Inflammation in Diabetic Nephropathy by Andy K. H. Lim, Gregory H. Tesch

“…This review examines the evidence for inflammation in the development and progression of diabetic nephropathy in both experimental and human diabetes, and provides an update on recent novel experimental approaches targeting inflammation and the lessons we have learned from these approaches. …”
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Regionalisation of the Republic of Slovenia by Stane Vlaj

“…The author recognises that in almost all CE member states, far-reaching reforms of regional authorities have been completed, are in progress or are planned for the years ahead. The CE, preparing a document (recommendation/convention) on regional self-government, respects the sovereignity and freedom of member states to determine their own internal organisation in conformity with the fundamental standards and principles of democracy. …”
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The culture of memory of Serbian builders of recent times by Kadijević Aleksandar

“…However, in spite of the progress evident, a culture of memory in terms of the architectural discipline(s) lacks organizational cohesion and consistent criteria, as well as a long-term plan for its fostering, as evident from the notable absence of such from Serbia's recently adopted National Architectural Strategy (2023-2035).…”
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Le développement durable face à sa crise : un concept menacé, sous-exploité ou dépassé ? by Jacques Theys

“…The concept of sustainable development seems progressively disappearing from the public and political debates, and partly from the scientific forefront – replaced by more “up to date” terms such as “resilience”, “transition”, “degrowth”, ”green economy”, “smart growth”…. …”
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Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas by Rebecca Leandri, Sara Buonocore, Karen Power

“…Altered iron pathways have been associated with cancer onset and progression; however, their role in canine tumors remains poorly explored. …”
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Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview by Katia D’Ambrosio, Anna Di Fiore, Emma Langella

“…It can enhance therapeutic outcomes, reduce side effects and avoid the emergence of drug resistance, particularly in conditions like cancer, inflammation and neurological disorders, where multiple pathways contribute to disease progression. Identifying suitable targets for a dual inhibitor approach requires a deep understanding of disease biology, knowledge of critical pathways, and selection of complementary or synergistic targets. …”
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Conflitti del lavoro, lavoro in conflitto. Trasformazioni aziendali globali e nuove forme di fragilità e precarizzazione by Fulvia D’Aloisio

“…Based on an ethnographic research on the Fiat-Sata factory of Melfi (founded in 1993), it shows the progressive change of the line of conflict between workers and owners towards a more subjective and existential conflict between time of work and private and familiar life. …”
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Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…Meta-analyses were performed to evaluate the frequencies of progression-free survival (PFS), overall survival (OS), complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD), objective response rate (ORR), disease control rate (DCR), and grade ≥ 3 treatment-related adverse events (trAEs).ResultsTotally six studies were included for meta-analysis. …”
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Protein kinase inhibitors as targeted therapy for glioblastoma: a meta-analysis of randomized controlled clinical trials by José Pinto-Fraga, Celia García-Chico, Simone Lista, Pedro Miguel Lacal, Giuseppe Carpenzano, Maurizio Salvati, Alejandro Santos-Lozano, Grazia Graziani, Claudia Ceci

“…Pooled analysis of shared clinical outcomes - progression-free survival (PFS) and overall survival (OS) - revealed a lack of significant improvements with the use of PKIs. …”
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Extensive Inactive Neurocysticercosis: A Case Report in Mbeya, Southern Highlands of Tanzania by Makasi CE, Ngowi BJ, Stelzle D, Kilale AM, Mahande MJ, Welte TM, Winkler AS, Mmbaga BT

“…Clinical presentation of NCC ranges from asymptomatic to manifestations, including epileptic seizures, severe progressive headache, and focal neurological deficits. …”
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Treating drug-resistant tuberculosis in an era of shorter regimens: Insights from rural South Africa by J-D K Lotz, J Porter, H Conradie, T Boyles, B Gaunt, S Dimanda, D Cort

“… Background. Progressive interventions have recently improved programmatic outcomes in drug-resistant tuberculosis (DR-TB) care in South Africa (SA). …”
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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…Patients were treated until disease progression, intolerability, or patient decision to discontinue. …”
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Efficacy and safety of 3D-therapy at HCV-related subcompensated liver cirrhosis (genotype 1b) by P. O. Bogomolov, M. V. Matsiyevich, A. O. Buyeverov, V. D. Beznosenko, Ye. V. Fedosova, M. Yu. Petrachenkova, S. V. Koblov, K. Yu. Kokina, O. S. Kuzmina, N. V. Voronkova

“…Most cases of the progression­related treatment termination due to liver failure were reversible after CAT interruption. …”
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Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…Disturbances of visual perception are usually considered to be a complication of PD progression predicting a probability of psychosis or coexisting dementia. …”
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The influence of exercise modality and intensity on ventricular arrhythmia burden and perception of effort in patients with Arrhythmogenic Right Ventricular Cardiomyopathy with pla... by Fernando G. Beltrami, Kyle G. P. J. M. Boyle, Guan Fu, Corinna Brunckhorst, Firat Duru, Christina M. Spengler, Ardan M. Saguner

“… Introduction Intense endurance exercise is discouraged for patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), as it can increase the risk for adverse cardiac events as well as accelerate disease progression. While a sedentary lifestyle is also not advisable, there is currently no prospective data on the safety of physical activity for ARVC patients. …”
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Strategies for preventing and managing osteoporosis in elderly breast cancer patients undergoing aromatase inhibitor therapy by Andi Tian, Chunyu Zhang

“…The development and progression of breast cancer are closely linked to estrogen levels. …”
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Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B... by Runhui Zheng, Xiaobo Chen, Chunyan Wang, Pengfei Qin, Huo Tan, Xiaodan Luo

“…A 50-year-old man presented with a 6-month history of hoarseness, and 10 days of progressive shortness of breath was diagnosed of DLBCL, stage IV. …”
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Review and outlook on reinforcement learning: Its application in agricultural energy internet by Xueqian Fu, Jing Zhang, Xiang Bai, Xinyue Chang, Yixun Xue

“…This research acts as a conduit, merging agricultural and energy domains to promote a cohesive progression that markedly aids in the enhancement of rural electrification and the adoption of sustainable energy methodologies through reinforcement learning.…”
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Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke by Jamal M. Alzahrani, Ashley J. Smuder, Bryce J. Gambino, Cristina Delgado, Michael T. Rua, Ryan N. Montalvo, Finleigh P. Fitton, Deborah A. Morse, Thomas L. Clanton

“…We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease. Following EHS, mice were followed for 3 months; after two weeks of recovery, half were placed on a Western diet to determine if previous EHS exposure amplifies the negative consequences of an atherogenic diet. …”
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The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game by Donika Ivanova, Severina Semkova, Boncho Grigorov, Milena Tzanova, Ana Georgieva, Dancho Danchev, Biliana Nikolova, Zvezdelina Yaneva

“…Because of the reported serious adverse effects of using synthetic ligands for PPARs in combination with chemotherapeutics, searches for less toxic and more active PPAR inhibitors, as well as blocking undesirable cellular PPAR-dependent processes, are in progress. On the other hand, recent research in modern immunotherapy has focused on the search for gentle immune-modulating natural compounds with harmless synergistic chemotherapeutic efficacy that can be used as an adjuvant. …”
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