Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy by Ruixia Ma, Ying Wang, Yan Xu, Rui Wang, Xianghua Wang, Ning Yu, Minghui Li, Yan Zhou

“…Our results suggest that tacrolimus protects podocytes during the progression of type 2 diabetic nephropathy, possibly ameliorating podocyte apoptosis by downregulating the expression of TRPC6.…”
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Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non–Small Cell Lung Cancer With High Programmed... by Alvin H.K. Cheung, MBBS, PhD, Zeta Mui, MPhil, Walter W. Yeung, PhD, Chit Chow, PhD, Mandy F. Yu, BSc, Olivia H. Chen, MD, PhD, Kit-Yee Wong, MPhil, Fuda Xie, MPhil, Yat Ming Lau, MBBS, Alfred S-L. Cheng, PhD, Wei Kang, PhD, Ka-Fai To, MBChB, Tony S. Mok, MD, Molly S.C. Li, MBBS

“…Results: It was observed that the germline HLA-C homozygosity and HLA-DRB1∗13 expression were related to a worse progression-free survival and treatment response. Importantly, all patients (7/7 patients) who developed pneumonitis in our cohort expressed the HLA-DPB1∗02 allele, and the incidence of pneumonitis was 31.8% (7/22 patients) in patients expressing this allele compared with 0% (0/20 patients) in those without this allele (p = 0.009). …”
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The integration of hospital pharmacists into primary care settings in Shenzhen, China: a qualitative study by Zhiling Deng, Pengxiang Zhou, Yiting Lu, Zhengrong Li, Mi Yao, Yang Li, Chuan Zou, Haixin Li, Songtao Cai, Yi Guo, Yuling Tong, Yang Zhao, Zhijie Xu

“…Efforts should focus on the targeted training of pharmacists’ practical skills, strategic campaigns to raise awareness among the public and healthcare providers, and policy-led efforts to foster technological progress.…”
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Serum Sclerostin as a Possible Biomarker in Ankylosing Spondylitis: A Case-Control Study by Fabio Massimo Perrotta, Fulvia Ceccarelli, Cristiana Barbati, Tania Colasanti, Antonia De Socio, Silvia Scriffignano, Cristiano Alessandri, Ennio Lubrano

“…Further studies are needed to prove the role of sclerostin as a disease activity biomarker and progression of disease in AS.…”
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Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines by Negin Imani Farahani, Negin Imani Farahani, Negin Imani Farahani, Lisa Lin, Lisa Lin, Lisa Lin, Shama Nazir, Shama Nazir, Shama Nazir, Alireza Naderi, Alireza Naderi, Alireza Naderi, Leanne Rokos, Leanne Rokos, Leanne Rokos, Anthony Randal McIntosh, Anthony Randal McIntosh, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian

“…This approach is favorable in the context of brain disorders, which are often heterogeneous in their pathophysiological features, patterns of disease progression and treatment response, resulting in limited therapeutic standard-of-care. …”
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Immunohistochemical evaluation of P53 in squamous cell carcinoma of the esophagus by Kala K, Sarumathy G, Nithya I, Prathiba A

“…Conclusion: In conclusion, the expression of p53 in ESCC patients significantly correlates with age, betel nut chewing and histological grade. p53 play an important role in tumor progression and an independent variable affecting the survival. …”
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Regulation of reactive oxygen species and the role of mitochondrial apoptotic-related genes in rheumatoid arthritis by Conghui Gao, Chengqiang Zhang, Lixing Wen, Gailian Zhang, Xiaoping Liu, Jie Wang, Luping Cui, Rui Li, Tingting Nie, Jiaoniu Duan, Yingying Guo

“…RA biomarkers (MRPS10, EEF2, HSPA9, TUFM) linked to energy & ROS, progression tied to AMPK/mTOR, CD74-MIF crucial. Study advances RA pathogenesis knowledge, supporting clinical diagnosis.…”
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Association of dietary decanoic acid intake with diabetes or prediabetes: an analysis from NHANES 2005–2016 by Huangxin Zhu, Huangxin Zhu, Qingan Fu, Ruxin Chen, Linfei Luo, Miao Yu, Yue Zhou

“…Compared with the DDA intake ≤0.18 g/day, DDA intake >0.58 g/day is related to reduced risk of progression to diabetes in prediabetic patients. However, the relationship between DDA intake and the risk of prediabetes was not statistically significant in the fully adjusted model (OR = 0.95, 95% CI: 0.84–1.07, p = 0.404).ConclusionThis study found that higher DDA intake may be associated with lower prevalence of diabetes among prediabetic population, and high education level strengthen this relationship.…”
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Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing by Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker L. Kothari

“…This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its potential as a therapeutic target, particularly in relation to tumor acidity and immune response. …”
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Dynamic retinal vessel analysis: flickering a light into the brain by Anna Peterfi, Anna Peterfi, Anna Peterfi, Ana Clara da C. Pinaffi-Langley, Ana Clara da C. Pinaffi-Langley, Zsofia Szarvas, Zsofia Szarvas, Zsofia Szarvas, Mihaly Muranyi, Mihaly Muranyi, Mihaly Muranyi, Zalan Kaposzta, Zalan Kaposzta, Zalan Kaposzta, Cheryl Adams, Camila Bonin Pinto, Camila Bonin Pinto, Peter Mukli, Peter Mukli, Peter Mukli, Konstantin Kotliar, Andriy Yabluchanskiy, Andriy Yabluchanskiy, Andriy Yabluchanskiy, Andriy Yabluchanskiy

“…In this context, non-invasive techniques may be used to identify early changes and monitor disease progression. Dynamic retinal vessel analysis (DVA) provides an opportunity to measure retinal vasoreactivity in a way that may be comparable to cerebral vasoreactivity, thus providing a window to the brain.MethodsWe conducted a literature search on PubMed and Scopus to identify studies utilizing DVA to describe retinal vasoreactivity in central nervous system diseases and compare it with brain function and structure. …”
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Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method by Qiu-Shi Feng, Xiao-Feng Shan, Vicky Yau, Zhi-Gang Cai, Shang Xie

“…Tumor stroma, representing the non-cancerous and non-cellular composition of the tumor microenvironment (TME), plays a crucial role in oncogenesis and progression, through its interactions with biological, chemical, and mechanical signals. …”
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Hopping backward to move forward: Single-leg backward hopping can better detect decreased quadriceps strength induced by a fatigue protocol compared to forward and vertical hopping by Yu Song, Lauren Salsgiver, Kaden Van Valkenburg, Natalie Christofferson, Yessica Lo, Zhichen Feng, Brenna McGuinness, Boyi Dai

“…The findings may contribute to the development of a clinically applicable and valid strength assessment to monitor the rehabilitation progress in patients following ACL reconstructions.…”
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ST-Elevation Myocardial Infarction: A Simulation Case for Evaluation of Interprofessional Performance in a Hospital by Hadiki Habib, Eka Ginanjar, Arif Mansjoer, Septo Sulistio, Imamul A. Albar, Radi M. Mulyana

“…Beginning in the emergency department, it detailed a 50-year-old male presenting with progressive chest pain since 7 hours before admission. …”
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Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Developme... by Márcia Dias Teixeira Carvalho, Diego Peres Alonso, Célia Maria Vieira Vendrame, Dorcas Lamounier Costa, Carlos Henrique Nery Costa, Guilherme Loureiro Werneck, Paulo Eduardo Martins Ribolla, Hiro Goto

“…In visceral leishmaniasis (VL) endemic areas, a minority of infected individuals progress to disease since most of them develop protective immunity. …”
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Identification of MYC and STAT3 for early diagnosis based on the long noncoding RNA-mRNA network and bioinformatics in colorectal cancer by Kunhou Yao, Hao Fan, Tiancheng Yang, Can Yang, Guibin Wang, Xingwang Li, Xin-Ying Ji, Qun Wang, Shaojiang Lv, Shihao Guo

“…Long non-coding RNAs (lncRNAs) have been implicated in various cancers, including CRC, playing key roles in tumor development, progression, and prognosis.MethodsA comprehensive search of the PubMed database was conducted to identify relevant studies on the early diagnosis of CRC. …”
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Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease by Maria Galluzzo, Elisa Ciraolo, Monica Lucattelli, Eriola Hoxha, Martina Ulrich, Carlo Cosimo Campa, Giuseppe Lungarella, Gerd Doring, Zhe Zhou-Suckow, Marcus Mall, Emilio Hirsch, Virginia De Rose

“…Neutrophil-dominated airway inflammation is a key feature of progressive lung damage in cystic fibrosis (CF). Thus, reducing airway inflammation is a major goal to prevent lung damage in CF. …”
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Tree shrew as a new animal model for musculoskeletal disorders and aging by Xiaocui Wei, Honghao Li, Jingyang Qiu, Jianlin Jiao, Xiongtian Guo, Gaosheng Yin, Ping Yang, Yi Han, Qiongzhi Zhao, Hao Zeng, Zhi Rao, Xuefei Gao, Kai Li, Pinglin Lai, Sheng Zhang, Chengliang Yang, Di Lu, Xiaochun Bai

“…Surgery-induced IDD models were successfully established in tree shrews, in which the lumbar spine instability model developed slow progressive disc degeneration with more similarity to the clinical state, whereas the needle puncture model led to the rapid development of IDD with more severe symptoms. …”
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Association of Subclinical Hypothyroidism in Type 2 Diabetic Individuals by Noor ul ain, Sheikh Abdul Saeed, Muhammad sajid Abbas jaffri, Shazia Shakoor, Shah jabeen, Sana Kashif

“…Conclusion: Increase in TSH level was considered as another risk factor for the progression of type 2 diabetes in euthyroid subjects and there is high prevalence of subclinical hypothyroidism among type 2 diabetes patients compared to non-diabetic subjects. …”
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The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells by Rafał Bieś, Agnieszka Mikosińska, Jakub Parys, Mateusz Litwin, Patrycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek

“…Dysregulation of this pathway has been implicated in cancer progression and poor prognosis. Despite its potential as a therapeutic target, the complexity of HGF/c-Met signaling and the associated challenges, such as off-target effects and limited understanding of its role in different disease contexts, pose significant obstacles to clinical translation. …”
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Clinical case of a pelvic fracture with massive retroperitoneal hematoma by D.A. Krishtafor, A.A. Krishtafor, A.V. Tsarev, D.V. Balyk, A.Y. Halushchak, V.A. Pelekh

“…On the 3rd day after the operation, the patient died due to progressive multiple organ failure. The described case demonstrates the severity of the condition of victims with a traumatic retroperitoneal hematoma and the difficulty of diagnosis and effective treatment using conservative methods.…”
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