Therapeutic Potential of <i>Lappula patula</i> Extracts on Germline Development and DNA Damage Responses in <i>C. elegans</i> by Qinghao Meng, Anna Hu, Weiyu Xiao, Robert P. Borris, Hyun-Min Kim

“…Results: Exposure to <i>L. patula</i> extracts resulted in a dose-dependent reduction in worm survival and larval developmental progress, with no significant impact on the male incidence. …”
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Efficacy and safety of new protease inhibitor faldaprevir in treatment of hepatitis C by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…To discuss potentials of application of new NS3/NS4 protease inhibitor faldaprevir at chronic hepatitis C with genotype 1 HCV, including patients without response to previous antiviral therapy, liver cirrhosis, and to estimate its antiviral activity in the range of treatment modes without interferon.Key points. Significant progress was achieved in development of new modes of antiviral treatment of patients with the 1st HCV genotype due to introduction of the third agent possessing direct antiviral action. …”
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Application of Surgical Protocols for the Treatment of Highly Irregular Astigmatism with Topographic Guided Ablation in a Case of Post-LASIK Ectasia by Motwani M, Agu E, Xu A, Yung M

“…Epithelium-off corneal cross-linking was performed at 3.0 mW/cm for 30 minutes.Results: The patient initially presented with a remote history of LASIK and progressive left eye blurring. His uncorrected distance visual acuity (UDVA) was 20/40, with a corrected distance visual acuity (CDVA) of 20/25 with a manifest refraction of − 1.25 +1.75 × 180. …”
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Molecular and serological investigation of hepatitis B virus in patients with acute undifferentiated febrile illness at Tha Song Yang hospital, Tak Province, Thailand by Narin Thippornchai, Anon Sae-Oueng, Akanitt Jittmittraphap, Wang Nguitragool, Pornsawan Leaungwutiwong

“…Abstract Background Hepatitis B virus (HBV) infection is associated with hepatitis, often progressing to liver cirrhosis or cancer, posing a significant public health challenge, particularly in Thailand. …”
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The potential of stem cell therapy in Multiple Sclerosis treatment: a review by Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

“…Most current clinical trials continue to focus on establishing the safety and efficacy of adipose derived stem cell-based therapeutics, with promising results becoming progressively evident. This review reports stem cell-based therapies as potential therapeutic approaches in the treatment and management of Multiple Sclerosis. …”
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Informing the development of diagnostic criteria for differential diagnosis of alcohol-related cognitive impairment (ARCI) among heavy drinkers: A systematic scoping review. by Lisa Jones, Lynn Owens, Andrew Thompson, Ian Gilmore, Paul Richardson

“…These studies revealed a lack of coordinated research and progress towards the development and standardisation of diagnostic criteria for ARCI. …”
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Impact of Comorbidities on the Severity of Disease & Outcome in Children with COVID 19 at a Tertiary Care Pediatric Hospital, Rawalpindi. by Rai Muhammad Asghar, Muddassar Sharif, Khalid Saheel, Isfandyar Khan, Abid Hussain, Rai Rijjal Ashraf

“…It is considered that COVID-19, in those with underlying health conditions or co-morbidities, has an increasingly rapid and severe progression, often leading to death. This study is designed to evaluate the impact of co-morbidities on the severity and outcome of COVID-19 infection in children. …”
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Early referral to nephrological care improves long-term survival and hospitalization after dialysis initiation, independent of optimal dialysis start – a call for harmonization of... by Mathias Haarhaus, Lavinia O. Bratescu, Nicolae Pana, Emanuela M. Gemene, Eliana M. Silva, Carla Alexandra R. Santos Araujo, Fernando Macario

“…Early treatment of kidney disease can slow disease progression and reduce the increased risk of mortality associated with end-stage kidney disease. …”
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Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes by Cheng C, Wang Y, Zhao J, Wu D, Li H, Zhao H

“…This article reviews recent progress in the application of deep learning, ultrasound, MRI, and radiomics for TNBC diagnosis and treatment, based on research from both domestic and international scholars.Keywords: deep learning, MRI, radiomics, triple negative breast cancer, ultrasound…”
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Interferon (IFN)-gamma (γ) inducible protein 10 (IP-10) in the diagnosis of latent and active tuberculosis in Bacille Calmette Guerin (BCG)-vaccinated pediatric population. by Magdalena Druszczynska, Michał Seweryn, Sebastian Wawrocki, Anna Pankowska, Anastasiia Kulbachko, Magdalena Jurczak, Magdalena Kowalewska-Pietrzak

“…Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.tb) infection (LTBI) that have a high risk of progressing to active TB disease remains a significant diagnostic hurdle.…”
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Influence of Dry Beach on the Dynamic Stability of Ash Storage Field: A Numerical Analysis by Fangtao She, Chang Liu, Xiangang Zhou, Changjun Qi, Jiulong Ding

“…As the length of the dry beach increases, the maximum horizontal displacements show a certain decrease, but they occur progressively further away from the third subdam, so that, under dynamic action, the dams become safer. …”
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基于车桥耦合的钢-混凝土组合连续梁桥局部疲劳分析 by 李喜梅, 章建成, 母渤海

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Sustainable Distance E-Learning for Enhanced Students Retention and Support: Faculty of Law National Open University of Nigeria in Focus by Erimma Gloria Orie

“…Despite the monumental progress made by NOUN, there are challenges related to students’ retention and support militating against realization of the objectives of establishing the university. …”
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Integrative Bioinformatics Analysis Unravel the Association between Intracerebral Hemorrhage and Cellular Apoptosis through Immune Infiltration by Pandi Chen, Gengfan Ye, Jia Li, Kuan Feng, Guangyao Zhu, Maosong Chen, Wei Chen

“…Through bioinformatics analysis, we identified PPP1R15A, IL1R1, and TYROBP as crucial genes in the occurrence and progression of ICH, with the potential involvement of Activated dendritic cells and CD56dim natural killer cells in these processes.…”
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Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review by Brijesh Singh Chauhan, Yash Pal Singh

“…Results: We conducted a comprehensive review of the research progress on ANE, focusing on its pharmacological effects on various diseases using animal models, mechanisms of action, and composition, are as not explored in preceding reviews. …”
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PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population by Gerard Criner, Fernando Martinez, Hitesh Gandhi, Norbert Feigler, Bruce Pyenson, Matthew Emery, Umang Gupta, Muthiah Vaduganathan

“…The US COPD population was modeled with 1000 simulations of patient progression over 10 years. Agent characteristics were based on literature and claims analysis of the 2016-2018 Medicare 100% fee-for-service and IBM MarketScan^®^ databases. …”
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Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats by Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan

“…The 28 days of DCXD (5 g/kg) treatment significantly reduced the increased BP effectively, inhibited the enhanced heart index, kidney index, and 24 h urinary protein, and improved the progressive pathological changes of heart and kidney, which was comparable to that of the positive control amlodipine. …”
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Linguistic means of creating an image of a person with intellectual disabilities in D. Keyes’s novel «Flowers for Algernon» by Olga Kanevska, Iryna Klymenko

“…But interfering with the character’s brain gives only a temporary improvement –– rapid progress is replaced by degradation. The changes in Charlie Gordon’s intellectual development are shown through his speech portrait –– an important means of revealing the image of the character and his inner world. …”
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矩形钢管-波折钢板组合墙端顶部承压性能与传力路径试验研究 by 李鑫杰, 罗金辉, 李国强, 楼国彪

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Assessment of fluoride bio-accessibility in early childhood diets by Jelena Kronic, Ralph M. Duckworth, Claudio Angione, Steven M. Levy, Fatemeh Vida Zohoori

“…However, the lack of data on fluoride bioavailability/bio-accessibility has hindered progress so far. This study aimed to measure fluoride bio-accessibility of the dietary sources commonly consumed by children below four years of age.MethodsA total of 103 food and meal samples were purchased, prepared, and analyzed for fluoride content, subjected to a standardized static in vitro digestion procedure and subsequent determination of fluoride concentration of resultant mixtures necessary for the final fluoride bio-accessibility calculation. …”
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