Undifferentiated Spindle-Cell Carcinoma of the Gallbladder: A Report of a Case, an Immunohistochemistry Profile, and a Review of the Literature by Kabir Bolarinwa Badmos, Laila Salah Seada, Fawaz Fahad Al Rashid, Hanan Abdulhafez Oreiby

“…The poor tumour differentiation coupled with advanced stage at presentation was partly responsible for the disease progression and patients' death one year after surgery. …”
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Gas Gangrene in Orthopaedic Patients by Zhimin Ying, Min Zhang, Shigui Yan, Zhong Zhu

“…We present a case of 55-year-old obese woman who developed rapidly progressive gas gangrene in her right leg accompanied by tibial plateau fracture without skin lacerations. …”
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The role of complement in tumor immune tolerance and drug resistance: a double-edged sword by Ronghui Yang, Di Fu, Di Fu, Aijun Liao

“…Concurrently, the complement system can also be implicated in the emergence of drug resistance through a multitude of complex mechanisms, directly or indirectly reducing the efficacy of therapeutic interventions and facilitating the progression of cancer. This paper analyses the role of the complement system in tumors and reviews recent research advances in the mechanisms of tumor immune tolerance and drug resistance.…”
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Capsule neural network and adapted golden search optimizer based forest fire and smoke detection by Luling Liu, Li Chen, Mehdi Asadi

“…This research highlights the importance of advanced computational techniques in reducing risks, ensuring safety, and progressing automatic forest fire detection systems. …”
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Topical Nitroglycerine for Neonatal Arterial Associated Peripheral Ischemia following Cannulation: A Case Report and Comprehensive Literature Review by Rafat Mosalli, Mohamed Elbaz, Bosco Paes

“…Applied interventions depend on the extent of tissue involvement and whether the condition is progressive and deemed life threatening. Standard, noninvasive measures include immediate catheter removal, limb elevation, and warming the contralateral extremity. …”
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Strengths and weaknesses of European integration for the Republic of Serbia by Đurović Mihajlo, Božović Ivan, Dramićanin Sandra

“…European integration as a process strengthens the economy and encourage progress, guarantee market competition, and control large companies, while at the same time protecting consumers and reducing the cost of living. …”
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Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease by Yajing Huang, Jingwei Chi, Fanxiang Wei, Yue Zhou, Yihai Cao, Yangang Wang

“…Diabetic kidney disease (DKD) is a common cause of end-stage renal disease, and diagnosis and treatment in time can help delay its progress. At present, there are more and more studies on the pathogenesis of DKD; mitochondrial dysfunction plays an important role in DKD. …”
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Periconceptional Folate Deficiency and Implications in Neural Tube Defects by J. Safi, L. Joyeux, G. E. Chalouhi

“…Since strategies to modify women’s dietary habits and vitamin use have achieved little progress, scientific as well as political effort is mandatory in order to implement global preventive public health strategies aimed at improving the alimentation of women in reproductive age, especially folic acid supplementation. …”
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Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation by Jungwoon Lee, Young-Jun Park, Haiyoung Jung

“…In this review, we highlight the recent progress made in defining the roles of protein kinase signaling pathways and their small molecule modulators in regulating the pluripotent states, self-renewal, reprogramming process, and lineage differentiation of PSCs.…”
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Appropriate management of Mirizzi syndrome. Literature review by Jorge Luis Estepa Pérez, Paolo Martini, Biagio Di Trani, Carmeni Picarelli, Angela Conti, Verónica Crocco

“…It is characterized by extrinsic compression of the bile duct, produced by pressure applied indirectly by one or more stones embedded in the infundibulum of the gallbladder (Hartmann's pouch); As the inflammatory process progresses, obstruction, necrosis, and even internal biliary fistula may occur. …”
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Suspected Spontaneous Aqueous Humor Misdirection Syndrome in a Boston Terrier by Ashley E. Zibura, Michael G. Davidson, Hans D. Westermeyer

“…The patient was successfully managed with topical carbonic anhydrase inhibitors (CAIs) and apraclonidine for eight months until progressive ulcerative keratitis necessitated enucleation of the affected globe. …”
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Routing and scheduling optimization for urban air mobility fleet management using quantum annealing by Renichiro Haba, Takuya Mano, Ryosuke Ueda, Genichiro Ebe, Kohei Takeda, Masayoshi Terabe, Masayuki Ohzeki

“…Formulating route planning as a maximum weighted independent set problem enables us to utilize various algorithms and specialized optimization hardware, such as quantum annealers, which has seen substantial progress in recent years. Our method is validated using a traffic management simulator tailored for the airspace in Singapore. …”
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Effects of Hole Perpendicularity Error on Mechanical Performance of Single-Lap Double-Bolt Composite Joints by Xueshu Liu, Yuxing Yang, Yiqi Wang, Yongjie Bao, Hang Gao

“…Hole tilting angle, varying from 1 to 4 degrees, and hole tilting direction to account for anisotropic properties of composite material were investigated. Progressive damage model (PDM) based on Chang-Lessard type criterion with an extension by Olmedo was created, which involved seven failure modes and made material properties be a direct function of predefined field variables. …”
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Maxillary Sinus Natural Killer/T-Cell Extranodal Lymphoma Mimicking a Dentoalveolar Abscess by Erika Antonia dos Anjos Ramos, Luciana Munhoz, Basílio Almeida Milani, Tomás Zecchini Barrese, Stephanie Kenig Viveiros, Emiko Saito Arita

“…However, the lesion progressed fastly showing an evident growth, so it was decided that an intraoral biopsy should be performed. …”
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Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy by Xi Li, Hanzhe Liu, Peiyu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong

“…These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). …”
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Nucleus pulposus cell network modelling in the intervertebral disc by Sofia Tseranidou, Maria Segarra-Queralt, Francis Kiptengwer Chemorion, Christine Lyn Le Maitre, Janet Piñero, Jérôme Noailly

“…This IVD RNM is a valuable tool for predicting IDD progression, offering insights into ECM degradation mechanisms and guiding experimental research on IVD health and degeneration.…”
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Cerebellar metastasis from colorectal cancer: a case report by Carla E. Angulo-Rojo, Luis J. Castillo-Gaxiola, Karen Gaxiola-Gastélum, Alma M. Guadrón-Llanos, Javier A. Magaña-Gómez, Diana L. Baldenebro-Félix, Diana L. Baldenebro-Félix

“…Despite extensive treatment, including surgery and chemotherapy, the disease progressed, ultimately leading to the patient’s demise. …”
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Administration of RAS Inhibitor before the Onset of Diabetic Nephropathy Counteracts the Adverse Effect of Chronic Hyperglycemia and Reduces the Augmentation of Urinary Albumin Exc... by Hidenori Hirukawa, Shinji Kamei, Tomohiko Kimura, Atsushi Obata, Kenji Kohara, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…RAS inhibitor exerted protective effect on the progression of urinary albumin excretion in subjects with type 2 diabetes without diabetic nephropathy. …”
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Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax by Waqas Jehangir, Alexander Karabachev, Taimoor Jahangir, Elvira Umyarova

“…They are a group of heterogeneous clonal stem cell malignancies with a high risk to progress to acute myeloid leukemia. Currently, there are no curative FDA-approved medications for myelodysplastic syndromes. …”
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The Role of the Microbiota in the Diabetic Peripheral Artery Disease by Federico Biscetti, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi, Andrea Flex

“…There is an urgency to develop the knowledge of modern medicine about the link between gut microbiota and its host’s metabolic pathways, and it would be useful to understand and justify the interindividual diversity of clinical disease presentation of diabetic vascular complication even if an optimization of pharmacological treatment has been made or in the case of young patients where hypertension, dyslipidemia, and diabetes are not able to justify a very quick progress of atherosclerotic process. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the microbiota in this field, from biomarker to possible therapeutic target.…”
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