Stalled disomes marked by Hel2-dependent ubiquitin chains undergo Ubp2/Ubp3-mediated deubiquitination upon translational run-off by Mario Scazzari, Ying Zhang, Anna Moddemann, Sabine Rospert

“…Our findings show that Hel2 occupancy progressively increases from translating monosomes to disomes and trisomes. …”
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BRAF Inhibitors for BRAF V600E Mutant Colorectal Cancers: Literature Survey and Case Report by Yasar Subutay Peker, Mehmet Fatih Can, Ismail Hakki Ozerhan, Gokhan Yagci, Nazif Zeybek, Kutan Kavakli, Sedat Gurkok, Alper Gozubuyuk, Onur Genc, Gokhan Erdem, Ahmet Ozet, Mustafa Gerek, Yusuf Peker

“…BRAF inhibitors in combination with MEK inhibitors are reported as feasible treatment to overcome BRAF inhibitor drug resistance on which phase studies are still in progress. To conclude, BRAF inhibitors alone or in combination with other drugs provide a chance for curing BRAF V600E mutant colorectal cancer patients.…”
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18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns by Sanjay Chandrasekaran, Andrew Hollander, Xiangsheng Xu, Joseph L. Benci, James J. Davis, Jay F. Dorsey, Gary Kao

“…PET imaging is a useful clinical tool for studying tumor progression and treatment effects. Conventional 18F-FDG-PET imaging is of limited usefulness for imaging Glioblastoma Multiforme (GBM) due to high levels of glucose uptake by normal brain and the resultant signal-to-noise intensity. 18F-Fluorothymidine (FLT) in contrast has shown promise for imaging GBM, as thymidine is taken up preferentially by proliferating cells. …”
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Replication timing in Drosophila and its peculiarities in polytene chromosomes by T. D. Kolesnikova, O. V. Antonenko, I. V. Makunin

“…In the recent two decades, the progress in our understanding of DNA replication was associated with new techniques. …”
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Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief by Nicholas J. Wright, Yutaka Matsuoka, Hyeri Park, Wei He, Caroline G. Webster, Kenta Furutani, Justin G. Fedor, Aidan McGinnis, Yiquan Zhao, Ouyang Chen, Sangsu Bang, Ping Fan, Ivan Spasojevic, Jiyong Hong, Ru-Rong Ji, Seok-Yong Lee

“…Abstract The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. …”
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Risk factors for inflammatory bowel disease: an umbrella review by Tingping Wu, Honghui Cheng, Jiamei Zhuang, Xianhua Liu, Zichen Ouyang, Rui Qian

“…The findings in this paper help to develop better prevention and treatment measures to reduce the incidence of IBD, delay its progression, and reduce the burden of IBD-related disease worldwide.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023417175.…”
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Dose-Escalated Hypofractionated Intensity-Modulated Radiotherapy in High-Risk Carcinoma of the Prostate: Outcome and Late Toxicity by David Thomson, Sophie Merrick, Ric Swindell, Joanna Coote, Kay Kelly, Julie Stratford, James Wylie, Richard Cowan, Tony Elliott, John Logue, Ananya Choudhury, Jacqueline Livsey

“…Five-year overall survival (OS) was 83% and biochemical progression-free survival (bPFS) was 50% for 57 Gy. …”
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Field switching of microfabricated metamagnetic FeRh MRI contrast agents by Stephen Dodd, Natalia Gudino, Oleksii Zadorozhnii, Michal Staňo, Jan Hajduček, Jon Ander Arregi, H. Douglas Morris, Vojtěch Uhlíř, Mladen Barbic, Alan P. Koretsky

“…A thin-film (200 nm) FeRh sample was fabricated and patterned into an array of progressively smaller squares with sizes ranging from 500 μm down to 1 μm. …”
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Selenium’s Role in Plant Secondary Metabolism: Regulation and Mechanistic Insights by Yan Zhou, Kaiqin Nie, Lulu Geng, Yixin Wang, Linling Li, Hua Cheng

“…By integrating existing research progress, this paper will delve into the potential molecular regulatory mechanisms of Se on plant secondary metabolism, aiming to unravel the interplay between Se and plant secondary metabolism. …”
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Cervical Ligamentum Flavum Cyst Causing Myelopathy: A Case Report by Thomas J Kishen, Prabhakar Sekar

“…Case description: A 68-year-old gentleman presented with progressive paresthesia and weakness of both upper limbs of 6 months duration, along with clumsiness of both hands and difficulty in walking. …”
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Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children by Alina Paganini, Nora Fritschi, Cornelia Filippi, Nicole Ritz, Urs Simmen, Katrin Scheinemann, Andreas Filippi, Tamara Diesch-Furlanetto

“…Abstract Salivary cytokines have the potential to serve as biomarkers for evaluating cancer progression and treatment response in specific cancer types. …”
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Numerical modeling of wave-induced liquefaction around a gravity-based structure by V. S. Ozgur Kirca, V. S. Ozgur Kirca, Mert Angin, B. Mutlu Sumer

“…The model was first validated against analytical solution for pore pressure buildup in the seabed under progressive waves, and against experimental data for residual liquefaction around a buried submarine pipeline. …”
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The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis by Kun Meng, Yuying Li, Xiaoyi Yuan, Hui-Min Shen, Li-Ling Hu, Danya Liu, Fujin Shi, Dandan Zheng, Xinyu Shi, Nengqiao Wen, Yun Cao, Yun-Long Pan, Qing-Yu He, Chris Zhiyi Zhang

“…However, the importance and underlying mechanisms of these microproteins in alternative splicing-driven tumor progression have rarely been studied. Here, we show that the novel protein TPM3P9, encoded by the lncRNA tropomyosin 3 pseudogene 9, exhibits oncogenic activity in clear cell renal cell carcinoma (ccRCC) by enhancing oncogenic RNA splicing. …”
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Resolution of tremor associated with brainstem arachnoid cyst following surgical intervention: A case report by Andrey Rostislavovich Sitnikov, Rezida Maratovna Galimova, Dmitriy Konstantinovich Krekotin

“…Case presentation: A 34-year-old man was admitted to our clinic with a two-year history of progressive disabling right-sided tremor and muscle weakness. …”
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Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase by Thomas Große-Steffen, Thomas Giese, Nathalia Giese, Thomas Longerich, Peter Schirmacher, G. Maria Hänsch, Matthias M. Gaida

“…Because in pancreatic cancers the transition to a mesenchymal phenotype coincides with the PMN infiltrate, a contribution of the inflammatory response to the induction of EMT and—by implication—to tumor progression is possible.…”
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Determination of the copy numbers of type A porcine endogenous retroviruses in domestic pigs and wild boars by R. B. Aitnazarov, N. S. Yudin, R. S. Kiril’chuk, N. N. Kochnev, S. P. Knyazev, M. I. Voevoda

“…To solve this problem, the use of animal organs and tissues for grafting to humans (xenografts) has been proposed. However, the progress in this direction is hampered by the risk of zoogenous infection of recipients. …”
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Quantum Fisher information of N-level atoms under the influence of the thermal field and the Stark effect by S. Jamal Anwar, M. Ibrahim, M. Khalid Khan, Haifa S. Alqannas, S. Abdel-Khalek

“…The QE of a higher dimensional atomic system such as the 5-level atom increases with the evolution of time at larger values of the SS parameter, and it also sustains as time progresses. The effect of the SS is more prominent on the 5-level atomic system. …”
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Expression of Annexin-A1 and Galectin-1 Anti-Inflammatory Proteins and mRNA in Chronic Gastritis and Gastric Cancer by Yvana Cristina Jorge, Mayra Mioto Mataruco, Leandro Pires Araújo, Ana Flávia Teixeira Rossi, Juliana Garcia de Oliveira, Marina Curado Valsechi, Alaor Caetano, Kenji Miyazaki, Célia Sebastiana de Jesus Fazzio, Jorge Alberto Thomé, Paula Rahal, Sonia Maria Oliani, Ana Elizabete Silva

“…The anti-inflammatory proteins annexin-A1 and galectin-1 have been associated with tumor progression. This scenario prompted us to investigate the relationship between the gene and protein expression of annexin-A1 (ANXA1/AnxA1) and galectin-1 (LGALS1/Gal-1) in an inflammatory gastric lesion as chronic gastritis (CG) and gastric adenocarcinoma (GA) and its association with H. pylori infection. …”
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Chemotherapeutic hormesis induced by the tumor microenvironment in refractory ovarian cancer by Xuboya Chang, Satoshi Tamauchi, Atsushi Nakagawa, Wang Xinyuan, Kosuke Yoshida, Akira Yokoi, Nobuhisa Yoshikawa, Hiroaki Kajiyama

“…Mechanistically, low-dose CDDP upregulates pathways involved in cell cycle progression, specifically the G2/M checkpoint and mitotic spindle formation, accelerating rather than arresting the cell cycle. …”
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Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection by Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Jinkang Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng

“…Since 2017, the morbidity and mortality rates associated with ARV infection in poultry have been on the rise, progressively emerging as a significant viral disease impacting the duck farming industry in China. …”
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