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6721
Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer
Published 2025-01-01“…<b>Background</b>: This study evaluated the prognostic impact of Trop-2, CD47, and CD163 expression on clinical outcomes in triple-negative breast cancer (TNBC) and investigated their interactions with tumor progression. <b>Methods</b>: A retrospective cohort of 92 patients with TNBC was analyzed. …”
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6722
Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis
Published 2025-01-01“…The key factors contributing to the onset and progression of atherosclerosis include the pro-inflammatory cytokines interferon (IFN)α and IFNγ and the pattern recognition receptor (PRR) Toll-like receptor 4 (TLR4). …”
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6723
Gut microbiota and kidney function in autosomal dominant polycystic kidney disease participants in Cameroon: a cross-sectional study
Published 2025-01-01“…Conclusion Decreased kidney function was associated with decreased symbiont and increased pathobiont abundance in ADPKD patients, suggesting a potential role for the microbiota in disease progression and possible targets for further research.…”
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6724
A novel interplay between bacteria and metabolites in different early-stage lung cancer: an integrated microbiome and metabolome analysis
Published 2025-01-01“…Ralstonia may be an important flora promoting the development of early lung adenocarcinoma, while Feacalibacterium and Blautia play a protective role in the progression of GGN to SN. Akkermansia, Escherichia-shigella, and Klebsiella exhibited high abundance in early lung squamous carcinoma. …”
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6725
Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins
Published 2025-02-01“…Here, we investigated whether LPS could contribute to the neurodegenerative disease progression via neuroinflammation, especially under conditions of aSyn pathology. …”
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6726
The Safety and Efficacy of the Repeated PRRT with [90Y]Y/[177Lu]Lu-DOTATATE in Patients with NET
Published 2021-01-01“…The study aims to evaluate the safety, efficacy, and progression-free survival (PFS) of patients after retreatment (R-PRRT) and re-retreatment (RR-PRRT) with tandem isotopes [90Y]Y/[177Lu]Lu-DOTATATE. …”
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6727
Identification of RAD51AP1 as a key gene in hepatitis B virus-associated hepatocellular carcinoma
Published 2025-01-01“…Conclusions: The LINC01419/miR-8070/RAD51AP1 axis promotes the HBV-associated HCC progression through an HBV-boosted positive feedback loop and Wnt/β-catenin signaling. …”
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6728
CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis
Published 2025-01-01“…Furthermore, we demonstrate that CASC8 acts as a crucial regulator of the pentose phosphate pathway and disulfidptosis, thereby promoting PDAC progression.…”
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6729
Qualitative evaluation of the Rehabilitation Exercise and psycholoGical support After COVID-19 InfectioN (REGAIN) randomised controlled trial (RCT): ‘you are not alone’
Published 2025-01-01“…The themes from group exercise were: (1) monitoring and modification of the online exercise; (2) catering for differing abilities; (3) feeling safe and confident to exercise; (4) progression of fitness; (5) optimal timing in the recovery trajectory; (6) group effect; (7) initial apprehension about exercise group; (8) gauging exercise capabilities; (9) translating exercises into life; and (10) on-demand supplementary videos. …”
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6730
METTL1 mediates PKM m7G modification to regulate CD155 expression and promote immune evasion in colorectal cancer
Published 2024-12-01“…However, the mechanisms by which m7G-modified RNA metabolism affects tumor progression are not fully understood, nor is the contribution of m7G-modified RNA to the CRC immune microenvironment. …”
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6731
CST2 promotes cell proliferation and regulates cell cycle by activating Wnt-β-catenin signalling pathway in serous ovarian cancer
Published 2024-12-01“…Functionally, CST2 played vital roles in promoting cell proliferation, orchestrating the G1-to-S phase transition, and driving malignant SOC progression through activating the Wnt-β-catenin signalling pathway.Conclusions The elevated expression of CST2 may be related to the occurrence and progression of SOC by activating the Wnt-β-catenin pathway. …”
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6732
Prognostic value of matrix metalloproteinases and transforming growth factor – β in kidney cancer
Published 2022-06-01“…Serum TGF‑β1 concentration isn't a sufficiently reliable marker of tumor progression.…”
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6733
Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation
Published 2025-02-01“…Compared to controls, a history of high-grade or treated rejection was significantly associated with progressive pathologic remodeling and future adverse outcomes (32.9% vs 5.1%, p < 0.001). …”
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6734
Retrospective, Non-Interventional, Multicenter Study on the Effectiveness and Safety of Intravesical Bacillus Calmette–Guerin in Patients with Non-Muscle-Invasive Bladder Cancer: R...
Published 2024-12-01“…Tumor recurrence and progression were monitored at scheduled time intervals. …”
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6735
Physicochemical Properties, Antioxidant Activity, and Flavor Profile of Strawberry Fruit-Based Novel Drinking Jelly Made with <i>Gracilaria fisheri</i> Seaweed as a Gelling Agent a...
Published 2025-01-01“…Increasing GF levels progressively enhanced the lightness (L*) and redness (a*) values while reducing the yellowness (b*), with optimal visual appeal achieved in the S4 samples compared to others. …”
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6736
Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections
Published 2023-01-01“…Finally, germline variation in genes that affect trained immunity was associated with recurrence and progression after BCG therapy in NMIBC.Conclusion We conclude that BCG immunotherapy induces trained immunity in NMIBC patients and this may account for the protective effects against respiratory infections. …”
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6737
Machine learning-based plasma metabolomics for improved cirrhosis risk stratification
Published 2025-02-01“…Pathway enrichment analysis revealed that disruptions in lipid and amino acid metabolism play a central role in the progression of cirrhosis. Conclusion 1 H-NMR serum metabolomics significantly improves the prediction of cirrhosis risk in patients with CLD. …”
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6738
How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review
Published 2025-02-01“…Conventional resistance training is commonly contraindicated in load compromised and/or persistent pain populations, compromising rehabilitation progression and potentially leading to extensive pharmacological intervention, invasive procedures, and reduced occupational status. …”
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6739
COMBINED TREATMENT OF LOCALLY-ADVANCED BLADDER CANCER
Published 2016-01-01“…In the group of ACT + NCT + CE 3 patients (15%) were alive at the time, passed the threshold of the 5‑year survival rate, there is no progression of cancer.Conclusion. Combined treatment mode NACT + CE + ACT can achieve significantly longer time to tumor progression and better overall survival; the reverse side is to increase the frequency of postoperative complications.…”
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6740
Barcelona scale for buccophonatory apraxia: Quantitative assessment tool
Published 2025-01-01“…The scale was administered to 64 participants with diagnoses of: nfvPPA, semantic variant of primary progressive aphasia (svPPA), logopenic variant of primary progressive aphasia (lvPPA), Huntington’s disease, Parkinson’s disease, as well as a group of healthy controls. …”
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