Updated Bayesian network meta-analysis on the efficacy and safety of PD−1 versus PD−L1 inhibitors in first−line treatment with chemotherapy for extensive−stage small-cell lung canc... by Ke Wang, Ke Wang, Chuangjie Zheng, Chuangjie Zheng, Xinrong Chen, Xinrong Chen, Penghui Lin, Mengge Lin, Cuizhen Chen, Linzhu Zhai

“…ObjectiveTo compare the efficacy and safety of programmed cell death 1 inhibitors plus chemotherapy (PD-1 + Chemo) and programmed cell death ligand 1 inhibitors plus chemotherapy (PD-L1 + Chemo) for the treatment of extensive-stage small-cell lung cancer (ES-SCLC).MethodsWe performed a meta-analysis of relevant data using R software, considering overall survival (OS), progression-free survival (PFS), and grade ≥ 3 treatment-related adverse events (TRAES).ResultsPD-1 + Chemo (OS: hazard ratio [HR] 0.71; PFS: HR 0.59) and PD-L1 + Chemo (OS: HR 0.72; PFS: HR 0.73) significantly prolonged survival and did not increase the incidence of grade ≥3 TRAEs compared with chemotherapy. …”
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Experimental investigation into the Impact of Cyclic High Low Pressure Water Immersion on the Pore structure and Mechanical properties of coal by Pi Zikun, Li Rui, Wang Yan, Xiong Jiawen, Li Jiayi, Zhang Yifu, Peng Bin

“…The findings reveal that the porosity of coal samples subjected to high-pressure continuous immersion and high-low pressure cyclic immersion initially decreases slightly before increasing as the immersion cycle progresses. The maximum porosity enhancements observed were 1.55% and 2.93%, respectively, while the total connectivity increased by 19.07% and 24.79%, respectively. …”
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In Vitro Effect of Estradiol and Progesterone on Ovine Amniotic Epithelial Cells by Annunziata Mauro, Hashimita Sanyal, Angelo Canciello, Paolo Berardinelli, Valentina Russo, Nicola Bernabò, Luca Valbonetti, Barbara Barboni

“…Since AEC amplifications are accompanied by the loss of their native epithelial phenotype and by the progressive reduction of relevant biological properties, the issue to be addressed is the development of effective culture protocols. …”
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Identification of a Ferroptosis-Related Signature Associated with Prognosis and Immune Infiltration in Adrenocortical Carcinoma by Xi Chen, Lijun Yan, Feng Jiang, Yu Lu, Ni Zeng, Shufang Yang, Xianghua Ma

“…Ferroptosis, a new form of cell death, differs from other forms of cell death and plays a vital role in tumor progress. Our study aimed to establish a ferroptosis-related signature with prognostic value in ACC. …”
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Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells by Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew J. K. Jones, Yaowu He, John D. Hooper, Nigel A. J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Daniela Cimini, Jing Chen, Brian Gabrielli

“…Investigation of mitosis in these cells revealed high numbers of centrosomes that were capable of supporting functional mitotic spindle poles, but these failed to progress to anaphase/telophase structures even when AURKB inhibitor was removed after 2–3 days. …”
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Navigating DR-TB Treatment care: a qualitative exploration of barriers and facilitators to retention in care among people with history of early disengagement from drug-resistant tu... by Ndiviwe Mphothulo, Sindisiwe Hlangu, Jennifer Furin, Mosa Moshabela, Marian Loveday

“…These challenges can hinder retention in care, undermining the progress made in DR-TB management. As a consequence, advances in DR-TB diagnostics and treatment have not resulted in DR-TB programs meeting the 75% treatment success targets set by the World Health Organization (WHO). …”
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Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study by Siqi Dong, Xiaoni Liu, Yanni Zhou, Jiatong Li, Zihan Qi, Zihan Wang, Wenbo Yang, Xiangjun Chen

“…Furthermore, baseline sNfL concentrations, as well as cNfL levels, emerged as predictive indicators of subsequent disease progression rate (sNfL: p < 0.0001, cNfL: p = 0.0005) and overall survival (sNfL: p = 0.0073, cNfL: p = 0.0044). …”
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OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer by Qihui Sun, Xiaoqi Zhu, Qi Zou, Yang Chen, Tingting Wen, Tingting Jiang, Xiaojia Li, Fang Wei, Keping Xie, Jia Liu

“…Methods We constructed a prognostic and risk assessment model for pancreatic cancer using 101 machine learning algorithms, identifying OSBPL3 as a key gene associated with disease progression and prognosis. We integrated multi-dataset analyses, single-cell transcriptomic data, and functional experiments to explore the role of OSBPL3 in pancreatic cancer. …”
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Analysis of Microstructure and Performance of Cr₃C₂/Ni60A Coating on 45 Steel for Laser Cladding Piston Rod by Jiafei Pu, Viacheslav Tarelnyk, Yao Ju, Bondarev Sergii Grigorievicth, Xingrong Wang, Qi Dong, Hongfeng Wang, Weiwei Song

“…The results reveal that the solidification structure of the molten pool exhibits a progression from coarse columnar crystals and dendrites near the interface with the substrate to equiaxial crystals at the coating surface. …”
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Long-Term Effects of Balance Training on Habitual Physical Activity in Older Adults with Parkinson’s Disease by Håkan Nero, Erika Franzén, Agneta Ståhle, Martin Benka Wallén, Maria Hagströmer

“…The HiBalance program is a progressive and highly challenging balance training intervention incorporating Parkinson’s disease (PD) specific balance components. …”
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Association between poor drug adherence and undernutrition among adult HIV patients in southern Ethiopia: an institution based cross sectional study by Muluken Bekele Sorrie, Nigus Kabtu Belete, Tesfaye Feleke Gadore, Darik Temesgen Assefa, Manaye Yihune Teshale, Eshetu Zerihun Tariku

“…Good adherence to antiretroviral therapy (ART) indirectly helps prevent undernutrition by suppressing viral load, increasing CD4 count, preventing viral resistance, enhancing immune reconstitution and delaying disease progression in HIV patients. This study aims to assess the association between poor drug adherence and undernutrition among adult HIV patients in southern Ethiopia.Study design An institution based cross sectional study design was used.Setting and participants The study was conducted in 406 randomly selected adult HIV patients from Gamo zone public health facilities.Primary and secondary outcomes The data were collected by a trained data collector using a structured interviewer administered questionnaire, patient record review and physical measurements. …”
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Regulatory factor X‐5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness by Zhi‐Zhong Zhang, Zi‐Ming Wang, Hao‐Wen Zhang, Yan‐Xin Gong, Hao‐Ran Sun, Wei Zhang

“…This study identified a novel role for the RFX5/STIL axis in HCC progression, which may offer treatment targets for HCC.…”
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Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer by Xiao-Xia Cai, Guo-Ming Chen, Zi-Qi Zheng, Yi-Xin Yin, Shuang Wang, Li Qiao, Xiao-Jiang Chen, Bai-Wei Zhao, Jin-Ling Duan, Cheng-Cai Liang, Ruo-Peng Zhang, Cheng-Zhi Wei, Fei-Yang Zhang, Bo-Wen Huang, Ze-Xian Liu, Zhi-Wei Zhou, Dan Xie, Mu-Yan Cai, Shu-Qiang Yuan, Yuan-Fang Li, Run-Cong Nie

“…Abstract Background Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research comprehensively exploring tissue-derived lncRNAs for predicting peritoneal recurrence in patients with GC remains limited. …”
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Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure by Rima Kamel, Aurélia Bourcier, Jean Piero Margaria, Valentin Jin, Audrey Varin, Agnès Hivonnait, Françoise Mercier‐Nomé, Delphine Mika, Alessandra Ghigo, Flavien Charpentier, Vincent Algalarrondo, Emilio Hirsch, Rodolphe Fischmeister, Grégoire Vandecasteele, Jérôme Leroy

“…Conclusions Cardiac gene therapy with PDE2A limits left ventricle remodeling, dysfunction, and arrhythmias evoked by catecholamines, providing evidence that increasing PDE2A activity acutely could prevent progression toward heart failure.…”
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Long-Term Anatomic and Functional Outcomes after Macular Hole Surgery by Karolina Kaźmierczak, Joanna Stafiej, Joanna Stachura, Paweł Żuchowski, Grażyna Malukiewicz

“…After a successful closing of the MH, the restoration of the retina progresses at a slower pace than improvement in visual acuity.…”
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Outcomes following immunosuppressive therapy withdrawal after complete renal response in proliferative lupus nephritis by Javier Narváez, Francesca Mitjavila, Joan M Nolla, Paola Vidal-Montal, Montserrat Gomà, Xavier Fulladosa, Olga Capdevila, Joan Torras

“…In contrast, an IST duration exceeding 48 months prior to discontinuation (HR: 0.26), maintaining CRR for at least 48 months (HR: 0.32), achieving complete remission per DORIS (definition of remission in systemic lupus erythematosus) criteria at IST withdrawal (HR: 0.21) and gradual IST tapering (HR: 0.09) were associated with a reduced risk of RR.Following reintroduction of IST, 20 out of 29 patients (68.9%) achieved CRR, 5 (17.2%) achieved a partial response and 4 (13.8%) did not respond; of these, 3 patients (10.3%) progressed to end-stage renal disease.Conclusions Successful withdrawal of IST is possible in carefully selected patients with proliferative LN. …”
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Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis by Xuejie Gao, Qilin Feng, Qikai Zhang, Yifei Zhang, Chaolu Hu, Li Zhang, Hui Zhang, Guanli Wang, Ke Hu, Mengmeng Ma, Zhuning Wang, Yujie Liu, Dong An, Hongfei Yi, Yu Peng, Xiaosong Wu, Gege Chen, Xinyan Jia, Haiyan Cai, Jumei Shi

“…Conclusion Our data suggest that ENO1 promotes MM tumorigenesis and progression. ENO1 activates mitophagy by promoting the stability of YWHAZ and inhibits apoptosis and thus, leads to the drug resistance. …”
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Simulation of Flow Around a Finite Rectangular Prism: Influence of Mesh, Model, and Subgrid Length Scale by Xutong Zhang, Maxime Savoie, Mark K. Quinn, Ben Parslew, Alistair Revell

“…Numerical predictions from the RANS models were generally quite reasonable but did not show improvement with further refinement, as one would expect, whereas DDES clearly demonstrated continuous improvement in predictive accuracy with progressive mesh refinement. The shear-layer-adapted (SLA) subgrid length scale (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mo>Δ</mo><mi>SLA</mi></msub></semantics></math></inline-formula>) displayed consistently superior performance compared to the more widely used length scale based on local cell volume, particularly for moderate mesh resolutions commonly employed in industrial settings with limited resources. …”
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A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2– Metastatic Breast Cancer by Elizabeth J. Anderson, Lea E. Mollon, Joni L. Dean, Terri L. Warholak, Ayal Aizer, Emma A. Platt, Derek H. Tang, Lisa E. Davis

“…Recent evidence suggests combination therapy with the PI3K inhibitor (PI3Ki) alpelisib and endocrine therapy (ET) improves response rates and progression-free survival (PFS) in PIK3CA-mutant, hormone receptor positive (HR+) BC versus ET alone; thus, better understanding the clinical and epidemiologic elements of these mutations is warranted. …”
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Trends in Real-World Clinical Outcomes of Patients with Anaplastic Lymphoma Kinase (ALK) Rearranged Non-Small Cell Lung Cancer (NSCLC) Receiving One or More ALK Tyrosine Kinase Inh... by Lara Chayab, Natasha B. Leighl, Mina Tadrous, Christine M. Warren, William W. L. Wong

“…Kaplan–Meier analysis was performed to evaluate progression-free survival (PFS) and overall survival (OS) among the treatment groups. …”
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