Promotion of beta cell proliferation through DYRK kinase inhibition using the marine natural product breitfussin C by Sara Ullsten, Kine Østnes Hansen, Guillaume Axel Petit, Espen Holst Hansen, Jeanette Hammer Andersen

“…Targeting cytokine signalling pathways offers a potential strategy to slow or even halt disease progression, reducing reliance on exogenous insulin and improving glucose regulation. …”
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Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis by Ky Thai Doan, Long Nguyễn Việt, Thinh Nguyen Tien, Binh Nguyen Canh, Hoai Ngo Thi, Ngoc Nguyen Thanh, Bieu Bui Quang, Quang Le Van, Hyun Woong Lee, Bang Mai Hong

“…Median overall survival and progression-free survival of all patients were 32 and 14 months, respectively. …”
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The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway by Sen Wang, Zhengwei Duan, Zihua Li, Dong Yang, Hengli Lu, Yiwei Zhang, Yuesong Fu, Yonghao Guan, Guodong Li, Feng Qian, Tianyang Xu

“…Abstract Background The study aimed to explore whether Miya (MY), a kind of Clostridium butyricum, regulated osteoarthritis (OA) progression through adenosine 5’-monophosphate-activated protein kinase (AMPK) pathway. …”
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Study on the stability of excavation process of permafrost subgrade slope in Alpine region by Zhilong Zhang, Jiyang Zhang, Jiangang Chen, Jing Luo, Bingbing Lei

“…The findings indicate that lower water content correlates with reduced shear strength at the frost-thaw interface; moreover, both cohesion and internal friction angle of soil samples diminish progressively with increasing water content. Under identical temporal conditions, slopes with gentler gradients exhibit relatively shallower thawing depths and demonstrate enhanced stability.When comparing slopes with equivalent ratios and initial water contents, it was observed that maximum thawing depth in frozen soils decreases over time as construction delays occur; thus, later construction leads to diminished impacts on slope stability alongside accelerated freezing rates. …”
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Amrubicin Monotherapy for Patients with Platinum-Refractory Gastroenteropancreatic Neuroendocrine Carcinoma by Takayuki Ando, Ayumu Hosokawa, Hiroki Yoshita, Akira Ueda, Shinya Kajiura, Hiroshi Mihara, Sohachi Nanjo, Haruka Fujinami, Jun Nishikawa, Kohei Ogawa, Takahiko Nakajima, Johji Imura, Toshiro Sugiyama

“…Eight males and two females (median age, 67 years (range, 52–78)) received platinum-based chemotherapy, including cisplatin plus irinotecan (n=7, 70%), cisplatin plus etoposide (n=2, 20%), and carboplatin plus etoposide (n=1, 10%) before amrubicin therapy. Median progression-free survival and overall survival after amrubicin therapy were 2.6 and 5.0 months, respectively. …”
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Quantitative Analysis of Micro-CT Imaging and Histopathological Signatures of Experimental Arthritis in Rats by Matthew D. Silva, Anneli Savinainen, Rasesh Kapadia, Jason Ruan, Elizabeth Siebert, Nicole Avitahl, Rebecca Mosher, Karen Anderson, Bruce Jaffee, Lisa Schopf, Sudeep Chandra

“…These data demonstrate that the destructive progression of disease in a rat AA model can be quantified using 3-D micro-CT image analysis, which allows assessment of arthritic disease status and efficacy of experimental therapeutic agents.…”
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Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil by Mariam Charkviani, Natia Murvelashvili, Francisco Barrera, Alisha Sharma, Randa Sharag Eldin, Nur Un Nisa Nabil

“…However, emergent coronary angiogram did not reveal any acute coronary occlusion. 5-FU-induced cardiotoxicity was suspected; the patient was admitted to a progressive care unit for close monitoring and infusion of calcium channel blockers was initiated. …”
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Modeling and Planning a Transmission Network Expansion System in a Regulated Electricity Market by Considering Demand-Side Management via a Developed Fuzzy-Salp Optimization Algori... by Yuying Zhang, Lei Xu, Ji Li, Long Zhang, Zhi Yuan

“…With the daily rise in power demand, the penetration of dispersed generations (DG) such as wind turbines, the operation of series reactive compensator devices, and the progress of reconfiguration in power system management, there is a dire need for optimally planning the expansion of transmission network lines. …”
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Proceedings of clinical trials on bile tract cancer by XIONG Yichen, YANG Ziyi, SANG Yuer, GONG Wei

“…So far, radical surgery is the main curative measure for BTC, most patients with BTC are already in progressive or advanced stage at the time of diagnosis. …”
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Mast cells: key players in digestive system tumors and their interactions with immune cells by Feihong Shu, Jie Yu, Youjia Liu, Fang Wang, Guoyou Gou, Min Wen, Chen Luo, Xianmin Lu, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie

“…Specifically, mast cells not only secrete mediators related to pro-tumor function such as trypsin-like enzymes, chymotrypsin, vascular endothelial cell growth factor and histamine, but also mediators related to anti-tumor progression such as cystatin C and IL-17F. This dual role of mast cells renders them an under-recognized but very promising target for tumor immunotherapy. …”
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Natural killer cell engagers for cancer immunotherapy by Shahryar Khoshtinat Nikkhoi, Geng Li, Arash Hatefi, Arash Hatefi

“…This review article critically examines the strategies for engineering bi-, tri-, and multi-specific NKCEs for cancer immunotherapy, providing an in-depth analysis of the latest advancements in NKCE platform technologies currently under development by pharmaceutical and biotech companies and discussing the preclinical and clinical progress of these products. While NKCEs show great promise, the review underscores the need for continued research to optimize their therapeutic efficacy and to overcome obstacles related to NK cell functionality in cancer patients. …”
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The impact of SMARCA4 loss in non-small cell lung cancer therapy by Mariano Lombardi, Marianna D'Ercole, Valeria Midolo De Luca, Matteo Chiari, Lorenzo Spaggiari, Luca Bertolaccini

“…By May 8, 2024, follow-up imaging revealed disease progression and central cavitation in the nodule. Following admission on June 14, 2024, the patient underwent a multidisciplinary evaluation, and a lobectomy of the right lower lobe was performed. …”
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Advances of research in diabetic cardiomyopathy: diagnosis and the emerging application of sequencing by Qianqian He, Ze Lai, Zhengyao Zhai, Beibei Zou, Yangkai Shi, Chao Feng

“…Therefore, this review meticulously consolidates the progress and utilization of various biomarkers, imaging methods, and sequencing technologies in the realm of DCM diagnosis, with the aim of furnishing novel theoretical foundation and guide future research endeavors towards enhancing the diagnostic and therapeutic landscape of DCM.…”
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GB Virus C Infection: Clinical Significance by Xiang Wei Meng, Masafumi Komatsu, Shigetoshi Ohshima, Kunio Nakane, Tomoo Fujii, Takashi Goto, Kazuo Yoneyama, Tomoyuki Kuramitsu, Motokazu Mukaide

“…On the basis of these findings, GBV-C appears to be an unlikely cause of initiation or progression of chronic hepatic diseases.…”
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Breast Carcinoma, Intratumour Heterogeneity and Histological Grading, Using Geostatistics by Vénus Sharifi‐Salamatian, Anne de Roquancourt, Jean Paul Rigaut

“…Tumour progression is currently believed to result from genetic instability. …”
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THE TOTAL LEUKOCYTE COUNT OF ELDERLY PATIENTS CONFIRMED COVID-19 WITH/WITHOUT A VENTILATOR IN A SURABAYA GENERAL HOSPITAL IN 2021 by Safira Indah Fitriani, Nur Septia Handayani, Erlinda Widyastuti, Anita Kurniati

“…Conclusion: Leukocyte count is an important parameter as the predictor of the progression of the disease and helps in the decision regarding treatment strategy to prevent the cytokine storm.…”
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Dielectric spectroscopy and TD-NMR investigation for assessing water solid dynamics in normal and wooden breast chicken by Francesca Soglia, Eleonora Iaccheri, Luca Laghi, Luigi Ragni, Pedro José Fito Suñer, Massimiliano Petracci

“…These outcomes may be ascribed to the re-organization of the skeletal muscle structure associated with the onset and progression of the WB abnormality.…”
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Antiglycating effects of citrus flavonoids and associated mechanisms by Yunli Xiao, Junfeng Shen, Jianfeng Zhan, Limin Guo, Chi-Tang Ho, Shiming Li

“…Herein, we reviewed the up to date progress of the antiglycation effects of citrus flavonoids and associated mechanisms. …”
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A Literature Review of Virtual Reality Exergames for Older Adults: Enhancing Physical, Cognitive, and Social Health by Xiacheng Song, Nazlena Mohamad Ali, Mohamad Hidir Mhd Salim, Muhammad Yudhi Rezaldi

“…Many experimental studies utilize existing games designed for general populations, lacking those specifically tailored for older adults; small sample sizes limit the generalizability of results; and issues such as cybersickness and technology adaptability remain challenges, although progress has been made. This literature review employs the PRISMA method to assess the latest research findings on the impact of VR sports games in improving cognitive and physical functions in older adults. …”
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Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population by Yan Su, Yuan Feng, Xinran Lin, Chunyang Ma, Jiali Wei

“…Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase (TERT) may be implicated in the development of CKD. …”
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