HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…Abstract Myeloid-derived suppressor cells (MDSCs) play a critical role in cancer progression and resistance, thus representing promising targets for immunotherapy. …”
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Developments and clinical experiences in collagenase chemonucleolysis for lumbar disc herniation: a narrative review by Hao Zhang, Chi Zhang, Lin Li, Ming-liang Hu, Jian-ning Zhao, Zhang Zheng, Wen-feng Ding

“…Key advancements include the transition from single-agent to combination therapies, exploration of diverse injection routes, and the progression from C-arm fluoroscopy to multi-slice CT guidance. …”
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An Evolutionary Federated Learning Approach to Diagnose Alzheimer’s Disease Under Uncertainty by Nanziba Basnin, Tanjim Mahmud, Raihan Ul Islam, Karl Andersson

“…Early diagnosis of AD is imperative to enable timely interventions that can slow the progression of the disease. This research tackles the complexity and uncertainty of AD by employing a multimodal approach that integrates medical imaging and demographic data. …”
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Evaluation of health-related quality of life among patients with chronic obstructive pulmonary disease at District Headquarter Hospital haripur, Pakistan by Mehwish Fayaz, Shahbaz Ahmad Zakki, Ijaz Ul Haq, Muhammad Afzal, Mudassar Latif, Ehtisham Altaf

“…Conclusion: The impairment of quality of life is a notable issue among patients diagnosed with COPD, and it tends to worsen as the disease progresses in severity. The need of the hour is to promote awareness about COPD in the community and sensitize healthcare professionals towards its effects on HRQoL.…”
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LDAViewer: An Automatic Language-Agnostic System for Discovering State-of-the-Art Topics in Research Using Topic Modeling, Bidirectional Encoder Representations From Transformers,... by Timothy Dillan, Dhomas Hatta Fudholi

“…Advancements in knowledge are pivotal to academic progress, necessitating efficient methods for discovering the state-of-the-art in various fields. …”
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Multiscale guided attention network for optic disc segmentation of retinal images by A Z M Ehtesham Chowdhury, Andrew Mehnert, Graham Mann, William H. Morgan, Ferdous Sohel

“…Optic disc (OD) segmentation from retinal images is crucial for diagnosing, assessing, and tracking the progression of several sight-threatening diseases. This paper presents a deep machine-learning method for semantically segmenting OD from retinal images. …”
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Effects of long-term adapted physical training on functional capacity and quality of life in older adults with Parkinson's disease by Oussama Gaied Chortane, Elmoetez Magtouf, Wael Maktouf, Sabri Gaied Chortane

“…Although physical activity is considered a therapeutic treatment to slow the progression of the disease, it is considered to be an effective non-pharmacological adjuvant to medication to improve the symptom management.MethodsThe training program was offered for all the participants (N = 50) in three non-consecutive sessions per week for 60 minutes and a total duration of 12 to 16 months. …”
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Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1 by Zhiming Wu, Peng Zhang, Wenyan Huang, Yifen Zhou, Zhengliu Cao, Chunhong Wu

“…Conclusion: Our findings indicate that Qufeng epimedium decoction suppresses FLSs pyroptosis and RA progression via CYLD-mediated Sirt1 deubiquitination and deactivation of the NF-kB /GSDMD signaling pathway. …”
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Interrelation of Natural Polyphenol and Fibrosis in Diabetic Nephropathy by Ye Ma, Jiakun Wang, Juyue Fan, Huiyang Jia, Jinyao Li

“…Renal fibrosis, which corresponds to excessive deposition of extracellular matrix and leads to scarring, is a characteristic feature of the various progressive stages of DN. It can trigger various pathological processes leading to the activation of autophagy, inflammatory responses and a vicious circle of oxidative stress and inflammation. …”
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A case of 49,XXXYY followed-up from infancy to adulthood with review of literature by Junko Kanno, Akinobu Miura, Sayaka Kawashima, Hirohito Shima, Dai Suzuki, Miki Kamimura, Ikuma Fujiwara, Masayuki Kamimura, Mitsugu Uematsu, Masataka Kudo, Atsuo Kikuchi

“…Aneuploidy of the X chromosome can lead to various progressive complications due to excess X chromosomes. …”
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Advances in growth factor-containing 3D printed scaffolds in orthopedics by Longwen Zhan, Yigui Zhou, Ruitang Liu, Ruilong Sun, Yunfei Li, Yongzheng Tian, Bo Fan

“…This paper aims to summarize the research progress of 3D printed scaffolds containing growth factors in orthopedics in recent years and summarize the use of different growth factors in 3D scaffolds, including bone morphogenetic proteins, platelet-derived growth factors, transforming growth factors, vascular endothelial growth factors, etc. …”
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Dynamic non-coding RNA biomarker reveals lung injury and repair induced by polystyrene nanoplastics by Sheng Yang, Yiling Ge, Tianyi Zhang, Lihong Yin, Yuepu Pu, Zaozao Chen, Geyu Liang

“…Moreover, temporal profiling highlighted distinct sets of ncRNAs as early and progression-associated biomarkers of PS-NP-induced lung injury. …”
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IL1RN and KRT13 Expression in Bladder Cancer: Association with Pathologic Characteristics and Smoking Status by Thomas S. Worst, Verena Reiner, Ute Gabriel, Christel Weiß, Philipp Erben, Thomas Martini, Christian Bolenz

“…Tobacco smoking may enhance the loss of IL1RN, indicating an overweight of proinflammatory mediators involved in UCB progression. Further validation of the influence of smoking on IL1RN expression is warranted.…”
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Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype by Xinzhi Xu, Tianwen Qiu, Kexin Sun, Xue Han, Junxia Huang, Xiuyuan Wang, Jianchao Ge, Ji Yang

“…Two chemokines, CXCL10 and CXCL11, were identified as highly associated with immune infiltration and DM progression. Conclusions Our data suggest that serum CXCL10 and CXCL11 reflect the inflammatory burden of DM. …”
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Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…The clinical symptoms include arrhythmias, progressive heart failure, and even sudden cardiac death but the mutation carrier can also be totally asymptomatic. …”
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Enhancing Social Media User’s Trust: A Comprehensive Framework for Detecting Malicious Profiles Using Multi-Dimensional Analytics by Sailaja Terumalasetti, S. R. Reeja

“…Traditional methods for distinguishing these accounts archetypally depend on an inadequate set of features, which hampers their effectiveness in contrast to the progressively sophisticated maneuvers employed by malicious users. …”
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Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies by Jayasri Basu, Bolek Bendek, Enyonam Agamasu, Carolyn M. Salafia, Aruna Mishra, Nerys Benfield, Ronak Patel, Magdy Mikhail

“…Our data reflects an increased oxidative stress in the placenta in the early phase of normal pregnancy. As pregnancy progressed, placental antioxidant protective mechanisms increased and lipid peroxidation markers decreased resulting in diminution in oxidative stress. …”
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Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma by Zhecheng Li, Yaxin Zhao, Peng Huang, Zhaoyi Wu, Dengjie Ouyang, Adolphus Osei Nyarko, Lei Ai, Zhejia Zhang, Shi Chang

“…Abstract ATAD2 (ATPase Family AAA Domain-Containing 2) is highly expressed across varies tumor types, yet its common roles in tumor progression and immune interaction remain unclear. We analyzed the expression and alteration profiles of ATAD2, along with its diagnostic and prognostic role in pan-cancer, utilizing TCGA, GTEx, CPTAC, HPA, and cBioPortal databases. …”
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Serial biomarker measurements may be helpful to predict the successful application of high flow nasal cannula in COVID-19 pneumonia patients by Reid Ikeda, Andrew Pham, Guangxiang Zhang, Jennifer F. Lai, James Davis, Gehan Devendra

“…C-reactive protein (CRP) and D-dimer are associated with COVID-19 severity and progression. However, no one has evaluated the use of serial CRP and D-dimer ratios to predict HFNC success. …”
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The doppel (Dpl) Protein Influences In Vitro Migration Capability in Astrocytoma-Derived Cells by Alberto Azzalin, Elena Sbalchiero, Giulia Barbieri, Silvia Palumbo, Cristina Muzzini, Sergio Comincini

“…Recently, the protein has been described to be ectopically expressed in astrocytomas and its potential association to the brain tumor malignancy progression has been advanced. In this study, we aimed to investigate in vitro the potential involvement of Dpl in the tumor cell migration: to this purpose, Dpl expression was reduced in the IPDDC-A2 astrocytoma-derived cell line, by means of antisense and siRNA approaches; migration rates were then evaluated by means of a scratch wound healing assay. …”
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