Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…Evidence indicates that in infectious diseases, cancer, and autoimmunity, NRs modulate immune and endocrine responses, altering the transcriptional profile of cells and organs and influencing disease progression. Chronic infectious diseases, characterized by pathogen persistence, are particularly notable for an exaggerated inflammatory process. …”
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Dynamic development of microglia and macrophages after spinal cord injury by Hu-Yao Zhou, Xia Wang, Yi Li, Duan Wang, Xuan-Zi Zhou, Nong Xiao, Guo-Xing Li, Gang Li

“…Our results showed that microglia were activated to a pro-inflammatory phenotype immediately after spinal cord injury, gradually transforming to an anti-inflammatory steady state phenotype as the disease progressed. Regarding macrophages, our findings highlighted abundant communication with other cells, including fibroblasts and neurons. …”
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IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A by Xiuxia Wang, Yating Yang, Xianyu Zhou, Shun Yu, Xusong Luo, Lin Lu, Zhen Gao, Jun Yang

“…Moreover, keloid SPOCD1 deficiency attenuates KFs progression and extracellular matrix (ECM) deposition. …”
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D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology by John P. Crow, John C. Marecki, Misty Thompson

“…D-serine is twofold higher in the spinal cords of mSOD1 (G93A) ALS mice, and the deletion of serine racemase (SR), the enzyme that produces D-serine, results in an earlier onset of symptoms, but with a much slower rate of disease progression. Localization studies within the brain suggest that mSOD1 and subsequent glial activation could contribute to the alterations in SR and D-serine seen in ALS. …”
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A case report of confirmed difficult pulmonary tuberculosis based on the hybrid capture-based tNGS method by Weiqian Chen, Huimin Chen, Ze Liu, Xinle Chi, Yaomeng Chen, Huan Ye, Wenjie Huang, Chenlei Cao, Wei Weng

“…Multiple chest CT scans revealed progressive enlargement of the right hilar lymph nodes and thickening of the interlobular septa in the right upper lobe. …”
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Clinical Features and Outcomes of Adrenal Cavernous Hemangioma: A Study of 8 Cases from a Single Center by Henghai Huang, Xiaoyun Wu, Xiaocao Lin, Delin Li, Jingjing Zeng

“…Well-defined borders and heterogeneous enhancement with characteristic progressive partial filling-in were characteristic CT features of ACH (tumor size>3 cm). …”
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Toll-Like Receptor Signaling and Liver Fibrosis by Tomonori Aoyama, Yong-Han Paik, Ekihiro Seki

“…This paper highlights the role of TLR signaling in stellate cell activation and the progression of liver fibrosis.…”
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Retrospective Analysis of Full-Arch Zirconia Rehabilitations on Dental Implants: Clinical Outcomes and Patient Satisfaction by Vincenzo Marchio, Chiara Cinquini, Fortunato Alfonsi, Stefano Romeggio, Marco Stoppaccioli, Francesco Zingari, Mattia Priami, Antonio Barone

“…This retrospective study investigated prosthetic and implant survival/success rates and patients’ satisfaction for ISFCDPs produced with three different techniques: zirconia-on-titanium (milled zirconia arch glued to a titanium bar), progressive monolithic zirconia (entirely made of zirconia and directly screwed to the implants) and zirconia-on-zirconia (milled esthetic zirconia crowns glued to a milled high resistance zirconia frame). …”
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PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases by Yanmei Yang, Bin Wang

“…The complex interplay among BrCa cells, stromal/osteoblastic cells, and osteoclasts in the osseous microenvironment creates a bone-tumor vicious cycle (a feed-forward loop) that results in excessive bone destruction and progressive tumor growth. Both the type 1 PTH receptor (PTH1R) and extracellular calcium-sensing receptor (CaSR) participate in the vicious cycle and influence the skeletal metastatic niche. …”
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Optical time-lapsed in situ mechanochemical studies on metal halide perovskite systems by Yonghao Xiao, David G. Bradley, Wei Xin Chan, Xinwen Hu, Lian Xiao, Zhenpeng Liu, Zi Yang Tan, Xin Zhao, Chenfei Li, Mansour Sadek, Vikash Kumar Ravi, Ying Hern Tam, Xiaotao Wang, Felipe García, Handong Sun, Seow Chin Low, Poh Boon Phua, Tze Chien Sum, Xiuwen Zhou, Yee-Fun Lim, John V. Hanna, Han Sen Soo

“…To overcome these challenges, solvent-free mechanochemical synthesis of perovskites can be conducted, although traditional opaque ball milling equipment hinder real-time monitoring of the reaction progress. Herein, mechanochemistry was performed with time-lapsed in situ (TLIS) measurements to elucidate the optical properties during the synthesis. …”
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Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study by Akihito Hishikawa, Erina Sugita Nishimura, Norifumi Yoshimoto, Ran Nakamichi, Eriko Yoshida Hama, Wataru Ito, Tomomi Maruki, Kengo Nagashima, Ryoko Shimizu-Hirota, Hiromasa Takaishi, Hiroshi Itoh, Kaori Hayashi

“…This study suggests the potential role of the DNA methylation clock and urinary DNA damage as predictive markers for the progression of chronic kidney disease.…”
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Asymptomatic Hyperuricemia and the Kidney: Lessons from the URRAH Study by Cecilia Barnini, Elisa Russo, Giovanna Leoncini, Maria Carla Ghinatti, Lucia Macciò, Michela Piaggio, Francesca Viazzi, Roberto Pontremoli

“…The interplay between hyperuricemia and CKD is complex; while in vitro studies and animal models support a role for uric acid mediating glomerular and tubule-interstitial damage, and HSUA has been shown to predict the onset and progression of CKD, the expectations of renal protection by the use of urate lowering treatment (ULT) are inconsistent. …”
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Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy by Anna Starshinova, Anna Starshinova, Leonid P. Churilov, Igor Kudryavtsev, Igor Kudryavtsev, Artem Rubinstein, Artem Rubinstein, Ekaterina Belyaeva, Anastasia Kulpina, Anastasia Kulpina, Hong Ling, Min Zhuang, Dmitry Kudlay, Dmitry Kudlay, Dmitry Kudlay

“…HIV infection poses a particular threat, exacerbating immune response disorders that affect the effectiveness of treatment and disease progression in general.…”
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Primary Hyperparathyroidism in Older People: Surgical Treatment with Minimally Invasive Approaches and Outcome by Chiara Dobrinja, Marta Silvestri, Nicolò de Manzini

“…Time elapsed from pHPT diagnosis to first surgical visit evidences that the elderly patients were referred after their disease had progressed. Conclusions. Our data show that minimally invasive approach to parathyroid surgery seems to be safe and curative also in elderly patients with few associated risks because of combination of modern preoperative imaging, advances in surgical technique, and advances in anesthesia care.…”
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Synovial Fluid Cell Proteomic Analysis Identifies Upregulation of Alpha-Taxilin Proteins in Rheumatoid Arthritis: A Potential Prognostic Marker by Ashish Sarkar, Shivani Sharma, Prachi Agnihotri, Tanmoy Sarkar, Pooja Kumari, Rajesh Malhotra, Barun Datta, Vijay Kumar, Sagarika Biswas

“…Identification of novel proteins associated with the progression of a disease is a prerequisite for understanding the pathogenesis of RA. …”
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Exploitation of olive mill wastewater in sorghum irrigation by Rachid Mahmoud, Fatimzahra Ainlhout, Mohamed Ben Abbou, Mustapha Taleb, Mounia El haji, Zakia Rais

“…Purpose In Morocco, the olive industry has made remarkable progress thanks to the "Green Morocco Plan" adopted by the Ministry of Agriculture. …”
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Cyclic Stress Response and Fracture Behaviors of Alloy 617 Base Metal and Weld Joints under LCF Loading by Seon Jin Kim, Rando Tungga Dewa, Woo Gon Kim, Min Hwan Kim

“…The cyclic stress response behavior of both base metal and weld joint specimens revealed initial cyclic hardening during first small number of cycles followed by progressive softening to failure. Higher strain amplitudes decreased the fatigue lives for both base metal and weld joint specimens; subsequently weld joint specimens had lower fatigue resistances relative to base metal specimens. …”
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Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy by Chin-Wei Chiang, Hsueh-Te Lee, Der-Cherng Tarng, Ko-Lin Kuo, Li-Ching Cheng, Tzong-Shyuan Lee

“…However, the role of sEH in progression of chronic kidney diseases such as obstructive nephropathy is still elusive. …”
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Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated... by Takekatsu Saito, Naotoshi Sugimoto, Kunio Ohta, Tohru Shimizu, Kaori Ohtani, Yuko Nakayama, Taichi Nakamura, Yashiaki Hitomi, Hiroyuki Nakamura, Shoichi Koizumi, Akihiro Yachie

“…Cyclic AMP (cAMP) is a small second messenger molecule that mediates signal transduction. The onset and progression of inflammatory responses are sensitive to changes in steady-state cAMP levels. …”
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Diagnosis and Treatment of Childhood Pulmonary Tuberculosis: A Cross-Sectional Study of Practices among Paediatricians in Private Sector, Mumbai by Carolyn Kavita Tauro, Nilesh Chandrakant Gawde

“…Sputum negative TB suspect is always tested with X-ray or tuberculin skin test. 61.4% prescribe regimen as recommended in ISTC and all monitor progress to treatment clinically. Drug-resistance at beginning of treatment is suspected for child in contact with a drug-resistant patient (67.7%) and with prior history of antitubercular treatment (12.9%). …”
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