LOW POWER BRACHYTHERAPY IN COMBINED TREATMENT IN PATIENTS WITH INTERMEDIATE RISK OF LOCALIZED PROST ATE CANCER by V. A. Biryukov, O. B. Karyakin, O. V. Morov, O. G. Lepilina, D. V. Neledov, D. B. Sanin, G. N. Grishin, M. S. Kalinina

“…It is possible to draw tentative conclusions about the high rate of survival without progression in both treatment groups on the background of the relatively low frequency of adverse reactions. …”
Get full text

Identification of mitophagy-related biomarkers and immune infiltration in polycystic ovarian syndrome by bioinformatic study by Hongjuan Ye, Xicheng Wang, Zhiying He

“…In this study, we aimed to investigate the potential prognostic value of mitophagy-related genes in PCOS patients and to analyze their role in immune infiltration during PCOS pathogenesis and progression. Methods: Training datasets were used for differential expression genes. …”
Get full text

Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis by Qian Guo, Xinxin Zhong, Zihan Dang, Baiquan Zhang, Zixin Yang

“…Conclusion GBN5 plays an important role in the genesis and progression of various tumors and is a potential tumor diagnostic and prognostic biomarker as well as an anti-cancer therapeutic target.…”
Get full text

Release of apoptosis inhibitor of macrophage (AIM) from pentameric IgM in serum predicts prognosis after hemodialysis initiation by Keisuke Yasuda, Akemi Nishijima, Tomoko Inoue, Toshio Takagi, Kazunari Tanabe, Jun Minakuchi, Satoko Arai, Toru Miyazaki

“…Results AIM dissociation from IgM increases with CKD progression and correlates with the serum uremic state, as shown by enhanced AIM release from IgM in vitro with sera from patients starting dialysis, but not those at earlier CKD stages. …”
Get full text

The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…The ORR was 45.5% (95% CI, 31.97-59.45). The median progression-free survival was 11.0 (95% CI, 8.21-15.24) months. …”
Get full text

METTL10 attenuates adriamycin-induced podocyte injury by targeting cell dedifferentiation by Jiwen Bao, Ziyang Li, Huanzhen Yao, Bei Wu, Leyi Gu, Yangbin Pan, Ling Wang

“…Beyond epidemic regulation, various lysine methyltransferases have been recently reported to participate in disease progression, including cancers and kidney diseases. …”
Get full text

A New Antibody–Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia by Michela Flego, Mauro Andreotti, Francesca Romana Mauro, Maria Beatrice Arasi, Silvia Zamboni, Zuleika Michelini, Sara Pepe, Clementina Maria Galluzzo, Roberta Amici, Diego Moricoli, Chiara Mazzei, Alessandro Ascione, Alessandra Mallano

“…In chronic lymphocytic leukemia (CLL), natural killer (NK) cells show a dysfunctional phenotype that correlates with disease progression. Our aim was to restore NK cell functionality in CLL through a specifically targeted IL15-stimulating activity; IL15 targeting could, in fact, potentiate the activity of NK cells and reduce off-target effects. …”
Get full text

Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients by Xue Tang, Luoyu Wang, Qi Feng, Hanjun Hu, Yidi Zhu, Zhengluan Liao, Zhongxiang Ding, Xiufang Xu

“…Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. …”
Get full text

The evolution of gender studies in physical education: insights from a bibliometric analysis by Bustanol Arifin, Abdurrohman Muzakki, Ratko Pavlović, Edi Setiawan

“…Contributions from influential authors and support from key academic journals have fuelled this progress. Emerging patterns and themes highlight the complexity of gender issues in this context, emphasising the need for ongoing research and practical interventions to promote gender equality. …”
Get full text

Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion by Jun Wang, Nan Xiao, Zhengnong Zhu, Haiyan Qiao, Fang Zhao, Lukun Zhang, Jizhou Gou, Mengji Lu, Yun He, Hongzhou Lu, Qian Li

“…The early intervention helps slow the progress of clonal expansion of infected cells, reducing the formation of stable and persistent reservoirs, and ultimately posing fewer barriers to achieving a functional cure.…”
Get full text

Machine Learning-Based Radiomics Analysis for Identifying KRAS Mutations in Non-Small-Cell Lung Cancer from CT Images: Challenges, Insights and Implications by Mirjam Schöneck, Nicolas Rehbach, Lars Lotter-Becker, Thorsten Persigehl, Simon Lennartz, Liliana Lourenco Caldeira

“…Kirsten Rat Sarcoma viral oncogene homolog (KRAS) is a frequently occurring mutation in non-small-cell lung cancer (NSCLC) and influences cancer treatment and disease progression. In this study, a machine learning (ML) pipeline was applied to radiomic features extracted from public and internal CT images to identify KRAS mutations in NSCLC patients. …”
Get full text

Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study by Biling Gan, Lei Wu, Shunan Zhou, Zhihong Chen, Fan Wu, Lianqun Xu, Zhenrong Chen, Honghui Ma, Peijia He, Dan Fang, Ning Shi

“…Early research primarily focused on angiogenesis, dendritic cells, and expression markers, while recent trends have shifted towards phase III trials, adverse reactions, and checkpoint inhibitors, underscoring the field’s dynamic progression.ConclusionFuture research will expand on the pathological mechanisms underlying these therapies and novel interventions and combination strategies. …”
Get full text

Validation of Ionospheric Modeled TEC in the Equatorial Ionosphere During the 2013 March and 2021 November Geomagnetic Storms by Min‐Yang Chou, Jia Yue, Jack Wang, J. D. Huba, Mostafa El Alaoui, Maria M. Kuznetsova, Lutz Rastätter, Ja Soon Shim, Tzu‐Wei Fang, Xing Meng, Dominic Fuller‐Rowell, John M. Retterer

“…This study aims to assess the current progress and capability of the CCMC‐hosted ionospheric models in capturing the storm time ionosphere during the low and moderate solar flux years. …”
Get full text

Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives by Domenica Lucia D’Antonio, Anna Zenoniani, Samia Umme, Adriano Piattelli, Maria Cristina Curia

“…<i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in several extra-oral human diseases and, lately, in pancreatic cancer progression and prognosis. It is now recognized as oncobacterium. …”
Get full text

Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review by Dan Wang, Yu Chen, Hua Duan, Shu-Yue Zheng, Chufan Luo, Xueni Fang, Haoyue Pang, Man Wang, Tian Zhou, Quanwang Li, Kaiwen Hu

“…The secondary outcomes will be adverse effects, health-related quality of life, changes of immune indicators and surrogate outcomes (disease control rate, progression-free survival and survival rate).Ethics and dissemination Ethics approval is not required, as this study will not involve patients. …”
Get full text

First International Conference on Lysophospholipids and Related Bioactive Lipids in Biology and Disease Sponsored by the Federation of American Societies of Experimental Biology by Edward J. Goetzl, Gabor J. Tigyi, Timothy Hla

“…More than 100 scientists from 11 countries discussed the recent results of basic and clinical research in the broad biology of this emerging field. Immense progress was reported in defining the biochemistry of generation and biology of cellular effects of the bioactive lysophospholipids (LPLs). …”
Get full text

Trace elements in children with pre-dialysis and end-stage renal disease by Alsalam Asmaa Abd, Ali Ruaa H., Hussain Haider K., Mahdi Montadher Ali

“…Trace elements as iron (Fe), zinc (Zn) and copper (Cu) are required for a variety of physiological activities and may influence CKD progression. The main goal of this work was to analyse the amounts of trace elements among children with CKD and ESRD and their potential as disease stage biomarkers. …”
Get full text

Chronic periodontitis clinical and epidemiological characterization by Bernardo Pérez Barrero, Clara Ortiz Moncada, Walkyria del Carmen González Rodríguez, Lilian Judith Del Todo Pupo

“…<br /><strong>Conclusions</strong>: a high prevalence of chronic periodontitis was obtained, significantly associated with age and initiating risk factors, which were represented progressively according to the stages of the disease.…”
Get full text

Neutrophil-to-lymphocyte ratio as a prognostic factor in patients with castration-resistant prostate cancer treated with docetaxel-based chemotherapy: a meta-analysis by Ying Zhang, Xiao Zhou, Ran Xu, Guangcheng Luo, Xinjun Wang

“…RevMan 5.4.1 was used to summarize the hazard ratio (HR) and its 95% confidence interval (CI) for overall survival (OS) and progression-free survival (PFS) with subgroup analysis. …”
Get full text

Influence of implant length on implant primary and secondary stability by Mauricio Toro, Javiera Leitao, Tomás Yoma, Alain Manuel Chaple Gil, Eduardo Fernández

“… Introduction: Implant stability can be measured at the moment of implant placement or once the osseointegration process is in progress. Many factors should be considered, including bone quality, osteotomy preparation, implant design, implant surface enhancement, and implant length and diameter. …”
Get full text