Time without PSA recurrence after radical prostatectomy as a predictor of future biochemical recurrence, metastatic disease and prostate cancer death: a prospective Scandinavian co... by Mats Steinholtz Ahlberg, Hans-Olov Adami, Hans Garmo, Lars Holmberg, Anna Bill-Axelson, Ove Andren, Gunnar Steineck, Jan-Erik Johansson

“…Objective Although surveillance after radical prostatectomy routinely includes repeated prostate specific antigen (PSA)-testing for many years, biochemical recurrence often occurs without further clinical progression. We therefore hypothesised that follow-up can be shortened for many patients without increasing the risk of prostate cancer death. …”
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Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“…The finite pool of oocytes established in utero declines progressively throughout life, which is a natural process but may result in diminished ovarian reserve (DOR) in some women. …”
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A Green Approach to Landfill Remediation: The Efficacy of Indigenous Zygophyllum coccineum L. and Leptadenia pyrotechnica L. in Phytoremediating a Heavy Oil Flay Ash-contaminated L... by Samir G.M. Al-Solaimani, Abdulrahman Alkurashi, Refaat A. Abohassan, Omer H.M. Ibrahim, Magdi A.A. Mousa

“…The results showed that vegetation within the landfill exhibited the lowest overall fresh and dry biomass values of aerial and root parts. However, growth progressively improved with the increasing distance, with maximum growth reached at 1000 m from the landfill. …”
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The efficacy and safety of induction chemotherapy combined with sintilimab followed by concurrent chemoradiotherapy plus sintilimab sequencing maintaining with sintilimab for patie... by Ruifeng Wang, Tianhui Guo, Qi Wang, Wen Gao, Yimiao Yu, Jun Zhang, Wenqian Fu, Haiji Wang, Biyuan Zhang

“…The primary endpoints included progression-free survival (PFS) and PFS rates at 6, 12, and 18 months. …”
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Interplay between physical activity volume and intensity with modeled life expectancy in women and men: A prospective cohort analysis by Francesco Zaccardi, Alex V. Rowlands, Paddy C. Dempsey, Cameron Razieh, Joe Henson, Jonathan Goldney, Benjamin D. Maylor, Atanu Bhattacharjee, Yogini Chudasama, Charlotte Edwardson, Jari A. Laukkanen, Ulf Ekelund, Melanie J. Davies, Kamlesh Khunti, Thomas Yates

“…At 60 years, life expectancy was progressively longer for higher physical activity volume and intensity profiles, reaching 95.6 years in women and 94.5 years in men at the 90th centile for both volume and intensity, corresponding to 3.4 additional years (95% confidence interval (95%CI): 2.4–4.4) in women and 4.6 additional years (95%CI: 3.6–5.6) in men compared to those at the 10th centiles. …”
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Early Effects of Bronchoscopic Cryotherapy in Metastatic Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Single-Center Prospective Study by Gediminas Vasiliauskas, Evelina Žemaitė, Erika Skrodenienė, Lina Poškienė, Gertrūda Maziliauskienė, Aurimas Mačionis, Skaidrius Miliauskas, Donatas Vajauskas, Marius Žemaitis

“…<b>Conclusions:</b> Our study demonstrated that combined bronchoscopic cryotherapy and immunotherapy with or without chemotherapy may reduce the rate of progressive disease in metastatic non-small cell lung cancer patients while maintaining a satisfactory safety profile.…”
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Evolution characteristics of overburden structure in inclined fully mechanized caving under residual coal pillars of the upper layer by LIU Yong, WANG Hongwei, WU Xuesong, TIAN Chengpeng, GUAN Rongfu, NIE Yunxiao, FAN Zhiwei, CAO Peipei

“…The roof structure within the disturbed zone evolved progressively into a composite structure of "low-level inverted step cantilever beams and high-level large masonry beams". …”
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Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis by Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang

“…These changes in the levels of intact N-glycopeptides are associated with various aspects of SSc, including diffuse SSc (dSSc), interstitial lung disease (ILD), disease progression, cardiovascular involvement and C-reactive protein in the peripheral blood. …”
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Research on equity analysis and forecasting of nursing human resource allocation in Jiangxi Province, China by Yunyu Du, Zhiqin Xie, Zhen Yang, Wanyin Xiong, Li Zhou, Min Zhang, Suhua Zeng, Min Wang

“…The absolute fairness of nurse human resources allocation by population highlights significant progress, although regional disparities persist. These findings provide a foundation for optimizing future nursing resource allocation to ensure equitable access to healthcare services.…”
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Biotechnological Effects of <i>Lactobacillus plantarum</i>, Cellulase, and Xylanase on Nutritional Quality and Microbial Community Structure of Corn Stover Silage by Jianliang Liu, Mingjian Liu, Panjie Sheng, Chaoran Song, Weiqin Ma, Baochao Bai, Jiayu Zhao, Shuai Du, Gentu Ge, Zhijun Wang, Yushan Jia

“…The findings revealed that the nutritional quality of corn stover silage improved progressively with fermentation time. Compared to the control group, the addition of <i>Lactobacillus plantarum</i>, cellulase, and xylanase significantly increased the abundance of lactic acid bacteria, reduced the pH value, and effectively suppressed the proliferation of spoilage microorganisms. …”
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The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team‐based approach to clinically validated, research‐ready electronic health record data by Andrea L. C. Schneider, Jennifer C. Ginestra, Meeta Prasad Kerlin, Michael G. S. Shashaty, Todd A. Miano, Daniel S. Herman, Oscar J. L. Mitchell, Rachel Bennett, Alexander T. Moffett, John Chandler, Atul Kalanuria, Zahra Faraji, Nicholas S. Bishop, Benjamin Schmid, Angela T. Chen, Kathryn H. Bowles, Thomas Joseph, Rachel Kohn, Rachel R. Kelz, George L. Anesi, Monisha Kumar, Ari B. Friedman, Emily Vail, Nuala J. Meyer, Blanca E. Himes, Gary E. Weissman

“…However, EHR data are not frequently available, cleaned, standardized, validated, and ready for use by stakeholders. We describe an in‐progress effort to overcome these challenges with cooperative, systematic data extraction and validation. …”
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Does Sex Matter in Obesity-Induced Periodontal Inflammation in the SS^LepR Mutant Rats? by Abdulmohsin Alhashim, Kim Capehart, Jocelyn Tang, Karim M. Saad, Rafik Abdelsayed, Marion A. Cooley, Jan M. Williams, Ahmed A. Elmarakby

“…Obesity has been shown to exacerbate the progression of periodontal disease. Studies suggest a sex difference in periodontitis, whereby males are more sensitive to periodontal inflammation compared to females. …”
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Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suri... by Antoon W Grünberg, William Hawkins, Wilco Zijlmans, Jeffrey Wickliffe, Ashna Hindori-Mohangoo, Sigrid MacDonald-Ottevanger, Paul Ouboter, Gwendolyn Landburg, John Codrington, Jimmy Roosblad, Gaitree Baldewsingh, Radha Ramjatan, Anisma Gokoel, Firoz Abdoel Wahid, Lissa Fortes Soares, Cecilia Alcala, Esther Boedhoe, Arti Shankar, Emily Harville, S S Drury, Hannah Covert, Maureen Lichtveld

“…A pesticide literacy assessment in pregnant women is in progress. Neurodevelopmental assessments and telomere length measurements of the children to evaluate long-term effects of prenatal exposures to toxicant mixtures are ongoing.…”
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Political economy analysis of health financing reforms in times of crisis: findings from three case studies in south-east Asia by Sophie Witter, Maria Paola Bertone, Sushil Baral, Ghanshyam Gautam, Saugat K. C. Pratap, Aungsumalee Pholpark, Nurmala Selly Saputri, Arif Budi Darmawan, Nina Toyamah, Rizki Fillaili, Valeria de Oliveira Cruz, Susan Sparkes

“…The objective is to understand whether and how crises can be utilised to progress UHC and to analyse the strategies used by reformers to benefit from potential windows of opportunity. …”
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Optimising (re-)irradiation for locally recurrent head and neck cancer: impact of dose-escalation, salvage surgery, PEG tube and biomarkers on oncological outcomes—a single centre... by Julia Katharina Schleifenbaum, Janis Morgenthaler, Shachi Jenny Sharma, Jens Peter Klußmann, Philipp Linde, Simone Wegen, Johannes Rosenbrock, Christian Baues, Emmanouil Fokas, Richard Khor, Sweet Ping Ng, Simone Marnitz, Maike Trommer

“…Overall survival (OS), progression-free survival (PFS) and toxicities according to Common Terminology Criteria for Adverse Events (CTCAE) v5.0 were assessed. …”
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Prevalence of Diabetes, Prediabetes, and Associated Factors in an Adult Chinese Population: Baseline of a Prediabetes Cohort Study by Xinjie Yu, Fang Duan, Da Lin, Hai Li, Jian Zhang, Qiuyu Wang, Xianglong Wang, Qian Zhao, Jiayu Deng, Guangwei Song, Qingqing Ji, Haihua Zheng, Xiang Chen, Guoyi Zhou

“…To report baseline information of a prediabetes mellitus (PDM) cohort with the aim of exploring related factors for the progression of PDM and its complications. Methods. This study is an exploratory and cross-sectional analysis of the baseline data from a cohort study. …”
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Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon by Kerry K. Cooper, Evangelos Mourkas, Francesca Schiaffino, Craig T. Parker, Tackeshy N. Pinedo Vasquez, Paul F. Garcia Bardales, Pablo Peñataro Yori, Maribel Paredes Olortegui, Katia Manzanares Villanueva, Lucero Romaina Cachique, Hermann Silva Delgado, Matthew D. Hitchings, Steven Huynh, Samuel K. Sheppard, Ben Pascoe, Margaret N. Kosek

“…ABSTRACT Campylobacter is a serious health threat because of the rapid progressive evolution of antimicrobial resistance and efficient transmission from zoonotic as well as human sources. …”
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…These results support the progress of this sEV-based therapy in an early-phase clinical trial, the details of which are presented and discussed in this work. …”
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Tp53 determines the spatial dynamics of M1/M2 tumor-associated macrophages and M1-driven tumoricidal effects by Yi-Jing Hsiao, Min-Shu Hsieh, Gee-Chen Chang, Yin-Chen Hsu, Chia-Yu Wang, Yan-Ming Chen, Yi-Ling Chen, Pan-Chyr Yang, Sung-Liang Yu

“…Stromal M1 TAMs were positively correlated with disease progression and smoking history. In contrast, islet M1/M2 TAMs were predominantly found in tumors with wild-type TP53 (wtp53) but not associated with EGFR status. …”
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MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…Abstract Background Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis and a high risk of progression to acute myeloid leukemia. Elucidating the mechanism underlying the dysfunction of MDS-HSCs is crucial for exploring the pathogenesis of the syndrome. …”
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