Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences by Muriel Javier, Escorial Mónica, Margarit César, Barrachina Jordi, Carvajal Cristian, Morales Domingo, Peiró Ana M.

“…More than half of patients with opioid use disorder for chronic non-cancer pain (CNCP) reduced their dose through a progressive opioid withdrawal supported by a rotation to buprenorphine and/or tramadol. …”
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Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway by Jiale Tian, Weiwei Wang, Jichao Zhu, Yun Zhuang, Chunrun Qi, Zhengxin Cai, Wenhui Yan, Wenying Lu, Anquan Shang

“…Tumors may develop a variety of immune evasion mechanisms during the progression of colorectal cancer (CRC). Here, we intended to explore the mechanism of histone methyltransferase SETDB1 in immune evasion in CRC. …”
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Oral Phosphatidylcholine Improves Intestinal Barrier Function in Drug-Induced Liver Injury in Rats by Meijuan Chen, Haijun Huang, Pengcheng Zhou, Jiajie Zhang, Yining Dai, Danhong Yang, Xuegong Fan, Hongying Pan

“…It has been reported to reverse the progression of liver fibrosis and to improve liver function. …”
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In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…Inherited retinal diseases (IRDs) are clinically and genetically heterogeneous disorders characterized by progressive photoreceptor degeneration and irreversible vision loss. …”
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In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice by Hana Biruk, Biruk Sentayehu, Yonatan Alebachew, Wondmagegn Tamiru, Abebe Ejigu, Solomon Assefa

“…Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. …”
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Evaluation of Inflammation-Related Proteins in Multiple Sclerosis Disease with Relapses and Remissions by Nisa Hocaoğlu, Nur Damla Korkmaz, Birsen Elibol, Zehra Cemre Karakayalı, Şule Terzioğlu-Uşak, Azize Esra Gürsoy

“…Although the cause of the disease is not known exactly due to its heterogeneous etiology, it is thought that inflammatory processes can be effective in the formation and progression of the MS pathology. Herein, the present study's aim was to evaluate the changes in inflammation-related proteins, which have a crucial role in the formation of neuroinflammation, according to the period of MS. …”
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Rating pome fruit quality traits using deep learning and image processing by Nhan H. Nguyen, Joseph Michaud, Rene Mogollon, Huiting Zhang, Heidi Hargarten, Rachel Leisso, Carolina A. Torres, Loren Honaas, Stephen Ficklin

“…Abstract Quality assessment of pome fruits (i.e. apples and pears) is used not only for determining the optimal harvest time but also for the progression of fruit‐quality attributes during storage. …”
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Multi-Scale Long- and Short-Range Structure Aggregation Learning for Low-Illumination Remote Sensing Imagery Enhancement by Yu Cao, Yuyuan Tian, Xiuqin Su, Meilin Xie, Wei Hao, Haitao Wang, Fan Wang

“…Profiting from the surprising non-linear expressive capacity, deep convolutional neural networks have inspired lots of progress in low illumination (LI) remote sensing image enhancement. …”
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On the ionospheric response in the Taiwan region to Typhoon Meranti in September 2016 by Peng Chen, Mingzhu Xiong, Yibin Yao, Hao Chen, Fucai Tang, Liangcai Qiu, Yuchen Zhang

“…In addition to the daily effects of traveling ionospheric disturbances (TIDs), TIDs of various intensities caused by Meranti-induced gravity waves were observed during this period, which is inseparable from the state of the typhoon and the topographic features during its progress. The ionospheric disturbance caused by the edge of a typhoon is usually larger than that at the typhoon eye. …”
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Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial by Jianli Zhao, Yunfang Yu, Wei Ren, Linxiaoxiao Ding, Yongjian Chen, Peng Yuan, Jian Yue, Yaping Yang, Guorong Zou, Tao Chen, Jie Chai, Li Zhang, Wenjing Wu, Yinduo Zeng, Xiujuan Gui, Yangyang Cai, Simin Luo, Zhongyu Yuan, Kang Zhang, Herui Yao, Ying Wang

“…The primary endpoint was progression‐free survival (PFS), while secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and safety. …”
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Stem Cells from Human Exfoliated Deciduous Teeth Attenuate Trigeminal Neuralgia in Rats by Xiaofeng Bai, Xuedi Zhang, Chun Wang, Yao Liu, Xuemei Liu, Yu Fan, Xia Zhang

“…Trigeminal neuralgia is an incurable progressive nervous system disease that can last for several months or years. …”
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Human Papilloma Virus Infection in Patients with Male Accessory Gland Infection: Usefulness of the Ultrasound Evaluation by Rosita A. Condorelli, Enzo Vicari, Laura M. Mongioi, Giorgio I. Russo, Giuseppe Morgia, Sandro La Vignera, Aldo E. Calogero

“…Finally, the seminal fluid concentration of CD45pos leukocytes (2.0 ± 0.2 versus 1.3 ± 0.3 versus 1.0 ± 0.3 mil/mL) was significantly higher and sperm progressive motility was significantly lower in these patients compared to other groups.…”
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Comparative Analysis of Immunoactivation by Nanosecond Pulsed Electric Fields and PD-1 Blockade in Murine Hepatocellular Carcinoma by Maiweilidan Yimingjiang, Talaiti Tuergan, Xinhua Chen, Hao Wen, Yingmei Shao, RuiQing Zhang, Kasimu Aihaiti, Jing Xue, Tuerganaili Aji, Wei Zhang

“…However, this approach is not sufficient to prevent cancer progression, and complementary approaches are necessary for effective immunotherapy. …”
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PMAIP1-mediated glucose metabolism and its impact on the tumor microenvironment in breast cancer: Integration of multi-omics analysis and experimental validation by Yidong Zhang, Hang Xu, Xuedan Han, Qiyi Yu, Lufeng Zheng, Hua Xiao

“…Background: Glucose metabolism in breast cancer has a potential effect on tumor progression and is related to the immune microenvironment. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…In this work, the aim is to summarize the progress made in HA-targeted development of small molecule fusion inhibitors. …”
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Towards a Rational Design of an Asymptomatic Clinical Herpes Vaccine: The Old, the New, and the Unknown by Aziz Alami Chentoufi, Elizabeth Kritzer, David M. Yu, Anthony B. Nesburn, Lbachir BenMohamed

“…Here we provide a brief overview of past clinical vaccine trials, outline current progress towards developing a new generation “asymptomatic” clinical herpes vaccines, and discuss future mucosal “asymptomatic” prime-boost vaccines that could optimize local protective immunity.…”
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Effect of friction on levelling of the maxillary canine with NiTi superelastic wire - an in silico experiment using a finite element method by Rikou Miyawaki, Yukiko Yokoi

“…As the levelling force was applied to the canine, it moved by accumulating the initial tooth movement caused by elastic deformation of the PDL.Results In the case without friction caused by ligation, although the kinetic friction decreased the levelling force during the early levelling stage, the progress of levelling remained unchanged. In the case with friction caused by ligation, as the ligation friction increased, the levelling force decreased, reducing the levelling speed. …”
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Kinetic Gait Changes after Robotic Exoskeleton Training in Adolescents and Young Adults with Acquired Brain Injury by Kiran K. Karunakaran, Naphtaly Ehrenberg, JenFu Cheng, Katherine Bentley, Karen J. Nolan

“…Results from the study showed improved step length, speed, and an overall progression towards healthy bilateral loading, with linearity of loading showing a significant therapeutic effect (p<0.05). …”
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Diabetes and gut microbiome by Kateřina Olša Fliegerová, Tiziana Maria Mahayri, Tiziana Maria Mahayri, Hana Sechovcová, Hana Sechovcová, Chahrazed Mekadim, Jakub Mrázek, Radka Jarošíková, Radka Jarošíková, Michal Dubský, Vladimíra Fejfarová, Vladimíra Fejfarová

“…Research in recent decades increasingly indicates the potential role of the gut microbiome in the initiation, development, and progression of this disease. Intestinal microbes and their fermentation products have an important impact on host metabolism, immune system, nutrient digestion and absorption, gut barrier integrity and protection against pathogens. …”
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PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

“…Hypoxia promoted the induction and progress of hepatic fibrosis and HSCs activation. Meanwhile, rosiglitazone significantly antagonized the effects induced by hypoxia. …”
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