Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy by A.J. Marthinus, D.T. Wademan, Z. Saule, Y. Hirsch-Moverman, L. Viljoen, J. Winckler, L. van der Laan, M. Palmer, S.L. Barnabas, R. Boyd, A.C. Hesseling, G. Hoddinott

“…BACKGROUND: TB preventive treatment (TPT) prevents the development of TB disease in individuals at risk of progression from infection to disease. However, implementation of TPT for children is poor in most high-burden settings. …”
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Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II by Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang

“…Abstract Nonalcoholic fatty liver disease (NAFLD) encompasses a broad range of conditions, commencing with simple steatosis and progressing to non‐alcoholic steatohepatitis, with the possibility of further deterioration into fibrosis, cirrhosis, and ultimately, hepatocellular carcinoma. …”
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Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy by Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi, Milad Yousefi Tehrani, Ali Bemani, Shahriar Kabirian, Javad Mohammadi, Sina Jabbari, Meysam Hushmand, Alireza Mokhtar, Mohammad Hossein Pourhanifeh

“…Abstract Background Colorectal cancer (CRC) remains one of the most common causes of cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. …”
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Management of rare and undiagnosed diseases: insights from researchers and healthcare professionals in Türkiye by Sinem Durmus, Emrah Yucesan, Sinem Aktug, Begum Utz, Ahmet Okay Caglayan, Ahmet Okay Caglayan, Pinar Gencpinar, Cagatay Günay, Yavuz Oktay, Ravza Nur Yildirim, Ayca Yigit, Ugur Ozbek

“…Despite increasing awareness and progress in the field of RD worldwide in recent years, a significant gap remains in our understanding of the specific barriers that these professionals face in their work with RD. …”
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Computational thinking in STEM education: current state-of-the-art and future research directions by Rasikh Tariq, Bertha Maria Aponte Babines, Jesus Ramirez, Inés Alvarez-Icaza, Fawad Naseer

“…Results allowed us to infer that (a) computational thinking promotes sustainable development through STEM education and novel teaching practices; (b) it is a fundamental skill for the problem-solving processes that evolve with technological progress; (c) its development is a global concern, not limited to a country’s development level; and (d) its introduction at an early stage provides opportunities for the advancement of vulnerable groups. …”
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circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD by Xiao-Lin Fu, Fu-Tao He, Mo-Han Li, Chun-Yan Fu, Jian-Zhi Chen

“…This study explored the role of circRNA zinc finger protein 532 (circZNF532) in regulating EndMT in DR progression. Human retinal microvascular endothelial cells (HRMECs) were exposed to high glucose (HG) to induce the DR cell model. …”
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Degree of Functionality and Perception of Health-Related Quality of Life in People with Moderate Stroke: Differences between Ischemic and Hemorrhagic Typology by Iratxe Unibaso-Markaida, Ioseba Iraurgi, Nuria Ortiz-Marqués, Silvia Martínez-Rodríguez

“…Both groups made significant progress in their health assessments and functionality after eight weeks, and no significant differences were found between them at that time. …”
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Epidemiological characterization of primary open-angle glaucoma by Leonor Rosario Díaz Alfonso, Bárbara Nuria Suárez Rodríguez, Mariela Julia Curbelo, Yusdenia Soto Serrano, Armando Rafael Milanés Armengol

“…It is a silent and slowly progressive disease leading to blindness. In most patients this can be prevented if the risk factors leading to the disease are detected in time. …”
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Effects of traditional concurrent training and multicomponent training composed by strength training and dance classes on functional and cognitive capacity of older adults: a study... by Eduarda Blanco-Rambo, Nadyne Rubin, Marcelo Bandeira-Guimarães, Caroline Muraro, Débora Marques, Andressa Fergutz, Greyse Dornelles, Caroline Pietta-Dias, Eduardo Lusa Cadore

“…Both interventions will occur twice a week for 12 weeks with progressive intensity and volume. Functional capacity will be assessed by gait, balance, sitting and standing and climbing tests. …”
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GV1001, hTERT Peptide Fragment, Prevents Doxorubicin-Induced Endothelial-to-Mesenchymal Transition in Human Endothelial Cells and Atherosclerosis in Mice by Wei Chen, Seojin Kim, Sharon Y. Kim, Cheyenne Beheshtian, Naryung Kim, Ki-Hyuk Shin, Reuben H. Kim, Sangjae Kim, No-Hee Park

“…These complications are partly attributed to doxorubicin’s ability to induce endothelial-to-mesenchymal transition (EndMT) in vascular endothelial cells, a critical process in the initiation and progression of atherosclerosis and cardiomyopathy. GV1001, a multifunctional peptide with anti-inflammatory, anti-cancer, antioxidant, and anti-Alzheimer’s properties, has demonstrated inhibition of EndMT. …”
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Dam-breach process simulation and risk assessment of outburst flood induced by the Tangjiashan landslide-dammed lake by Junxue Ma, Chong Xu, Jian Chen

“…The proposed numerical simulations highlight significant variations in OF dynamics across different terrain types, with narrow sections experiencing faster flood progression and higher water depths. The importance of artificial drainage for mitigating flood severity is emphasized, and the findings underline the necessity of considering terrain heterogeneity and sediment transport in future flood risk assessments. …”
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An Exploratory Study of Training Intensity in EEG Neurofeedback by Inês Esteves, Wenya Nan, Cristiana Alves, Alexandre Calapez, Fernando Melício, Agostinho Rosa

“…The findings suggest that the progression within session is favored by the intensive design. …”
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β-Glucan induced plasma B cells differentiation to enhance antitumor immune responses by Dectin-1 by Yu Bai, Jun Ding, Liuyang He, Zhichao Zhu, Jie Pan, Chunjian Qi

“…In mouse models of Lewis lung cancer (LLC) tumors, combining β-glucan with programmed death-1(PD-1) blocking antibodies led to increase recruitment of CD19+ B cells in the tumor microenvironment (TME), higher numbers of germinal centers B cells (GC B) in the spleen and draining lymph node (DLN), elevate Ig production, and delay tumor progression. Conclusions These findings reveal that β-glucan can serve as a potent adjuvant to modulate B cell immune responses in a Dectin-1 dependent manner and improve immune checkpoint blockade (ICB) therapy in antitumor. …”
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Using maternal sepsis patient journeys to map and prioritise barriers to quality maternal healthcare in Malawi: a multidisciplinary stakeholder consultation workshop by Yamikani Chimwaza, Dalisto Ndaferankhande, Leonard Mndala, Chifundo Ndamala, Emily Lifa, Mercy Machilika, Esther Mwagomba, Bernard Dossie, Meliya Kwelepeta, Bertha Maseko, David Lissauer, Maria Lisa Odland

“…Background Malawi has made progress in improving access to maternity care services, shifting the focus to quality of care as an essential determinant of maternal health outcomes. …”
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From the guest editors by Urszula Ledzewicz, Avner Friedman, Jacek Banasiak, Heinz Schättler, Edward M. Lungu

“…Therefore, a second focus area of the workshop was on improved and morerealistic models for the dynamic progression and treatment of various types ofcancer, a truly globally challenging problem. …”
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Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study by Sakis Lambrianides, Christiana A. Demetriou, Andis Tillyris, Elena Kkolou, Eftychia Gaglia, Eleni Agkastinioti, Eleni Leonidou, Yiolanda-Panayiota Christou, Savvas S. Papacostas, Kleopas A. Kleopa, Theodoros Kyriakides, Marios Pantzaris

“…Background and Purpose. Progressive multifocal leukoencephalopathy (PML) is a debilitating disease of the central nervous system caused by the ubiquitous polyomavirus JC (JCV) in immunocompromised hosts. …”
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Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7 by Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu

“…However, the function of LMW-HA in PTC progression remains to be elucidated. In this study, we found that receptor of LMW-HA, TLR4, was aberrantly overexpressed in PTC tissues and cell line W3. …”
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VR-based body tracking to stimulate musculoskeletal training by Neidhardt M., Gerlach S., Schmidt F. N., Fiedler I. A. K., Grube S., Busse B., Schlaefer A.

“…We present an application for the HoloLens 2 to enable musculoskeletal training for elderly and impaired persons to allow for autonomous training and automatic progress evaluation. We designed a virtual downhill skiing scenario that is controlled by body movement to stimulate balance and body control. …”
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Research trends and hotspots in post-stroke speech rehabilitation: A bibliometric analysis by Nan Huang, Kang Zou, Fang Liu, Zhen Su, Long Chen, Yanbiao Zhong, Yun Luo, Maoyuan Wang, Li Xiao

“…However, comprehensive bibliometric analyses on post-stroke language rehabilitation are limited, restricting understanding of progress in this field. Objective: This study aimed to identify hotspots and trends in post-stroke speech rehabilitation research from 2003 to 2023 to guide future studies. …”
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A Strain Rate-Dependent Damage Evolution Model for Concrete Based on Experimental Results by Peng Wan, Xiaoyan Lei, Bin Xu, Hui Song

“…Cyclic uniaxial compression tests were conducted on concrete samples at three strain rates of 10−3s−1, 10−4s−1, and 10−5s−1, respectively, and ultrasonic wave measurements were made at specified strain values during the loading progress. A damage variable was defined using the secant and initial moduli, and concrete damage evolution was then studied using the experimental results of the cyclic uniaxial compression tests conducted at the different strain rates. …”
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