Tratamiento farmacológico de la obesidad. Situación actual y nuevos tratamientos by Julio Sagredo Pérez, Gonzalo Allo Miguel

“…Abstract: The high incidence of obesity in our environment, the progressive and recurrent nature of this disease makes it necessary to know and use all the possibilities of prevention and treatment.When a person suffers from obesity we must offer a treatment plan with specific objectives that will include healthy eating, physical activity and, if necessary, treatment with medication or even surgery.At present in Spain, there are 3 medications available: • Orlistat, with low efficacy and little use. • Liraglutide and semaglutide, both based on incretins and capable of improving obesity, diabetes and other obesity-related conditions. …”
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ALDH1A3–Linc00284 Axis Mediates the Invasion of Colorectal Cancer by Targeting TGFβ Signaling via Sponging miR-361-5p by Chunlin Ke, Minmin Shen, Peirong Wang, Zhihua Chen, Suyong Lin, Feng Dong

“…Knockdown ALDH1A3 or Linc00284 significantly reduced TGFβ expression and suppressed the EMT process, while overexpression had opposite effects. miR-361-5p targeted TGFβ directly, which negatively correlated with ALDH1A3–Linc00284 expression and CRC progression. Mechanistically, upregulation of ALDH1A3–Linc00284 promotes colorectal cancer invasion and migration by regulating miR-361-5p/TGFβ signaling pathway. …”
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传统风格建筑方形CFST-圆形RC截面混合柱侧移刚度及延性分析 by 薛建阳, 马林林, 林建鹏

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Pharmacogenomics Tools for Precision Public Health and Lessons for Low- and Middle-Income Countries: A Scoping Review by Borbón A, Briceño JC, Valderrama-Aguirre A

“…A total of 40 documents were selected, which revealed the continuous evolution and progressive development of pharmacogenomic tools. The technological tools developed come from high-income countries, particularly the United States, Canada, China, and several European nations, where international collaboration has been essential to maintain and expand these tools, which have evolved to keep pace with the rapid generation of genomic data. …”
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Military and Political Studies by A. I. Podberyozkin

“…A specialist in military and political issues should not only be an expert in the field of international relations and diplomacy, but also have a deep knowledge of military-technical issues to understand the basic trends in the development of scientific and technological progress and its impact on the balance of forces in the world. …”
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钢框架-覆竹木碳纤维板轻钢剪力墙结构抗震性能研究 by 张铮, 林韩, 陈南龙

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Filtering Data of High-Resolution Terrestrial Laser Scanner and Effects of Filtrations on the Landslide Monitoring by Mustafa Zeybek, İsmail Şanlıoğlu, Aşır Genç

“…In this article, automatic filtering of terrestrial laser scanning data, filtering of trees and other objects on the earth and acquiring digital elevation model (DEM) and by means of this model, assessing changes occurring in the elevation components on the land surface and the effect of filtering algorithms on analysis were investigated. Progressive Morphological Filtering (PMF) algorithm was used for this research. …”
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双层斜开槽钢板剪力墙受力性能研究 by 薛子蓬, 王庆杰, 王培军

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The essence and features of corruption as an object of administrative and legal influence by E. O. Muzychuk

“…The article states that the formation of an understanding of the essence of corruption begins at the turn of the New Age, when the progressive thought of contemporary philosophers outlined the essence of legal behaviour, which was no longer influenced by religious dogmas. …”
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Endogenous economic growth from the perspective of Islamic economic doctrine by Qasemi Abdulkhaliq, Tavakkoli Mohammad Javad

“…Humans are responsible for solving each other's problems, and economic growth should be aimed at goals such as welfare, salvation, human excellence, and social progress. The research method related to this treatise is analytical and descriptive in terms of writing and addressing the research problem, but in terms of the purpose, it is applied and developmental with a qualitative approach. …”
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‘Health Camp’ model: a unique approach for child vaccination in non-state armed actor controlled, inaccessible geographies in Somalia by Mohamed Hussein Kahow, Salad Ahmed Halane, Asma Ali, Rashed Shah

“…The project has achieved significant milestones aligned with national health strategic plans, including progress towards universal health coverage and improved immunization access in Somalia’s most challenging regions.…”
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Nursing students in isolation during the COVID-19 pandemic: A phenomenological study by Vistolina Nuuyoma, Frieda Makambuli

“…Conclusion: Students experienced isolation as a period of reflecting on how their symptoms commenced and progressed from minor to major. Students’ sources of resilience and coping mechanisms were to remain opportunistic, learn new skills and lean on family support. …”
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Development and internal validation of a metabolism-related model for predicting 30-day mortality in neonatal sepsis by Xiangwen Tu, Junkun Chen, Wen Liu

“…Abstract Objective Neonatal sepsis, a severe infectious disease associated with high mortality rates, is characterized by metabolic disturbances that play a crucial role in its progression. The aim of this study is to develop a metabolism-related model for assessing 30-day mortality in neonatal sepsis. …”
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Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management by Anitha Sriram, Harshada Ithape, Pankaj Kumar Singh

“…Arthritis is an inflammatory joint disorder that progressively impairs function and diminishes quality of life. …”
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Experience of MOOC designing and implementation in teaching philology students by Olga M. Osiyanova, Anna V. Osiyanova

“…The paper is devoted to one of the most important problems for the modern education, connected with educational process modernization, based on progressive information technologies. The authors focus their attention on theoretical and practical aspects of Massive Open Online Course (MOOC) designing and implementation as an educational resource and independent educational system element. …”
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铝合金结构构件的设计公式及其可靠度研究 by 沈祖炎, 郭小农

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Polatuzumab vedotin combined with bendamustine and rituximab for relapsed/refractory diffuse large B-cell lymphoma: A systematic review protocol. by Mohammadreza Eslami, Mahdi Mehrabi, Mehrdad Payandeh, Fakhredin Saba

“…The primary endpoint is overall survival, with secondary endpoints being progression-free survival and incidence of adverse events. …”
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屈曲约束钢板联肢剪力墙结构的弹性分析 by 王海江, 李国强, 黄小坤, 孙飞飞

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SOCIAL-PSYCHOLOGICAL PORTRAIT OF A SOCIALLY ACTIVE STUDENT OF A TECHNICAL HIGHER EDUCATION INSTITUTE by Elena O. Tarasova, Konstantin V. Yuriev

“…The majority of them have an active position in life, independence, responsibility for themselves, and they consider their actions to be important factors in their progress. They are capable of achievingtheir goals in future, controlling their interactions with other people and to gain sympathy and respect at the same time. …”
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Treatment of tardive dyskinesia caused by long-term antipsychotic use: case reports and literature review by I. Pabarčiūtė, M. Karnickas

“…Akathisia and hand dyskinesia appeared ~7 years ago and gradually progressed to choreoathetoid movements of the face, neck, arms, and torso. …”
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