Folded and Unfolded Conformations of Proteins Involved in Pancreatic Cancer: a Layman's Guide by Jerónimo Bravo, José L. Neira

“…Since cancer deregulation and progression are associated with changes in at least one biochemical pathway, the knowledge of the structure of the proteins involved in such routes seems to be crucial in order to understand how this cancer progresses and, more importantly, to design more efficient and rationally designed drugs. …”
Get full text

Chronic Myeloid Leukemia: Part II—Cost of Care Among Patients in Advanced Phases or Later Lines of Therapy in Chronic Phase in the United States from a Commercial Perspective by Ehab L. Atallah, Rodrigo Maegawa, Dominick Latremouille-Viau, Carmine Rossi, Annie Guérin

“…Moreover, even with TKIs, some patients progress to accelerated phase/blast crisis (AP/BC), which is associated with particularly poor clinical outcomes. …”
Get full text

Short-Term and Long-Term Effects of Bariatric Surgery on Diabetic Retinopathy: A Systematic Review by Erika Butkutė, Monika Zieniūtė, Agnė Morkūnaitė, Vilma Jūratė Balčiūnienė

“…Rapid glycemic changes after surgery may pose risks of DR progression. Large-scale, longitudinal studies are needed to clarify the role of BS in DR progression and regression.…”
Get full text

Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants by null Turyadi, Billy Witanto, Korri E. El-Khobar, M. Luthfi Parewangi, M. Rezki Rasyak, Dhita P. Wibowo, Meta D. Thedja, Irawan Yusuf, Muh. Nasrum Massi, Ilhamjaya Patellongi, Din Syafruddin, David H. Muljono

“…Genetic polymorphisms of several inflammatory cytokines, including TNF-α and IL-10, have been associated with chronic hepatitis B (CHB) progression, although with contradicting results. CHB progression can be categorized into four phases, immune tolerance (IT), immune clearance (IC), low/no replicative (LR), and e-negative hepatitis (ENH), with HBeAg seroconversion as an important milestone. …”
Get full text

Kinetic pH Titration to Predict the Acid and Hydrothermal Conditions for the Hydrolysis of Disaccharides: Use of a Microcapillary System by Toshinori Shimanouchi, Ryota Mano, Yu Yoshioka, Ayaka Fukuda, Kyung-Min Park, Yukitaka Kimura

“…The hydrolysis reaction showed a sigmoidal progression with time, especially under alkaline conditions. …”
Get full text

Treating Penile Cancer in the Immunotherapy and Targeted Therapy Era by Gavin Hui, Sanaz N. Ghafouri, John Shen, Sandy Liu, Alexandra Drakaki

“…We report a case series of two patients who improved on immunotherapy after progressing with standard chemotherapy regimens. The first case describes a 64-year-old male with a penile mass and significant lymphadenopathy who had surgical resection and adjuvant chemotherapy prior to continued disease progression. …”
Get full text

Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin by M. Tesauro, A. Mascali, O. Franzese, S. Cipriani, C. Cardillo, N. Di Daniele

“…Several elements contribute to determine a progression of the kidney injury, inducing a worsening of renal damage and accelerating the decline of renal function: obesity and hypertension are two known factors of kidney progression. …”
Get full text

Criteria-Based Rehabilitation Following Revision Hip Arthroscopy: A Clinical Commentary by Haley Leo, Trevor Shelton, Helen Bradley

“…This criterion based progression promotes range of motion (ROM), strength, gait, neuromuscular control, load introduction and gradual return to play…”
Get full text

Utilizing fuzzy banana curve for project monitoring and control by Mahmood Jahanbani, Hamid Shahbandarzadeh

“…A key responsibility of project management is to control and monitor project progress. One commonly used tool is the S-curve, which highlights any deviations from the project plan. …”
Get full text

Understanding the phases and objectives of the career development process in the context of successful career management by Ilić Đurđijana

“…The basis of a quality organization consists of reliable employees who are satisfied with their work, ready to learn and progress, and thus continuously bring profit and progress to themselves and the organization. …”
Get full text

Construction Payment Automation Through Scan-to-BIM and Blockchain-Enabled Smart Contract by Hamdy Elsharkawi, Emad Elbeltagi, Mohamed S. Eid, Wael Alattyih, Hossam Wefki

“…This study leveraged accurate, real-time building progress data to automate payments using blockchain-enabled smart contracts upon work completion, thus reducing payment disputes by tying payments to verifiable construction progress, leading to faster release of payments. …”
Get full text

Roles of Copper Transport Systems Members in Breast Cancer by Yichang Chen, Chen Li, Mengxin Li, Bing Han

“…ABSTRACT Background The occurrence and progression of breast cancer are closely linked to copper ion homeostasis. …”
Get full text

Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease by Symeon Savvopoulos, Haralampos Hatzikirou, Herbert F Jelinek

“…Objectives: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. Thus, identifying high-risk individuals can delay or prevent diabetes and its complications. …”
Get full text

Regulation of T Helper 17 by Bacteria: An Approach for the Treatment of Hepatocellular Carcinoma by Cecilia Ying Ju Sung, Nikki Pui-yue Lee, Hani El-Nezami

“…Its presence seems to be linked with HCC progression, possibly via facilitating angiogenesis. …”
Get full text

The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective by Bshra A. Alsfouk, Hayder M. Al-Kuraishy, Ali K. Albuhadily, Ali I. Al-Gareeb, Ahmed M. Abdelaziz, Athanasios Alexiou, Marios Papadakis, Mubarak Alruwaili, Gaber El-Saber Batiha

“…However, the molecular mechanism of BRB against the development of epilepsy and progression of epileptic seizure mainly in TLE was not fully elucidated. …”
Get full text

Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers by Siebren Dijkstra, Agus Rizal A. H. Hamid, Gisèle H. J. M. Leyten, Jack A. Schalken

“…The main challenge in PCa diagnosis, therefore, is to distinguish patients with low-risk PCa who will show slow progression of disease from patients at risk for progression to a more aggressive cancer. …”
Get full text

The Effects of Poverty on Rural Lively Hoods: A Case Study of Bufumbo Sub-County and Bufumeo Sub-Couny, Mbale District. by Muduwa, Jennifer

“…This is because progress in reducing poverty has been very slow in Eastern parts of Uganda. …”
Get full text

Human microbiomes in cancer development and therapy by Chenglai Xia, Jiyan Su, Can Liu, Zhikai Mai, Shuanghong Yin, Chuansheng Yang, Liwu Fu

“…Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy. …”
Get full text

Will South Africa meet the Sustainable Development Goals target for maternal mortality by 2030? by Y Pillay, J M Moodley

“…With a mere 6 years to go before 2030, it is useful to understand what progress SA is making towards their attainment. In this short report, we assess progress towards meeting the maternal mortality target, globally and in SA. …”
Get full text

The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis by Gordon P. Flake, Alicia B. Moore, Norris Flagler, Benita Wicker, Natasha Clayton, Grace E. Kissling, Stanley J. Robboy, Darlene Dixon

“…Based upon our morphologic observations, we hypothesize and also provide morphometric evidence for the occurrence of progressive developmental changes in many uterine fibroids, which can be arbitrarily divided into 4 phases. …”
Get full text