Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases by Soumaya Touzani, Abderrahim El Bouazzaoui, Fatima Bouyarmane, Kaoutar Faraj, Nawfal Houari, Brahim Boukatta, Nabil Kanjaa

“…Early recognition, antibiotics, resuscitation, and minimally invasive biliary drainage have improved patient outcomes although there is still progress to be made. Moreover, as multiple organ failure is often associated with mortality in severe acute cholangitis, predictive risk factors of organ failure should be more investigated.…”
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From fibrosis to granuloma: drug induced systemic sarcoidosis-like reaction after rituximab in a patient with primary Sjögren’s syndrome by Rui Rua Coelho, Sara Xavier Pires, José Ricardo Brandão, Inês Furtado

“…The authors present the very rare case of a woman with a primary Sjögren’s syndrome (pSS) started on rituximab for disease control, which evolved with a 3-year indolent progressive systemic sarcoid reaction. There has been much speculation about the potential role of B cells in sarcoidosis. …”
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Research hotspots and trends in the antioxidant effects of acupuncture: A bibliometric analysis from 2003 to 2024 by Zhilin Huang, Song Li, YiHao Zhou, Anhong Dai, Yi Zhang, Meifang Liu, Mengqi Le, Jing Shi

“…Objective: Oxidative stress is an important factor mediating the pathologic progression of many diseases. In recent years, the antioxidant effects of acupuncture have been gradually confirmed. …”
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Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends by Hong-Yu Jiang, Hong-Yu Jiang, Bo Shao, Bo Shao, Hong-Da Wang, Hong-Da Wang, Wen-Qi Zhao, Shao-Hua Ren, Shao-Hua Ren, Shao-Hua Ren, Yi-Ni Xu, Yi-Ni Xu, Tong Liu, Tong Liu, Cheng-Lu Sun, Cheng-Lu Sun, Yi-Yi Xiao, Yi-Yi Xiao, Yi-Cheng Li, Yi-Cheng Li, Qiang Chen, Qiang Chen, Peng-Yu Zhao, Peng-Yu Zhao, Guang-Mei Yang, Guang-Mei Yang, Xu Liu, Xu Liu, Yu-Fan Ren, Yu-Fan Ren, Hao Wang, Hao Wang, Hao Wang

“…Emerging directions are highlighted as crucial for further progress in this evolving area.…”
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Different immunological characteristics of asymptomatic and symptomatic COVID-19 patients without vaccination in the acute and convalescence stages by Li Li, Xin Zhang, Huimin Yan, Muwei Dai, Huixia Gao, Yuling Wang, Ping Jiang, Erhei Dai

“…Further analysis of the subsets of major immune cell types in COVID-19 patients with different clinical presentations in different stages showed that in the acute stages of disease progression, the T helper cell 1 (Th1), IgD+ B and neutrophil subsets increased in COVID-19 patients, especially in symptomatic patients, while the central memory CD4+T cells (CD4 TCM), mucosa-associated invariant T (MAIT) and NK cell subsets decreased significantly, especially in symptomatic patients. …”
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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B. Stöckl, Manuel Schmid, Gianluca Santamaria, Karin Klingel, Damir Kračun, Xinpei Chen, Sabine Bauer, Joachim P. Schmitt, Florian Flenkenthaler, Josh Gorham, Christopher N. Toepfer, David Potěšil, Pavel Hruška, Zbyněk Zdráhal, Zsuzsanna Mayer, Mathieu Klop, Luisa Lehmann, Yishi Qin, Laura Papanakli, Nadine Spielmann, Alessandra Moretti, Thomas Fröhlich, Peter Ewert, Stefan Holdenrieder, Jonathan G. Seidman, Christine E. Seidman, Agnes Görlach, Cordula M. Wolf

“…Targeting Hif-1α might serve as a therapeutic option to mitigate HCM disease progression.…”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…Secondary endpoints included the objective response rate (ORR), progression-free survival (PFS) and overall survival (OS). …”
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YOLO-TC: An Optimized Detection Model for Monitoring Safety-Critical Small Objects in Tower Crane Operations by Dong Ding, Zhengrong Deng, Rui Yang

“…Additionally, we propose the HA-PANet architecture to achieve progressive feature fusion, addressing scale disparities and prioritizing small object detection while reducing noise from unrelated objects. …”
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Experimental case study for optimizing heat sink performance using ZnO nanocarriers integrated with phase change materials for environmental sustainability by Muhammad Farooq, Imran Zahid, M. Yasar Javaid, Noreen Sher Akbar, Enio Pedone Bandarra Filho, M. Farrukh Shahzad, M. Imran Khan, Mohammad Ilyas Khan, Mohammad Rehan, Fahid Riaz

“…Hence, the incorporation of nanocarriers into nontoxic environment friendly PCMs is strongly advocated to promote sustainable progress in electronic thermal management, as it offers clean, zero-emission energy storage solution.…”
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Quercetin inhibits truncated isoform of dopamine- and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer by Han-Sheng Chang, Tzu-Chun Cheng, Shih-Hsin Tu, Chih-Hsiung Wu, You-Cheng Liao, Jungshan Chang, Min-Hsiung Pan, Li-Ching Chen, Yuan-Soon Ho

“…The truncated isoform of dopamine- and cAMP-regulated phosphoprotein (t-DARPP) has been reported to be involved in trastuzumab therapy resistance and promoting tumor progression. To evaluate the t-DARPP expression in BC, paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+ BC tumor tissues. …”
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Analysis of diagnostic genes and molecular mechanisms of Crohn’s disease and colon cancer based on machine learning algorithms by Jie Xiao, Junyao Liang, Tao Zhou, Man Zhou, Dexu Zhang, Hui Feng, Chusen Tang, Qian Zhou, Weiqing Yang, Xiaoqin Tan, Wanjia Zhang, Yin Xu

“…It also offers more connections and pathways for reference regarding the progression of CD to COAD.…”
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The Brain Waves During Reaching Tasks in People With Subacute Low Back Pain: A Cross-Sectional Study by Hsin-Hui Hsu, Yea-Ru Yang, Li-Wei Chou, Yung-Cheng Huang, Ray-Yau Wang

“…Subacute low back pain (sLBP) is a critical transitional phase between acute and chronic stages and is key in determining the progression to chronic pain. While persistent pain has been linked to changes in brain activity, studies have focused mainly on acute and chronic phases, leaving neural changes during the subacute phase—especially during movement—under-researched. …”
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CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy by Samya Jezine Da Silva, Mauro Jorge Cabral-Castro, Luiz Claudio Faria, Carolina Rosadas, Maria Fernanda Lopes de Araújo, Ana Caroline Soares Dutra, Yoshihisa Yamano, Graham Taylor, Marzia Puccioni-Sohler

“…Background and Objectives: HTLV-1-associated myelopathy (HAM) is a chronic progressive inflammatory disease of the spinal cord. …”
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Refined Mapping of Subsurface Water Ice on Mars to Support Future Missions by G. A. Morgan, N. E. Putzig, D. M. H. Baker, A. Pathare, C. M. Dundas, M. B. Russell, M. R. Perry, M. Chojnacki, H. G. Sizemore, A. M. Bramson, E. I. Petersen, S. Nerozzi, R. H. Hoover, Z. Bain

“…Nevertheless, both direct and indirect evidence indicates extensive buried ice across the midlatitudes, including locations where it is presently unstable. While much progress has been made in exploring the processes responsible for ice deposition and preservation during recent climatic fluctuations, a global assessment of the multiple ice reservoirs remains elusive. …”
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STUDY OF THE EFFECT OF HYPOTHERMIC CONSERVATION ON THE INTRACELLULAR SODIUM CONCENTRATION IN THE ENDOTHELIUM OF CORNEAL TRANSPLANTS by G. S. Baturina, I. G. Palchikova, A. A. Konev, E. S. Smirnov, L. E. Katkova, E. I. Solenov, I. А. Iskakov

“…Advancements in the surgical treatment of corneal endothelial diseases depend on progress in graft conservation and its related advantages in assessing the suitability of grafts for transplantation. …”
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Aging Does Not Affect Beta Modulation during Reaching Movements by Serena Ricci, Ramtin Mehraram, Elisa Tatti, Aaron B. Nelson, Martina Bossini-Baroggi, Priya Panday, Nancy Lin, M. Felice Ghilardi

“…Peak latency analysis revealed a progressive delay of the ERS peak that correlated with the total movement time. …”
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Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia by Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Tatsushi Yoshida

“…Cell viability was assessed using the trypan blue dye exclusion assay, while cell cycle progression was analyzed by flow cytometry. The expression of pro-apoptotic proteins Bax and Bak was measured by RT-qPCR. …”
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The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway by Yalan Jiang, Pingping He, Ke Sheng, Yongmiao Peng, Huilan Wu, Songwei Qian, Weiping Ji, Xiaoling Guo, Xiaoou Shan

“…Type 1 diabetes mellitus (T1DM), known as insulin-dependent diabetes mellitus, is characterized by persistent hyperglycemia resulting from damage to the pancreatic β cells and an absolute deficiency of insulin, leading to multi-organ involvement and a poor prognosis. The progression of T1DM is significantly influenced by oxidative stress and apoptosis. …”
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An Actor-Oriented and Architecture-Driven Approach for Spatially Explicit Agent-Based Modeling by Eric Fotsing, Severin Vianey Tuekam Kakeu, Eric Desire Kameni, Marcellin Julius Antonio Nkenlifack

“…Domain experts generally use an ad hoc approach for model development, which relies on a code-and-fix life cycle, going from a prototype model through progressive refinement. This adaptive approach does not capture systematically actors’ knowledge and their interactions with the environment. …”
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Mosaic Structure of GaN Film Grown on Sapphire Substrate by AP-MOCVD: Impact of Thermal Annealing on the Tilt and Twist Angles by J. Laifi, M. F. Hasaneen, H. Bouazizi, Fatimah Hafiz Alsahli, T. A. Lafford, A. Bchetnia

“…The intensity and broadening of the yellow band (YL) in the PL spectra progressively increased with the increasing annealing temperature, suggesting the presence of additional defect states. …”
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