Pullout Characteristics and Damage Softening Model of the Geogrid-Soil Interface by Xiaoyong Liang, Jing Jin, Guangqing Yang, Xizhao Wang, Yitao Zhou

“…Analytical solutions of interface tension, shear stress, and displacement at different stages are derived considering strain softening based on damage, and the development of shear stress and progressive failure mode of the geogrid-soil interface at different pullout stages is revealed. …”
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Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer by Manish Kohli, Rui Qin, Rafael Jimenez, Scott M. Dehm

“…Recent therapeutic advances for managing advanced prostate cancer include the successful targeting of the androgen-AR axis with several new drugs in castrate resistant prostate cancer including abiraterone acetate and enzalutamide (MDV3100). This translational progress from “bench to bed-side” has resulted in an enlarging repertoire of novel and traditional drug choices now available for use in advanced prostate cancer therapeutics, which has had a positive clinical impact in prolonging longevity and quality of life of advanced prostate cancer patients. …”
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Effect of cold rolling and annealing temperature to the characteristics of α + β' phases in Cu-29.5Zn-2.5Al alloy produced by gravity casting by Angela I., Basori I., Sofyan B.T.

“…Visible traces of slip, intersecting slip bands, and shear bands were observed in microstructure images of the samples after each progressive deformation stage. Deformation-induced martensites were present after 20 % cold rolling. …”
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Chloride intracellular channel CLIC3 mediates fibroblast cellular senescence by interacting with ERK7 by Changjiao Luan, Yue Gao, Jun Zhao, Xiaohui Zhang, Chaofan Wang, Wentao Sun, Yucheng Li, Xinxing Yang, Jiaxiao Chen, Weili Liu, Weijuan Gong, Xingjie Ma

“…Furthermore, our findings revealed that the knockdown of CLIC3 mitigated intracellular chloride ion lose, mitochondrial dysfunction, nuclear enlargement, DNA damage, CS progression, and expression of senescence-associated secretory phenotype (SASP) triggered by bleomycin. …”
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Cystic Fibrosis Atypical Forms Presentation: Edema, Anemia and Skin Lesions by Chabelys de la Caridad Rodríguez Membrides, Carlos Enrique Cruz Carrazana, Milda Díaz Martínez

“…Cystic fibrosis or mucoviscidosis is the most common genetic disease in the Caucasian race characterized by thickening of secretions due to abnormal ion transport of epithelial cells, manifested with pancreatic insufficiency, progressive lung disease, alteration in the secretion of electrolytes in sweat, azoospermia in males and decreased fertility in females. …”
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Diagnostic, Treatment, and System Challenges in the Management of Recurrent Neuroleptic Malignant Syndrome on a General Medical Service by Karan Verma, Vivek Jayadeva, Raymond Serrano, Karthik Sivashanker

“…We educated our inpatient colleagues for timely recognition of hyperexcited subtype of catatonia to avoid iatrogenic progression to neuroleptic malignant syndrome and our medical colleagues on the clinical course of catatonic symptoms to avoid any further disagreements and delays in treatment. …”
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Numerical Study of the Effects of Topography and Urbanization on the Local Atmospheric Circulations over the Beijing-Tianjin-Hebei, China by Yucong Miao, Shuhua Liu, Yijia Zheng, Shu Wang, Bicheng Chen

“…It was found that, in the summer day time, the multiscale thermally induced local atmospheric circulations may exist and interact in the same time over the BTH region; the topography played a role in the strengthening of the sea breeze circulations; after sunset, the inland progress of sea breeze was slowed down by the opposite mountain breeze; when the land breeze circulation dominated the Bohai bay, the mountain breeze circulation can couple with the land breeze circulation to form a large circulation ranging from the coastline to the mountains. …”
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Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning by Yue Pang, Yating Qin, Zeyu Du, Qun Liu, Jin Zhang, Kai Han, Jiali Lu, Zengbao Yuan, Jun Li, Shanshan Pan, Xinrui Dong, Mengyang Xu, Dantong Wang, Shuo Li, Zhen Li, Yadong Chen, Zhisheng Zhao, Zhe Zhang, Shunqin Chuan, Yue Song, Mingjie Sun, Xiaodong Jia, Zhangyong Xia, Liping Zhan, Zhen Yue, Wei Cui, Jun Wang, Ying Gu, Ming Ni, Huanming Yang, Xun Xu, Xin Liu, Qingwei Li, Guangyi Fan

“…However, the lack of cytomic studies on multiple lamprey organs has hindered progress in this field. Therefore, the present study constructed a comprehensive cell atlas comprising 604,460 cells/nuclei and 70 cell types from 14 lamprey tissue samples. …”
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Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics by Haisong Li, Can Li, Cong Fu, Yizhuo Wang, Tingting Liang, Haitao Wu, Chenxi Wu, Chang Wang, Tianmeng Sun, Shuhan Liu

“…While they help capture and eliminate pathogens, NETs’ excessive or dysregulated formation can lead to tissue damage and disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly in achieving precise drug delivery and maintaining drug stability. …”
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Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma by Ge Zhang, Wan-Li Liu, Lin Zhang, Jun-Ye Wang, Miao-Huan Kuang, Peng Liu, Yue-Hao Lin, Shu-Qin Dai, Jun Du

“…These results suggested that impairing CD8+ TIL functions by IDO expressed in ESCC possibly contributed to the finding that patients with higher IDO expression have more aggressive disease progression and shorter overall survival time.…”
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New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy by Mengran Li, Mengran Li, Hu Tian, Yanshuang Zhuang, Zili Zhang, Zili Zhang

“…Due to its intricate participation in both normal cellular processes and the course of disease, as well as its critical role in determining cell fate, N6-methyladenosine (m6A) alteration has recently attracted a lot of interest. The formation and progression of many diseases, especially cancer, can be attributed to dysregulated m6A alteration, which can cause disturbances in a variety of cellular functions, such as immunological responses, cell proliferation, and differentiation. …”
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Quantum Algorithms for the Physical Layer: Potential Applications to Physical Layer Security by Toshiki Matsumine, Hideki Ochiai, Junji Shikata

“…The field of quantum technologies has garnered considerable interest and witnessed noteworthy progress in recent years. It is also anticipated that these technologies will continue to flourish and exert a considerable influence on society, i.e., a plethora of real-world problems that cannot be solved by classical algorithms are believed to benefit from the implementation of quantum algorithms. …”
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The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets by Peng Wang, Qian Zhang, Liang Tan, Yanan Xu, Xubiao Xie, Yong Zhao

“…We herein mainly focused on the recent progress in understanding the roles of mTOR in regulating the development and differentiation of CD4+ T cell subsets.…”
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Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells by Patrícia S. de Araújo-Souza, Steffi C. H. Hanschke, João P. B. Viola

“…However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymphocytes (CTL) and memory cells, which are capable of producing high levels of this cytokine. …”
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What’s in a name? Memory NK cells for cancer immunotherapy by William J Murphy, Robert J Canter, Sean J Judge, Megan C Purl

“…Application of these cells to the clinic is progressing with promising results, but important questions remain about the essential molecular, phenotypic, and functional characteristics that define a memory NK cell.…”
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Elevated levels of neutrophils with a pro-inflammatory profile in Turner syndrome across karyotypes by Jesper Just, Lukas Ochsner Reynaud Ridder, Emma Bruun Johannsen, Jens Magnus Bernth Jensen, Mikkel Steen Petersen, Helene Viborg Christensen, Kenneth Kjærgaard, Jacob Redder, Simon Chang, Kirstine Stochholm, Anne Skakkebæk, Claus Højbjerg Gravholt

“…Identifying TS individuals with increased neutrophil activation could potentially mitigate the progression towards more severe metabolic issues.…”
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The relationship between epistemic curiosity and creativity: Research status and educational implications by Yadan Li, Merbiya Emin, Qianzhu Zhou, Jing Zhang, Weiping Hu

“…AbstractCreativity is a core driver of social development and technological progress. Epistemic curiosity (EC), as an important intrinsic motivation, is a prerequisite for creativity. …”
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Subacute Stroke in a Young Female: A Case of Moyamoya Syndrome Initially Anchoring with Anxiety by Saira Chaughtai, Zeeshan Chaughtai, Muhammad Shaheryar Haider, Hasnan M. Ijaz, Sarah Elmedani, Mohamed Bakr, Mohammad A. Hossain, Arif Asif

“…This is a chronic condition causing progressive cerebrovascular disease due to bilateral stenosis and occlusion of the arteries around the circle of Willis, with prominent arterial collateral circulation. …”
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Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation by Nivedita U. Jerath, Cameron D. Crockett, Steven A. Moore, Michael E. Shy, Conrad C. Weihl, Tsui-Fen Chou, Tiffany Grider, Michael A. Gonzalez, Stephan Zuchner, Andrea Swenson

“…With long-standing pes cavus and toe walking, our patient developed progressive weakness, cramps, memory loss, and paresthesias at age 52. …”
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Two Cases of Periprosthetic Atypical Femoral Fractures in Patients on Long-Term Bisphosphonate Treatment by Takanori Miura, Hiroaki Kijima, Takayuki Tani, Toshihito Ebina, Naohisa Miyakoshi, Yoichi Shimada

“…Here, we report two rare cases of PAFFs that fulfilled the major criteria for AFFs in patients with prolonged use of BPs. Both cases progressed to a complete fracture with minor trauma from an incomplete fracture at the distal tip of the well-fixed femoral stem. …”
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