Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study by Ying Fan, Qingyuan Zhang, Min Yan, Xiujuan Qu, Yongmei Yin, Tao Sun, Jin Yang, Ying Wang, Xu Wang, Zhaofeng Niu, Xinshuai Wang, Sanyuan Sun, Weihong Zhao, Yanping Liu, Miao Niu, Xuemin Zhao, Binghe Xu

“…The secondary endpoints were pharmacokinetic profiles and efficacy including objective response rate (ORR) and disease control rate (DCR) (all patients) and Central Nervous System ORR and clinical benefit rate (CBR, for patients with HER2-negative BCBM), duration of response, progression free survival (PFS), overall survival (OS). …”
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Renal Dysfunction among Ghanaians Living with Clinically Diagnosed Hypertension in the Asutifi-South District: A Cross-Sectional Descriptive Study at the St. Elizabeth Hospital, Hw... by Sylvester Yao Lokpo, James Osei-Yeboah, William K. B. A. Owiredu, Francis Abeku Ussher, Verner Ndudiri Orish, Felix Gadzeto, Paul Ntiamoah, Felix Botchway, Ivan Muanah, Romeo Asumbasiya Aduko

“…Regular screening and management are therefore recommended to avert progression to end-stage renal failure (ESRD).…”
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Exploring the association between pro-inflammatory diets and chronic liver diseases: evidence from the UK Biobank by Lili Pan, Lili Pan, Zhengrong Xu, Yining Li, Guoen Cai, Haibing Gao, Shenglong Lin

“…Moreover, a higher DII was positively associated with the progression of CLD to cirrhosis. Sensitivity analyses, including energy-adjusted DII and typical dietary DII, reinforced our results. …”
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Preparation and quality assessment of innovative gluten-free biscuit enriched with galangal (Alpinia galanga Linn.) powder by Eatemad M. El-Sayed, Essam Mohamed Elsebaie, Shaymaa A. Hozifa, Marwa Fawzi Ahmed El-Farsy, Dalia M. El-Mesiry, Soher Abd-Elfattah ElMeslamy, Heba Ali Yousef Shaat, Rehab A. Shehata, Marwa A. Ahmed, Amira Lotfy Abd Allah, Suzan S. Ibraheim

“…All biscuits enriched with galangal powder had lower levels of free fatty acids percentage, peroxide value, and TBARS than the control group, which increased progressively as storage duration was extended. Galangal powder is a promising idea for fortifying gluten-free baked items to increase their nutritional value and safety.…”
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Evaluation of treatment strategies for patients with stage IIIA non-small cell lung cancer in the immunotherapy era by Amy Alabaster, Jeffrey B. Velotta, Haley I. Tupper, Mark S. Walker, Yanina Natanzon

“…Data was from ConcertAI's curated EHR Patient360™ NSCLC real-world care product. Real-world progression-free survival (rwPFS) and overall survival (rwOS) were evaluated among patients treated with SC or CRI using Kaplan-Meier and Cox proportional hazard methods. …”
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Evaluation of Treatment Outcomes Using dNLR and GNRI in Combination Therapy With Atezolizumab and Bevacizumab for Hepatocellular Carcinoma by Atsushi Naganuma, Satoru Kakizaki, Atsushi Hiraoka, Toshifumi Tada, Takeshi Hatanaka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hidenori Toyoda, Chikara Ogawa, Hiroki Nishikawa, Takashi Nishimura, Kazuhito Kawata, Hisashi Kosaka, Masashi Hirooka, Yutaka Yata, Hideko Ohama, Hidekatsu Kuroda, Tomomitsu Matono, Tomoko Aoki, Yuki Kanayama, Kazunari Tanaka, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Shinichiro Nakamura, Hirayuki Enomoto, Masaki Kaibori, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada

“…The dNLR, NLR, and GNRI were calculated, and their impact on progression‐free survival (PFS) and overall survival (OS) was assessed. …”
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Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis by Kai Tang, Kai Tang, Kai Tang, Wei Deng, Wei Deng, Wei Deng, Wei Deng, Zhiying Huang, Zhiying Huang, Zhiying Huang, Simin Chen, Simin Chen, Simin Chen, Zilin Zhu, Zilin Zhu, Shukun Lin, Shukun Lin, Lubin Zhong, Lubin Zhong, Quanxin Zheng, Quanxin Zheng, Wenhua Zhao, Wenhua Zhao, Zhida Zhang, Zhida Zhang, Ling Mo, Ling Mo, Ling Mo

“…BackgroundOsteoporosis (OP), as the prevalent systemic metabolic bone disease worldwide, progresses insidiously and slowly. The clinical discomfort and complications associated with OP impose a significant burden on patients. …”
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Machine learning algorithms in constructing prediction models for assisted reproductive technology (ART) related live birth outcomes by Junwei Peng, Xiaoyujie Geng, Yiyue Zhao, Zhijin Hou, Xin Tian, Xinyi Liu, Yuanyuan Xiao, Yang Liu

“…A total of seven predictors were identified, namely maternal age, duration of infertility, basal follicle-stimulating hormone (FSH), progressive sperm motility, progesterone (P) on HCG day, estradiol (E2) on HCG day, and luteinizing hormone (LH) on HCG day. …”
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Clinical validation of explainable AI for fetal growth scans through multi-level, cross-institutional prospective end-user evaluation by Zahra Bashir, Manxi Lin, Aasa Feragen, Kamil Mikolaj, Caroline Taksøe-Vester, Anders Nymark Christensen, Morten B. S. Svendsen, Mette Hvilshøj Fabricius, Lisbeth Andreasen, Mads Nielsen, Martin Grønnebæk Tolsgaard

“…We used a modified Progressive Concept Bottleneck Model with pre-established clinical concepts as explanations (feedback on image optimization and presence of anatomical landmarks) as well as segmentations (outlining anatomical landmarks). …”
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Therapeutic effect and potential mechanism of Fufang Danshen dripping pills for stable coronary heart disease: a randomized controlled trial by Li-qin Meng, Li-qin Meng, Pei-ying Huang, Qing-min Li, Yu-chao Feng, Yu-chao Feng, Yu-chao Feng, Ding-jian Li, Guang-long Wu, Bo-wen Ao, Guo-chao Wu, Guo-xiong Zhang, Bo-jun Chen, Bo-jun Chen, Bo-jun Chen

“…This study aims to investigate the efficacy and preliminary mechanism by which FFDS may impact the progression of SCHD.MethodsBased on randomization, we administered oral FFDS to 30 patients with SCHD in addition to conventional treatment for 30 days. …”
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Genetic variations and clinical significance in young-onset nasopharyngeal cancer: Analysis of EBV interaction with cellular receptor variants and viral glycoproteins by Sulistyo Emantoko Dwi Putra, Farizky Martriano Humardani, Hikmawan Wahyu Sulistomo, Yulanda Antonius, Jonathan Jonathan, Riyan Charlie Milyantono, Artika Uthary, Risma Ikawaty

“…Considering EBV's widespread prevalence, understanding its role in NPC's future occurrence, disease progression, clinical symptoms, metastatic tendencies, and prognosis is crucial. …”
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Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice by Lorena Bavia, Íris A. de Castro, Mariane Tami Amano, Ana Maria Gonçalves da Silva, Silvio Arruda Vasconcellos, Lourdes Isaac

“…Our results showed that in A/J genetic background, the Complement component C5 modulates a cytokine profile in the liver and kidney of infected mice, which may play a role in the control of disease progression.…”
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A novel open-source cultivation system helps establish the first full cycle chemosynthetic symbiosis model system involving the giant ciliate Zoothamnium niveum by P. E. Contarini, E. Emboule, P. Jean-Louis, T. Woyke, S. V. Date, O. Gros, J-M. Volland, J-M. Volland, J-M. Volland

“…Chemosynthetic symbioses are globally distributed and ecologically significant, yet the lack of model systems has hindered research progress. The giant ciliate Zoothamnium niveum and its sulfur-oxidizing symbionts represent the only known chemosynthetic symbiosis with a short life span that has been transiently cultivated in the laboratory. …”
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Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery by Jeng-Fu You, Cheng-Chi Lee, Yun-Shien Lee, Yih-Jong Chern, Chun-Kai Liao, Hung-Chih Hsu

“…Additionally, a higher NKA recovery in patients with advanced stage exhibited improved recurrence-free survival (RFS) and progression-free survival (PFS) (hazards ratio (HR): 0.2442). …”
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Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Existence of a small subset of cancer cells referred to as tumor initiating stem cells (TISCs) largely responsible for tumor progression and resistance to chemotherapeutic cytostatic drugs reperesent an important recent paradigm shift. …”
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Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy by Guillermo Paz-López, Teresa M. Linares-Pineda, Andrés González-Jiménez, Raquel Sancho-Marín, Luis Ocaña-Wilhelmi, Francisco J. Tinahones, Sonsoles Morcillo, Carolina Gutiérrez-Repiso

“…Objective: Although DNA methylation has been suggested to be a potential predictor of the progression of obesity and obesity-related diseases, little is known about its potential role as predictive marker of successful weight loss after bariatric surgery. …”
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Early Identification of the Non-Transplanted Functional High-Risk Multiple Myeloma: Insights from a Predictive Nomogram by Yanjuan Li, Lifen Kuang, Beihui Huang, Junru Liu, Meilan Chen, Xiaozhe Li, Jingli Gu, Tongyong Yu, Juan Li

“…Patients who do not undergo maintenance therapy are prone to early progression or relapse.…”
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Circulating (CD3−CD19+CD20−IgD−CD27highCD38high) Plasmablasts: A Promising Cellular Biomarker for Immune Activity for Anti-PLA2R1 Related Membranous Nephropathy? by Agnieszka Pozdzik, Ingrid Beukinga, Chunyan Gu-Trantien, Karen Willard-Gallo, Joëlle Nortier, Olivier Pradier

“…Concomitantly, anti-PLA2R1 Ab increased progressively. Our single case report suggests that, besides monitoring of serum anti-PLA2R1 Ab level, enumeration of circulating plasmablasts and memory B cells represents an attractive and complementary tool to assess immunological activity and efficacy of RTX induced B cells depletion in anti-PLA2R1 Ab related MN.…”
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Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy by CHEN Min, AN Liying, LIN Xiaojing, ZHAO Pan, ZOU Xingli, WEI Jin, NI Xun

“…The results of univariate and multivariate analysis using the Cox regression model showed that a HALP score <29.15 was an independent risk factor for progression-free survival (PFS) and overall survival (OS) (P<0.05). …”
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Watermelon Germplasm with Resistance to Whitefly-transmitted Viruses by Alex Luckew, Nebahat Sari, Swikriti Pandey, Ted McAvoy, Alvin M. Simmons, Geoffrey Meru, Cecilia McGregor

“…Phenotypic data were collected weekly to determine viral disease severity, and the cumulative season data were calculated as the area under the disease progress curve. Leaves were collected 5 weeks after transplanting (WAT) in 2022 and at 7 WAT in 2023 to determine the viral loads of Cucurbit leaf crumple virus (CuLCrV), Cucurbit yellow stunting disorder virus (CYSDV), and Cucurbit chlorotic yellows virus (CCYV) via a quantitative polymerase chain reaction. …”
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