Assessment of Strategy Disclosure Drivers in Annual Company Report: A Meta-Synthesis Analysis by Akram Taftiyan, Mohammad Salari Abarghuoi

“…While disclosing forward-looking statements, like the progress of business strategies' implementation, in annual reports offers insight into the company's direction from management to financial analysts, it can also entail certain costs by potentially harming the company's competitive position.   …”
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Telaprevir: options of application in separate patient groups by M. V. Mayevskaya, I. N. Tikhonov, V. T. Ivashkin

“…Studying of telaprevir application options for treatment of patients with CHC relapse in post-transplantation period, patients with chronic renal disease, including those, receiving renal substitution therapy is still in progress. The primary data received in studies, devoted to these issues, enable to expect expansion of indications and options of three-componential AVT application.Conclusion. …”
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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn’s Disease by Yang X, Pan Y, Gao CP, Li H, Zhang YH, Huang CL, Cao L, Xiao SY, Zhou Z

“…The intestinal microbiota plays a crucial role in the development and progression of CD. However, its role in intestinal fibrous stenosis is poorly understood. …”
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Efficiency and safety of HAIC combined with lenvatinib and tislelizumab for advanced hepatocellular carcinoma with high tumor burden: a multicenter propensity score matching analys... by Zhonghua Zhao, Xiongying Jiang, Shiping Wen, Yanzhang Hao

“…Our primary endpoint was overall survival (OS); and secondary endpoints included adverse events (AEs), progression-free survival (PFS), disease control rate (DCR) and objective response rate (ORR) according to RECIST 1.1 criteria, respectively.ResultsAfter eligibility reviewed, total 162 patients treated with lenvatinib and tislelizumab were enrolled: 63 patients with HAIC (HTP group), and the remaining 99 patients without HAIC (TP group). …”
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Assessment of Teachers’ Turnover and its Impact on Academic Performance in Government Aided Secondary Schools of Kayonza Sub-County Kanungu District. by Biryomumeisho, Gideon

“…Respondents indicated that the frequent changes in teaching staff disrupt the continuity of learning, weaken teacher-student relationships, and ultimately hinder students’ academic progress. Several factors were identified as contributing to teacher turnover. …”
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Jiedu Xiaozheng Decoction Augments 5-fluorouracil Induced Anti-hepatic Carcinoma Effect <italic>in Vitro</italic> and <italic>in Vivo</italic> by Zhiyun CAO, Liangpu ZHENG, Wei LIN, Xuzheng CHEN, Xiaoqin ZHU, Jiumao LIN, Wei LIN, Jian DU

“…In contrast, mice treated with either 5-FU, EE-JXD or 5-FU plus EE-JXD showed slower progression of established tumors. Control mice reached a total tumor weight of(0.43±0.06)g within 30 days. …”
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A preliminary study on the prognostic significance of cysteine-rich EGF ligand domain 2 protein (CRELD2) in patients with triple negative breast cancer by Mehmet Zahid Kocak, Murat Araz, Siddika Findik, Aykut Demirkiran, Mustafa Korkmaz, Melek Karakurt Eryilmaz, Mehmet Artac

“…In the survival analysis of the non-metastatic patient group, five-year overall survival (OS) rate was 91.7% in the CRELD2-positive patient group and 91% in the negative group (P = 0.91). Median progression free survival (PFS) was 9.4 (95% confidence interval [CI]: 6.4–12.4) months in the CRELD2-positive group and 11.9 (95% CI: 8.2–18.6) months in the CRELD2-negative group (P = 0.04). …”
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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…A better understanding of those pathways is important for the progress of knowledge on the pathophysiology of severe mental disorders according to the one health model, that promotes a collaborative, multisectoral, and transdisciplinary approach across various levels to optimize health outcomes by recognizing the interconnectedness of humans, animals, plants, and their shared environment.…”
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VCP regulates early tau seed amplification via specific cofactors by Sushobhna Batra, Jaime Vaquer-Alicea, Clarissa Valdez, Skyler P. Taylor, Victor A. Manon, Anthony R. Vega, Omar M. Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J. Cairns, Charles L. White, Marc I. Diamond

“…Abstract Background Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. …”
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Relationship between CTF1 gene expression and prognosis and tumor immune microenvironment in glioma by Hongqing Cai, Shen Tian, Angsi Liu, Guanchao Xie, Hongsheng Zhang, Xiaogang Wu, Jinghai Wan, Sai Li

“…The involvement of CTF1 in m6A modifications contributed to glioma progression. Enrichment analysis revealed immune response pathways linked with CTF1 in glioma, including natural killer cell cytotoxicity, NOD-like receptor signaling, Toll-like receptor signaling, antigen processing, chemokine signaling, and cytokine receptor interactions. …”
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Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Lev... by Fabiana Corsi-Zuelli, Gary Donohoe, Siân Lowri Griffiths, Cristina M. Del-Ben, Andrew J. Watson, Tom Burke, Paris A. Lalousis, Declan McKernan, Derek Morris, John Kelly, Colm McDonald, Saahithh R. Patlola, Carmine Pariante, Nicholas M. Barnes, Golam M. Khandaker, John Suckling, Bill Deakin, Rachel Upthegrove, Maria R. Dauvermann

“…Cognitive deficits, reduced brain cortical thickness and volumes, and inflammation may contribute to depressive and negative symptoms, but pharmacological treatment and disease progression may confound the associations. Methods: We evaluated whether higher plasma interleukin 6 (IL-6) levels would be associated with more severe negative or depressive symptoms in schizophrenia and explored illness stage utilizing early (BeneMin [Benefit of Minocycline on Negative Symptoms of Psychosis: Extent and Mechanism], n = 201, 72.8% male) and established (iRELATE [Immune Response &amp; Social Cognition in Schizophrenia], n = 94, 67.3% male) schizophrenia cohorts. …”
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Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study by Jie Yuan, Hai Long, Min Liu, Juan He, Jue Liu, Yu Wu, Wenzhan Jing, Min Du, Manna Zhang, Yaping Wang, Su Song, Siqi Liu, Guiying Cao, Yuedong Liang, Xiaoxin Xie, Yanhua Fu

“…Determination of anaemia predictors, early detection and timely management of anaemia are crucial to prevent anaemia progression.…”
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Fusobacterium nucleatum and Treponema denticola are robust biomarkers for gingivitis and periodontitis in small dogs by Daehyun Kwon, Daehyun Kwon, Kisuk Bae, Kwangsik Jang, Kwangsik Jang, Hyun Min Jo, Hyun Min Jo, Seong Soo Kang, Seong Soo Kang, Jonghoe Byun, Se Eun Kim, Se Eun Kim

“…It starts with gingivitis, a reversible condition, and progresses to an irreversible condition, periodontitis. …”
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Effectiveness of a specialist palliative home care nurse–patient consultation followed by an interprofessional telephone case conference compared with usual care among patients wit... by Judith Dams, Hans-Helmut König, Tim Friede, Nils Schneider, Stephanie Stiel, Martin Scherer, Silke Böttcher, Gabriella Marx, Ingmar Schäfer, Nadine Janis Pohontsch, Hendrik van den Bussche, Friedemann Nauck, Michael Freitag, Eva Hummers, Tina Mallon, Franziska Schade, Manuel Zimansky, Thomas Asendorf, Christiane A Mueller

“…Introduction Progressive chronic, non-malignant diseases (CNMD) like congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and dementia are of growing relevance in primary care. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

“…Secondary endpoints included duration of response (DoR), disease control rate, progression-free survival (PFS), overall survival (OS), and safety. …”
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Case report: Successful treatment of hyperbaric oxygen for radiation-induced hemorrhagic cystitis in a 95-year-old patient with bladder cancer by Li Lin, Li Lin, Man He, Yanyan Zeng, Xiaoxiao Ni, Yequn Guo, Xiaojuan Xie, Lingling Sun, Huai Huang

“…After a series of subsequent therapies that failed to control the hematuria, the patient received 196 HBOTs between 11 October 2022 and 23 October 2023. Following a progressively adjusted HBOT protocol, the patient’s hematuria (urine red blood cell (RBC) count showed 210,859 RBC/μL at maximum) was effectively controlled, and his symptoms subsequently resolved after 69 HBOTs. …”
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Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer by Fangze Wei, Xiaotian Xu, Jing Wang, Shi Wen Mei, Fu Qiang Zhao, Fei Huang, Ti Xian Xiao, Guo Jing Wang, Baojun Wei, Shengkai Huang, Wei Cui

“…Microsatellite stability (MSS) and microsatellite instability (MSI-high) are important molecular subtypes of CRC closely related to tumor occurrence and progression and immunotherapy efficacy. The presence of CD8+ CXCR5+ follicular cytotoxic T (TFC) cells is strongly associated with autoimmune disease and CD8+ effector function. …”
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Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation by Jessy Sirera, Saharnaz Sarlak, Manon Teisseire, Alexandrine Carminati, Victoria J. Nicolini, Coline Savy, Patrick Brest, Thierry Juel, Christophe Bontoux, Marcel Deckert, Mickael Ohanna, Sandy Giuliano, Maeva Dufies, Gilles Pages, Frederic Luciano

“…The impact of USP39 knockdown via SiRNA was assessed through in vitro assays measuring cellular metabolism, clonogenic capacity, cell cycle progression, apoptosis, and sensitivity to BTZ. Co-immunoprecipitation and deubiquitination assays were conducted to elucidate the interaction and regulation of ZEB1 by USP39. …”
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From pollution to sustainable environment: unlocking the role of energy intensity and renewable energy in highly pollutant nations by Zhi Zhen Zhou, Muhammad Shahid Hassan, Muhammad Ibrahim Saeed, Haider Mahmood, Rukhsana Kalim, Amira Houaneb

“…The causal relation suggests feedback between emissions and economic progress, EI, REC, and non-REC, which highlights the interdependence of the energy sector and environmental outcomes. …”
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Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma by Nailya Kubysheva, Marina Boldina, Tatyana Eliseeva, Svetlana Soodaeva, Igor Klimanov, Anastasia Khaletskaya, Venera Bayrasheva, Valery Solovyev, Luis Alfonso Villa-Vargas, Marco Antonio Ramírez-Salinas, Moisés Salinas-Rosales, Dmitry Yu. Ovsyannikov, Ildar Batyrshin

“…In patients with COPD, the levels of IL-17 and TNF-α increased progressively against the background of a decrease in numerous spirometric indicators, which allows us to consider these cytokines as systemic biomarkers of disease severity. …”
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