Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma by Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. deAraujo, Heidi A. Neubauer, Anna Orlova, Sanna H. Timonen, Diaaeldin I. Abdallah, Aleksandr Ianevski, Heikki Kuusanmäki, Marta Surbek, Elisabeth Heyes, Thomas Eder, Christina Wagner, Tobias Suske, Martin L. Metzelder, Michael Bergmann, Maik Dahlhoff, Florian Grebien, Roman Fleck, Christine Pirker, Walter Berger, Emir Hadzijusufovic, Wolfgang R. Sperr, Lukas Kenner, Peter Valent, Tero Aittokallio, Marco Herling, Satu Mustjoki, Patrick T. Gunning, Richard Moriggl

“…JPX‐0700/−0750 decreased the mRNA and protein levels of STAT3/5 targets involved in cancer survival, metabolism, and cell cycle progression, exhibiting nanomolar to low micromolar efficacy. …”
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Severe anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis with prolonged hyperammonemia: a case report by Chunxia Yan, Lingling Bai, Jingwei Du, Zonglei Chong, Guangjun Xu, Xiaoqian Yang

“…The patient’s condition rapidly progressed to coma, which persisted for 2 months, manifesting as a fulminant course. …”
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Exercise training and chronic kidney disease: characterization and bibliometrics of citation classics of clinical intervention trials by Fan Zhang, Shan Liu, Yan Bai, Liuyan Huang, Yifei Zhong, Yi Li

“…Background Exercise research targeting chronic kidney disease (CKD) has been conducted for more than 30 years, and the benefits of exercise for CKD patients have been progressively demonstrated. This study analyzes citation classics on clinical intervention trials on exercise training and CKD to describe the research landscape and hotspots through bibliometric analysis.Methods To identify clinical trials of exercise training interventions for CKD with more than 100 citations from the Web of Science Core Collection database. …”
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Hypoxia signature derived from tumor-associated endothelial cells predict prognosis in gastric cancer by Ruiheng Wang, Ruiheng Wang, Guijun Liu, Guijun Liu, Ke Wang, Zhanglei Pan, Zhanglei Pan, Zhihua Pei, Xijiao Hu, Xijiao Hu

“…BackgroundA hypoxic metabolism environment in the tumors is often associated with poor prognostic events such as tumor progression and treatment resistance. In gastric cancer, the mechanism of how hypoxia metabolism affects the tumor microenvironment and immunotherapy efficacy remains to be elucidated.MethodsWe used the bulk-mapping method to analyze the signatures correlated with the response of immunotherapy in the single-cell dataset. …”
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Whole transcriptome analysis of unmutated sporadic ALS patients' peripheral blood reveals phenotype-specific gene expression signature by Francesca Dragoni, Maria Garofalo, Rosalinda Di Gerlando, Bartolo Rizzo, Matteo Bordoni, Eveljn Scarian, Camilla Viola, Veronica Bettoni, Giuseppe Fiamingo, Danilo Tornabene, Lucia Scanu, Orietta Pansarasa, Luca Diamanti, Stella Gagliardi

“…There are no well-established molecular biomarkers for early diagnosis, prognosis, and progression monitoring of this fatal disease. Classification based on clinical phenotypes could be associated with peculiar gene expression patterns shaped during lifespan, allowing the identification of specific sporadic ALS (sALS) subtypes with less heterogeneous clinical and biological features. …”
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Parasite-Specific IL-17-Type Cytokine Responses and Soluble IL-17 Receptor Levels in Alveolar Echinococcosis Patients by Christian J. Lechner, Beate Grüner, Xiangsheng Huang, Wolfgang H. Hoffmann, Peter Kern, Peter T. Soboslay

“…Resistance to AE has been reported, but the determinants which confer protection are not known. ln this study, we analyzed in patients at distinct stages of Alveolar Echirococcosis, that is cured, stable and progressive AE, as well as in infection-free controls, the cellular production and plasma levels of pro-inflammatory cytokines lL-17A, lL-17B, lL-17F and their soluble receptors lL-17RA (slL-17RA) and IL-17RB (sIL-17RB). …”
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Multiscale Attention Feature Fusion Based on Improved Transformer for Hyperspectral Image and LiDAR Data Classification by Aili Wang, Guilong Lei, Shiyu Dai, Haibin Wu, Yuji Iwahori

“…This structure combines the advantages of the Swin transformer, featuring a nonlocal receptive field fusion by progressively expanding the window's receptive field layer by layer while preserving the spatial features of the image. …”
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Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity by Sung-Soo Jang, Sara E. Royston, Gunhee Lee, Shuwei Wang, Hee Jung Chung

“…Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Pathologic accumulation of soluble amyloid-β (Aβ) oligomers impairs synaptic plasticity and causes epileptic seizures, both of which contribute to cognitive dysfunction in AD. …”
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Squamous Cell Carcinoma of Nasofacial Groove by Tamajit Sau, Saumitra Kumar, Ankita Atin Mukherjee, Debalina Mazumdar

“…Case Report: A 65-year-old housewife with hypertension and type 2 Diabetes Mellitus presented with painless swelling over right nasofacial groove for last 5 months which was insidious in onset, gradually progressive to reach the present size. On clinical examination, oval, localized, non-tender, hard 2cm x 2cm swelling was found over right nasofacial groove. …”
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Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study by Razieh Zare, Leila Izadi, Mario Alberto Alarcón-Sánchez, Masumeh Taghva, Mohammad Ali Ranjbar

“…Abstract Background Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. …”
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Improving the provision of clinical pharmacy services in low- and middle-income countries: a qualitative study in tertiary health facilities in Tanzania by Fredrick Kalokola, Dorkasi L Mwakawanga, Ritah F Mutagonda, Hamu J Mlyuka, Wigilya P Mikomangwa, Manase Kilonzi, Wema A Kibanga, Alphonce Ignace Marealle, Bertha Mallya, Deogratias Katabalo, Sofia Sanga, John Rwegasha, Rose Magambo, John Mmassy, Sungwa Kabissi, Josephine A Balati, Peter Maduki, Omary Mashiku Minzi, Appolinary A R Kamuhabwa

“…The latter calls for multifaceted engagement from pharmacists, training institutions, policymakers, regulatory bodies and health systems for sustainable progress.…”
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Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis by Zeli Tang, Zeli Tang, Zeli Tang, Caibiao Wei, Xueling Deng, Qiumei Lin, Qiping Hu, Qiping Hu, Qiping Hu, Shitao Li, Jilong Wang, Yuhong Wu, Dengyu Liu, Dengyu Liu, Dengyu Liu, Min Fang, Min Fang, Tingzheng Zhan, Tingzheng Zhan, Tingzheng Zhan

“…Key molecules ILF2, CNN2, OLFM4, NOTCH3, and LysoPA were implicated in HCC progression. Furthermore, C. sinensis triggered inflammation, insulin resistance, and pro-tumor immune escape, and exacerbated the complication of degenerative diseases.ConclusionThis study not only provides compelling evidence for elucidating the mechanisms underlying C. sinensis-mediated HCC development but also identifies potential therapeutic targets for HCC patients co-infected with C. sinensis.…”
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Depression and Associated Factors Among Patients with Spinocerebellar Ataxia by Sirivipa Jekpoo, Nahathai Wongpakaran, Tinakon Wongpakaran, Chayasak Wantaneeyawong, Punjaree Wiriyacosol, Pised Methapatara

“…<i>Background and Objectives:</i> Spinocerebellar ataxia (SCA) is a progressive neurodegenerative disease often accompanied by depression. …”
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A novel machine learning-based immune prognostic signature for improving clinical outcomes and guiding therapy in colorectal cancer: an integrated bioinformatics and experimental s... by Yuanchun Zhao, Dexu Xun, Jiajia Chen, Xin Qi

“…Abstract Immune cells are pivotal components in the tumor microenvironment (TME), which can interact with tumor cells and significantly influence cancer progression and therapeutic outcomes. Therefore, classifying cancer patients based on the status of immune cells within the TME is increasingly recognized as an effective approach to identify prognostic biomarkers, paving the way for more effective and personalized cancer treatments. …”
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Parallel Hatching: A New Method of Hand Deformity Surgery in Epidermolysis Bullosa by Siamak Farokh Forghani, MD, Rana Irilouzadian, MD, Ali Shabbak, MD, Amir Saraee, MD

“…Purpose: In dystrophic epidermolysis bullosa (EB), progressive blistering, scarring, and fusing of digits lead to mitten-hand and pseudosyndactyly in early childhood, inflicting psychosocial stress and low self-esteem in EB patients. …”
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Mercury Vapour Long-Lasting Exposure: Lymphocyte Muscarinic Receptors as Neurochemical Markers of Accidental Intoxication by E. Roda, A. Giampreti, S. Vecchio, P. Apostoli, T. Coccini

“…At t2 (eight months after two cycles of DMSA chelating therapy ending), gradual improving of clinical manifestations was accompanied by progressive decrease of BHg and UHg (4.0 and 2.8 microg/L, resp.) and peripheral l-MRs neurochemical marker (24.89 femtomoL/million lymphocytes). …”
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FGF23-related hypophosphatemia in a patient with small cell lung cancer: a case report and literature review by Hajime Kato, Soichiro Kimura, Maho Taguchi, Takashi Sunouchi, Yoshitomo Hoshino, Naoko Hidaka, Nadia Edvige Foligno, Minae Koga, Katsunori Manaka, Hiroyuki Tamiya, Masanori Kawakami, Hidenori Kage, Yoichi Yasunaga, Masaomi Nangaku, Noriko Makita, Nobuaki Ito

“…Even after two subsequent courses of chemotherapy, the small cell lung cancer progressed, and the FGF23 level was further elevated (83.7 pg/mL). …”
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Advances in carbon dioxide capture and conversion technologies: Industrial integration for sustainable chemical production by Okezie Emmanuel, Rozina, Thaddeus C. Ezeji

“…This review highlights significant progress made in CO2 capture and its integration into various industrial applications. …”
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Synthetic Hydrogel Dilutes <i>Serratia plymuthica</i> Growth— Promoting Effect on <i>Brassica napus</i> L. Under Drought Conditions by Grażyna B. Dąbrowska, Daniel Krauklis, Milena Kulasek, Magdalena Nocny, Marcel Antoszewski, Agnieszka Mierek-Adamska, Beata Kaliska

“…Progressive climate change increases drought frequency, severely impacting crop growth and yield. …”
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Clinical profile, treatment, and outcomes of testicular cancer in a resource-limited setting: a study from Sudan by Eltahir Ahmed Eltahir, Sami Mahjoub Taha Awad, Yassin Mohammed Osman, Mohammed El Imam Mohammed Ahmed, Moawia Mohammed Ali Elhassan

“…At the last follow-up, 44% of patients were in remission, 18% were alive with disease progression, and 36% had died. Conclusions This study highlights the high mortality rate associated with testicular cancer in this resource-limited setting, which is likely due to delayed diagnosis and the advanced stage at presentation. …”
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