Factors associated with successful treatment outcomes among tuberculosis patients in a district municipality of Vhembe, Limpopo by Busisiwe Mkhavele, Slindile Zondi, Lindiwe Cele, Mabina Mogale, Margeret Mbelle

“…Background: Treatment success rate is a critical indicator for monitoring the progress of tuberculosis (TB) treatment programmes at both the patient and population levels. …”
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Impaired Growth during Childhood in Patients with Primary Ciliary Dyskinesia by Tamara Svobodová, Jana Djakow, Daniela Zemková, Adam Cipra, Petr Pohunek, Jan Lebl

“…In children with PCD, body length/height progressively decreased from +0.40±0.24 SDS (the 1st birthday), +0.16±0.23 SDS (3 years old), and -0.13±0.21 SDS (5 years old) to -0.54±0.19 SDS (7 years old; P=0.01 versus 0), -0.67±0.21 SDS (9 years old; P=0.005 versus 0), -0.52±0.24 SDS (11 years old; P=0.04 versus 0), and -0.53±0.23 SDS (13 years old; P=0.03 versus 0). …”
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Weakly Supervised Nuclei Segmentation with Point-Guided Attention and Self-Supervised Pseudo-Labeling by Yapeng Mo, Lijiang Chen, Lingfeng Zhang, Qi Zhao

“…Due to the labor-intensive manual annotations for nuclei segmentation, point-supervised segmentation based on nuclei coordinate supervision has gained recognition in recent years. Despite great progress, two challenges hinder the performance of weakly supervised nuclei segmentation methods: (1) The stable and effective segmentation of adjacent cell nuclei remains an unresolved challenge. (2) Existing approaches rely solely on initial pseudo-labels generated from point annotations for training, and inaccurate labels may lead the model to assimilate a considerable amount of noise information, thereby diminishing performance. …”
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Using Real‐Time Power BI Formative Feedback to Improve Nurse Anesthesia Students' Clinical Competence: An Educational Intervention by Ali Khalafi, Sajjad Choopani, Nooshin Sarvi‐Sarmeydani, Elham Maraghi

“…The intervention group showed a notable progression in clinical competency scores from baseline to endpoint (mean scores: 35.06 ± 1.62 to 79.58 ± 1.02), significantly outperforming the control group (mean scores: 29.93 ± 1.38 to 62.09 ± 1.47, p‐value < 0.0001). …”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Abstract Repeat expansions in the C9ORF72 gene are a frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Considerable progress has been made in identifying C9ORF72-mediated disease and resolving its underlying etiopathogenesis. …”
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Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding by Yasunari Hayashi, Yasunari Hayashi, Seungil Kim, Seungil Kim, Seungil Kim, Taro Fujii, Taro Fujii, Drake Dalton Pedersen, Drake Dalton Pedersen, Takahiro Ozeki, Takahiro Ozeki, Hongbin Jiang, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, William R. Wagner, William R. Wagner, William R. Wagner

“…IntroductionIn a model of right heart failure secondary to pulmonary artery banding (PAB), a mechanical approach using an elastic, biodegradable epicardial patch with integrated extracellular matrix digest was evaluated for its potential to inhibit disease progression.MethodsAdult male syngeneic Lewis rats aged 6–7 weeks old were used. …”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…Abstract Histone lactylation plays a crucial role in cancer progression, but its impact on breast cancer (BC) tumorigenesis is still unclear. …”
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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. …”
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Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective by Wenhao Liao, Jing Wang, Yuchen Li

“…The classic Correa's cascade of intestinal GC specifies a trilogy of malignant transformation of the gastric mucosa, in which normal gastric mucosa gradually progresses from inactive or chronic active gastritis (Phase I) to gastric precancerous lesions (Phase II) and finally to GC (Phase III). …”
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Evaluating a multicomponent intervention for managing kidney outcomes among patients with moderate or advanced chronic kidney disease (CKD): protocol for the Strategies for Kidney... by Tazeen Hasan Jafar, Ngiap Chuan Tan, Mihir Gandhi, Sungwon Yoon, Eric Finkelstein, Peter Moey Kirm Seng, Ruiheng Ong, Anandan Gerard Thiagarajah, Bing Long Lee, Ka Chi To, Aminath Shiwaza Moosa

“…Early detection and prompt intervention are critical in preventing progression to end-stage kidney disease (ESKD) and cardiovascular complications. …”
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Lyme neuroborreliosis as initial expression of Lyme disease in an elderly patient by Emidio Mata, Bárbara Lage Garcia, André Pereira, Joana Rego, Flávia Santos, Carlos Fernandes, Jorge Cotter

“…Prompt recognition and intervention are essential to prevent progression and ensure favourable outcomes.…”
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Mapping indefinite causal order processes to composable quantum protocols in a spacetime by Matthias Salzger, V Vilasini

“…However, the interface between these information-theoretic approaches and spatiotemporal notions of causality is less understood, and questions relating to the physical realisability of ICS in a spatiotemporal context persist despite progress in their information-theoretic characterisation. …”
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CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence by Zijian Qiu, Jiaji Wu, Guanchao Pang, Xia Xu, Jun Lin, Pingli Wang

“…Thus, the detection of intratumoral MVD is of great significance for understanding disease progression and predicting patient prognosis.MethodsTumor tissue sections of 238 patients with lung adenocarcinoma (LUAD) who underwent radical surgery were retrospectively analyzed. …”
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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

“…If successful, the REASSESS study could demonstrate that reduction of ICH volume is a critical target to reduce the risk of progressive cognitive decline, establish targets for residual haematoma volume reduction and determine if greater residual haematoma volume leads to a long-term inflammatory state.Ethics and dissemination Approval of this study was obtained from the Johns Hopkins University Institutional Review Board (IRB00311985). …”
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Enhancing Therapy Adherence: Impact on Clinical Outcomes, Healthcare Costs, and Patient Quality of Life by Urszula Religioni, Rocío Barrios-Rodríguez, Pilar Requena, Mariola Borowska, Janusz Ostrowski

“…The findings reveal that poor adherence exacerbates the risk of disease progression, complications, and higher healthcare costs. …”
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Retained Shrapnel from a Blast Injury as a Rare Cause of Secondary Osteoarthritis of the Hip Joint: A Case Report and Review of Literature by Oshan Basnayake, Ahamed Nihaj, Ranji Pitagampalage, Umesh Jayarajah, Yasith Mathangasinghe, Harsha Mendis

“…A 74-year-old otherwise healthy Sri Lankan male with a history of blast injury to the right hip 35 years ago presented with an isolated, right sided mild hip pain with a progressive limp for an 8-year duration. He had a true right limb shortening of 3.6 cm and limited range of motion. …”
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Efficacy and safety of reduced-port laparoscopic surgery versus conventional laparoscopic surgery for colorectal cancer by Zhi-min Liu, Qi-jun Yao, Fengyun Pei, Fang He, Yandong Zhao, Jun Huang

“…There were no statistically significant differences in overall survival (OS) and progression-free survival (PFS) between the two groups (P value was 0.773 and 0.579 respectively). …”
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Impact of thoracic radiotherapy on first‐line treatment outcomes in ES‐SCLC patients by Xiaoli Mu, Yixin Zhou, Qing Liu, Jiantao Wang, Feng Xu, Feng Luo, Ke Wang, Lu Li, Panwen Tian, Yalun Li, Jiewei Liu, Yan Zhang, Jiyan Liu, Yan Li

“…The primary outcomes were overall survival (OS) and progression‐free survival (PFS). Cox regression analysis was utilized to identify potential independent predictors of prognosis and to compare the treatment outcomes across various patient subgroups. …”
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Effect of shot peening intensities on surface integrity of DD6 single crystal superalloy by GAI Pengtao, WU Yunhua, CAO Ziwen, WEI Dasheng, FU Xuesong

“…A gradient plastic severe deformation layer emerges near the surface，its depth progressively increasing from 45 μm at 0.15 mmA to 98 μm at 0.25 mmA. …”
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Hydrogen sulfide attenuates disturbed flow-induced vascular remodeling by inhibiting LDHB-mediated autophagic flux by Xia Wang, Xiying Huang, Yongya Zhang, Huanhuan Huo, Guo Zhou, Linghong Shen, Long Li, Ben He

“…Disturbed flow (DF) plays a critical role in the development and progression of cardiovascular disease (CVD). Hydrogen sulfide (H2S) is involved in physiological processes within the cardiovascular system. …”
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