Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease by Chao-Chao Yu, Tao Jiang, Ao-Fei Yang, Yan-Jun Du, Miao Wu, Li-Hong Kong

“…Epigenetic modifications, such as noncoding RNA regulation, DNA methylation, and histone modification, can directly or indirectly affect the regulation of tau phosphorylation, thereby participating in AD development and progression. This review summarizes the current research progress on the mechanisms of epigenetic modification associated with tau phosphorylation.…”
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Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning by Yiqin Yang, Mei Dong

“…Results We show that the up-regulation of oxidative stress-related genes such as IDH1 and CD36 in resident-like macrophages and foam macrophages play a key role in the formation and progression of carotid atherosclerotic plaques. Conclusions We discuss the role of oxidative stress and immune inflammation in the formation, progression, and stabilization of plaques by combining predictive models with analysis of single-cell data. …”
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Prosthetic Aortic Valve Stenosis in End-Stage Renal Failure by Michael Mao, Mirelle El Ters, Sunil Mankad, Mira Keddis, Soon Park, Qi Qian

“…Although renal failure is one of the known comorbidities associated with rapid progression of aortic stenosis, it is unclear whether hemodialysis alters the progression of prosthetic aortic valve stenosis. …”
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Randomized geographic-based routing with nearly guaranteed delivery for three-dimensional ad hoc network by Alaa E. Abdallah, Emad E. Abdallah, Mohammad Bsoul, Ahmed Fawzi Otoom

“…The third algorithm G_3DRanDomProb tries to progress as much as possible to the destination, if the progress is not possible, the algorithm switches to 3DRanDomProb. …”
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The Biomechanics of Cervical Spondylosis by Lisa A. Ferrara

“…The altered posture of the cervical spine will progress into kyphosis and continue if the load balance and lordosis is not restored. …”
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A DOE (Response Surface Methodology) Approach to Predict the Strength Properties of Concrete Incorporated with Jute and Bamboo Fibres and Silica Fumes by Jayaprakash Sridhar, Dhanapal Jegatheeswaran, Ravindran Gobinath

“…Design of Experiment approach is adopted for deriving progression variables comprising jute fibres, bamboo fibres, and silica fumes. …”
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Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease by Jason R. Richardson, Muhammad M. Hossain

“…At present, it is not clear what causes this progression, and there are no current therapies that have been successful in preventing PD progression. …”
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Superficial Bladder Cancer Therapy by Emmanuel Schenkman, Donald L. Lamm

“…Intravesical chemotherapy reduces short-term tumor recurrence by about 20%, and long-term recurrence by about 7%, but has not reduced progression or mortality. Presently, BCG immunotherapy remains the most effective treatment and prophylaxis for TCC (Ta, T1, CIS) and reduces tumor recurrence, disease progression, and mortality. …”
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Potent Oral Hypoglycemic Agents for Microvascular Complication: Sodium-Glucose Cotransporter 2 Inhibitors for Diabetic Retinopathy by Eun Hyung Cho, Se-Jun Park, Seongwook Han, Ji Hun Song, Kihwang Lee, Yoo-Ri Chung

“…The purpose of this study was to investigate the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the progression of diabetic retinopathy (DR) in patients with type 2 diabetes. …”
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Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis by Làzaro Aurelio Vàzquez Gòmez, Carlos Hidalgo Mesa, Yunier Broche Pèrez, Yanet Valdés Morales

“…New lesions in T2 after the first 12 months of treatment was 0.90 ± 1.16 for the study group and 1 ± 1.10 for the control. Extended-scale progression of disability status, pretreatment annualized relapse rate, age of disease onset, time since disease progression, and gadolinium-enhancing lesions were significantly associated with the odds ratio of older Probability of non-progression for the study group with respect to the control group for the combined variable progression by extended disability status scale and relapses.…”
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Structural modeling of the effect of school culture on psychological well-being with the mediating role of narcissism and achievement emotions by maryam fallahi, samaneh salimi

“…The results of data analysis based on regression coefficients show that school culture has a 0.58 effect on psychological well-being, school culture has a 0.71 effect on progress emotions, school culture has an effect on narcissism 0.69, progress emotions have a 0.37 effect on psychological well-being, and narcissism has an effect on 0.71. …”
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Deciphering Parkinson’s Disease through Eye Movements: A Promising Tool for Early Diagnosis in the Face of Cognitive Impairment by Xianglian Liao, Jian Yao, Hongyin Tang, Yilan Xing, Xin Zhao, Daao Nie, Ping Luan, Guihua Li

“…However, there is still a lack of effective biomarkers to evaluate the decline in cognitive function and predict the progression of the disease, especially in the early stage. …”
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Associations between depressive and anxiety symptoms and incident kidney failure in patients with diabetic nephropathy by Chunmei Qin, Yucheng Wu, Yutong Zou, Yuancheng Zhao, Deying Kang, Fang Liu

“…The study endpoint was defined as progression to kidney failure. The cox proportional hazard analysis was performed to investigate the risk factors for progression to kidney failure in DN patients. …”
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Melanoma: From Melanocyte to Genetic Alterations and Clinical Options by Corine Bertolotto

“…Metastatic melanoma remained for decades without any effective treatment and was thus considered as a paradigm of cancer resistance. Recent progress with understanding of the molecular mechanisms underlying melanoma initiation and progression revealed that melanomas are genetically and phenotypically heterogeneous tumors. …”
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From Recurrent Syncope to Sudden Cardiac Death: Clinical Characteristics in a Chinese Patient Carrying a Plakophilin-2 Gene Mutation by Wenling Liu, Xiaoliang Qiu, Wen Liu, Dayi Hu, Tiangang Zhu, Chunling Wang, Dominik Beer, Li Zhang

“…Electrocardiograms and cardiac imaging show the progress of ARVC and these clinical milestones of disease are presented herein.…”
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Finerenone in the management of diabetes kidney disease by Parijat De, May T Khine, Andrew Frankel, Gabrielle Goldet, Debasish Banerjee, Rosa M Montero, Tahseen A Chowdhury, Damien Fogarty, Janaka Karalliedde, Ritwika Mallik, Dipesh C Patel, Mona Wahba, Peter Winocour, Sagen Zac-Varghese, Stephen Bain, Adnan Sharif, Srikanth Bellary, Indranil Dasgupta

“…Abstract People with type 2 diabetes are at risk of developing progressive diabetic kidney disease (DKD) and end stage kidney failure. …”
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Interleukin IL1a and IL6 gene polymorphism: search for association with APOE genotype and clinical course of sporadic Alzheimer’s disease by G. Pšemeneckienė, K. Petrikonis, D. Rastenytė

“…No significant differences of genotype frequencies in rapidly progressing AD compared to slowly progressing AD were revealed (p (IL1A -889C>T)=0.638; p (IL6 -174G>C)=0.118). …”
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Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy by Lorena Perrone, Carmela Matrone, Lalit P. Singh

“…Moreover, increasing evidences suggest that environmental factors such as chronic hyperglycemia are implicated DR progression and may also affect the epigenetic state. …”
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A Case of Definitive Therapy for Localised Prostate Cancer: Report of a Urological Nightmare by Andreas Sommerhuber, Verena Traxlmayr, Wolfgang Loidl

“…A case with local and later systemic progression after permanent brachytherapy is presented here.…”
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Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer by Perumal Elumalai, Jagadeesan Arunakaran

“…Thus, a non-toxic and effective mode of treatment is needed to control cancer development and progression. Some medicinal plants offer a safe, effective and affordable remedy to control the cancer progression. …”
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