Donafenib combined with sintilimab for advanced hepatocellular carcinoma: a single arm phase II trial by Xiaoyang Hong, Yongjian Guo, Wenbo Shi, Kangshun Zhu, Licong Liang, Liteng Lin, Ye Chen, Jingwen Zhou, Jingjun Huang, Jiabai Huang, Yaozhu Wu, Wensou Huang, Mingyue Cai

“…The primary endpoint of this study was progression-free survival (PFS) per mRECIST. Results 30 patients were enrolled. …”
Get full text

Disorders of circadian rhythms of heart rate variability in diabetic cardiac autonomic neuropathy: mechanisms and consequences by V.A. Serhiyenko, M.I. Dolynay, V.B. Sehin, Y.V. Lazur, A.A. Serhiyenko

“…Particular attention is paid to the risk factors of diabetic CAN; insights into the mechanisms of excess mortality associated with CAN; the pathogenesis of diabetic CAN; possible pathogenic pathways binding CAN and atherosclerosis progression; genetic and epigenetic factors and CAN; DM and circadian rhythms of HRV; diabetic CAN and circadian rhythm disorders. …”
Get full text

Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retro... by Ha Young Jo, Hyun Ji Jang, Chong Kun Cheon, Ju Young Yoon, Sukdong Yoo, Jung Hyun Lee, Jeong Eun Lee, Ye Jin Kim, Sejin Kim, Hyun-Ji Kim, Im Jeong Choi, Min Jung Kwak

“…Notably, there was significantly rapid bone age progression among patients without GHD. The findings showed differences in GH dose according to GHD starting from the 2nd year of therapy, with the non-GHD group receiving a significantly higher dose. …”
Get full text

Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells by Adhish S. Walvekar, Marc Warmoes, Dean Cheung, Tim Sikora, Najmesadat Seyedkatouli, Gemma Gomez-Giro, Sebastian Perrone, Lisa Dengler, François Unger, Bruno F. R. Santos, Floriane Gavotto, Xiangyi Dong, Julia Becker-Kettern, Yong-Jun Kwon, Christian Jäger, Jens C. Schwamborn, Nicole J. Van Bergen, John Christodoulou, Carole L. Linster

“…Pathogenic loss-of-function variants in NAXE and NAXD lead to development of the neurometabolic disorders progressive, early-onset encephalopathy with brain edema and/or leukoencephalopathy (PEBEL)1 and PEBEL2, respectively. …”
Get full text

Clinical analysis of molecular typing of 146 cases of endometrial carcinoma by Bo Zhang, Bo Zhang, Dan Zhou, Shuo Zhang, Jinbowen Yan, Qingwei Meng, Qiubo Lv

“…There were significant differences observed among the four TCGA types and pathological types, pathological grades, FIGO stage, lymph node metastasis, and LVSI. The progression-free survival (PFS) rates of patients with POLE hypermutation, MSI-H type, CNL type, and CNH type were 100%, 100%, 93.62%, and 73.3%, respectively. …”
Get full text

Tumor-associated-fibrosis and active collagen-CD44 axis characterize a poor-prognosis subtype of gastric cancer and contribute to tumor immunosuppression by Yingqi Yang, Haohan Sun, Hongkai Yu, Luyao Wang, Chang Gao, Haokun Mei, Xiaomeng Jiang, Minghui Ji

“…Single-cell transcriptome analysis showed active Collagen-CD44 signaling axis between cancer-associated fibroblasts (CAFs) and immune cells in gastric cancer, with ECM-related genes upregulated during tumor progression. The expression of CD44 was significantly elevated in the subtype, associated with poor prognosis and tumor immune suppression in gastric cancer, potentially involved in the recruitment of immunosuppressive cells such as M2 macrophages and regulatory T cells (Tregs) and the upregulation of multiple immune checkpoints including PD-1/PD-L1. …”
Get full text

Impact of Prophylactic Use of PEG-rhG-CSF on First-Line Immunochemotherapy in Advanced NSCLC: A Cohort Study by Li Sun, MD, Yuan Tian, MD, Shuling Zhang, MD, PhD, Letian Huang, MD, Jietao Ma, MD, PhD, Chengbo Han, MD, PhD

“…The primary end points were progression-free survival (PFS), overall survival (OS), overall response rate, and safety. …”
Get full text

A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

“…Background: The intricate interactions between malignant cells and endothelial cells (ECs) are crucial in the progress of colorectal cancer (CRC). Identifying molecular signatures associated with this interaction could yield critical prognostic insights and inform personalized therapeutic approaches. …”
Get full text

Immune checkpoint inhibitors in cancer patients with autoimmune disease: Safety and efficacy by Jiayuan Le, Yuming Sun, Guangtong Deng, Yating Dian, Yanli Xie, Furong Zeng

“…However, no statistically significant differences were observed in the incidence of grade ≥3 irAEs, objective response rate (ORR), disease control rate (DCR), overall survival (OS), and progression-free survival (PFS) between the two groups. …”
Get full text

Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease by Wenxuan Wang, Sarah J. Myers, Nikita Ollen-Bittle, Shawn N. Whitehead

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease that accounts for two-thirds of all dementia cases, and age is the strongest risk factor. …”
Get full text

Guillain-Barré syndrome following falciparum malaria infection: a case report by Molla Asnake Kebede, Alemayehu Beharu Tekle, Misikir Alemu Eshetu, Erkyehun Pawlos Shash, Melaku Tsediew Berhanu, Elias Tabiet Ahmed, Hashime Meketa Negatie

“…Subsequently, the weakness progressed upward to involve her upper extremities. …”
Get full text

Network characteristics of referrals for chronic disease patients: results from hierarchical medical reform in Shenzhen, China by Fangfang Gong, Junxia Luo, Zhihong Wang, Ping Tang, Guangyu Hu, Ying Zhou, Hanqun Lin

“…However, poor communication between secondary hospitals and other institutions, high demand for data informatisation, and the gap between private and public PCFs may hinder further progress.…”
Get full text

Computational studies and structural insights for discovery of potential natural aromatase modulators for hormone-dependent breast cancer by Snehal Aditya Arvindekar, Sanket Rathod, Prafulla Balkrishna Choudhari, Pradnya Kiran Mane, Aditya Umesh Arvindekar, Suraj Narayan Mali, Bapu Thorat

“…Introduction: The aromatase enzyme plays an important role in the progress of hormone-dependent breast cancer, especially in estrogen receptor-positive (ER+) breast cancers. …”
Get full text

Machine learning for the diagnosis accuracy of bipolar disorder: a systematic review and meta-analysis by Yi Pan, Pushi Wang, Bowen Xue, Yanbin Liu, Xinhua Shen, Shiliang Wang, Xing Wang

“…However, in current research, they are predominantly utilized for binary classification tasks, limiting their progress in clinical practice. Therefore, in future studies, we anticipate the development of more multi-class classification tasks to enhance the clinical applicability of these methods.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
Get full text

Comparison of the clinicopathological characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis with/without infection at diagnosis by Li-Li Long, Mei Tan, Hui Deng, Hui Tang, Xiao-Qing Lin, Miao Zhang, Hui-Ying Deng, Xia Gao

“…Besides, lower levels of eGFR and ALB were also observed in the infected group. 5 (45.5%) and 13 (59.1%) patients died or progressed to ESRD, respectively, in the non-infected group and infected group at the last follow-up. …”
Get full text

A Collision-Free Path-Planning Method for an Articulated Mobile Robot by P. Quintero-Alvarez, G. Ramirez, S. Zeghloul

“…Even in a free environment, under some circumstances, the robot may be blocked by its trailers in its progression towards the goal. The proposed approach, compared to other methods, has the main advantage of integrating anti-collision constraints between the articulated robot itself and the environment, in order to avoid and resolve dead-lock situations. …”
Get full text

Hantavirus Cardiopulmonary Syndrome and Diffuse Alveolar Hemorrhage in the Era of COVID-19 by Khizar Hamid, Swaminathan Perinkulam Sathyanarayanan, Touba Naim, Muhammad Hamza, Mirza Omer Mahmood Baig, Emad Abu Sitta

“…The cardiopulmonary phase occurs from increased permeability of pulmonary capillaries and in severe cases can progress to cardiogenic shock. Diagnosis is based on the presence of IgM and IgG Hantavirus antibodies. …”
Get full text

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results... by Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stéphanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwé, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frédéric Amant, Katrien Vandecasteele, Hannelore G. Denys

“…Median interval-censored progression-free survival was 4.1 weeks (95% CI 4.1–25.7) in cervical cancer and 3.6 weeks (95% CI 3.6–15.4) in endometrial cancer; median overall survival was 39.6 weeks (95% CI 15.0–67.0) and 37.4 weeks (95% CI 19.0–50.3), respectively. …”
Get full text

LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…One early-onset PD subject was homozygous for p.Ala419Val who developed fast progression and severe dyskinesias. p.Ala419Val was associated with early-onset PD. …”
Get full text

Association between chronic respiratory diseases and frailty in Chinese elderly: a population-based longitudinal study by Ting Yang, Ping He, Dawei Zhu, Dan Guo, Ruoxi Ding, Ke Huang, Yanan Zhao, Xiaolong Guan

“…Active treatment and control of CRDs are necessary to avoid frailty caused by primary lung disease progression or exacerbation.…”
Get full text