Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…Abstract Agonists of the stimulator of interferon genes (STING) pathway are increasingly being recognized as a promising new approach in the treatment of cancer. Although progress in clinical trials for STING agonists in antitumor applications has been slow, there is still an urgent need for developing new potent STING agonists with versatile potential applications. …”
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TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

“…T cell immunoglobulin domain and mucin domain molecule 4 (TIM‐4), known for promoting cancer progression in various malignancies, is implicated in the suppressive immune microenvironment of tumors. …”
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Comparative Study of Microorganisms in Diabetic and non-diabetic Patients with Moderate and Severe Periodontitis by Grace Alejandra Cabezas Cantos, Jonathan Armando Yanza Freire, Ingrid Polethe Morillo Gavilema, Aisha Adamarys Pineda Gómez

“…<strong>Foundation:</strong> periodontal disease is a common oral condition, characterized by inflammation and progressive destruction of the supporting tissues around the teeth. …”
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Matrix Metalloproteinase 9 as Biomarker for Malignant Mammary Tumors in Dogs by Islam S Alani, Huda S Al Biaty

“…In terms of stage and grade of the disease, the mean levels of MMP-9 increased as the disease progressed (Stage IV: 343.235 ng/ml). However, there was no correlation with the grade of the disease, and in regard to MMP-9 serum levels, it was not feasible to distinguish between newly diagnosed cases and recurring cases. …”
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Cardiac Myxoma: Typical Presentation but Unusual Histology by Hassan H. AlAhmadi, Noor Said Alsafwani, Mohamed A. Shawarby, Fayez Ahmed

“…A 43-year-old Saudi male was referred with a two-month history of progressively increasing shortness of breath. Cardiovascular examination demonstrated a soft first heart sound with a plopping sound in the mitral area and a mid-diastolic murmur. …”
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Characterization and miRNA Profiling of Extracellular Vesicles from Human Osteoarthritic Subchondral Bone Multipotential Stromal Cells (MSCs) by Clara Sanjurjo-Rodríguez, Rachel E. Crossland, Monica Reis, Hemant Pandit, Xiao-nong Wang, Elena Jones

“…Osteoarthritis (OA) is a heterogeneous disease in which the cross-talk between the cells from different tissues within the joint is affected as the disease progresses. Extracellular vesicles (EVs) are known to have a crucial role in cell-cell communication by means of cargo transfer. …”
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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy by Zhihui Zhang, Haifeng Wang, Li Zhang, Rebecca Crew, Nan Zhang, Xiaolei Liu, Yanfang Jiang

“…No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. …”
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The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients by Li Wang, Yingjun Kong, Yao Zhang, Chuanyong Mu

“…PD-L1 positive patients were predominantly male, over 55 years old, and presented more clinical symptoms, higher Ki-67 expression, larger tumor sizes, and more advanced disease stages. The progression-free survival (PFS) and overall survival (OS) were significantly lower in the ALK+PD-L1+ group compared to the ALK+PD-L1- group. …”
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LipBengal: Pioneering Bengali lip-reading dataset for pronunciation mapping through lip gesturesHugging Face by Md. Tanvir Rahman Sahed, Md. Tanjil Islam Aronno, Hussain Nyeem, Md. Abdul Wahed, Tashrif Ahsan, R Rafiul Islam, Tareque Bashar Ovi, Manab Kumar Kundu, Jane Alam Sadeef

“…The LipBengal dataset represents a significant advancement in Bengali lip-reading and visual speech recognition research, poised to drive future applications and technological progress. Despite Bengali's global status as the seventh most spoken language with approximately 265 million speakers, linguistically rich and widely spoken languages like Bengali have been largely overlooked by the research community. …”
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Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma by Xiangqian Zhang, Jie Wang, Hanyang Su, Xiaojin Liu

“…However, its role in cancer progression, especially in lung adenocarcinoma (LUAD), has not been fully elucidated. …”
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Clostridium Scindens Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling by Jintao Xiao, Yanliang Hou, Xingyang Luo, Yuhao Zhu, Wenhu Li, Bingbing Li, LinXiang Zhou, Xia Chen, Ying Guo, Xiaomei Zhang, Haiyue He, Xiaowei Liu

“…However, the mechanism by which vancomycin impacts the progression of PSC remains unknown. Mice treated with vancomycin exhibit increased hepatic collagen deposition and injury, due to the inhibition of intestinal FXR‐FGF15/19 axis and the elevation of bile acid levels. …”
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Jusvinza treatment resolution in confirmed COVID-19 patients. Santiago de Cuba, 2021 by Sandra Caridad Laurencio Vallina, Martha María Arias Carbonell, Leonardo Ramos Hechavarría, Dayami Lescay Balanquet, Roger Pina Núñez

“…Some clinical variables (clinical status, associated non-communicable diseases, clinical progression), epidemiological (age, sex) and pharmacological (resolving, duration in days) were analyzed. …”
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A Case Study Assessing the Auditory and Speech Development of Four Children Implanted with Cochlear Implants by the Chronological Age of 12 Months by Birgit May-Mederake, Wafaa Shehata-Dieler

“…Effects on auditory development were determined using the German LittlEARS Auditory Questionnaire, closed- and open-set monosyllabic word tests, aided free-field, the Mainzer and Göttinger speech discrimination tests, Monosyllabic-Trochee-Polysyllabic (MTP), and Listening Progress Profile (LiP). Speech production and grammar development were evaluated using a German language speech development test (SETK), reception of grammar test (TROG-D) and active vocabulary test (AWST-R). …”
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The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance by Katharina Otten, J. Christopher Edgar, Heather L. Green, Kylie Mol, Marybeth McNamee, Emily S. Kuschner, Mina Kim, Song Liu, Hao Huang, Marisa Nordt, Kerstin Konrad, Yuhan Chen

“…Results showed a nonlinear decrease in N1m and P1m latency as a function of age, characterized by rapid changes followed by slower progression, with the N1m latency plateauing at 6–7 months and the P1m latency plateauing at 8–9 months. …”
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Hypoxia Promotes Vascular Smooth Muscle Cell (VSMC) Differentiation of Adipose-Derived Stem Cell (ADSC) by Regulating Mettl3 and Paracrine Factors by Jiaying Lin, Qianqian Zhu, Jialyu Huang, Renfei Cai, Yanping Kuang

“…These observations might contribute to novel progress in understanding the role of epitranscriptomic regulation in the VSMC differentiation of ADSCs and provide a promising perspective for new therapeutic strategies for tissue regeneration.…”
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Effect and Safety of Mycophenolate Mofetil in Idiopathic Pulmonary Fibrosis by Argyris Tzouvelekis, Evangelos Bouros, Anastasia Oikonomou, Paschalis Ntolios, George Zacharis, George Kolios, Demosthenes Bouros

“…Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease with ineffective treatment. …”
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Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment by Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato

“…Tumor microenvironment has been implicated in tumor development and progression. As a three-dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture from oncogene transgenic mouse gastrointestinal tissues was recently produced. …”
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A Modified Newmark Methodology for Permanent Deformation Analysis of Rock-Fill Dams by Hongjun Li, Hong Zhong, Zuwen Yan, Jianming Zhao

“…Newmark sliding block approach has been extensively studied by many researchers in the past decades. Significant progress has been made to alleviate its deficiencies and overcome its simplifying assumptions, but some aspects such as the cyclic shear strength and time history vertical acceleration in the Newmark sliding displacement analysis are seldom considered strictly. …”
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PROSPECTS FOR THE DEVELOPMENT OF THE TRADITIONAL ECONOMY IN THE CONTEXT OF THE DIGITAL TRANSFORMATION OF THE ARCTIC ECONOMY by Elena N. Bogdanova, Tatiana M. Romanenko

“…Technological and digital equity remains an elusive goal for rural areas and agribusinesses operating in the Russian Arctic, where digitalization is still insufficient and progressing at a much slower pace compared to businesses in other regions of the country. …”

Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer by Wan-Xiao Wu, Jia-Wei Feng, Jing Ye, Gao-Feng Qi, Li-Zhao Hong, Jun Hu, Sheng-Yong Liu, Yong Jiang, Zhen Qu

“…However, the association between obesity and the progression of papillary thyroid cancer (PTC) remains controversial. …”
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