Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis by Noelia Marquez Pete, Cristina Perez Ramirez, Maria del Mar Maldonado Montoro, Fernando Martinez Martinez, Fernando Fernández-Llimos, Antonio Sánchez Pozo, María del Carmen Ramirez Tortosa, Alberto Jiménez Morales

“…Introduction Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration of the joints, leading to severe pain and functional disability. …”
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MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology by Jin Wang, Jinyong Jiang, Haoliang Hu, Linxi Chen

“…Background: Globally, the onset and progression of multiple human diseases are associated with mitochondrial dysfunction and dysregulation of Ca2+ uptake dynamics mediated by the mitochondrial calcium uniporter (MCU) complex, which plays a key role in mitochondrial dysfunction. …”
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Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study by Malte Beckmann, Julian Schlüter, Michael Erdmann, Rafaela Kramer, Sarah Cunningham, Holger Hackstein, Robert Zimmermann, Lucie Heinzerling

“…In addition, the influence of coagulation parameters on progression-free, recurrence-free and overall survival was investigated. …”
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Acute and chronic glycemic effects of aerobic training in patients with type 2 diabetes by Rodrigo Sudatti Delevatti, Nathalie Netto, Isabel Heberle, Cláudia Gomes Bracht, Éder Santiago, Salime Donida Chedid Lisboa, Rochelle Rocha Costa, Alexandra Hübner, Marco Fossati, Luiz Fernando Martins Kruel

“…It is concluded that, after 16 weeks of training without progression of duration and intensity, the exercise loses its acute glycemic effect, and may be even insufficient to reduce HbA1c levels. …”
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Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personal... by Zhongqiu Yang, Yuquan Chen, Yaping Miao, Haisheng Yan, Kexin Chen, Yaoqin Xu, Lanqian Su, Lanyue Zhang, Yalan Yan, Hao Chi, Jin Fu, Lexin Wang

“…Objective Utilizing Mendelian randomization, we determined that stearoyl metabolism significantly contributes to the progression of gastric cancer (GC). Following this, bulk transcriptome analyses and single-cell multiomics techniques to investigate the roles of stearoyl-GPE metabolism-related genes, particularly NCOA4, in regulating LMGC TME. …”
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THE COURSE OF ACUTE RESPIRATORY COVID-19 DISEASE, COMPLICATED BY COMMUNITY-ACQUIRED PNEUMONIA AGAINST THE BACKGROUND OF THE CARDIOVASCULAR SYSTEM PATHOLOGY by T.A. Trybrat, Yu.M Kazakov, O.O. Honcharova, S.V Shut, V.D. Sakevich

“…It had a more pronounced clinical course in a combination of two or more diseases and was characterized by progressive arrhythmias, subendocardial myocardial ischemia, volume overload of the left and right ventricles. …”
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Prevalence of Hepatitis C Virus Infection in a Surgical Population of Southeast China: A Large-Scale Multicenter Study by Ping Chen, Yang Zheng, Yubo Cai, Pengfei Zou, Nan Li, Conggao Peng, Hainv Gao, Jimin Liu, Yongping Chen, Zhaowei Tong, Lanjuan Li

“…Chronic HCV infection affects 80 million people globally and may progress to advanced liver disease. The present study aims to investigate the present epidemiology of HCV infection in a southeastern Chinese surgical patient cohort. …”
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Studies on the Effect of Laser Shock Peening Intensity on the Mechanical Properties of Wire Arc Additive Manufactured SS316L by Geethapriyan Thangamani, Santosh Kumar Tamang, Md Saad Patel, Jinoop Arackal Narayanan, Muthuramalingam Thangaraj, Jufan Zhang, Pardeep Kumar Gianchandani, Palani Iyamperumal Anand

“…The UTS of the as-manufactured WAAM specimen was 548 MPa, which progressively increased with higher LSP intensities to 595 MPa for LSP-1, 613 MPa for LSP-2, and 634.5 MPa for LSP-3, representing a maximum improvement of 15.8%. …”
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Effect of cubebin against streptozotocin-induced diabetic nephropathy rats via inhibition TNF-α/NF-κB/TGF-β: in vivo and in silico study by Rahamat Unissa Syed, Sivakumar S. Moni, Weiam Hussein, Taghreed Mohammad Saad Alhaidan, Sondos Mohammed Y. Abumilha, Lama Khalid Alnahdi, Ling Shing Wong, Vetriselvan Subramaniyan, Vinoth Kumarasamy

“…DN is a well-identified complication of diabetes mellitus (DM) characterized by renal hypertrophy that progressively declines kidney function. Wistar rats were randomly divided into groups- normal, STZ control (65 mg/kg/body weight), and STZ + cubebin (10 and 20 mg/kg). …”
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Premorbid and current intellectual performance reflects different backgrounds in patients with Parkinson's disease by Hidetomo Murakami, Machiko Kezuka, Junnosuke Ozawa, Kaoru Matsuoka, Tatsuya Nakanishi, Atsushi Ishida, Naohito Ito, Mizuki Kanemoto, Mitsuru Kawamura

“…MoCA was significantly correlated with current age (r=−0.401, p = 0.005) and UPDRS part III (r=−0.374, p = 0.009), both of which continue to progress gradually after onset of PD. In multiple regression analyses, these correlations were significant and independent. …”
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The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases by Rojin Sarallah, Shima Jahani, Alireza Soltani Khaboushan, Amir Kian Moaveni, Maryam Amiri, Masoumeh Majidi Zolbin

“…Neurodegenerative diseases, including Alzheimer's Disease (AD), Parkinson's Disease (PD), Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS), are characterized by progressive neuronal loss and cognitive impairment (CI). …”
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Liver transplantation for homozygous familial hypercholesterolemia: a retrospective analysis from Chinese experience by Hao-Su Zhan, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Yu-Le Tan, Jun Wang, Liang Zhang, En-Hui He, Guang-Peng Zhou, Hai-Ming Zhang, Zhi-Jun Zhu, Li-Ying Sun

“…At the same time, the blood cholesterol level of patients should be continuously monitored after LT to further control the progression of vascular complications.…”
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Radiomics-based Machine Learning Approach to Predict Chemotherapy Responses in Colorectal Liver Metastases by Yuji Miyamoto, Takeshi Nakaura, Mayuko Ohuchi, Katsuhiro Ogawa, Rikako Kato, Yuto Maeda, Kojiro Eto, Masaaki Iwatsuki, Yoshifumi Baba, Toshinori Hirai, Hideo Baba

“…Treatment response was classified as responder (complete or partial response) or non-responder (stable or progressive disease), based on the best overall response according to RECIST criteria, version 1.1. …”
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Developing a machine learning model for predicting varicocelectomy outcomes: a pilot study by Coşkun Kaya, Mehmet Erhan Aydın, Özer Çelik, Aykut Aykaç, Mustafa Sungur

“…We aimed to develop a model to predict the improvement in semen parameters after varicocelectomy using ML.The data for male patients who had clinical varicocele, abnormal semen parameters (low sperm concentration, reduced total motile sperm count, decreased progressive motility, and/or poor sperm morphology) and had received a varicocelectomy were recorded retrospectively. …”
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Patient-centered outcomes for gastrointestinal cancer care: a scoping review protocol by Natalie G Coburn, Frances C Wright, Alyson L Mahar, Lesley Gotlib Conn, Julie Hallet, Amy T Hsu, Paul D James, Joanna Yang, Tori Barabash, Luckshi Rajendran, Claire Ludwig, Ekaterina Kosyachkova, Julie Deleemans

“…Traditionally, clinical studies have largely focused on a few concrete and easily measurable outcomes such as survival, disease progression and immediate treatment toxicities. These outcomes do not capture other important factors that patients consider when making treatment decisions. …”
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Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration by Yared Nigusu, Teshome Bekana, Eshetu Chilo, Sisay Teferi, Dereje Oljira Donacho, Dereje Gemeda, Tefera Darge, Abeza Mitiku, Abdi Geda Gedefa, Tadesse Sime, Wubishet Gezimu, Oda Gizaw, Gemechu Tadila, Miressa Bekana, Berhanu Erko

“…Abstract As 2030 approaches, the World Health Organization’s due date for ending intestinal schistosomiasis as a public health problem in all endemic areas, understanding the current trends in the burden of schistosomiasis among schoolchildren in endemic areas is critical for monitoring the progress, identifying areas for improvement, and developing strategies to plan for instant response to mitigate the burden of schistosomiasis. …”
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Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations by Lucas Tricoli, Sunetra Sase, Julia L. Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife Roche, John Everett, Frederic Bushman, Peter Kurre, Rebecca Ahrens-Nicklas, Laura A. Adang, Adeline L. Vanderver, Stefano Rivella

“…Insufficient enzyme levels can lead to the progression of motor symptoms, undermining treatment goals. …”
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FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer by Shun Zhang, Dongyi Yan, Qi Sun, Tao Du, Dongliang Cao, Yao Yang, Biao Yuan, Haiqiang Li, Xiaohua Jiang, Chun Song

“…There were 3 (13.0%) complete responses, 13 (56.5%) partial responses, 4 (26.1%) of stable disease, and 1 (4.3%) of progressive disease. The clinical efficacy response rate was 69.6%. …”
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Milestones and Timescale of Poststroke Recovery: A Cohort Study by Marianna Loi, Alberto Zaliani, Marta Abbamonte, Elena P. Ferrari, Roberto Maestri, Luigi Trojano, Pietro Balbi

“…Background. Progressive increase of an aging population in Western countries will result in a growth of stroke prevalence. …”
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Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…In path_MLH1 and path_MSH2 carriers, second hits lead to the formation of microscopically detectable, microsatellite unstable (MSI) crypts, from which CRC develops in about half of carriers over their lifetime, often without progressing through a diagnosable adenoma stage. These divergent outcomes reflect the distinct functions of. the APC and MMR genes. …”
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