Noninvasive Evaluation of Liver Function in Morbidly Obese Patients by Patrick H. Alizai, Isabella Lurje, Andreas Kroh, Sophia Schmitz, Tom Luedde, Julia Andruszkow, Ulf P. Neumann, Florian Ulmer

“…More than half of the obese patients develop nonalcoholic fatty liver disease (NAFLD), which may further progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. …”
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Noninvasive hemodynamic assessment of type 2 diabetes mellitus using four-dimensional flow magnetic resonance imaging by Di Wu, Jiachen Ji, Yuancheng Wang, Shujun Zhang, Hong Ge, Mingzhu Fu, Yunduo Li, Shenghong Ju, Rui Li

“…Background: Noninvasive and early evaluation of hemodynamic conditions in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) is crucial for assessing disease progression. This study aimed to investigate early hemodynamic changes in patients with T2DM and evaluated the efficacy of Four-Dimensional Flow Magnetic Resonance Imaging (4D Flow MRI) in detecting and diagnosing T2DM and DN. …”
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Prognostic role of aetiological agent vs. clinical pattern in candidates to lead extraction for cardiac implantable electronic device infections by Giulia Massaro, Renato Pascale, Mauro Biffi, Cristian Martignani, Matteo Ziacchi, Andrea Simeone, Raimondo Pittorru, Manuel De Lazzari, Federico Migliore, Igor Diemberger

“…The developed BOP2D score presented a 0.807 AUC (95%CI 0.703–0.910, p < 0.001) and a good predictive value (OR 2.355, 95%CI 1.754–3.162; p < 0.001), and was associated with a progressive increase in mortality with a score > 2. …”
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The fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis by Thomas J. Harr, Nikesh Gupta, Babita Rahar, Kristen Stott, Yadira Medina-Guevara, Metti K. Gari, Angie T. Oler, Ivy Sohee McDermott, Hye Jin Lee, Morteza Rasoulianboroujeni, Ashley M. Weichmann, Amir Forati, Kelsey Holbert, Trevor S. Langel, Kade W. Coulter, Brian M. Burkel, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo, Ksenija Bernau

“…Abstract Progressive forms of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF), are deadly disorders lacking non-invasive biomarkers for assessment of early disease activity, which presents a major obstacle in disease management. …”
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Insights from the single-cell level: lineage trajectory and somatic-germline interactions during spermatogenesis in dwarf surfclam Mulinia lateralis by Yajuan Li, Huilan Wei, Xiaoting Dai, Lijing Zhang, Liangjie Liu, Xiaomei Chen, Tian Liu, Ya Shu, Yaxin Yang, Shi Wang, Zhenmin Bao, Lingling Zhang

“…The four types of germ cells exhibited disparate cell cycle statuses and an uninterrupted developmental trajectory, progressing from spermatogonia to spermatids/spermatozoa. …”
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A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report by Jingjing Chai, Jiaqi Lv, Jian Xiong, Xiuwen Chen, Senyuan Luo, Zhiguo Luo, Zhiguo Luo, Ming Luo

“…The patient was unable to tolerate chemotherapy; therefore, radiotherapy was administered initially to prevent airway compression resulting from disease progression. During the course of radiotherapy, pulmonary metastasis developed, yet the patient remained intolerant to both chemotherapy and anti-angiogenic therapy. …”
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The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients by Pangbo Wang, Pangbo Wang, Jing Huang, Liwei Xu, Rong Hu

“…The RCS function showed a progressive increase in the risk of delirium with higher NLR and PLR and lower LMR. …”
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The impact of technologies on the development of repetitive speed in handball, basketball and volleyball by Dana Badau, Adela Badau, Virgil Ene-Voiculescu, Carmen Ene-Voiculescu, Dragos Florin Teodor, Constantin Sufaru, Corina Claudia Dinciu, Victor Dulceata, Dan Cristian Manescu, Catalin Octavian Manescu

“…While analyzing the results of the male/female sports game groups, the most significant differences in progress were recorded in TP_dominant hand between Volleyball-Basketball with 0.179/0.126 executions; TPR_ dominant hand between Volleyball-Basketball -0.126/0.086 executions; TP_bilateral between Volleyball-Basketball -0.154/-0.173 executions; bilateral TPR_ between Volleyball-Handball -0.016/-0.033 executions. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…Abstract Epithelial-to-mesenchymal transition (EMT) is a critical and complex process involved in normal embryonic development, tissue regeneration, and tumor progression. It also contributes to retinal diseases, such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR). …”
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Atrial flutter/fibrillation in adult congenital heart disease: Insights from a large Asian cohort by Shuenn-Nan Chiu, Wei-Chieh Tseng, Chun-Wei Lu, Ming-Tai Lin, Chun-An Chen, Jou-Kou Wang, Mei-Hwan Wu

“…Incidence of AF/AFL increased with age and was higher in patients with pulmonary hypertension (PH), severe CHD, and metabolic syndrome. We found a progressive trend in the onset age of arrhythmia: AFL at a younger age, followed by paroxysmal and sustained AF. …”
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Charlson syndrome index predicted survival in pancreatic cancer patients received immunotherapy by Nan Zhang, Nan Zhang, Shiyun Chen, Yue Shi, Zhikuan Wang, Ru Jia, Guanghai Dai, Guanghai Dai

“…The statistical analysis focused on examining the correlation between CCI score and survival outcome.ResultsThe high CCI group exhibited significantly lower overall survival (OS) and progression-free survival (PFS) compared to the low CCI group (p&lt;0.05). …”
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The oral disposition index calculated from a meal tolerance test is a crucial indicator for evaluating differential normalization of postprandial glucose and triglyceride excursion... by Yukako Yamamoto, Takeshi Togawa, Osamu Sekine, Yuki Ozamoto, Junko Fuse, Choka Azuma, Jun Ito-Kobayashi, Yasumitsu Oe, Akeo Hagiwara, Masaki Kobayashi, Tadahiro Kitamura, Masanori Iwanishi, Akira Shimatsu, Atsunori Kashiwagi

“…., [Matsuda index] × (Glucose-induced insulin secretion) was progressively worsened from normal glucose tolerance to DM patients after LSG. …”
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Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study by Adeline Ruyssen-Witrand, Jacques-Eric Gottenberg, Philippe Dieude, Rene-Marc Flipo, Jerome Avouac, Emanuelle Dernis, Anne Tournadre, Marie-Elise Truchetet, Raphaele Seror, André Ramon, Nicolas Roux, André Basch, Pascal Chazerain, Fabienne Coury-Lucas, Richard Damade, Pierre-Antoine Juge, Thao Pham, Clément Prati, Olivier Brocq, Jean Hugues Salmon, Christian hubert roux, Félicien Triboulet, Charles Leské, Émilie Shipley

“…Chest HRCT lesions remained stable in 69% of patients. Progressive ILD was identified in 8 patients (19%). 16 (38%) respiratory tract infections were observed. …”
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Responses of α-amylase and protease activity to chemical agents and metallic salts in barley seeds (Hordeum vulgare L.) by Amin Hossain, Umma Fatema Shahjadee, Abu Tareq Mohammad Abdullah, Mohammad Nazrul Islam Bhuiyan, Anjum Zerin Rupa

“…The application of CaCl2 led to a progressive increase for both the enzyme activities, but the maximum increases were observed 137.26 ± 1.42 % and 135.65 ± 1.17 % due to 0.50 M Ca2+. …”
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Rapid landslide detection from free optical satellite imagery using a robust change detection technique by Rosa Coluzzi, Angela Perrone, Caterina Samela, Vito Imbrenda, Salvatore Manfreda, Letizia Pace, Maria Lanfredi

“…Abstract In the last decades, the availability of multi-source, multi-scale, and multi-resolution remote sensing data and the consequent progress of processing techniques brought a significant positive impact for landslide detection. …”
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Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated L... by Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang

“…Subsequent examination of an independent ALD patient cohort corroborated the substantial enrichment of GZMK+CD4+ T lymphocytes, primarily within liver fibrotic zones, suggesting their potential involvement in disease progression. Additionally, we noted shifts in myeloid populations, with expanded APOE+ macrophage and FCGR3B+ monocyte subsets in ALD samples relative to MASLD and healthy tissues. …”
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Development of a Mobile Application Platform for Self-Management of Obesity Using Artificial Intelligence Techniques by Sylvester M. Sefa-Yeboah, Kwabena Osei Annor, Valencia J. Koomson, Firibu K. Saalia, Matilda Steiner-Asiedu, Godfrey A. Mills

“…Moreover, the system is able to adequately track the progress of the user’s weight loss over time, daily nutritional needs, daily calorie intake, and predictions of meals that must be taken to avoid compromising their health. …”
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Short-term survivors with brain metastases have modest benefits from focal and systemic therapies and remain frequent despite improving treatment landscape by M. Czogalla, J. Stöhr, N. Gleim, K. Papsdorf, S. Klagges, P. Hambsch, T. Kuhnt, F. Nägler, A. Barrantes-Freer, J. Wach, N.H. Nicolay, C. Seidel

“…However, survival benefits were very modest, with a median gain of 6 weeks following resection and focal radiotherapy compared to whole-brain radiotherapy, and 3 weeks from systemic treatment. Systemic tumor progression was documented as the cause of death in the majority of patients. …”
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Comparative Efficacy and Tolerability of Imiquimod 3.75% Cream vs 5-Fluorouracil 4% cream in the Treatment of Actinic Keratosis: A Split-Face Study by Cesare Ariasi, Carola Romanò, Cesare Tomasi, Gaetano Licata, Davide Geat, Piergiacomo Calzavara-Pinton, Mariachiara Arisi

“… Introduction: Actinic keratosis (AK) is a common precancerous skin lesion that arises on chronically UV-exposed skin and can progress to keratinocyte carcinoma. Objective: The aim of this study is to compare efficacy, safety, local skin reaction, time to wound closure, and patient preference of imiquimod (IMQ) 3.75% vs 5-fluorouracil (5-FU) 4% cream treatment for AKs. …”
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Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients by Narges َArab-Moghaddam, Karim Asgari Mobarakeh, Gholamreza Daryabor, Maryam Poursadeghfard

“…These patients were divided into three groups: 23 newly diagnosed patients (ND), 23 patients with relapsing-remitting MS (RRMS), and 22 patients with secondary progressive types (SPMS). The patients were 55 women and 13 men. …”
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