<i>Pseudomonas syringae</i> Pathovar <i>syringae</i> Infection Reveals Different Defense Mechanisms in Two Sweet Cherry Cultivars by Claudia Carreras, Alan Zamorano, Luis Villalobos-González, Paula Pimentel, Lorena Pizarro, María Francisca Beltrán, Weier Cui, Manuel Pinto, Franco Figueroa, Carlos Rubilar-Hernández, Analia Llanes, Assunta Bertaccini, Nicola Fiore

“…Through this study, it has been possible to progress the knowledge of relevant factors related to the susceptibility of the two studied cherry cultivars to <i>P. syringae</i> pv. …”
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Early Diagnosis and Severity Assessment of Weligama Coconut Leaf Wilt Disease and Coconut Caterpillar Infestation Using Deep Learning-Based Image Processing Techniques by Samitha Vidhanaarachchi, Janaka L. Wijekoon, W. A. Shanaka P. Abeysiriwardhana, Malitha Wijesundara

“…This paper presents a study conducted in Sri Lanka, demonstrating the effectiveness of employing transfer learning-based Convolutional Neural Network (CNN) and Mask Region-based-CNN (Mask R-CNN) to identify WCWLD and CCI at their early stages and to assess disease progression. Further, this paper presents the use of the You Only Look Once (YOLO) object detection model to count the number of caterpillars distributed on leaves with CCI. …”
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Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis by Udari Eshani Perera, Louise Organ, Simon G. Royce, Chrishan S. Samuel, Habtamu B. Derseh, Sasika N. V. Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J. Snibson

“…Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by excessive deposition of extracellular matrix in the interstitial lung parenchyma, often manifested by dyspnea and progressive loss of lung function. The role of inflammation in the pathogenesis of IPF is not well understood. …”
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Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML by Petra Bašová, Lubomír Minařík, Lubomír Minařík, Silvia Carina Magalhaes-Novais, Jana Balounová, Zuzana Zemanová, Tatiana Aghová, Martin Špaček, Anna Jonášová, Kristýna Gloc Pimková, Jan Procházka, Radislav Sedláček, Tomáš Stopka, Tomáš Stopka

“…IntroductionProgressing myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) is an indication for hypomethylating therapy (HMA, 5-Azacytidine (AZA)) and a BCL2 inhibitor (Venetoclax, VEN) for intensive chemotherapy ineligible patients. …”
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Interaction Between Malat1 and miR-499-5p Regulates Meis1 Expression and Function with a Net Impact on Cell Proliferation by Salma A. Fahim, Manon Ragheb, Ibrahim Hassan Fayed, Aya Osama, Ahmed Karam, Sameh Magdeldin, Rana Metwale, Mohamed Dief Allah Abdalmoneam Elsayed, Ahmed Abdellatif, Hesham A. Sadek, Shereen Ahmed El Sobky, Nada El-Ekiaby, Injie Omar Fawzy, Ahmed Ihab Abdelaziz

“…Meis1 is a transcription factor involved in numerous functions including development and proliferation and has been previously shown to harness cell cycle progression. In this study, we used in silico analysis to predict that miR-499-5p targets Meis1 and that Malat1 sponges miR-499-5p. …”
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A Review on The Impact of Thermal Stress on Fish Biochemistry by Manoj Kumar Pati, Mohammad Aftabuddin, Prasun Roychowdhury

“…Stress responses occur at neurotransmitter and hormonal levels, progressing to peripheral and organism-wide effects. …”
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The qualifying features of minors’ corruption: a criminal law analysis by Pysmenska O.

“…On the basis of the analysis, a number of new research findings have been made that are important for improving the quality of criminal legislation in Ukraine and for the progressive development of criminal law science. Particularly, the need to change the current state of legal regulation of the features that qualify corruption of minors is substantiated. …”
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Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them by Philip Smith, Stuart Bloom, Christian Selinger, Ailsa Hart, Christopher Lamb, Anjan Dhar, Helen Steed, Matthew Brookes, Jonathan Macdonald, Ian Arnott, Shellie Radford, Gordon W Moran, Susan Ritchie, Victoria Fletcher, Jonathan Segal, N Sharma, Shahida Din, Daniel Gaya, J Butterworth, S Andrews, P Adams, Deborah Morris, Pearl Avery, Philip Oppong, Mario Guslandi, Maro Kyriacou, Rachel Linger, Madhoor Ramdeen, John Appleton, John Anneh, B Kussel

“…Background Refractory ulcerative proctitis presents a huge clinical challenge not only for the patients living with this chronic, progressive condition but also for the professionals who care for them. …”
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Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes by Cosimo Mazzotta, Antonio Moramarco, Claudio Traversi, Stefano Baiocchi, Alfonso Iovieno, Luigi Fontana

“…Methods. 21 eyes of 20 patients with progressive keratoconus were enrolled. All patients underwent accelerated cross-linking using an ultraviolet-A (UVA) exposure with an energy release varying from 7.2 J/cm2 up to 15 J/cm2, according to the topographic corneal curvature. …”
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Contributions of Hope in physical activity and exercise goal attainment in college students by Corinthian E. B. Blythe, Hayami H. Nishio, Alyssa Wright, Perla Flores, Kevin L. Rand, Kelly M. Naugle

“…The second (Time 2) included the IPAQ, and scales for goal progress and success. One-hundred seven participants completed both surveys and included an exercise goal.ResultsPredictors of exercise goal attainment included moderate PA at Time 1, goal importance, hope-agency, and the hope-agency by major interaction. …”
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Design of an Early Prediction Model for Parkinson&#x2019;s Disease Using Machine Learning by K. Velu, N. Jaisankar

“…Parkinson&#x2019;s Disease (PD) is a chronic and progressive neurological disorder that impairs the body&#x2019;s nervous system pathways. …”
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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…The median duration of response was 5.7 months (95% CI: 4.3–9.1), and the median progression-free survival was 5.4 months (95% CI: 1.8–6.7). …”
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GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway by Chenhua Luo, ZhiMing Xiao, WenLong Yang

“…Our study suggests that GNG2 contributes to tumor suppression in CRC, particularly in preventing brain metastasis, and could serve as a promising biomarker and treatment target for mCRC, offering fresh insights into the molecular processes driving cancer progression and metastasis.…”
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46,XY Disorder of Sex Development Caused by 17α-Hydroxylase/17,20-Lyase Deficiency due to Homozygous Mutation of CYP17A1 Gene: Consequences of Late Diagnosis by Giampaolo Papi, Rosa Maria Paragliola, Paola Concolino, Carlo Di Donato, Alfredo Pontecorvi, Salvatore Maria Corsello

“…Hydrocortisone and ethinyl-estradiol supplementation therapy led to incomplete withdrawal of antihypertensive drug and breast development progression to Tanner stage B2 and slight height increase, respectively. …”
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Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study by Evi Lusiana, Ernawati Sinaga, Zen Hafy, Debby Handayati Harahap, Ramzi Amin, Irsan Saleh

“…Anthocyanins derived from I. batatas can suppress the action of Transforming Growth Factor beta Type II Receptor (TGFβRII) to prevent fibrosis progression. This study aims to examine the molecular features and bioactivity of anthocyanins in I. batatas and determine the interaction of six anthocyanins in I. batatas against TGFβRII through in silico studies. …”
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Real-world outcomes of maintenance therapy post-autologous stem cell transplantation in newly diagnosed multiple myeloma by Ka-Won Kang, Dae Sik Kim, Se Ryeon Lee, Mi Hwa Heo, Hyeon-Seok Eom, Jongheon Jung, Ji Hyun Lee, Sung-Hyun Kim, Youngil Koh, Chang-Ki Min, Seung Shin Lee, Sung-Nam Lim, Ho-Young Yhim, Myung-won Lee, Je-Jung Lee, Sung-Hoon Jung, Soo-Mee Bang, Kihyun Kim, the Korean Multiple Myeloma Working party [KMMWP]

“…Among those receiving maintenance therapy, 104 (68%) received thalidomide, 33 (21%) lenalidomide, and 16 (10%) bortezomib or ixazomib. The median progression-free survival (PFS) from the time of ASCT was 26.4 and 44.1 months in the no-maintenance and maintenance groups, respectively. …”
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Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease by Anna Papazoglou, Julien Soos, Andreas Lundt, Carola Wormuth, Varun Raj Ginde, Ralf Müller, Christina Henseler, Karl Broich, Kan Xie, Dan Ehninger, Britta Haenisch, Marco Weiergräber

“…Alzheimer’s disease (AD) is a multifactorial disorder leading to progressive memory loss and eventually death. In this study an APPswePS1dE9 AD mouse model has been analyzed using implantable video-EEG radiotelemetry to perform long-term EEG recordings from the primary motor cortex M1 and the hippocampal CA1 region in both genders. …”
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A Comprehensive Review of Vision-Based Sensor Systems for Human Gait Analysis by Xiaofeng Han, Diego Guffanti, Alberto Brunete

“…Analysis of the human gait represents a fundamental area of investigation within the broader domains of biomechanics, clinical research, and numerous other interdisciplinary fields. The progression of visual sensor technology and machine learning algorithms has enabled substantial developments in the creation of human gait analysis systems. …”
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Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain by Xiaoang Zhang, Yuping Liao, Daying Zhang, Weichen Liu, Zhijian Wang, Yaxin Jin, Shushu Chen, Jianmei Wei

“…However, these findings require validation with longitudinal data to confirm predictive validity for MCI progression.…”
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Defining the Need for Causal Inference to Understand the Impact of Social Determinants of Health: A Primer on Behalf of the Consortium for the Holistic Assessment of Risk in Transp... by Nrupen A. Bhavsar, PhD, Rachel E. Patzer, PhD, David J. Taber, PharmD, Katie Ross-Driscoll, PhD, Rhiannon Deierhoi Reed, PhD, Juan C. Caicedo-Ramirez, MD, Elisa J. Gordon, PhD, MPH, Roland A. Matsouaka, PhD, Ursula Rogers, BS, Wendy Webster, MBA, Andrew Adams, MD, PhD, Allan D. Kirk, MD, Lisa M. McElroy, MD

“…We illustrate that biases can arise due to socioeconomic status, race/ethnicity, and incongruencies in language between the patient and clinician. Conclusions:. Progress towards an equitable transplant system requires establishing causal pathways between psychosocial risk factors, access, and outcomes. …”
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