Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Macrophage population is active in inflammatory process, yet the clear understanding of the causative roles for these macrophage cells in HF development and progression is actually incomplete. Long ago, it was thought that macrophages are of importance in the heart after MI. …”
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The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: a study protocol by Christina S. Thornton, Nicole Boechler, Vidhi Desai, Ranjani Somayaji, Swathi Purighalla, Sarah Brode, Theodore K. Marras, Ryan Cooper, Maeve Smith, Julie Jarand

“…The comprehensive Canadian Bronchiectasis and Nontuberculous Mycobacterial (NTM) Registry aims to 1) outline the clinical characteristics and natural history of bronchiectasis in Canada, 2) identify risk factors contributing to disease progression within Canadians, 3) integrate comprehensive clinical information to better understand the phenotypes of bronchiectasis and 4) support the development of large-scale, randomised controlled trials in Canada. …”
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The Expression of T Cell FOXP3 and T-Bet Is Upregulated in Severe but Not Euthyroid Hashimoto’s Thyroiditis by Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Sonja Jaman, Eva Novosadová, Jana Petrkova, Zdenka Navratilova, Mirjana Suver Stević, Martin Petrek

“…Hashimoto’s thyroiditis (HT) is an organ-specific autoimmune disorder characterized by progressive thyroid failure. Th1 and Treg subset of CD4+ cells have been implicated in the pathogenesis; however, less is known about their respective roles across the spectrum of HT clinical presentations. …”
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Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation by Xuan Deng, Lu Chang, Lingyu Tang, Haoqin Jiang, Xiao Xu, Xinju Zhang, Jian Chen, Liu Dong, Qianqian Xu, Ruoshui Cao, Jianbin Xiang, Ming Guan

“…Therapeutic strategy targeting GSH synthesis has been developed, however, failed to produce desirable effects in preventing cancer progression. Thus, uncovering mechanisms of rewired GSH metabolism may aid in the development of additional therapeutic strategies to overcome or delay resistance. …”
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piR-26441 inhibits mitochondrial oxidative phosphorylation and tumorigenesis in ovarian cancer through m6A modification by interacting with YTHDC1 by Jing Yuan, Bu-Min Xie, Yu-Meng Ji, Hai-Juan Bao, Jie-Lin Wang, Jia-Chen Cheng, Xiang-Chun Huang, Yang Zhao, Shuo Chen

“…The resultant TSFM loss reduced mitochondrial complex I activity and mitochondrial OXPHOS, leading to mitochondrial dysfunction in OC cells, increased reactive oxygen species levels, and thus, DNA damage and apoptosis in OC cells, thereby inhibiting OC progression. Additionally, ago-piR-26441 suppressed tumor growth and mitochondrial metabolism in the patient-derived organoid model. …”
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New trends in AA amyloidosis with renal involvement: a single-center experience by Nídia Marques, Catarina Oliveira-Silva, Ana Pinho, Ana Teresa Nunes, Susana Sampaio, Ana Oliveira, Isabel Tavares

“…Global and renal outcomes did not improve, but the average life expectancy increased, suggesting progress in general management and supportive care of renal and underlying pathology.…”
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Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications by Xiao Zhang, Jiatao Liu, Yaolin Cao, Wei Wang, Haoran Lin, Yue Yu

“…Recognizing the pivotal role of mitochondrial RNA modifications (MRM) in cancer progression, this study aims to provide a comprehensive analysis of MRM-related genes and their clinical relevance in lung adenocarcinoma (LUAD). …”
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Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis by Aseel Ghassan Daoud, Wassan Abdul Kareem Abbas, Ahmed Yousif Hasan, Maha N. Abu Hajleh

“…Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is an important biomarker of atherosclerosis progression through pro-inflammatory and anti-inflammatory effects. …”
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Complications and Mortality Characterization in Acute Ischemic Cerebrovascular Disease by Ricardo Leyva Tornés, Lázaro Ibrahim Romero García, Esther Mayor Guerra, Yordanis Páez Candelaria, Karima Gondres Legró, Pedro Alexei Bacardí Zapata

“…Its prevalence is progressively increasing worldwide, as well as associated morbidity, general and premature mortality. …”
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PPIH is a novel diagnostic biomarker associated with immune infiltration in cholangiocarcinoma by Jun Ye, Zhitao Chen, Chuan Zhang, Rui Xie, Haini Chen, Peng Ren

“…Moreover, PPIH may influence tumor progression through its involvement in cell cycle regulation and spliceosome pathways, and is associated with immune cell infiltration levels. …”
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Incidence and Predictors of Advanced Liver Fibrosis by a Validated Serum Biomarker in Liver Transplant Recipients by Mamatha Bhat, Kathleen C. Rollet-Kurhajec, Aparna Bhat, Amanda Farag, Marc Deschenes, Philip Wong, Peter Ghali, Giada Sebastiani

“…Chronic HCV infection, hypoalbuminemia, and hyponatremia predict progression to advanced liver fibrosis following LT. …”
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Reducing Hospital Readmissions in Chronic Obstructive Pulmonary Disease Patients: Current Treatments and Preventive Strategies by Claudia Di Chiara, Giulia Sartori, Alberto Fantin, Nadia Castaldo, Ernesto Crisafulli

“…However, the burden of COPD is still conditioned by frequent acute events defined as exacerbations (exacerbation of COPD-ECOPD), which have a significant impact not only on the patient’s quality of life but also on the progression of the disease, morbidity, and mortality. …”
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CD7‐targeting pro‐apoptotic extracellular vesicles: A novel approach for T‐cell haematological malignancy therapy by Bei Zhang, Jianqiang Chen, Jiming Chen, Yingying Shen, Yinghu Chen, Shibo Wang, Chengyan Zhang, Yuzhou He, Huajun Feng, Jiaoli Wang, Zhijian Cai

“…Abstract T‐cell haematological malignancies progress rapidly and have a high mortality rate and effective treatments are still lacking. …”
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The perspectives of metabolomics studies of potato plants by R. K. Puzanskiy, V. V. Yemelyanov, T. A. Gavrilenko, M. F. Shishova

“…It is obvious that the search for biochemical markers depends on standartization of cultivation techniques, sample preparation and subsequent analysis similar to what has been developed for progress in genomic and transcriptomic studies. In the future, potato metabolome studies might complete classical and molecular approaches to develop new lines and varieties.…”
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Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus by Nina C. B. B. Veiby, Aida Simeunovic, Martin Heier, Cathrine Brunborg, Naila Saddique, Morten C. Moe, Knut Dahl-Jørgensen, Hanna D. Margeirsdottir, Goran Petrovski

“…Lower VD in DCP (OR 0.65, 95% CI 0.51–0.83), longer diabetes duration (OR 1.51, 95% CI 1.22–1.87), and higher waist circumference (OR 1.08, 95% CI 1.02–1.14) were significantly associated with progression of NPDR. VD in SCP and DCP were significantly lower in T1D patients without diabetic retinopathy than in controls. …”
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The evolution and morphodynamic characteristics of shoals and troughs in Lingdingyang Bay of the Pearl River Estuary by Linxi Fu, Linxi Fu, Yuhang Zhong, Yuhang Zhong, Ping Zhang, Ping Zhang, Lixia Niu, Lixia Niu, Xiaohe Zhang, Xiaohe Zhang, Jianliang Lin, Jianliang Lin, Huayang Cai, Huayang Cai, Qingshu Yang, Qingshu Yang

“…Stabilized curves observed between 2008 and 2018 indicate that this estuary is progressively achieving new equilibrium states. The depth–area spatial function is useful for identifying shoals and troughs within various estuaries, which also provides a geomorphological framework for understanding the estuarine evolution and sediment dynamics.…”
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Development of a 50K SNP array for whole-genome analysis and its application in the genetic localization of eggplant (Solanum melongena L.) fruit shape by Chuying Yu, Qihong Yang, Weiliu Li, Yaqin Jiang, Guiyun Gan, Liangyu Cai, Xinchun Li, Zhiqiang Li, Wenjia Li, Min Zou, Yang Yang, Yikui Wang

“…To accelerate the research progress of eggplant genetics and molecular breeding, it is necessary to implement a genome-based breeding strategy.MethodsTherefore, in this study, a SNP array containing 50K liquid-phase probes was designed on the basis of the resequencing data of 577 eggplants.ResultsThe developed 50K liquid-phase probes were used to perform targeted capture sequencing on 12 eggplant lines, and the efficiency of probe capture exceeded 99.25%. …”
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Combined Treatment With Leuprolide Acetate and Burosumab in X-linked Hypophosphatemia and Precocious Puberty: A Therapeutic Response by Gustavo Tempone Cardoso Penna, MS, Carolina Costa Figueiredo, MD, MSc, Nara Michelle de Araújo Evangelista, MD, MSc, Vânia de Fátima Tonetto Fernandes, MD, PhD, Patricia Salmona, MD, Guido de Paula Colares Neto, MD, PhD

“…Conclusion: In the described XLH patient with CPP, the combined use of gonadotropin-releasing hormone analogs and burosumab was a safe strategy to stabilize pubertal progression and bone age, minimize anthropometric loss, and avoid exacerbating bone deformities.…”
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Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment by Ananda Kishore Mukherjee, Subhajit Dutta, Ankita Singh, Shalu Sharma, Shuvra Shekhar Roy, Antara Sengupta, Megha Chatterjee, Soujanya Vinayagamurthy, Sulochana Bagri, Divya Khanna, Meenakshi Verma, Dristhi Soni, Anshul Budharaja, Sagar Kailasrao Bhisade, Vivek Anand, Ahmad Perwez, Nija George, Mohammed Faruq, Ishaan Gupta, Radhakrishnan Sabarinathan, Shantanu Chowdhury

“…Telomeres are crucial for cancer progression. Immune signalling in the tumour microenvironment has been shown to be very important in cancer prognosis. …”
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Smart building energy management with renewables and storage systems using a modified weighted mean of vectors algorithm by Mohamed Ebeed, Sabreen hassan, Salah Kamel, Loai Nasrat, Ali Wagdy Mohamed, Abdel-Raheem Youssef

“…Abstract With the advancement of automation technologies in household appliances, the flexibility of smart home energy management (EM) systems has increased. However, this progress has brought about a new challenge for smart homes: the EM has become more complex with the integration of multiple conventional, renewable, and energy storage systems. …”
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