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7561
Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies
Published 2012-01-01“…These results suggest an important role of extracellular NM23-H1 in the malignant progression of leukemia and a potential therapeutic target for these malignancies.…”
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7562
Agentive and Independent Older Female Adult in Strong Woman Gang Nam-Soon: Going Against Prevalent Gendered Ageism in K-Dramas
Published 2024-12-01“…This article argues that the positive representation of Gil Jung-Gan is the manifestation of the progressive movement and influence of local and global feminism, which can be traced through the fulfillment of the majority of the principles. …”
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7563
Intraoperative rescue of a dislodged renal stent during fenestrated endovascular aortic repair for treatment of type 1A endoleak
Published 2025-02-01“…In the past 15 years, fenestrated-branched endovascular aortic repair (F-BEVAR) has progressively become the first-line option for management of most complex abdominal aortic aneurysms (AAAs); with increasing experience, as well as persistent technological refinements, F-BEVAR indications have been expanded to include rescue of failures after prior EVAR. …”
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7564
Présence/absence du monde rural dans la presse libérale et républicaine andalouse (1880-1892)
Published 2015-03-01“…The first one is considered to be rather “independent” and the second one, founded in Cadix, to be “progressive republican”. Knowing this, it invites us to examine their way of operating and the way both approached rurality. …”
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7565
PSTK exerts protective role in cisplatin‐tubular cell injury via BAX/BCL2/Caspase3 pathway
Published 2025-01-01“…The study is significant for developing therapeutic strategies that could manipulate PSTK to delay AKI progression.…”
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7566
Carbon Nanotube Composites for Electronic Packaging Applications: A Review
Published 2013-01-01“…Recent research has made progress in fabricating carbon nanotube metal matrix and polymer-based composites. …”
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7567
L’Entreprise-agence de Jean Walter. 1918-1957. L’architecture au service de l’affairisme ?
Published 2020-12-01“…In a context of progressive regulation of the architectural profession in France throughout the first half of the 20th century, Jean Walter’s career testifies to the liberties taken by some professionals before the enactment of the loi du 31 décembre 1940, as he seemingly ignored any of the deontological debates taking place in the profession. …”
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7568
Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules
Published 2024-10-01“…This review explores the multifaceted potential of various phytochemicals in modulating key mechanisms involved in the development and progression of cancer and inflammation. The diverse array of phytochemicals discussed here encompasses polyphenols, flavonoids, alkaloids, terpenoids, and many others, each with distinct molecular targets and modes of action. …”
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7569
COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps
Published 2020-01-01“…Coronavirus disease 2019 (COVID-19) is a virus-induced respiratory disease that may progress to acute respiratory distress syndrome (ARDS) and is triggered by immunopathological mechanisms that cause excessive inflammation and leukocyte dysfunction. …”
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7570
Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation
Published 2024-09-01“…The poor prognosis can be attributed to the complex tumor microenvironment (TME) in OSCC, which is crucial for tumor progression, angiogenesis, invasion, metastasis, and therapeutic resistance. …”
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7571
Changing patterns of global nitrogen deposition driven by socio-economic development
Published 2025-01-01“…Our findings underscore the need for policies that align agricultural and industrial progress to facilitate the peak shift or reduction of nitrogen deposition in developing countries and to strengthen measures to address NH3 emission hotspots in developed countries.…”
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7572
Designing an effective educational toy: incorporating design-thinking in the design classroom
Published 2025-01-01“…Utilising the ‘Double Diamond Model of Design’, the research methodically progresses through the stages of observation, generation, prototyping, and testing to create a 3D letter-building set with the goal of improving children's educational experiences. …”
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7573
Asymptomatic Barrett’s Oesophagus-Complicated Gastroesophageal Reflux Disease at Ineffective Antisecretory Therapy
Published 2021-06-01“…The main challenge to prevent progression into oesophageal adenocarcinoma is an adequate personalised patient management leveraging the modern diagnostic techniques, control of antisecretory treatment and its correction a situ.…”
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7574
The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease
Published 2018-01-01“…In this review, we highlight recent progress in the study of roles for necroptosis in cerebral ischemic disease and discuss how these modifications delicately control necroptosis.…”
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7575
The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications
Published 2025-01-01“…Myocardial energy metabolism disturbances in DbCM, encompassing glucose, fatty acid, ketone body and lactate metabolism, are crucial factors that contribute to the progression of DbCM. In recent years, novel protein post-translational modifications (PTMs) such as lactylation, β-hydroxybutyrylation, and succinylation have been demonstrated to be intimately associated with the myocardial energy metabolism process, and in conjunction with acetylation, they participate in the regulation of protein activity and gene expression activity in cardiomyocytes. …”
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7576
A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
Published 2021-01-01“…The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer.…”
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7577
Varicella Zoster Meningitis, Optic Neuritis Preceding the Development of Posterior Outer Retinal Necrosis, and Central Retinal Artery Occlusion in a HIV Patient
Published 2019-01-01“…Funduscopic examination showed patchy areas of necrosis in the periphery which were rapidly progressive, diagnostic of posterior outer retinal necrosis (PORN). …”
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7578
BeiDou satellites cross-regional communication path assignment model and resource management
Published 2021-07-01“…Time division inter-satellite communication and ranging link assignment of BeiDou satellites have made important progress; however, there is still the unsolved issue of integrated communication between ground gateway, aircraft, or even ship, and the BeiDou satellites. …”
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7579
Trachoma and Ocular Chlamydial Infection in the Era of Genomics
Published 2015-01-01“…The mechanisms driving the chronic immunopathology in the conjunctiva, which largely progresses in the absence of detectable Ct infection in adults, are likely to be multifactorial. …”
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7580
A Case of Non-Small Cell Lung Cancer with Possible “Disease Flare” on Nivolumab Treatment
Published 2016-01-01“…Six weeks later, after 3 cycles of nivolumab treatment, rapid lung cancer progression was observed with an increase in the size of the primary lesion, multiple novel nodules on both lungs, and multiple novel brain metastases. …”
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