Electronic nudge tool technology used in the critical care and peri-anaesthetic setting: a scoping review protocol by Frank Kee, Martin Dempster, Bronagh Blackwood, Lisa McIlmurray, Lynne Lohfeld, Murali Shyamsundar, Charles Gillan, Rachael Hagan

“…Furthermore, the pace of progress in this field has allowed little time to effectively evaluate the experience of the intended user. …”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Abstract Background Endothelin 1 receptors are one of the drivers of tumor progression in many cancers. Inhibition of their signaling pathways with antagonist drugs has been the subject of numerous clinical trials, but the results have not met expectations probably due to the high endothelin concentrations in the tumor microenvironment and their unusually high affinity for their receptors. …”
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A case report of Gorham-Stout disease diagnosed during the course of recurrent meningitis and cholesteatoma by Makoto Hosoya, Naoki Oishi, Jun Nishiyama, Kaoru Ogawa

“…Skull base reconstruction was abandoned because the osteolysis was considered to be progressive. Conservative treatment with infectious control was implemented as an alternative. …”
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Somatic Mutaome Profile in Human Cancer Tissues by Nayoung Kim, Yourae Hong, Doyoung Kwon, Sukjoon Yoon

“…Somatic mutation is a major cause of cancer progression and varied responses of tumors against anticancer agents. …”
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Vascular Endothelial Growth Factor in Tear Samples of Patients with Systemic Sclerosis by Anikó Rentka, Jolán Hársfalvi, András Berta, Krisztina Köröskényi, Zoltán Szekanecz, Gabriella Szücs, Peter Szodoray, Ádám Kemény-Beke

“…Systemic sclerosis is an autoimmune disease, characterized by widespread small vessel vasculopathy, immune dysregulation with production of autoantibodies, and progressive fibrosis. Changes in levels of proangiogenic cytokines had already been determined largely in serum. …”
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Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction by Mariko Asada, Tomoaki Morioka, Yuko Yamazaki, Yoshinori Kakutani, Reina Kawarabayashi, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba

“…This study indicates a potential role of CTRP9 in atherosclerosis progression in human type 2 diabetes.…”
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Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach by Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia

“…The pathways of Eicosanoid Synthesis, TGF-beta signaling pathway, Prostaglandin Synthesis and Regulation, and Integrated Pancreatic Cancer Pathway were found to be significantly dysregulated in the progression of T2D. The genes of ZADH2 (zinc binding alcohol dehydrogenase domain containing 2), BTBD3 (BTB (POZ) domain containing 3), Cul3-based ligases,  LTBP1 (latent-transforming growth factor beta binding protein 1), PDGFRA (alpha-type platelet-derived growth factor receptor), and FST (follistatin) were determined to be significant nodes regulated by potential transcription factors and microRNAs. …”
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Opportunistic Infections in Patients with HTLV-1 Infection by Toshiki Tanaka, Toshio Sekioka, Masakatsu Usui, Shinsaku Imashuku

“…The second patient was a 78-year-old female, a known asymptomatic HTLV-1 carrier, who presented with persistent herpes zoster, followed by Pneumocystis jirovecii pneumonia. Disease progression of smoldering ATL along opportunistic infections was observed with very high levels of serum sIL-2R (14,058 U/mL) and an increased percentage of CD4+CD25+ T cells (87.2%) in peripheral blood. …”
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Timing of nitrogen fertilization and shading affect the transition of nitrogen metabolism in senescing leaves of ripening wheat (Triticum aestivum L.) by Hideki Araki, Hirotaka Ueno, Keisuke Mizuta, Tadashi Takahashi, Masaru Shibata, Jun’ichi Mano

“…Nitrogen regimes were adjusted by intensive nitrogen applications in the early (IN (E)) or late stages (IN (L)) along with or without top-dressing at anthesis (±TD). The progress of leaf nitrogen metabolism towards terminal senescence appeared to be split into two phases: the first phase (from pre-anthesis to about 15 days after anthesis (DAA), when leaf greenness did not change appreciably) was characterized by a decrease in soluble protein, and the second phase (after 15 DAA) was characterized by drastic increases in the protease activity followed by a rapid decrease in leaf greenness. …”
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Challenges in Medicine: The Odyssey of a Patient with Isolated IgG4-Related Eosinophilic Angiocentric Fibrosis Presenting as a Locally Destructive Sinonasal Mass by Snigdha Nutalapati, Richard O’Neal, William O’Connor, Brett T. Comer, Gerhard C. Hildebrandt

“…Steroids are the recommended first-line therapy; however, our case was resistant to steroids needing rituximab to halt the disease progression. Our case interestingly also had T-cell clonality and isolated isocitrate dehydrogenase 2 enzyme mutation on next-generation sequencing, suggesting a possible role of novel molecular-targeted therapies in this rare disease. …”
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Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons by Ewa Ocłoń, Artur Gurgul, Tomasz Szmatoła, Igor Jasielczuk, Miroslaw Kucharski, Joanna Zubel-Łojek, Dorota Anna Zieba

“…Understanding these dynamics is essential for elucidating the role of hypothalamic inflammation in the progression of leptin resistance and associated metabolic disorders.…”
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Accounting and Reporting in Supporting the Transition to a Circular Economy: a Bibliometric Analysis by Yuliia Maksymiv, Nadiia Skromyda, Jurij Urbancic

“…It was established that, despite significant progress in the theoretical development of the circular economy from an interdisciplinary perspective, organizational and economic tools—particularly accounting and reporting—remain underexplored. …”
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Modifiable Coronary Heart Disease Risk Factors in the Population Aged 20-49 Years by Francisco Carlos Valladares Mas, Francisco de Jesús Valladares Carvajal, Nicolás Ramón Cruz Pérez

“…Their coexistence and progress with age was significant. <br /><strong>Conclusion:</strong> prevalence of modifiable risk factors for coronary heart disease in a young population was high, with frequent association, predominating factors related to unhealthy lifestyles.…”
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A minimal mathematical model for the initial molecular interactions of death receptor signalling by Christian Winkel, Simon Neumann, Christina Surulescu, Peter Scheurich

“…TNF itself is a strong proinflammatory regulator of the innate immune system, but has been also recognized as a major factor in progression of autoimmune diseases. A subgroup of the TNF ligand family, including TNF, signals via so-called death receptors, capable to induce a major form of programmed cell death, called apoptosis. …”
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Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization by Luchen Chang, Jiamei Liu, Jialin Zhu, Shuyue Guo, Yao Wang, Zhiwei Zhou, Xi Wei

“…In radiomics, AI can analyze high-dimensional features from computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) images to discover imaging biomarkers associated with tumor heterogeneity, treatment response, and disease progression, thereby enabling non-invasive, real-time assessments for personalized therapy. …”
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A General Review on Longwall Mining-Induced Fractures in Near-Face Regions by Qingsheng Bai, Shihao Tu

“…Remarks are made on the current progress of, fundamental problems with, and developments in methodologies for characterizing mining-induced fractures using methods such as field observations, small-scale laboratory tests, physical modeling, and numerical modeling. …”
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Alpinetin Attenuates Persistent Inflammation, Immune Suppression, and Catabolism Syndrome in a Septic Mouse Model by Yukun Liu, Kang Wang, Qaunrui Feng, Yongsheng Zhang, Chuntao Wang, Qinxin Liu, Xinghua Liu, Xiang Wang, Wei Gao, Xiangjun Bai, Zhanfei Li, Yuchang Wang

“…Patients who survive the acute phase of sepsis can progress to persistent inflammation, immunosuppression, and catabolism syndrome (PICS), which usually results in extended recovery periods and multiple complications. …”
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Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats by Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L. Cruz, Marian T. Sepulveda-Orengo, Richard J. Noel

“…Cocaine and HIV neurotoxins play roles in neuronal damage during neuroHIV progression by disrupting glutamate homeostasis in the brain. …”
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Current challenges, and potential solutions to increase acceptance and long-term consumption of cultured meat and edible insects – A review by Jia Wen Xanthe Lin, Narmatha Maran, Amanda JiaYing Lim, Siew Bee Ng, Pey Sze Teo

“…Despite notable developments, achieving parity with animal meat is still a work in progress. Suggestions on future research directions to bridge the gap in quality of cultured meat and edible insects, as well as understanding consumer perceptions and motivations behind adopting these novel proteins into habitual diet were provided.…”
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Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease – 2003 by Denis E O’donnell, Shawn Aaron, Jean Bourbeau, Paul Hernandez, Darcy D Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Roger Goldstein, Rick Hodder, Francois Maltais, Jeremy Road

“…Smoking cessation remains the single most effective intervention to reduce the risk of COPD and to slow its progression. Education, especially self-management plans, are key interventions in COPD. …”
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