Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD by Lijuan Zhou, Jingyi Zhao, Kaile Ma, Rui Hao, Chensi Yao, Xiaowen Gou, Chuanxi Tian, Li Wan, Min Li, Xiaolin Tong

“…BackgroundNon-alcoholic fatty liver disease (NAFLD) constitutes the most prevalent chronic liver disease worldwide. Progression to non-alcoholic steatohepatitis (NASH), the immune cell reservoir within the liver undergoes remodeling, exacerbating liver inflammation and potentially leading to liver fibrosis. …”
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MicroRNA-451 as an Early Predictor of Chronic Kidney Disease in Diabetic Nephropathy by Mostafa Abdelsalam, A. M. Wahab, Maysaa El Sayed Zaki, Mohamad Motawea

“…MicroRNAs are not only new and promising markers for early diagnosis but also, but they may also play a role in the prevention of disease progression. Methods. This study included ninety patients with type 2 DM in addition to 30 control subjects. …”
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Mixed Cutaneous Infection Caused by Leishmania and Dermatophytes: A Rare Coincidence or Immunological Fact by Amresh Kumar Singh, Ankur Kumar, Jayesh Pandey, Vivek Gaur, Pratima Tripathi, Indra Prasad Adhikari

“…We present a rare case of a 52-year-old house wife with a history of recurrent itching, depigmentation of the skin of extremities, and loss of appetite for 2-3 months followed by progressive spread of such lesion all over the body in an apparently healthy female. …”
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CBGS-YOLO: A Lightweight Network for Detecting Small Targets in Remote Sensing Images Based on a Double Attention Mechanism by Zhenyuan Wu, Di Wu, Ning Li, Wanru Chen, Jie Yuan, Xiangyue Yu, Yongqiang Guo

“…With the continuous progress of remote sensing technology, the demand for means of detecting small targets in remote sensing images is escalating. …”
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Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms by Mohammad Mehdi Banoei, Abdulrazagh Hashemi Shahraki, Kayo Santos, Gregory Holt, Mehdi Mirsaeidi

“…This study aimed to leverage metabolomics for the early diagnosis of sarcoidosis and to identify metabolic phenotypes associated with disease progression. <b>Methods:</b> Serum samples from patients with sarcoidosis (<i>n</i> = 40, including stage 1 to stage 4), were analyzed for metabolite levels by semi-untargeted liquid chromatography–mass spectrometry (LC-MS). …”
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Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…This result provides a new direction for uncovering how ERS regulates EMT and a foundation for preventing the progression of EMT in HCC.…”
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SACWOM: Synergistic Adaptive Congestion Window Optimization Mechanism for Self-Clocked Algorithm by Haider Dhia Zubaydi, Ahmed Samir Jagmagji, Sandor Molnar

“…While CC algorithms like Self-Clocked Rate Adaptation for Multimedia (SCReAM) and Bottleneck Bandwidth and Round-trip propagation time (BBR) have shown progress, each faces limitations: BBR encounters difficulty in balancing responsiveness and fairness when rapid fluctuations in network conditions arise, which can lead to inefficient performance in shared environments. …”
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The socioeconomic impact of kidney disease on African families: a scoping review by Ikponmwosa Jude Ogieuhi, Nicholas Aderinto, Gbolahan Olatunji, Emmanuel Kokori, Victor Oluwatomiwa Ajekiigbe, Komolafe Babajide Ayodeji, Adetola Emmanuel Babalola, Ifeanyichukwu Muogbo, Alabi Badrudeen Olalekan, Aarushi Venkatraman, Oluwaseun Oyewo

“…Unfortunately, most people are unaware that they have this condition until it has progressed. Research aimed at systematically summarizing findings on the socioeconomic effects of kidney disease on families in Africa was reviewed. …”
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EGFR-TKIs or EGFR-TKIs combination treatments for untreated advanced EGFR-mutated NSCLC: a network meta-analysis by Ao Liu, Xiaoming Wang, Lian Wang, Han Zhuang, Liubo Xiong, Xiao Gan, Qian Wang, Guanyu Tao

“…Osimertinib plus chemotherapy and lazertinib plus amivantamab showed the highest efficacy in improving progression-free survival. New third-generation EGFR-TKIs demonstrated comparable efficacy to osimertinib alone but did not surpass it. …”
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A Novel Attention-Guided Enhanced U-Net With Hybrid Edge-Preserving Structural Loss for Low-Dose CT Image Denoising by Muhammad Zubair, Helmi Md Rais, Talal Alazemi

“…The proposed model undergoes iterative training, using a custom loss function to refine its parameters and improve CT image denoising progressively. Its performance is rigorously evaluated both qualitatively and quantitatively on the &#x2018;2016 Low-dose CT AAPM Grand Challenge dataset&#x2019;. …”
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Adolescent girls’ explanations of high rates of low mood and anxiety in their population: a co-produced qualitative study by Ola Demkowicz, Rebecca Jefferson, Pratyasha Nanda, Lucy Foulkes, Jo Lam, Steven Pryjmachuk, Rhiannon Evans, Bernadka Dubicka, Liz Neill, Laura Anne Winter, Georgina Nnamani

“…There is a paucity of mental health research that meaningfully progresses understanding of these gender disparities, including that engages adolescent girls’ own perspectives, limiting our ability to direct further research and enhance intervention approaches. …”
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Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…This manuscript describes the conception, establishment, and progress of Young TPI from its start to present, detailing its strategy for communication, activities, and funding mechanisms, and ongoing endeavors to enlist new members and forge strategic alliances in pursuit of its mission.…”
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Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice by Henry Tan, Devon J. Griggs, Devon J. Griggs, Lucas Chen, Kahte Adele Culevski, Kathryn Floerchinger, Alissa Phutirat, Gabe Koh, Nels Schimek, Pierre D. Mourad, Pierre D. Mourad

“…Given the near ubiquity of diagnostic ultrasound systems, further progress along this line of research could one day lead to the widespread use of diagnostic ultrasound to intentionally modulate human brain function during exogenous stimulation.…”
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Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats by Diego Salagre, Miguel Navarro-Alarcón, Luis Gerardo González, Mohamed A. Elrayess, Marina Villalón-Mir, Rocío Haro-López, Ahmad Agil

“…Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and muscle atrophy. …”
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Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer by Xiaohong Liu, Xing Wang, Jie Ren, Yuan Fang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Jialu Bai, Decheng Jiang, Yuemeng Tang, Bo Ren, Lei You, Yupei Zhao

“…Amino acids play a prominent role in the occurrence and progression of pancreatic cancer as essential building blocks for protein synthesis and key regulators of cellular metabolism. …”
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Integrating Information Gain and Chi-Square for Enhanced Malware Detection Performance by Fauzi Adi Rafrastara, Wildanil Ghozi, Ramadhan Rakhmat Sani, Lekso Budi Handoko, Abdussalam Abdussalam, Elkaf Rahmawan Pramudya, Faizal M. Abdollah

“…Detecting malware is essential to safeguard devices and systems from risks such as data corruption, data theft, account compromises, and unauthorized access that could result in total system takeover. As malware has progressed from its simpler, monomorphic variants to more sophisticated forms like oligomorphic, polymorphic, and metamorphic, a machine learning-based detection system is now required, surpassing the limitations of traditional signature-based methods. …”
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Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Despite new immunotherapeutic strategies entering standard clinical care for various tumors, progress in AML remains poor. Multi-omics analyses, such as single-cell transcriptomics, have revealed many potential new targets to improve AML prognosis from an immunological perspective.MethodsDNA from 307 AML patients and 316 healthy individuals were extracted. …”
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A Collaborative Control Framework: Achieving Emergency Vehicle Priority While Minimizing Negative Impact on Ordinary Vehicles at Signalized Intersection by Ke-jun Long, Zhong-gen Zhang, Zhi-bo Gao, Si-qi Zhong, Jian Gu

“…In addition, there is a progressive increase in the proportion of dynamic emergency lane utilization, with activation occurring at earlier locations.…”
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Practices of Breast Self-Examination and Associated Factors among Female Debre Berhan University Students by Kalayu Birhane, Miskir Alemayehu, Belayneh Anawte, Gebru Gebremariyam, Ruth Daniel, Semeneh Addis, Teshome Worke, Abdurrahman Mohammed, Wassie Negash

“…It is considered to be a progressive disease with a poor prognosis if detected late. …”
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Open-source code for analysis of the lifetime total physical activity questionnaire (LTPAQ) by Coral Sánchez-Martín, Javier Leal-Martín, Timo Rantalainen, Irene Rodríguez-Gómez, Luis M. Alegre, Ignacio Ara

“…Advancing research to understand the impact of lifetime physical activity patterns on health is essential. While some progress on the topic has been made, further research is nevertheless warranted. …”
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