antenatal screening would identify HCV-positive mothers and allow follow-up of their infants so that any infected mothers and infants could be offered effective curative therapy and prevent the progression of liver disease. The inclusion of HCV antenatal screening would complete the blood-borne virus profile and enhance the WHO target to eliminate HCV in the UK.…”
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Simultaneous Liver Venous Deprivation Following Hepatic Arterial Chemoembolization Before Major Hepatectomy for Hepatocellular Carcinoma: A New Methods to Achieve Hypertrophy Liver... by Zhang S, Song R, Hou C, Yao H, Xu J, Zhou H, Li S, Cai W, Fei Y, Meng F, Yin D, Wang J, Zhang S, Liu Y, Wang J, Liu L

“…The modified response evaluation criteria for solid tumor assessment revealed a disease control rate of 95.7%, with only 1 patient (Barcelona Clinic Liver Cancer stage C) developing intrahepatic disease progression.Conclusion: TACE-LVD seems to be a feasible, safe, and effective strategy for rapid FLR hypertrophy. …”
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Plaider la « bonne gouvernance sécuritaire » au Maroc : Domestiquer les savoirs de réforme en régime de contrainte consensuelle by Irene Lizzola

“…During this pivotal moment, the Moroccan regime opened up the outsourcing of the production of reform knowledge relating to security, through the progressive association of NGOs and transnational actors in the development of public policies. …”
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Pengembangan Business Intelligence Dashboard untuk Monitoring Aktivitas Pariwisata (Studi Kasus: Dinas Pariwisata Provinsi Bali) by Evan Himawan Saragih, I Putu Agung Bayupati, Gusti Agung Ayu Putri

“…Based on this, local governments need strategies and decisions in the development of facilities and infrastructure that can support the development and progress of tourism in Bali. The use of business intelligence technology in analyzing large amounts of data will help. …”
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α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…These findings underscore the role of SLC6A14 in regulating intestinal immune cell infiltration during CD progression.Discussion: Our findings suggest that SLC6A14 could serve as a potential diagnostic biomarker and therapeutic target for CD. …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…In silico studies have shown that sarcosine is able to bind to unique plasmodia proteins (P. falciparum ATCase), whereas aniline can be a ligand to target protein (enoyl acyl carrier protein reductase), hence suppressing the progression of the disease. The main objective of this study was to synthesize and determine the efficacy and safety of antiplasmodial hybrid drug comprising the sarcosine and aniline derivative for management of plasmodial infections. …”
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Early Detection and Intervention of Preschool-Aged Children Using Android-Based Monitoring during the COVID-19 Pandemic in Central Java by Triwiji Lestari, Elisa

“…The study’s results underscore a significant influence between the initial developmental status of children and their subsequent progress following developmental intervention, with a remarkable p-value of 0.001. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Loss of H3K27me3 signal peaks may up-regulate the expression of SLC7A11 in diffuse gastric cancer cells， and thereby promote tumor progression. …”
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Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study. by Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen, Peter von Dadelszen

“…We recommend using the models for consecutive prediction with greater caution and interpreting predictions with increasing uncertainty as the pregnancy progresses. For clinical practice, models should be adapted to retain accuracy when deployed serially. …”
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Perancangan Sistem Informasi Basis Data IKM Binaan Pada Dinas Perindustrian dan Perdagangan Provinsi Jawa Barat by Iman Sudirman, Atya Nur Aisha, Joe Monang, Taufan Fadhilah Iskandar

“…In general, the information system can be used by SMEs to report business profiles and propose facilitation needs by online and can be utilized by the Agency to view SME business profiles, obtain data about facilitation activities, analyze the progress of facilitation, and evaluate the facilitation that has been provided to SMEs based on the database in generated by the system. …”
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An efficient method for predicting the morphology of proppant packs based on a surrogate model by Tao ZHANG, Hangyu ZHOU, Yifan ZHANG, Jianchun GUO, Haoran GOU, Tang TANG

“…For the time-concentration model, the prediction results were closely aligned with the numerical simulation outcomes, successfully capturing the characteristics of a constant placement height and a progressive increase in placement length after reaching the equilibrium height. …”
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