Contiguous Multilevel Thoracic Ossification of Ligamentum Flavum in a Young Adult Spine by Tsuyoshi Yamada, Ichiro Torigoe, Kenichiro Sakai, Atsushi Okawa, Yoshiyasu Arai

“…This female with obesity presented with a 6-month history of progressively worsening dorsal cord disorders. Resection or floating of the enormous OLF could be successfully achieved using O-arm-based navigation, and sensory loss, numbness, and gait disturbance were improved after operation.…”
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Corticosteroids in Patients with IgA Nephropathy and Severe Chronic Renal Damage by Claudio Pozzi, Francesca Ferrario, Bianca Visciano, Lucia Del Vecchio

“…In conclusion, these preliminary observations suggest a possible efficacy of corticosteroids in slowing down the progression of renal disease and in postponing the need of dialysis in IgAN patients with stage IV CKD and severe chronic histological lesions.…”
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TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models by Giuseppe Malleo, Emanuela Mazzon, Ajith K. Siriwardena, Salvatore Cuzzocrea

“…In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. …”
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Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome by Fei Gao, Lijun Qi, Zhongzhen Yang, Tao Yang, Yan Zhang, Hui Xu, Huan Zhao

“…More and more studies demonstrated that attenuated GABAergic circuits in the absence of FMRP are critical for abnormal progression of FXS. Here, we reviewed the changes of GABA neural circuits that were attributed to intellectual-deficient FXS, from several aspects including deregulated GABA metabolism, decreased expressions of GABA receptor subunits, and impaired GABAergic neural circuits. …”
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Ozone therapy as support in the treatment of diabetic foot ulcer. A case report by Isidro Matos Lamote, Jorge Enrique Rodríguez León, Carlos García Arencibia, Maydelin Pérez Reina

“…From week 18 on, the patient progressed favorably, with the presence of good granulation, gradual disappearance of pain and acceleration of the complete healing process of the lesion, in addition to achieving efficient metabolic control. …”
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Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models by Pallavi Sontakke, Jenny Jaques, Edo Vellenga, Jan Jacob Schuringa

“…These models not only mimic CML but also have been instrumental in uncovering various fundamental mechanisms of CML disease progression and tyrosine kinase inhibitor (TKI) resistance. …”
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Enamel Pearls Implications on Periodontal Disease by Elton Gonçalves Zenóbio, Thaís Ribeiral Vieira, Roberta Paula Colen Bustamante, Hayder Egg Gomes, Jamil Awad Shibli, Rodrigo Villamarin Soares

“…Local factors such as enamel pearls can lead to inadequate removal of the subgingival biofilm, thus favoring the establishment and progression of periodontal diseases.…”
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Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer by Yanlong Wang, Yulin Peng, Wenjun Hao, Chengjian He, Xiang Gao, Peng Liang, Haolin Zhao, Ying Wang, Liang Wang, Zhenlong Yu, Zhiyu Liu

“…Additionally, Trillin enhances the expression of miR-145-5p, further modulating pathways critical for CRPC progression. These findings suggest that Trillin may offer a promising alternative approach for targeting CRPC, highlighting its potential as a therapeutic agent to improve patient outcomes.…”
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Predictions of bimanual self-touch determine the temporal tuning of somatosensory perception by Noa Cemeljic, Xavier Job, Konstantina Kilteni

“…We observed that forces felt progressively weaker during the reaching, reached their minimum perceived intensity at the time of self-touch, and recovered after the movement ended. …”
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How to Achieve Diversity, Equity, and Inclusion in The Korean Society of Gastroenterology? by Nayoung Kim, Kwangwoo Nam, Ki-Nam Shim, Hyo Jung Kim, Su Youn Nam, Sae Kyung Joo, Seun Ja Park, Yonghoon Choi, Yoon Ju Jung, Yong Sung Kim, Ja Kyung Kim, Seon Mee Park

“…The key strategies include establishing a DEI committee, setting clear targets, and conducting formal assessments to measure DEI progress. This study focused on enhancing workforce diversity, particularly among women and young doctors, and advocates for the need to support their academic development through male allyship and the promotion of equitable and inclusive academic cultures.…”
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Towards a long-term model construction for the dynamic simulation of HIV infection by M. Hadjiandreou, Raul Conejeros, Vassilis S. Vassiliadis

“…Furthermore, the simulation resultsemphasize the importance of macrophages in HIV infection and progressionto AIDS and show a clear correlation between the level of CTLs andHIV progression. The ability of the model to correlate analyticaldata gives credibility to its predictions, a fact that will beexploited in future research in modelling immunological and pharmacologicalavenues of treatment.…”
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Knockdown of RFC4 inhibits cell proliferation of oral squamous cell carcinoma in vitro and in vivo by Pengyue You, Di Wang, Zheng Liu, Shuzhen Guan, Ning Xiao, Haotian Chen, Xin Zhang, Lichuan Wu, Guizhen Wang, Haitao Dong

“…In the present study, bioinformatics analysis identified RFC4 as a potential key target in OSCC progression. Additional experiments showed that RFC4 expression was significantly higher in OSCC tumor tissues than in normal tissues. …”
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Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management by Adil Hassan, Yin Huang, Mahjabina, Otmilda Hapsari Sudiro, Xiangxiu Wang, Jingqin He, Yan Wei, Xiaoling Liao, Guixue Wang

“…Dysbiosis is key to establishing and progressing human diseases, including neurodegenerative disorders. …”
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Gender-Specific Variation in the Prognosis of Papillary Thyroid Cancer TNM Stages II to IV by Sheng-Hwu Hsieh, Szu-Tah Chen, Chuen Hsueh, Tzu-Chieh Chao, Jen-Der Lin

“…There were 65 from 316 female (20.6%) and 49 from 120 male (40.8%) patients who had a postoperative disease progression. A total of 55 (12.6%) patients died of thyroid cancer. …”
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Robotization of Miniature-Scale Radio-Controlled Excavator: A New Medium for Construction- Specific DNN Data Generation by Seyedeh Fatemeh Saffari, Daeho Kim, Byungjoo Choi

“…Digital management of excavators has seen limited progress due to challenges in artificial intelligence (AI) training. …”
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Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders by Emanuela Castiglioni, Dario Finazzi, Stefano Goldwurm, Gianni Pezzoli, Gianluca Forni, Domenico Girelli, Federica Maccarinelli, Maura Poli, Maurizio Ferrari, Laura Cremonesi, Paolo Arosio

“…In the brain, an accumulation of iron or an increase in its availability has been associated with the development and/or progression of different degenerative processes, including Parkinson's disease, while iron paucity seems to be associated with cognitive deficits, motor dysfunction, and restless legs syndrome. …”
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Vasculopathy: a possible factor affecting hereditary angioedema by Anna Laura Colia, Alessandra Ranaldi, Rosa Santacroce, Giovanna D'Andrea, Angela Bruna Maffione, Maurizio Margaglione, Maria D'Apolito

“…This review summaries recent progress in genetic characterization of angioedema and discusses future potential for identifying additional genetic abnormalities in HAE. …”
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Interaction of GPER-1 with the endocrine signaling axis in breast cancer by Luis Molina Calistro, Yennyfer Arancibia, Marcela Alejandra Olivera, Sigrid Domke, Rodrigo Flavio Torres

“…G Protein-Coupled Estrogen Receptor 1 (GPER-1) is a membrane estrogen receptor that has emerged as a key player in breast cancer development and progression. In addition to its direct influence on estrogen signaling, a crucial interaction between GPER-1 and the hypothalamic-pituitary-gonadal (HPG) axis has been evidenced. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…These findings underscore the pivotal role of ACSL4 in HB progression and highlight its potential as a therapeutic target for aggressive HB subtypes.…”
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Oxidized Lipoproteins Suppress Nitric Oxide Synthase in Macrophages: Study of Glucocorticoid Receptor Involvement by K. E. Matthys, P. G. Jorens, B. Marescau, M. Rosseneu, H. Bult, A. G. Herman

“…Activated cholesterol-laden macrophages in atherosclerotic lesions are believed to influence the progression of this disease. The induction of nitric oxide synthase (iNOS) activity was investigated in control and cholesterol-laden J774 macrophages, obtained by pre-incubation with oxidized or acetylated low density lipoproteins (oxLDL, acLDL). …”
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