Glycated hemoglobin and microalbuminuria in patients with type 2 diabetes mellitus by Afrim Zeqiraj, Dafina Zeqiraj, Teuta MullaGoga, Fidel Krasniqi, Agim Shabani, Sanije Berisha, Agim Berisha, Blerim Morina, Florjana Zogaj

“…Microalbuminuria is the earliest stage of progressive kidney damage, the simplest and most reliable predictor for assessing the probability of overt nephropathy in diabetes. …”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…Abstract Background Anti‐N‐methyl‐D‐aspartate receptor encephalitis (anti‐NMDARE) is a prevalent type of autoimmune encephalitis caused by antibodies targeting the NMDAR's GluN1 subunit. While significant progress has been made in elucidating the pathophysiology of autoimmune diseases, the immunological mechanisms underlying anti‐NMDARE remain elusive. …”
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Dual disease co-expression analysis reveals potential roles of estrogen-related genes in postmenopausal osteoporosis and Parkinson’s disease by Dongdong Yu, Dongdong Yu, Jian Kang, Chengguo Ju, Qingyan Wang, Ye Qiao, Ye Qiao, Long Qiao, Long Qiao, Dongxiang Yang

“…There is a possibility that PMO and PD may share underlying molecular mechanisms that are pivotal in their development and progression. The objective of this study was to identify critical genes and potential mechanisms associated with PMO by examining co-expressed genes linked to PD.MethodsInitially, pertinent data concerning PMO and PD were obtained from the GWAS database, followed by conducting a Bayesian colocalization analysis. …”
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Functional and Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels by Elina Polunosika, Joel Simren, Arta Akmene, Nikita Klimovskis, Kaj Blennow, Daina Pastare, Henrik Zetterberg, Renars Erts, Guntis Karelis

“…The disease can manifest and progress with both physical and cognitive symptoms, affecting the patient’s daily activities. …”
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Preparation of oat galactolipid and anti-liver cancer effects of oat galactolipid–modified curcumin-loaded liver targeting vesicle by Huiying Ren, Nuo Chen, Yanqing Liu, Meimei Wu, Meimei Wu, Meimei Wu, Jingsong Yan, Jingsong Yan, Jingsong Yan, Mingxiang Chang, Mingxiang Chang, Mingxiang Chang, Hanmin Li, Hanmin Li, Hanmin Li

“…IntroductionThe mortality rate for liver cancer is extremely high but clinical treatments have not made much progress, so it is necessary to develop anticancer agents with lower toxicities and more effective liver-targeting drug delivery systems (LTDDSs). …”
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Lower Plasma β-Amyloid 1-42 Levels in Amnestic Mild Cognitive Impairment Compared to Healthy Individuals by Cynthia Cynthia, Jusak Nugraha, Muhammad Hamdan, Hari Basuki Notobroto, Silvia Francina Lumempouw, Rahajuningsih Dharma

“…BACKGROUND: Amnestic mild cognitive impairment (aMCI) is strongly associated with an increased risk of progression to Alzheimer’s disease (AD). In AD, cerebrospinal fluid (CSF) β-Amyloid 1-42 levels are known to decrease, a pattern which is also observed in aMCI. …”
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Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria by Michael Gilligan, Smathorn Thakolwiboon, Emma Orozco, Samantha Banks, Eoin P. Flanagan, Sebastian Lopez‐Chiriboga, Jan‐Mendelt Tillema, John R. Mills, Sean J. Pittock, Cristina Valencia Sanchez, Anastasia Zekeridou, Divyanshu Dubey, Andrew McKeon

“…Kaplan–Meier analysis revealed faster progression to wheelchair in patients who were immunotherapy refractory and with elevated CSF IgG index. …”
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Pancreatoduodenectomy without Vascular Resection in Patients with Primary Resectable Adenocarcinoma and Unilateral Venous Contact: A Matched Case Study by Luca Morelli, Raffaella Berchiolli, Simone Guadagni, Matteo Palmeri, Niccolò Furbetta, Desirée Gianardi, Matteo Bianchini, Niccola Funel, Giovanni Caprili, Luca Emanuele Pollina, Giulio Di Candio, Franco Mosca, Gregorio Di Franco, Alfred Cuschieri

“…Additionally, there were no statistical differences in the systemic progression of the disease (42.5% sPD vs. 45% nvrPD, p=0.82) or local plus synchronous systemic disease rates (2.5% sPD vs. 7.5% nvrPD, p=0.30). …”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…Conclusions Delayed effects of significantly declined lung function and high mortality were observed in the sRRLI model. DAD with progressive inflammation and fibrosis in bilateral lungs contributed to severe or even fatal complications after partial thoracic irradiation. …”
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LcProt: Proteomics‐based identification of plasma biomarkers for lung cancer multievent, a multicentre study by Hengrui Liang, Runchen Wang, Ran Cheng, Zhiming Ye, Na Zhao, Xiaohong Zhao, Ying Huang, Zhanpeng Jiang, Wangzhong Li, Jianqi Zheng, Hongsheng Deng, Yu Jiang, Yuechun Lin, Yun Yan, Lei Song, Jie Li, Xin Xu, Wenhua Liang, Jun Liu, Jianxing He

“…Furthermore, we explored the different patterns of plasma protein changes during the progression of lung cancer and used the explanations method to elucidate the roles of proteins in the multitask predictive model.…”
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Uncovering the role of tumor cGAS expression in predicting response to PD-1/L1 inhibitors in non-small cell lung cancer by Yuichi Ozawa, Yasuhiro Koh, Ryota Shibaki, Yuhei Harutani, Hiroaki Akamatsu, Atsushi Hayata, Takeya Sugimoto, Yuka Kitamura, Junya Fukuoka, Masanori Nakanishi, Nobuyuki Yamamoto

“…Unexpectedly, patients with high cGAS (H-score ≥ 220) demonstrated significantly shorter progression-free survival (PFS) of PD-1/L1 inhibitors when the PD-L1 TPS was high (median PFS: 143 days vs. not reached; p = 0.028); PFS at 18 months was 7% and 53% in the high and low cGAS groups, respectively while STING expression did not impact PFS. …”
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Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice by Xinyu Sun, Long Yun, Keming Xie, Renhui Liu, Xinyue Ren, Bokun Zeng, Xudong Cao, Zhi Li, Guihao Zhou, Bang Liu, Luo Peng, Lihong Yuan

“…PurposeGut microbiota dysbiosis significantly impacts ulcerative colitis (UC) progression and exacerbation. Probiotics show promise in UC management. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

“…Alzheimer's disease (AD) is a progressive condition marked by multiple underlying mechanisms. …”
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Molecular Mechanisms of Synergistic Effect of PRIMA‐1met and Oxaliplatin in Colorectal Cancer With Different p53 Status by Xiao‐lan Li, Jianbiao Zhou, Nicole Xin‐Ning Tang, Yi Chai, Meng Zhou, Ai‐di Gao, Zhong‐kai Lu, Han Min

“…PRIMA‐1met (APR‐246, eprenetapopt) restores the DNA‐binding capacity of different mutant P53 proteins. PRIMA‐1met has progressed to the Phase III clinical trial. Our study explores the combination therapy of PRIMA‐1met and L‐OHP for CRC with different p53 status. …”
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Basolateral amygdala volume in affective disorders using 7T MRI in vivo by Benedikt Kürzinger, Stephanie Schindler, Martin Meffert, Anja Rosenhahn, Robert Trampel, Robert Turner, Peter Schoenknecht, Peter Schoenknecht, Peter Schoenknecht

“…No quadratic associations were observed between surrogate parameters of disease progression and any of the examined amygdala volumes. …”
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Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT by Mateusz Koziński, Doruk Oner, Jakub Gwizdała, Catherine Beigelman-Aubry, Pascal Fua, Angela Koutsokera, Alessio Casutt, Argyro Vraka, Michele De Palma, John-David Aubert, Horst Bischof, Christophe von Garnier, Sahand Jamal Rahi, Martin Urschler, Nahal Mansouri

“…Performance correlates with BOS progression, with ROC-AUC values of 0.88 for stage I, 0.91 for stage II, and 0.94 for stage III BOS. …”
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Elevated miR-221-3p inhibits epithelial–mesenchymal transition and biochemical recurrence of prostate cancer via targeting KPNA2: an evidence-based and knowledge-guided strategy by Dingchao Li, Jingang Jian, Manhong Shi, Zihao Chen, Anguo Zhao, Xuedong Wei, Yuhua Huang, Yalan Chen, Jianquan Hou, Yuxin Lin

“…Then a knowledge-guided network strategy was applied to prioritize key targets of miR-221-3p in PCa progression based both on topological and functional characterization of genes in multi-omics miRNA-mRNA and protein-protein interaction networks. …”
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Role of stability analysis and waste discharge concentration of ternary hybrid nanofluid in a non-Newtonian model with slip boundary conditions by Nurhana Mohamad, Shuguang Li, Umair Khan, Anuar Ishak, Ali Elrashidi, Mohammed Zakarya

“…In pollutant-free conditions, the heat and mass transfer of ternary hybrid nanofluid (Ag-Cu-TiO2) progresses up to 0.34 % and 0.26 %, respectively, compared to H2O. …”
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Middle Cerebral Artery Pulsatility Index for Prediction of Successful Induction of Labour in Postdated Pregnancy: A Prospective Observational Study by Yashi Nagar, Rekha Bharti, Kajal Baleja, Amita Malik, Divya Pandey, Jyotsna Suri

“…Women were followed for progression to active labour, and mode of delivery was noted. …”
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Nesting population trend of the leatherback sea turtle in Bocas del Toro province and Comarca Ngäbe-Buglé, Panama for the period 2002–2022 by Sonia Gutiérrez Parejo, Susan E. Piacenza, Raúl García, Cristina Ordóñez, Roldán A. Valverde

“…Sea turtle biologists have made sustained efforts to understand the global status of leatherback sea turtle populations. However, despite progress in assessments, demographics, and ecology, key uncertainties persist in tracking leatherback population trends. …”
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