Soybean and avocado unsaponifiables: a review of their potential use in the treatment of osteoarthritis by Ana Sabucedo-Suárez, Ana Sabucedo-Suárez, Mónica López-Peña, Mónica López-Peña, María Permuy, María Permuy, Fernando Muñóz, Fernando Muñóz

“…Despite some discrepancies regarding structural changes in the joints, clinical trials typically demonstrate symptom relief and slow down the disease progression. While ASU demonstrates significant promise in alleviating OA symptoms and reducing reliance on NSAIDs, further research is essential to fully understand its mechanisms of action. …”
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Cardiovascular Disease Detection through Innovative Imbalanced Learning and AUC Optimization by Karthikeyan Palanisamy, Krishnaveni Krishnasamy, Praba Venkadasamy

“…This similarity means it inherits PSVM's benefits, particularly in addressing progressive CVD scenarios with rapid incremental updates. …”
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Ezrin Polarization as a Diagnostic Marker for Circulating Tumor Cells in Hepatocellular Carcinoma by Ibrahim Büdeyri, Olaf Guckelberger, Elsie Oppermann, Dhruvajyoti Roy, Svenja Sliwinski, Felix Becker, Benjamin Struecker, Thomas J. Vogl, Andreas Pascher, Wolf O. Bechstein, Anna Lorentzen, Mathias Heikenwalder, Mazen A. Juratli

“…Circulating tumor cells (CTCs) expressing the dynamic polarity of the cytoskeletal membrane protein, ezrin, have been proposed to play a crucial role in tumor progression and metastasis. This study investigated the diagnostic and prognostic potential of polarized circulating tumor cells (p-CTCs) in HCC patients. …”
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Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial by Pavlos Msaouel, Kai Yu, Ying Yuan, Jianfeng Chen, Xinmiao Yan, Menuka Karki, Fei Duan, Rahul A. Sheth, Priya Rao, Kanishka Sircar, Amishi Y. Shah, Amado J. Zurita, Giannicola Genovese, Min Li, Chih-Chen Yeh, Minghao Dang, Guangchun Han, Yanshuo Chu, Max Hallin, Peter Olson, Rui Yang, Daniela Slavin, Hirak Der-Torossian, Curtis D. Chin, Nizar M. Tannir, Linghua Wang, Jianjun Gao

“…Secondary endpoints were objective response rate (ORR), disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), 1-year survival probability, and sitravatinib pharmacokinetics. …”
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Inferior Outcomes of Fludarabine–Cyclophosphamide–Rituximab Chemotherapy in Korean Chronic Lymphocytic Leukemia Patients with Concurrent Thrombocytopenia and Anemia by Tong-Yoon Kim, Gi-June Min, Young-Woo Jeon, Seung-Ah Yahng, Seok-Goo Cho, Jong-Mi Lee, Myungshin Kim, Ki-Seong Eom

“…<b>Results</b>: The 5-year overall survival (OS) and 5-year progression-free survival (PFS) for all patients were 84.4% and 68.3%, respectively. …”
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Outcomes of Surgical Treatment for Localized Tenosynovial Giant-Cell Tumor of the Foot and Ankle: A Case Series by Edoardo Ipponi, Alfio Damiano Ruinato, Leonardo Lombardi, Martina Cordoni, Silvia De Franco, Antonio D'Arienzo, Lorenzo Andreani

“…Localized lesions in this area are often manifested as firm masses or nodules with slow but continuous progression through months and years. Pain associated with weight-bearing, as well as limitations in joint motions, may be reported, depending on tumor’s location. …”
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Neuroprotective Effect of Melatonin Loaded in Human Serum Albumin Nanoparticles Applied Subconjunctivally in a Retinal Degeneration Animal Model by Sofia Mickaela Martinez, Ayelen Inda, Maximiliano Nicolás Ríos, Carolina del Valle Bessone, Abril Bruera Bossio, Mario Eduardo Guido, José Domingo Luna Pinto, Daniel Alberto Allemandi, Daniela Alejandra Quinteros

“…Oxidative stress plays a key role in their development, damaging retinal cells and accelerating disease progression. Melatonin (Mel) is a potent antioxidant with neuroprotective properties; however, it faces limitations such as low solubility. …”
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Efficacy and Safety Evaluation of Immune Checkpoint Inhibitors in Combination With Chemotherapy for Extensive Small Cell Lung Cancer: Real‐World Evidence by Yuta Yamanaka, Yukiko Okuno, Keisuke Kamisako, Yuta Okazaki, Kentaro Nakanishi, Yume Sanada, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Utae Katsushima, Hiroshige Yoshioka, Takayasu Kurata

“…We assessed the efficacy of the two ICIs across various factors. Results The progression‐free survival (PFS) and overall survival (OS) did not significantly differ between Atezo + CE and Durva + CE/PE as first‐line chemotherapy treatments for SCLC. …”
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Integrated risk analyses as part of national climate risk assessments: lessons learnt from the climate risk assessment of Germany by Walter Kahlenborn, Maike Voss, Luise Porst, Marc Zebisch, Kathrin Renner, Inke Schauser

“…Findings – The authors show that even though progress in establishing integrated assessment methods has been made, no common framework exists so far and only few national CRAs include extensive integrated analyses. …”
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Genetic Parameters of Semen Traits and Their Correlations with Conformation Traits in Chinese Holstein Bulls by Xiao Wang, Jian Yang, Jie Xue, Miao Zhang, Fan Zhang, Kun Wang, Yanqin Li, Yuanpei Zhang, Xiaoping Wu, Feng Wang, Xiuxin Zhao, Junqing Ni, Yabin Ma, Rongling Li, Lingling Wang, Guosheng Su, Yundong Gao, Jianbin Li

“…The elite bull plays an extremely important role in the genetic progression of the dairy cow population. The previous results indicated the potential positive relationship of large scrotal circumference (SC) with improved semen volume, concentration, and motility. …”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

“…Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. …”
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MSTD: A Multi-Scale Transformer-Based Method to Diagnose Benign and Malignant Lung Nodules by Xiaoyu Zhao, Jiao Li, Man Qi, Xuxin Chen, Wei Chen, Yongqun Li, Qi Liu, Jiajia Tang, Zhihai Han, Chunyang Zhang

“…The identification of benign and malignant lung nodules is crucial for timely treatment to reduce the risk of the progression and metastasis of diseases. However, the varied sizes, diverse morphologies, non-fixed positions, and dynamic growth of lung nodules in computed tomography (CT) images make their accurate identification challenging. …”
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Quantifying the sources and health risks of groundwater nitrate via dual NO isotopes and Monte Carlo simulations in a developed planting-breeding area by Jianwei Liu, Shuo Qiao, Shilong Zhao, Hui Chen, Yong Wu, Donghao Li, Ping Liu, Ling Li

“…However, the contribution of N fertilizer may be underestimated because it has undergone a long-term applied history and have progressively accumulated in the soil, and then promoted the entry of groundwater under frequent rainfall and irrigation practices. …”
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Influence of Adipose Tissue-Derived Stem Cells on the Burn Wound Healing Process by Claudio Luciano Franck, Alexandra Cristina Senegaglia, Lidiane Maria Boldrini Leite, Sérgio Adriane Bezerra de Moura, Nathália Forti Francisco, Jurandir Marcondes Ribas Filho

“…The first was on the same day of the burn, when 3.2×106 ADSCs were transplanted shortly after the burned region cooled, while the second stage occurred four days later with the same number of ADSCs. The progress was evaluated by immunohistochemical methods and H&E, Masson’s trichrome, Picrosirius red, and Lyve-1 immunofluorescence staining. …”
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Bioinformatics combining machine learning and single-cell sequencing analysis to identify common mechanisms and biomarkers of rheumatoid arthritis and ischemic heart failure by Ziyi Sun, Jianguo Lin, Xiaoning Sun, Zhangjun Yun, Xiaoxiao Zhang, Siyu Xu, Jinlong Duan, Kuiwu Yao

“…The findings underscore the critical roles of sarcomere organization, prolactin signaling, protein methyltransferase activity, and immune responses in the progression of IHF in RA patients. These insights not only identify valuable biomarkers and therapeutic targets but also offer promising directions for early diagnosis, personalized treatments, and preventive strategies for IHF in the context of RA. …”
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Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome by Kun-Chen Lin, Christopher Glenn Wallace, Tsung-Cheng Yin, Pei-Hsun Sung, Kuan-Hung Chen, Hung-I Lu, Han-Tan Chai, Chih-Hung Chen, Yi-Ling Chen, Yi-Chen Li, Pei-Lin Shao, Mel S. Lee, Jiunn-Jye Sheu, Hon-Kan Yip

“…Flow cytometry demonstrated that albumin levels and numbers of inflammatory cells (Ly6G+/CD14+/CD68+/CD11b/c+) in bronchoalveolar lavage fluid were the highest in untreated ARDS, were progressively reduced across SW, Mito, and SW + Mito (all p<0.0001), and were the lowest in sham controls. …”
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Self-Reported Disability in Adults with Severe Obesity by I. Kyrou, G. Osei-Assibey, N. Williams, R. Thomas, L. Halder, S. Taheri, P. Saravanan, S. Kumar

“…Self-reported disability in performing daily life activities was assessed in adults with severe obesity (BMI ≥ 35 kg/m2) using the Health Assessment Questionnaire (HAQ). 262 participants were recruited into three BMI groups: Group I: 35–39.99 kg/m2; Group II: 40–44.99 kg/m2; Group III: ≥45.0 kg/m2. Progressively increasing HAQ scores were documented with higher BMI; Group I HAQ score: 0.125 (median) (range: 0–1.75); Group II HAQ score: 0.375 (0–2.5); Group III HAQ score: 0.75 (0–2.65) (Group III versus II P<0.001; Group III versus I P<0.001; Group II versus I P=0.004). …”
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Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis by Allysson Cramer, Bruno Cabral de Lima Oliveira, Paulo Gaio Leite, David Henrique Rodrigues, Fatima Brant, Lisia Esper, Pollyana Maria Oliveira Pimentel, Rafael Machado Rezende, Milene Alvarenga Rachid, Antonio Lucio Teixeira, Ana Maria Caetano Faria, Mauro Martins Teixeira, Fabiana Simão Machado

“…However, while in WT mice, maximal clinical EAE score was followed by a progressive recovery; the SOCS2-/- mice were unable to recover from locomotor impairment that occurred during the acute phase. …”
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The individualization of the educational and training process in fencing in the context of improving efficiency and health of young athletes of different ages by Mykhailo Bocharov, Georgiy Korobeynikov, Iryna Kryventsova, Victoriia Klymenchenko, Igor Vypasniak

“…The training program lasted for 12 months, including specialized exercises and tests to evaluate progress in physical and technical-tactical readiness. …”
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A novel validation approach shows new, solid reasons why vertical jump height should not be used to predict leg power by Luis Fernando Aragón-Vargas, María Isabel González-Lutz

“…Jump height continues to bewidely used to predict power in humans. Individual progress is often monitored on the basis of estimated power, butprediction equations are based on group data. …”
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