Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia by Olga Plisko, Jana Žodžika, Irina Jermakova, Inta Liepniece-Karele, Jeļena Eglīte, Dace Rezeberga

“… Background: Persistent human papillomavirus (HPV) infection is a necessary cause for development of cervical precancerous lesions and cervical cancer, however, only a small percentage of women progress to cervical cancer. The local immune response, determined, among other factors, by Human Leucocyte Antigen (HLA) genes, is thought to be significant. …”
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The role of the Hygiene Department of Stephen Bathory University in the development and promotion of Public Health in Vilnius in the years 1922–1939 by Aistis Žalnora

“…Hygienists and doctors encouraged cooperation and coordination of their activities with the central and local authorities as well as education of the local population. The progress of medical science in Europe and the World, as well as the Soviet ideology in Eastern Europe distracted doctors from the search for the etiology of social illness. …”
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To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…Angiogenesis is essential for HCC progression and metastasis. Some angiogenesis-related genes promote this process, whereas other antiangiogenic genes inhibit HCC growth and metastasis. …”
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Role of visual function and performance of activities of daily living in cognitive function in patients with mild cognitive impairment: a cross-sectional study by Chunhui Zhou, Ganfeng Yang, Marc Theeboom, Hua Yang, Ruiting Zhu, Zijian Zhou, Dong Zhu

“…This gap is crucial because early interventions targeting visual impairments could potentially delay progression to dementia, offering new avenues for supporting MCI patients.ObjectiveThis study investigates the relationship between visual function and cognitive abilities in patients with MCI. …”
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Crocin improves post-thaw quality, fertility-associated gene expression and fertilization potential of buffalo bull sperm by Amjad Riaz, Ghulam S. Khan, Muhammad Zahid Tahir, Muhammad Yasir Zahoor, Hifz-ul-Rahman Hifz-ul-Rahman

“…Moreover, 1mM crocin improved progressive motility, kinematics, and DNA integrity than control (p<0.05). …”
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Overcoming barriers to the development of clean and digital energy start-ups: access to credit and protection of minority investors' rights by Artyukhov Artem, Oleksii Havrylenko, Olena Churikanova, Kseniia Mohylna

“…These measures are critical to creating resilient entrepreneurial ecosystems that support clean and digital energy start-ups, driving global progress toward sustainability and economic growth. …”
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A method for evaluating the accessibility of underground auxiliary transportation vehicles in coal mines based on multi feature fusion by Fan JIANG, Yifan LIU, Zhencai ZHU, Chaofan ZHANG, Gongbo ZHOU, Yuxing PENG

“…The railway track is divided into two models: straight track and curved track by setting a threshold value using vanishing point coordinates. Progressive probability Hough transform and Catmull Rom spline curve with improved feature point selection are used to fit the straight track and curved track separately, forming a railway track detection method based on a switchable model; Secondly, based on the color attributes of coal mine underground tunnel wall pipelines, a pipeline feature detection strategy is constructed through HSV color space transformation, edge detection, and least squares fitting algorithms; Once again, a weighted fusion method based on pipeline and rail feature points is proposed to extract the centerline trajectory of auxiliary transportation vehicles, and to construct rules for generating safe passage areas for auxiliary transportation vehicles; Then, for the over-segmentation problem in the traditional watershed algorithm, two-dimensional edge and area feature extraction of static obstacles is carried out by using improved watershed segmentation based on markers and GraphCut algorithm, and a small-sample classification support vector mechanism is selected to build a pedestrian detection model based on the fusion of HOG (Histograms of Oriented Gradients)features and LBP(Local Binary Pattern) features for underground coal mine, so as to realize the comprehensive detection of dynamic and static obstacles in front of auxiliary transportation vehicles; Finally, the positional relationship between obstacles and safe passage area is judged by Euclidean distance to determine the obstacle invasion, and the results of auxiliary transportation vehicle passability assessment are obtained. …”
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New Approach to Improving the Prognosis of Ischemic Stroke by Regulating SCFAs with Acupuncture-Rehabilitation Therapy Based on Gut-Brain Axis by TANG Qiang, LIU Chong, CHAI Fanglei, ZHANG Jinpeng, LI Hongyu, ZHU Luwen

“…Inflammation plays an important role in the progression of stroke.The inflammatory response of ischemic stroke is a dynamic process,which occurs within a short time after ischemia and then affects the central nervous system. …”
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Le port antique de Chelles (Seine-et-Marne) : une course après la rivière by Yann Le Jeune, Corinne Charamond, Christian Charamond

“…The harbor was therefore established on the convex riverbank of an old meander, in an environment marked by very strong alluvial sedimentation linked to the progressive loss of energy from the channel, its migration northward, and its subsequent abandonment in favor of another secondary branch of the Marne located 2 km further south. …”
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Investigating the Role of the basic Components of Smart Governance in Realizing a Smart City with the ISM Method (Case Study: Tehran) by ALi Asghar Pourezzat, Tayebeh Abbasi, Shahryar Maghsoodi Kenari, Mohammad Mehdi Namdar Joybari

“…The study highlights that Tehran has made substantial progress in establishing e-government, followed by the adoption of smart management practices, technology utilization, and the creation of a supportive political and institutional environment, which are all recognized as key drivers in this process. …”
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Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method and compared between treatments in a univariate Cox proportional hazards model.Results In total, 472 patients with MBM who received first-line nivolumab plus ipilimumab (n=246), anti-PD-1 monotherapy (n=112) or BRAF/MEK inhibitors (n=114) were identified. …”
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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…Intervening in pretangle tau pathology could significantly delay the progression of AD. The gut-brain axis, increasingly recognized as a contributor to AD, represents a promising therapeutic target due to its role in regulating neuroinflammation and neurodegeneration. …”
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Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role? by Alexandra Maria Boieriu, Cezar Dumitrel Luca, Carmen Daniela Neculoiu, Alina Bisoc, Diana Țînț

“…<i>Background and Objectives</i>: Endothelial dysfunction (ED) and oxidative stress play major contributions in the initiation and progression of atherosclerosis. Diabetes is a pathological state associated with endothelial damage and enhanced oxidative stress. …”
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Prognostic value of body adipose tissue parameters in cancer patients treated with immune checkpoint inhibitors by Yan Li, Yean Yu, Kun Lv, Rongjuan Ge, Xie Xie

“…The primary outcomes analyzed were hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS), as well as odds ratios (ORs) for disease control rate (DCR). …”
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Cloned buffalo bulls and their somatic cell donor bulls exhibit similar in-vitro embryo production efficienc by Tanya Gupta, Gaurav Tripathi, Sonal Gupta, Naresh L. Selokar, Manoj Kumar Singh

“…Semen from cloned bulls vs. donor bulls showed progressive motility with distance average path (17.70 ± 0.835 vs. 18.72 ± 0.53 μm), distance curvilinear (28.30 ± 2.85 vs. 31.61 ± 1.71 μm), distance straight line (15.89 ± 0.56 vs. 16.36 ± 0.20 μm), velocity average path (74.84 ± 7.23 vs 69.59 ± 9.96 μm/s), velocity curvilinear (113.77 ± 15.28 vs 113.49 ± 16.94 μm/s), and velocity straight line (66.71 ± 6.01 vs. 61.94 ± 9.13 μm/s). …”
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Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis by Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S

“…Chondrocyte inflammation, apoptosis, and extracellular matrix degradation accelerated OA progression. MicroRNA (miRNA) has the potential to be a therapeutic method for osteoarthritis. …”
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Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status? by Tissa Wijeratne, Melanie J. Murphy, Chanith Wijeratne, Paolo Martelletti, Leila Karimi, Vasso Apostolopoulos, Carmela Sales, Nina Riddell, Sheila G. Crewther

“…The control group displayed similar findings to MO inpatients, suggesting persistent systemic inflammation in a subset of migraine patients regardless of in patient or outpatient of presentation and highlighting the need for future studies to more rigorously evaluate the role of systemic inflammation in migraine pathophysiology, chronicity, and progression though the multiple phases of migraine including the interictal phase.…”
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钢板-混凝土组合梁桥的活载结构效率指数研究 by 熊治华, 刘旭尧, 朱厚达, 刘玉擎

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Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C. by Abhishek Bhatia, Alexander J Preiss, Xuya Xiao, M Daniel Brannock, G Caleb Alexander, Robert F Chew, Hannah Davis, Megan Fitzgerald, Elaine Hill, Elizabeth P Kelly, Hemalkumar B Mehta, Charisse Madlock-Brown, Kenneth J Wilkins, Christopher G Chute, Melissa Haendel, Richard Moffitt, Emily R Pfaff, N3C Consortium

“…<h4>Background</h4>Nirmatrelvir with ritonavir (Paxlovid) is indicated for patients with Coronavirus Disease 2019 (COVID-19) who are at risk for progression to severe disease due to the presence of one or more risk factors. …”
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miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma by Xiaoyuan Lu, Li Jing, Sicong Liu, Haihong Wang, Buze Chen

“…High miR-149-3p expression predicted poorer overall survival (OS) (HR: 2.56; 95% CI: 1.64–4.00; P<0.001), progression-free interval (PFI) (HR: 1.85; 95% CI: 1.29–2.65; P=0.001), and disease-specific survival (DSS) (HR: 2.33; 95% CI: 1.37–3.99; P=0.002). …”
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