Comparative Effects of Crocin and Losartan on RAGE, TGF‐β, TNF‐α Gene Expression and Histopathological Changes of the Liver Tissue in Rats With Diabetes by Shahnaz Rajabi, Yaser Mohammadi, Hamid Kabiri‐rad, Mahdiyeh Rajabi‐moghaddam, Azam Rezaei Farimani

“…ABSTRACT Background and Objectives AGEs, via RAGE, increase the development of hyperglycemia‐induced liver damage, and blocking this axis is associated with a reduction in liver disease progression. The goal of this study was to determine how crocin and losartan influenced RAGE, TNF‐α and TGF‐β gene expression in diabetic rats, as well as histological changes in liver tissue. …”
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预制星形螺箍SRC柱的轴压与反复荷载抗震性能 by 翁正强, 尹衍梁, 王瑞祯, 施祖涵, 吕承儒

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Effective interventions to prevent youth vaping behaviours: a rapid review by Ana Paula Belon, Laura Nieuwendyk, Tasha Allen, Melissa Worrell, Candace I J Nykiforuk

“…To classify interventions by levels of intrusiveness, we used the PLACE Research Lab Intervention Ladder Policy Analysis Framework. We applied PROGRESS-Plus (Place of residence, Race/ethnicity/culture/language, Occupation,Gender/sex, Religion, Education, Socioeconomic status, Social capital, and additional context-specific factors) for an equity analysis. …”
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加强与削弱并用型工字形柱弱轴连接节点滞回性能分析 by 刘明明, 徐静伟

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Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity by Shin Koike, Hideo Kimura, Yuki Ogasawara

“…Prolonged UPR activation is associated with the development and progression of various diseases, making it essential to understanding the redox regulation of PERK. …”
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受轴压、双向弯曲和扭矩作用的两端简支工形截面压弯构件的稳定设计 by 陈骥

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Establishing a GRU-GCN coordination-based prediction model for miRNA-disease associations by Kai-Cheng Chuang, Ping-Sung Cheng, Yu-Hung Tsai, Meng-Hsiun Tsai

“…Abstract Background miRNAs (microRNAs) are endogenous RNAs with lengths of 18 to 24 nucleotides and play critical roles in gene regulation and disease progression. Although traditional wet-lab experiments provide direct evidence for miRNA-disease associations, they are often time-consuming and complicated to analyze by current bioinformatics tools. …”
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Efficacy and safety of antifibrotic drugs for interstitial lung diseases other than IPF: A systematic review, meta-analysis and trial sequential analysis. by Mei Yang, Yuying Tan, Ting Yang, Dan Xu, Mei Chen, Lei Chen

“…<h4>Conclusion</h4>Our study suggests that antifibrotic drugs are beneficial for patients with non-IPF ILDs in slowing disease progression, whereas may not correlate to all-cause mortality and SAEs. …”
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Protocol for a feasibility study evaluating a supported self-management intervention for stroke survivors with aphasia (StarStep study) by Faye Wray, Madeline Cruice, Ian Kellar, Anne Forster

“…Feasibility data will inform decision-making regarding progression to a future definitive cluster randomised controlled trial to evaluate the effectiveness of the intervention. …”
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波形腹板部分包覆组合柱弱轴方向偏心受压试验研究 by 王威, 包海洋, 白淙尤, 刘磊, 陈乐乐

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Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Targeted therapies against key targets in GC, including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR), have shown remarkable therapeutic efficacies by inhibiting tumor progression and/or blood supply. In particular, markable breakthroughs have been made in HER2-targeting drugs for HER2-positive GC patients. …”
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Enhanced Bayesian model for multienvironmental selection of winter hybrids maize: assessing grain yield using ‘ProbBreed’ by Bikas Basnet, Chitra Bahadur Kunwar, Umisha Upreti

“…Over and above, integrating genomic information into Bayesian models expected to enhance prediction accuracy and expedite breeding progress.…”
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Impact of early versus late artificial rupture of membranes during oxytocin induction of labour on the incidence of chorioamnionitis: a randomised controlled trial (ARM trial) by Meghan G. Hill, Michelle R. Wise, Emmanuelle Pauleau, Beatrice Treadwell, Lynn Sadler

“…Some institutions favour performing artificial rupture of membranes prior to commencement of oxytocin infusion, with the belief that the labour will progress more efficiently. In other institutions, the approach recommended is for oxytocin infusion with intact amniotic membranes until the person has reached the active phase of labour, citing risk of infection with early amniotomy. …”
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Anti-VEGF-therapy for pseudoxanthoma elasticum (case reports) by A.D. Chuprov, S.M. Kim, E.A. Pidodniy, A.M. Iserkepova

“…The leading signs of eye disorder are angioid streaks and choroidal neovascularization (CNV). Progressive destruction of Bruch's membrane favors CNV, whereas macular neovascularization is the key reason for a reduction in central vision in PXE. …”
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Cost Effectiveness of Insulin Glargine versus Neutral Protamin Hagedorn Insulin in the Treatment of Type 2 Diabetes Patients in Turkey by Ilhan Satman, Hayley Bennett, Candeger Yilmaz, Sazi Imamoglu, Goksun Ayvaz, Abdurrahman Comlekci, Demet Ozkaya, Toros Sahin

“…**Methods:** A previously published discrete event simulation model of T2DM progression was utilised to characterise the cost-effectiveness of insulin glargine in a Turkish population given the benefits observed in clinical practice. …”
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La villégiature anglaise et l’invention de la Côte d’Azur by Alain Bottaro

“…Finally came « launch time », as the expression goes: that is, the progressive inclusion of local towns in the ranks of top resorts for international travelers. …”
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Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study by L. Guiducci, C. Vassalle, P. Parchi, S. Maffei

“…All BMs, except for total calcium and BALP, progressively decreased over time (P≤0.05). No fractures and significant adverse events were reported. …”
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Impact of trachoma elimination efforts in afar regional state, Ethiopia: survey findings from 26 evaluation units by Getachew Gebreselassie, Kasahun Negash, Dawit Woga, Misrak Makonnen, Baye Deneke, Muluken Desalegn, Seada Ali, Colin L. Beckwith, Fentahun Tadesse, Fikre Seife, Genet Kiflu, Fikreab Kebede

“…Addressing these WASH (Water, Sanitation, and Hygiene) challenges remains critical for sustaining progress in trachoma control and achieving long-term public health improvements in the Afar region. …”
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装配式钢结构H形钢梁-钢管柱连接节点的力学性能研究 by 王燕, 马强强, 杨怡亭, 刘秀丽

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Molecular subtype of ovarian clear cell carcinoma: an analysis of 80 Chinese patients using the TCGA molecular classification of endometrial cancer by Wei Chen, Lu Yan, Qin Li, Shuling Zhou, Ting Hou, Huijuan Yang, Shuang Ye

“…No significant differences were observed between the molecular subtypes and clinicopathological features. The progression-free survival and overall survival of the entire cohort were closely associated with FIGO stage (p < 0.01), the presence of residual tumour (p < 0.01), and the platinum response (p < 0.01). …”
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