Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer by Feng Qi, Yihang Xu, Zicheng Xu, Qing Zou

“…All patients were divided into cytoreductive surgery group and no local therapy group according to the administration of cytoreductive surgery before progression to metastatic castration-resistant prostate cancer (mCRPC). …”
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Does therapy with immunosuppressive drugs improve gastrointestinal symptoms in patients with systemic sclerosis? by Oliver Distler, Cosimo Bruni, Suzana Jordan, Carina Mihai, Muriel Elhai, Rucsandra Dobrota, Alexandru Garaiman, Mike Oliver Becker, Lea Stamm, Sherif Ismail, Norina Zampatti, Aurora Maria Tatu

“…Objectives While important progress was made regarding the treatment of systemic sclerosis (SSc), there is still no evidence-based disease-modifying treatment available for SSc-related gastrointestinal (GI) manifestations. …”
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Ibuprofen-Induced Multiple Fixed Drug Eruption Confirmed by Re-Challenge: A Case Report and Literature Review by Yoshihito Mima, Masako Yamamoto, Hiyo Obikane, Yuta Norimatsu, Ken Iozumi

“…However, in multiple FDE, CD8-positive T cell activity may outweigh that of regulatory T cells, causing uncontrolled inflammation and leading to the spread of poorly-demarcated lesions that can progress to severe drug reactions such as Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). …”
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High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience by Veronica González‐Calle, Paula Rodriguez‐Otero, Maria J. Calasanz, Manuela Guijarro, Joaquin Martínez‐López, Laura Rosiñol, Miguel T. Hernández, Ana I. Teruel, Mercedes Gironella, Albert Oriol, Javier de laRubia, Ana P. González‐Rodríguez, Joan Bargay, Felipe deArriba, Luis Palomera, Marta‐Sonia González‐Pérez, Anna Sureda, Enrique Ocio, Juan J. Lahuerta, Joan Bladé, Jesus F. San Miguel, Maria V. Mateos, Norma C. Gutiérrez

“…The median follow‐up was 61 months, and the median progression‐free survival (PFS) and overall survival (OS) were 44 months and not reached, respectively. …”
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Chemokine family significance and prognostic value in colorectal cancer by Yi Ding, Yi Ding, Yi Ding, Yinnan Chen, Yinnan Chen, Yinnan Chen, Siyun Xie, Quanpeng Qiu, Quanpeng Qiu, Xiaolong Guo, Yun Feng, Yun Feng, Hongxia Li, Hongxia Li, Fang Zhu, Yaping Liu, Yaping Liu, Yaping Liu

“…The intricate tumor microenvironment plays a crucial role in CRC development and progression, where chemokines contribute significantly. …”
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Use of Attention Maps to Enrich Discriminability in Deep Learning Prediction Models Using Longitudinal Data from Electronic Health Records by Lucía A. Carrasco-Ribelles, Margarita Cabrera-Bean, Jose Llanes-Jurado, Concepción Violán

“…Methods: We developed four deep learning-based architectures with attention mechanisms that were progressively more complex to handle longitudinal data from EHRs. …”
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Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology by Xin Chen, Xing Ji, Zhaobai Lao, Bin Pan, Yu Qian, Wanlei Yang

“…This systematic review summarizes current research progress, identifies unaddressed areas, and highlights potential future research directions. …”
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Challenges and Prospects of Digital Core-Reconstruction Research by Linqi Zhu, Chong Zhang, Chaomo Zhang, Xueqing Zhou, Zhansong Zhang, Xin Nie, Weinan Liu, Boyuan Zhu

“…Additionally, 2D slice-based digital core stochastic reconstruction techniques are classified into four types: a stochastic reconstruction method based on 2D slice mathematical-feature statistical constraints, a stochastic reconstruction method based on statistical constraints that are related to 2D slice morphological characteristics, a physics process-based stochastic reconstruction method, and a hybrid stochastic reconstruction method. The progress related to these various stochastic reconstruction methods, the characteristics of constructed 3D digital cores, and the potential of these methods are analysed and discussed in detail. …”
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Evolving perspectives in dental marketing: A study of Jordanian dentists' attitudes towards advertising and practice promotion by Rami J. Anshasi, Nizar Alsubahi, Ahmad A. Alhusein, Abd Alwali Lutfi Khassawneh, Mahmaod Alrawad, Adi Alsyouf

“…Although the dental advertising landscape in Jordan has made considerable progress, research on dentists' perspectives regarding advertising in the country remains limited. …”
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Characteristics and Management of Uncontrolled Gout Prior to Pegloticase Therapy: A 2-year Claims Analysis by Robert J. Morlock, Deepan Dalal, Victoria Divino, Mitchell DeKoven, Stephanie D. Taylor, Atsuko Powers, Naina Barretto, Robert J. Holt, Brian LaMoreaux

“…Abstract Objective Gout is a progressive form of arthritis that causes significant pain and disability. …”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…A better understanding of the underlying pathogenesis is essential in order to better assess long-term progress.…”
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Harnessing artificial intelligence in sepsis care: advances in early detection, personalized treatment, and real-time monitoring by Fang Li, Shengguo Wang, Zhi Gao, Maofeng Qing, Shan Pan, Yingying Liu, Chengchen Hu

“…Sepsis remains a leading cause of morbidity and mortality worldwide due to its rapid progression and heterogeneous nature. This review explores the potential of Artificial Intelligence (AI) to transform sepsis management, from early detection to personalized treatment and real-time monitoring. …”
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Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study by Peter Koch, Inke König, Johann Roider, Jan Tode, Konstantine Purtskhvanidze, Claus von der Burchard, Helge Sudkamp, Cristoph Ehlken, Moritz Moltmann, Britta Heimes, Michael Münst, Malte vom Endt, Timo Kepp, Dirk Theisen-Kunde, Gereon Hüttmann

“…Improvements are in progress to reduce device size and to improve handling, image quality and success rates.Trial registration number DRKS00013755, CIV-17-12-022384.…”
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Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases by Sára Mravinacová, Sofia Bergström, Jennie Olofsson, Nerea Gómez de San José, Sarah Anderl-Straub, Janine Diehl-Schmid, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Johannes Kornhuber, G. Bernhard Landwehrmeyer, Martin Lauer, Johannes Levin, Albert C. Ludolph, Johannes Prudlo, Anja Schneider, Matthias L. Schroeter, Jens Wiltfang, Petra Steinacker, FTLD Consortium, Markus Otto, Peter Nilsson, Anna Månberg

“…Here, we measured the levels of 69 pre-selected proteins in cerebrospinal fluid using antibody-based suspension bead array technology in a multi-disease cohort of 499 individuals with neurodegenerative disorders including Alzheimer’s disease (AD), behavioral variant frontotemporal dementia, primary progressive aphasias, amyotrophic lateral sclerosis (ALS), corticobasal syndrome, primary supranuclear palsy, along with healthy controls. …”
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Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

“…We assessed EV-derived miR-21 levels in one hundred women: 30 with early BC (EBC), 30 with metastatic BC on treatment progression (MBC), 30 cancer survivors on follow-up (FU) and 10 healthy donors (HD) as age- and body mass index (BMI)-matched controls. …”
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An investigator-blinded, 24-month, parallel-group, non-inferiority study to compare aesthetic restorations in primary anterior teeth in a paediatric dental clinic: study protocol f... by Ana Paula Taboada Sobral, Elaine Marcilio Santos, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Elza Padilha Ferri, Juliana Maria Altavista Sagretti Gallo, Thais Gimenez, José Carlos Pettorossi Imparato

“…The explanatory variables—gender, age, toothbrushing, use of fluoridated toothpaste and dental floss, and socioeconomic status—will be collected through a questionnaire with open questions. The progression of caries lesions after 24 months of follow-up will be considered as the primary outcome. …”
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INdependenT prEscribinG in community phaRmAcy; whaT works for whom, why and in what circumstancEs (INTEGRATE): Realist review study protocol [version 1; peer review: 2 approved] by Andrew Sturrock, Tony Kelly, Vivienne Hibberd, Ian Maidment, Ola Amr Abdelfatah, Nia Roberts, Ellen Schafheutle, Andrea Hilton, Keith Holden, Geof Wong, Nick Haddington, Lesley Scott

“…Method and analysis Realist research seeks to explore and explain complex social interventions by utilising programme theories providing causal explanations of outcomes in terms of context-mechanism-outcome configurations. INTEGRATE will progress through six stages. In the first stage, we will partner with Patient, Public, Involvement and Engagement Group (PPIE) and Practitioner Stakeholder Group (SG), to further scrutinise the review’s focus. …”
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Deregulated methylation and expression of PCDHGB7 in patients with non-small cell lung cancer: a novel prognostic and immunological biomarker by Yue Yuan, Yue Yuan, Xin Nie, Jiayi Gao, Jiayi Gao, Yumeng Tian, Yumeng Tian, Liuer He, Liuer He, Xue Wang, Ping Zhang, Junling Ma, Lin Li, Lin Li

“…Patients with PCDHGB7 hypermethylation in baseline plasma had shorter progression-free survival (PFS) and overall survival (OS), while those with early reduction of PCDHGB7 methylation had the best prognosis. …”
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Quantifying research hotspots and trends in brucella spondylitis: a bibliometric analysis by Zhangui Gu, Zhangui Gu, Zongqiang Yang, Zongqiang Yang, Le Fei, Le Fei, Daihao Wei, Daihao Wei, Long Ma, Qiang Liu, Jiandang Shi

“…Analysis of abstracts and keyword trends revealed that post-2020, emerging research frontiers include “instrumentation,” “management,” and “debridement.”ConclusionThere has been significant progress in BS research, with a steady increase in publications. …”
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Human Herpesviruses, Bacteria, and Fungi in Gingivitis and Periodontitis Pediatric Subjects: A Systematic Review by Federica Di Spirito, Massimo Pisano, Mario Caggiano, Giuseppina De Benedetto, Maria Pia Di Palo, Gianluigi Franci, Massimo Amato

“…<b>Conclusions:</b> These findings highlight the role of microbial interactions in periodontal health and disease progression.…”
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