Integrating Two-Tier Optimization Algorithm With Convolutional Bi-LSTM Model for Robust Anomaly Detection in Autonomous Vehicles by Moneerah Alotaibi, Manal Abdullah Alohali, Khalid Mahmood, Asma A. Alhashmi, Jehad Saad Alqurni, Sultan Refa Alotaibi, Ahmad A. Alzahrani, Imene Issaoui

“…Machine learning (ML) and deep learning (DL) based anomaly recognition has progressed as a new study track in autonomous driving. …”
Get full text

Reliability of radiomics features as imaging biomarkers for evaluating brain aging: A study based on myelin protein and diffusion tensor imaging by Yuting Yan, Mengmeng Hu, Xiaodong He, Yuyun Xu, Xiaojun Sun, Jiaxuan Peng, Fanfan Zhao, Yuan Shao

“…Radiomics has made considerable progress in neurodegenerative diseases. However, previous studies only explored the feasibility of radiomics in clinical applications. …”
Get full text

Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, and chromatin remodeling, in pancreatic tumors progression is becoming increasingly recognized. Moreover, in PDAC these aberrant epigenetic mechanisms can also limit therapy efficacy. …”
Get full text

A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Patients treated with RC48 MT or RC48 combined with anti-PD-1 IT from July 2021 to April 2023 were recruited for the study. The progression-free survival (PFS), overall survival (OS), objective-response rate (ORR), disease-control rate (DCR), and safety were studied. …”
Get full text

CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation by Hussain Z, Abdulrahim Abdul Moti L, Jagal J, Thu HE, Khan S, Kazi M

“…Moreover, the lowest cell viability depicted in MCF-7 (~25%), SK-BR-3 (~20%), and RAW 264.7 cells (~20%), induction of apoptosis, cell cycle arrest, enhanced cell internalization, and alleviation of MCF-7 and SK-BR-3 migration proved the superior anticancer potential of HA-PTX-TMX-CS-NPs compared to unfunctionalized NPs and other control medicines.Conclusion: HA-functionalization of NPs is a promising multiprong strategy for CD44-receptors-mediated targeting of BC cells and TAMs to mitigate the progression, metastasis, and relapse in the BC. Keywords: paclitaxel, tamoxifen, hyaluronic acid, polymeric nanoparticles, CD44-receptors, breast cancer, cell uptake, anticancer efficacy…”
Get full text

ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…A major challenge in managing PrCa is the early identification of aggressive cases for targeted treatment, while avoiding unnecessary interventions in slow-progressing cases. Therefore, there is a critical need for genetic biomarkers that can distinguish between aggressive and non-aggressive PrCa cases. …”
Get full text

Bank collapse-landslide failure mechanism of typical reverse rock bank slope in Three Gorges Reservoir area by Yang LI, Hailin ZHAO, Bolin HUANG, Honglin LI, Kaikai XU

“…At present, most of the reverse rock slope toppling instability failure is interpreted as a progressive overall instability failure controlled by dip angle and structural plane. …”
Get full text

Size distribution of extracellular vesicles in pretreatment ascites and plasma is correlated with primary treatment outcome in advanced high-grade serous carcinoma by Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe

“…The correlations of the EV concentration and size distribution in ascites and plasma with treatment outcome, progression-free survival (PFS) and overall survival (OS) were analysed. …”
Get full text

Identification and Analysis of Key Immune- and Inflammation-Related Genes in Idiopathic Pulmonary Fibrosis by Tan Y, Qian B, Ma Q, Xiang K, Wang S

“…It is submitted to the journal not only because of its high international recognition, but also because of its emphasis on a progress in this field. The research scope covers a wide range of content from basic theory to practical cases, which has a guiding effect on clinical research.This manuscript is closely related to the core purpose and readership of Journal of Inflammation Research, a journal known for its in-depth and comprehensive coverage of the immune system and encouragement of original research. …”
Get full text

Sustainable Energy Sector Using Waste Woody Biomass and Miscanthus in the Energy Transition by Nihad Hodžić, Kenan Kadić, Anes Kazagić

“…None of the treated types of biomass, up to the level of applicable content in the mixture with lignite and brown coal, does not worsen the progress of the process from the aspect of possible slagging/fouling heating surfaces in the boiler.…”
Get full text

The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah

“…We can conclude that our nanocomplex is a potent effector that prevents tumoral progression by activating three main immunological strategies: switching the surface expression profile of the activated macrophages into a proinflammatory M1-like phenotype, downregulating the expression of proinflammatory cytokines, and upregulating the expression level of anti-inflammatory cytokines.…”
Get full text

Transgressive hybrids as hopeful holobionts by Benjamin Thomas Camper, Andrew Stephen Kanes, Zachary Tyler Laughlin, Riley Tate Manuel, Sharon Anne Bewick

“…By contrast, there has been substantially less progress made towards understanding the positive eco-evolutionary consequences of hybridization on holobionts. …”
Get full text

L’échelon manquant ? Les archives municipales en Algérie : histoire de fonds et possibilités historiographiques by Thierry Guillopé

“…The results of this survey show that the situations vary significantly: there are differences in the volumes conserved, in the chronological ranges covered, in the physical condition of the archives and repositories, and in the degree of progress made in filing.The third part of this study concludes with a presentation of the archive’s holdings. …”
Get full text

Conditional diffusion-generated super-resolution for myocardial perfusion MRI by Changyu Sun, Changyu Sun, Neha Goyal, Yu Wang, Darla L. Tharp, Senthil Kumar, Talissa A. Altes

“…The forward diffusion process introduces Gaussian noise incrementally, while the reverse process employs a U-Net architecture to progressively denoise the images, conditioned on the low-resolution input image.ResultsWe trained and validated the model on a retrospective dataset of dynamic contrast-enhanced (DCE) perfusion MRI, consisting of both stress and rest images from 47 patients with heart disease. …”
Get full text

Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study by Bo-Ning Cao, Cai-Yan Zhang, Zhen Wang, Yao-Xian Wang, Yao-Xian Wang

“…The bacterial microbiota involved in fatty acid oxidation is associated with diabetic kidney disease (DKD) progression, positively correlated with glycocholenate sulfate levels, and negatively correlated with the phosphate linoleyl-tetraenyl-glycerol (18:2 to 20:4) ratio. …”
Get full text

Evaluating the impact of faculty development programs at the workplace by using reflective critique writing technique by Sarah Amin, Shabana Ali Muhammad, Rahila Yasmeen

“…REFLECT rubric grading showed that in 3rd Reflective Critique writing almost 80% of the participants became critical reflectors, improving from an initial 60% progress in first writing, showing the effectiveness of the training program & increased effectiveness of teaching skills, learning transfer & behavior change at workplace. …”
Get full text

Comparison of radiation esophagitis associated with daytime versus evening radiotherapy in patients with esophageal carcinoma by Yun Xing, Yutian Yin, Liang Yu, Cong Zhang, Guangjin Chai, Bo Lyu, Bin Wang, Lina Zhao, Geng Xiang

“…There was no difference in the overall survival (OS), locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and progression-free survival (PFS) (all p > 0.05) between the daytime treatment group and evening treatment group. …”
Get full text

Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis by Leonie Ruths, Jana Hengge, Graciosa Q. Teixeira, Melanie Haffner-Luntzer, Anita Ignatius, Jana Riegger

“…Overall, targeting TCC formation could be a future approach to attenuate OA progression.…”
Get full text

Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Rand... by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

“…This suggests that nonguided ICBT may be effective in preventing SI and SD from progressing to the full threshold. However, appropriate definitions of subthreshold symptoms are necessary. …”
Get full text

Tradition and Development of Lithuanian Terminology by Antanas Smetona

“…The first stage is characterised by elemental terminology development, marked by unsystematic progress before the Industrial Revolution. Due to Lithuania’s socio-cultural circumstances—such as the prevalence of science in international languages, the absence of a standardised public Lithuanian language, occupation, and its peripheral status within the empire—terminology primarily relied on the spoken folk language, lacking a structured scientific foundation. …”
Get full text