Impact of Chronic Liver Diseases on Specific Health-Related Quality of Life among a Sample in Babylon Governorate by Karrar G. Rasheed Al-Azzawi, Abdulkhaleq A. Ali Ghalib Al-Naqeeb, Muna A. Kadhum Zeidan

“…The necessity to carry out similar further large-scale studies in different Iraqi regions in order to identify aspects of excellence and regression that progress and slow in the light of which the results of evaluating the health status related to the specific quality of life for (CLDs) patients. …”
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Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration by Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Sylvia Bolz, Andjela Sekulic, Marius Ueffing, Marius Ueffing, Simon J. Clark, Simon J. Clark, Simon J. Clark, Nadine Reichhart, Sergio Crespo-Garcia, Nicola Wilck, Nicola Wilck, Nicola Wilck, Nicola Wilck, Olaf Strauß

“…T cells were intimately associated with the RPE, suggesting transmigration and participating in local micro-inflammation.DiscussionOur data support that activation and accumulation of memory T cells can be considered as a hallmark of early AMD, and that adaptive immunosenescence likely to contribute to the chronic inflammation associated with RPE damage and the progression to large lesions as seen in GA.…”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

“…Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.Methods and analysis This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. …”
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The Influence of Depression and Anxiety on Neurological Disability in Multiple Sclerosis Patients by Vitalie Văcăraș, Veronica Văcăraș, Cristina Nistor, Daniela Văcăraș, Adrian Nicolae Opre, Petronela Blaga, Dafin F. Mureșanu

“…As a chronic incurable disease, in most cases, it can lead to progressive neurological impairment and severe disability. …”
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Evaluating the accuracy of earth rotation parameters based on the BDS observations by Chenxiang Wang, Pengfei Zhang, Tengxu Zhang, Ziyu Shen, Jizhang Sang, Wenbin Shen

“…The BeiDou satellite system (BDS) has progressed with the full operationalization of the second-generation regional system (BDS-2) and the third-generation global system (BDS-3). …”
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Current molecular understanding of central nervous system schwannomas by Takahiro Tsuchiya, Satoru Miyawaki, Yu Teranishi, Kenta Ohara, Yudai Hirano, Shotaro Ogawa, Seiei Torazawa, Yu Sakai, Hiroki Hongo, Hideaki Ono, Nobuhito Saito

“…Conclusion A deeper exploration of these molecular findings could clarify the mechanisms of schwannoma tumorigenesis and progression, ultimately guiding the development of new therapeutic targets. …”
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The content of yellow pigments in durum wheat (Titicum durum Desf.) grains: biosynthesis, genetic control, marker selection by P. N. Malchikov, M. G. Myasnikova

“…However, the prevalence of strong additive gene effects and high heritability have contributed to significant progress in breeding for this trait. Molecular labeling of quantitative trait loci (QTL) that control the synthesis of the carotenoid pigment and the yellowness index (YI) found that they are distributed across all chromosomes of the durum wheat genome. …”
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Growing old before growing rich: a scoping review on ageing-related policy interventions from the WHO Southeast Asian Region by Nachiket Gudi, Anu Mohan, Teddy Andrews Jaihind Jothikaran, Abhijith A K, Lena Ashok

“…The notable delimitations of the given policy interventions are ambiguity regarding the monitoring of the programmes, lack of benchmark standards for evaluation of progress, inadequate attention to rural poverty and lack of decentralisation.Conclusion WHO SEARO countries can respond better to ageing by reinforcing areas such as caregiver support and allowances, public financing in older care, old age health insurance, public-private partnership in mobile and institutional caring and social security systems including old age and disability pension.…”
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Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing by Wei Duan, Yue Gao, Ruru Xu, Sheng Huang, Xueqian Xia, Jingwen Zhao, Longhuan Zeng, Qiaolin Wei, Jia-Wei Shen, Jianmin Wu, Yongke Zheng

“…Although nanozymes have made progress in inflammation modulation and antibacterial management, they often lack the ability in pro-angiogenesis, which greatly limits their functional application in the synergistic treatment of burn infected wounds. …”
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Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) cause neuroinflammation, alter brain function, and accelerate disease development. Despite progress in understanding these pathways, effective medicines targeting brain inflammation are still limited. …”
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Clinical application of optical and electromagnetic navigation system in CT-guided radiofrequency ablation of lung metastases by Zenan Chen, Liangliang Meng, Yueyong Xiao, Jing Zhang, Xiaobo Zhang, Yingtian Wei, Xiaofeng He, Xin Zhang, Xiao Zhang

“…Complete ablation was achieved in 84 lesions (90.3%). 7 lesions showed incomplete ablation and were completely inactivated after repeat ablation. 2 lesions progressed locally, and one of them still had an increasing trend after repeat ablation. …”
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Water quality characteristics of municipal wastewater treatment plants and the prospect of reclaimed water utilization in lower-middle income and water-scarce areas: A case study o... by Yutong Duan, Hongbo Xi, Zhikai Qin, Ruili Guo, Fang Wang, Yue Yuan

“…However, challenges such as inadequate regulatory frameworks, limited infrastructure and the need for systematic planning have hampered progress. This study provides a comprehensive evaluation of reclaimed water utilization in Puyang, offering valuable insights for sustainable water resource management in similar regions.…”
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Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer by Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang

“…Moreover, IFN-γ and IL-2 secretion were found to be enriched in the tumor TME.ConclusionOur study indicated that combination of PO and anti-PD-1 could synergistically suppress CRC progression and altered the tumor microenvironment in favor of antitumor immune responses.…”
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Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic SteatosisSummary by Xiao-lin Wang, Jia-hao He, Ping Xie, Yuan Wu, Ling-yue Dong, Wei An

“…Augmenter of liver regeneration (ALR) is an important liver regulatory protein, and the insufficiency of ALR expression is reported to accelerate liver steatosis progression to liver fibrosis or even hepatic carcinoma (HCC). …”
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Development and Validation of LAMP Assays for Distinguishing MPXV Clades with Fluorescent and Colorimetric Readouts by Nazente Atceken, Sara Asghari Dilmani, Ahmed Choukri Abdullah, Mutlu Sarıkaya, Defne Yigci, Gozde Korkmaz, Savas Tasoglu

“…Clade-I has been associated with more severe disease progression and higher mortality compared to Clade-II, and thus the differentiation between clades can play an important role in predicting disease prognosis. …”
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Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids by Suya Shen, Bing Liu, Wenyan Guan, Ziyao Liu, Yuqing Han, Yingzhe Hu, Yiqiang Chen, Siyuan Liu, Jian He, Zhiwen Li, Weifeng Tang, Pengju Zhang, Wei Ren, Yudong Qiu, Hongping Zheng, Jingjing Li

“…The paclitaxel plus cisplatin (TP)-sensitive group demonstrated significantly longer progression-free survival (PFS) compared to the resistant groups, Hazard ratio (HR), 5.12; 95% confidence intervals (CI 0.58–44.71; p < 0.05), thus illustrating the potential of this approach for guiding personalized treatment strategies. …”
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Systemic Therapy of Neuroendocrine Neoplasia: Single Center Experience from a Cohort of 110 Consecutive Cases by Karin Mayer, Selina Kiry, Anna Yordanova, Hojjat Ahmadzadehfar, Florian C. Gaertner, Ralph A. Bundschuh, Markus Essler, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Hanno Matthaei, Philipp Lingohr, Savita Bisht, Peter Brossart, Georg Feldmann

“…Combination chemotherapy with etoposide plus cisplatin or carboplatin showed disease control rates (DCRs) of overall 74%, with a short median progression-free survival (PFS) of 7 or 5 months, respectively. …”
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Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Res... by Yu. O. Shulpekova, I. V. Maev, V. B. Grinevich, I. B. Khlynov, Yu. G. Shvarts, V. T. Ivashkin

“…None of the patients in Kolofort® group had progression of FD symptoms or required additional therapy. …”
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The Potential Effect of Bualuang (White <i>Nelumbo nucifera</i> Gaertn.) Extract on Sperm Quality and Metabolomic Profiles in Mancozeb-Induced Oxidative Stress in Male Rats by Jiraporn Laoung-on, Pimchanok Nuchniyom, Ketsarin Intui, Churdsak Jaikang, Kanokporn Saenphet, Kongsak Boonyapranai, Giatgong Konguthaithip, Nopparuj Outaitaveep, Sasitorn Phankhieo, Paiwan Sudwan

“…The gavaging of the rats with WNPE before poisoning them with MZ improved creatine, carnitine, acetylcholine, progressive sperm motility, sperm viability, and normal sperm morphology compared to rats who only received MZ. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…Despite advancements in anticancer drugs and optimised chemotherapy regimens that have improved cure rates for malignant tumours, the presence of tumour heterogeneity has resulted in substantial variations among patients in terms of disease progression, clinical response, sensitivity to therapy, and prognosis, posing significant challenges in attaining optimal therapeutic outcomes for each patient. …”
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