Prognostic significance of mast cell and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1 by Roberto André Torres de Vasconcelos, Pedro Guimarães Coscarelli, Thyago Marsicano Vieira, Washington Silva Noguera, Davy Carlos Mendes Rapozo, Marcus André Acioly

“…The role of mast cells in tumor progression is unclear and lacks prognostic value. Higher MVD has prognostic significance with possible therapeutic implications in MPNST.…”
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Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

“…Background and purpose: Prior work on adaptive organ-at-risk (OAR)-sparing radiation therapy has typically reported outcomes based on fixed-number or fixed-interval re-planning, which represent one-size-fits-all approaches and do not account for the variable progression of individual patients’ toxicities. The purpose of this study was to determine the personalized optimal timing of re-planning in adaptive OAR-sparing radiation therapy, considering limited re-planning resources, for patients with head and neck cancer (HNC). …”
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The Ukrainian war and the pandemic: the impact on public health and the need for new health digital tools and the next level of intelligence by M. Geanta, B. Cucos, A. Boata, A.C. Nuta, F.M. Nuta, V.V. Semenov

“…The aim: to review the progress regarding viral surveillance technologies that use genomics, digital, and informational tools, to find the gap in the literature and formulate policy recommendations for continuing surveillance in the context of permacrisis. …”
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Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence by Ekaterina I. Kim, Anna K. Eremkina, Alina R. Elfimova, Natalia G. Mokrysheva

“…The risk factors of disease progression are crucial for choosing the optimal treatment strategy, including adjuvant methods and patient,s follow-up. …”
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Time Series Classification of Raw Voice Waveforms for Parkinson's Disease Detection Using Generative Adversarial Network-Driven Data Augmentation by Marta Rey-Paredes, Carlos J. Perez, Alfonso Mateos-Caballero

“…In this context, many recent studies have focused on the automatic detection and progression tracking of PD from voice-related characteristics, being feature engineering the most common approach. …”
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Intramedullary Stress and Strain Correlate with Neurological Dysfunction in Degenerative Cervical Myelopathy by Mahmudur Rahman, Karthik Banurekha Devaraj, Omkar Chauhan, Balaji Harinathan, Narayan Yoganandan, Aditya Vedantam

“…Degenerative cervical myelopathy (DCM) is characterized by progressive neurological dysfunction, yet the contribution of intramedullary stress and strain during neck motion remains unclear. …”
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Not All SLAPs Are Created Equal: A Comparison of Patients with Planned and Incidental SLAP Repair Procedures by Mark C. Dougherty, J. Erik Kulenkamp, Haroutioun Boyajian, Jason L. Koh, Michael J. Lee, Lewis L. Shi

“…Epidemiological studies have shown a progressive increase in the rate of superior labrum anterior-posterior (SLAP) repair surgery after the year 2000. …”
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Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD by Charles I. V. Drummer, Fatma Saaoud, Yu Sun, Diana Atar, Keman Xu, Yifan Lu, Ying Shao, Candice Johnson, Lu Liu, Huimin Shen, Nirag C. Jhala, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…Our findings provide novel insights on the synergies between hyperlipidemia and hypomethylation in establishing TI and promoting inflammation in NASH and NAFLD progression and novel targets for future therapeutic interventions for NASH and NAFLD, metabolic diseases, transplantation, and cancers.…”
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Subject Advisors’ Understanding of their Curriculum Leadership Roles for Mathematics Improvement in South African Schools by Thabo France Sithole, Simon Adjei Tachie, Tafirenyika Mafugu

“…Many expressed a need for training, particularly in managing and supporting progressed learners. These findings suggest the need for a standardized model to guide leadership training for Mathematics subject advisors. …”
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Advanced heart failure: guideline‐directed medical therapy, diuretics, inotropes, and palliative care by Daniela Tomasoni, Julie K.K. Vishram‐Nielsen, Matteo Pagnesi, Marianna Adamo, Carlo Mario Lombardi, Finn Gustafsson, Marco Metra

“…The number of patients that progress to an advanced stage of HF is growing. Only a limited proportion of these patients can undergo heart transplantation or mechanical circulatory support. …”
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Congenital Malaria and Its Associated Factors at Issaka Gazobi Maternity of Niamey in Niger by I. Tahirou, M. O. Zara, M. L. Moustapha, M. Kamayé, D. Mahamadou, A. Ibrahim, M. Daou, A. Soumana, M. L. Ibrahim

“…In Niger, one out of four newborns is infected with Plasmodium. Infection can progress to congenital malaria disease. The use of mosquito nets and intermittent preventive treatment would reduce the incidence of congenital malaria.…”
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Prevalence of Myopia among Children Attending Pediatrics Ophthalmology Clinic at Ohud Hospital, Medina, Saudi Arabia by Aisha Mohammed Alemam, Mohammed Hamad Aldebasi, Abdulkarem Rehmatullah, Rami Alsaidi, Ishraq Tashkandi

“…We hope that the results of this study will contribute to a better understanding of this public health issue in Saudi Arabia in order to implant a strict screening program for early detection and interventions to reduce the risk of further progression of visual impairment.…”
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Molecular dynamics simulation of wild and mutant proteasome subunit beta type 8 (PSMB8) protein: Implications for restoration of inflammation in experimental autoimmune encephalomy... by Shamrat Kumar Paul, Md Saddam, Nisat Tabassum, Mahbub Hasan

“…MS has inflammatory progression characterized by its hallmark inflammatory plaques. …”
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Do goats recognise humans cross-modally? by Marianne A. Mason, Stuart Semple, Harry H. Marshall, Alan G. McElligott

“…Accordingly, heart rate decreased as the playback sequence progressed, but only when the face and voice presented were incongruent. …”
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Risk factors and metabolic control degree in diabetic patients older than 8 years by Antonio Masot Rangel, Dinorah Janet Torres Lugo, Iván Castillo Ledo, Silvia Janet Masot Torres, Laura Vazquez Pis, Iriam Rojas Díaz

“…<p><strong>Foundation</strong>: Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. The progressively longer survival of diabetic children is associated with an increase in the prevalence of complications. …”
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Impact of Obesity Visceral Adiposity and Metabolic Syndrome on Male Fertility by Esra Bahar Gur, Ebru Sahin Gulec, Sadik Ince, Mehmet Zeynel Keskin, Ahmet Demir, Baris Sengul, Mehmet Serkan Gur

“…In multiple regression analysis, the effect of anthropometric measurements, including visceral fat thickness, on semen parameters was not found, but only smoking was found to be a factor affecting sperm concentration, progressive motility, and morphology (p=0.03, p=0.03, and p=0.01). …”
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Evolution of Functional and Paraclinical Markers as Predictive Factors in Pediatric Late-Onset SMA Under Nusinersen Treatment: The Role of CSF pNF-H by Mihaela Badina, Gabriel Cristian Bejan, Corina Sporea, Andrada Mirea

“…Spinal Muscular Atrophy (SMA) is a rare neurodegenerative disease caused by insufficient synthesis of SMN protein, characterized by progressive muscle weakness, atrophy, and complications affecting the respiratory and digestive systems. …”
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The opposite association of HRAS and KRAS mutations with clinical variables of bladder cancer by M. P. Smal, A. I. Rolevich, T. N. Nabebina, S. A. Krasny, R. I. Goncharova

“…The aim of this study was to determine the frequency and spectrum of HRAS, KRAS and NRAS mutations, to analyze their relationships with clinicopathological variables and to determine the prognostic value of these alterations in terms of recurrence, progression and mortality, in a prospective cohort of 249 bladder cancer patients. …”
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Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease by Hui Xu, Anakha Ajayan, Ralf Langen, Jeannie Chen

“…Thus, the eye may serve as a useful system to track disease progression and to test therapeutic intervention strategies for HD.…”
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Clinical utility of tumour mutational burden on efficacy of immune checkpoint inhibitors in malignant solid tumours: protocol for a systematic review and meta-analysis by Xiaoguang Yang, Yunming Li, Xuemei Xiang, Wang Guo, Pengfei Zhou

“…We will compare the efficacy of ICIs between TMB high group and TMB low group in terms of the HRs of overall survival (OS) and progression-free survival (PFS), and the OR of the objective response rate/overall response rate (ORR). …”
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