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16781
Transition to home after very preterm birth: improving outcomes of children and their families—a systematic review protocol
Published 2024-12-01“…Introduction Medical progress has significantly improved the survival rates of very preterm-born infants in recent decades. …”
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16782
Efficacy of first-line chemotherapy combined with immunotherapy or anti-angiogenic therapy in advanced KRAS-mutant non-small cell lung cancer
Published 2025-03-01“…The correlation between these factors and progression-free survival (PFS) and overall survival (OS) were analyzed. …”
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16783
Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth
Published 2025-01-01“…Abstract Background The colon and rectum are highly innervated, with neural components within the tumor microenvironment playing a significant role in colorectal cancer (CRC) progression. While perineural invasion (PNI) is associated with poor prognosis in CRC, the impact of nerve density and diameter on tumor behavior remains unclear. …”
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16784
Long-term trends in the prevalence of cardiovascular-kidney-metabolic syndrome in South Korea, 2011–2021: a representative longitudinal serial studyResearch in context
Published 2025-02-01“…Our findings emphasize the urgent need for tailored public health strategies targeting metabolic risk factors, particularly in vulnerable subgroups, to prevent progression to advanced CKM stages. Funding: National Research Foundation of Korea.…”
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16785
Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease
Published 2025-01-01“…Altered membrane and synaptic properties of R6/2 CPNs recovered progressively, and by P21 they were similar to WT CPNs. …”
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16786
Psychological counselling interventions to improve perceived quality of life and counter anxiety and depression in pulmonary-arterial-hypertension patients: A clinical trial
Published 2020-12-01“…Introduction: Pulmonary Arterial Hypertension (PAH) is a rare and progressive disease, frequently associated with a worsening of perceived quality of life as well as anxiety and depression symptomatology. …”
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16787
Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib
Published 2025-01-01“…Evaluation was based on the Akaike information criterion (AIC) and concordance index(c-index). Median progression-free survival (mPFS) was 9.3/6.8/4.6 months for GNRI no-risk/low-risk/moderate-to-major risk (p < 0.01, AIC 4742.4/c-index 0.585). …”
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16788
The spatiotemporal changes and influencing mechanisms of the coastline in the Yellow River Delta, China
Published 2025-01-01“…Over the past 40 years, the modern YRD coastline has generally advanced seaward at an average rate of 109.64 m/a. This progression can be divided into three distinct phases: (i) The rapid transition period from 1984 to 2000, during which the total coastline length reached its maximum of nearly 440.65 km in the last 40 years. …”
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16789
Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients
Published 2020-01-01“…Carriage of PNPLA3 G∗ allele was associated with a trend of progressively more severe liver disease, from mild fibrosis to significant fibrosis, cirrhosis, and HCC (p=0.007). …”
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16790
Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy
Published 2025-01-01“…A potentially effective regimen was speculated for patients with high PCDI scores who tend to exhibit worse progression‐free survival.…”
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16791
The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers
Published 2025-02-01“…HIV-induced immunosuppression promotes the persistence of high-risk HPV infection and increased the progression to cervical cancer. The aim of this systematic review was to assessed the impact of HPV/HIV co-infection on the prevalence and distribution of HR-HPV genotypes, the level of immunosuppression and expression of cervical cancer biomarkers. …”
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16792
Perancangan User Experience Aplikasi Bimbingan Akademik Mahasiswa FILKOM Menggunakan Metode Human-Centered Design
Published 2022-02-01“…The new Standard Operating Procedure (SOP) guidelines at the Faculty of Computer Science (FILKOM) have been specially developed so that lecturers and students can periodically monitor the progress of student studies and see the shortcomings of student studies based on data analysis of student study results. …”
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16793
Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer
Published 2025-02-01“…In addition, subgroup analyses further showed that high RAD51 expression was associated with worsened OS [HR = 1.475, 95%CI (1.275–1.706), P < 0.01], DFS [HR = 1.584, 95%CI (1.133–2.215), P < 0.01] and progression-free survival (PFS) [HR = 2.439, 95%CI (1.172–5.075), P = 0.02]. …”
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16794
Navigating the Challenges of Sustainable Dental Practices: Opportunities for Green Innovation in Dentistry
Published 2025-01-01“… As environmental concerns progress, it is becoming increasingly crucial to consider the transition to sustainable periodontal care. …”
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16795
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16796
GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia
Published 2025-01-01“…Conclusions The study demonstrated that knockdown of GATA1 modulates M2 polarization of macrophage through the TrkB/cGMP–PKG signaling pathway, influencing the progression of PE. In addition, significant associations between GATA1 and the TrkB/cGMP–PKG signaling pathway were identified in the transcriptomic data from PE patient placentas.…”
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16797
UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer
Published 2025-01-01“…Abstract Background Immune cells within tumor tissues play important roles in remodeling the tumor microenvironment, thus affecting tumor progression and the therapeutic response. The current study was designed to identify key markers of plasma cells and explore their role in high-grade serous ovarian cancer (HGSOC). …”
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16798
Effects of dribbling restrictions in small-sided games on aerobic and anaerobic fitness in youth basketball players
Published 2025-01-01“…Both experimental groups followed identical SSG formats, court dimensions, and training regimens, with the only difference being that one group participated in free play while the other group was prohibited from dribbling during progression. Aerobic capacity was assessed using the Yo-Yo Intermittent Recovery Test Level 1 (YYIRT), while the 30-second Wingate Test measured peak power output (PPO) and average power output (APO) at baseline and post-intervention. …”
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16799
Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy
Published 2025-01-01“…Increasing evidence suggests that autophagy plays a crucial role in the initiation and progression of epilepsy. However, the precise mechanisms by which autophagy deficiencies involved in epileptogenesis are still not fully understood.MethodsTwo datasets of epilepsy (GSE143272 and GSE256068) were downloaded from the Gene Expression Omnibus (GEO) database. …”
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16800
c-FLIP and microRNA 708-5p gene expression in newly diagnosed and chemotherapy in acute myeloid leukemia of Iraqi patient
Published 2024-12-01“…Furthermore, miRNA 708-5p can act as a prognostic indicator in AML, with its expression levels offering valuable insights into disease progression and patient response to treatment. Further research into miRNA 708-5p can lead to a better understanding of its role in AML pathogenesis and its potential applications in clinical practice.…”
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