Case Report: Cholestatic liver disease in the course of erythropoietic protoporphyria associated with renal hypodysplasia and atrial septal defect by Patryk Lipiński, Agnieszka Lipniacka, Maja Klaudel-Dreszler, Lidia Ziółkowska, Grażyna Kostrzewa, Edyta Odnoczko, Robert Wasilewski, Rafał Płoski, Anna Tylki-Szymańska

“…This paper presents the case of a Polish infant with EPP associated with two novel missense FECH variants accompanied by other congenital anomalies, namely atrial septal defect and renal hypodysplasia. Progressive cholestatic liver disease (with subsequent congestive heart failure) was observed in the course of EPP. …”
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Role of heat shock protein in radiation-induced effect and related potential clinical application by Ying Xu, Wentao Hu, Guangming Zhou

“…This paper reviews the biological effects of HSP under radiation and the latest research progress of combined radiation and HSP inhibitors or hyperthermia, in the hope of having a more comprehensive understanding of its mechanism in physiological processes such as cell survival, apoptosis, inflammation, immune response, as well as radiation response, which will help to enhance the therapeutic effect and to provide more effective and safer radiotherapy for cancer patients in the future.…”
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Assessing the Burden of Neglected Tropical Diseases in Low-Income Communities: Challenges and Solutions by Francesco Branda, Abdisalam Yusuf Ali, Giancarlo Ceccarelli, Mattia Albanese, Erica Binetti, Marta Giovanetti, Massimo Ciccozzi, Fabio Scarpa

“…Although international programs have marked significant progress, achieving elimination targets by 2030 requires sustained commitment, innovation, and increased research capacity in endemic countries.…”
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Partial Thickness Rotator Cuff Tears: Current Concepts by Graeme Matthewson, Cara J. Beach, Atiba A. Nelson, Jarret M. Woodmass, Yohei Ono, Richard S. Boorman, Ian K. Y. Lo, Gail M. Thornton

“…While recent studies have helped to elucidate the anatomy and natural history of disease progression, the optimal treatment, both nonoperative and operative, is unclear. …”
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Scalability of Phase Change Materials in Nanostructure Template by Wei Zhang, Biyun L. Jackson, Ke Sun, Jae Young Lee, Shyh-Jer Huang, Hsin-Chieh Yu, Sheng-Po Chang, Shoou-Jinn Chang, Ya-Hong Xie

“…By depositing the material onto a nanopatterned substrate, individual In2Se3 nanoclusters are confined in the nanosize pits with well-defined shape and dimension permitting the systematic study of the ultimate scaling limit of its use as a phase change memory element. In2Se3 of progressively smaller volume is heated inside a transmission electron microscope operating in diffraction mode. …”
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Simultaneous Bilateral Spontaneous Pneumothorax Revealed Birt-Hogg-Dubè Syndrome by Alessandro Tamburrini, Francesco Sellitri, Federico Tacconi, Francesco Brancati, Tommaso Claudio Mineo

“…Clinical signs and symptoms may vary from mild chest pain and dyspnea to severe respiratory failure; nevertheless immediate treatment is mandatory as this condition can deteriorate and progress to tension pneumothorax. An underlying lung disease has been commonly described; in most istances primary or secondary tumors, interstitial diseases, and infectious diseases. …”
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Postoperative Acute Exacerbation of IPF after Lung Resection for Primary Lung Cancer by Atsushi Watanabe, Nobuyoshi Kawaharada, Tetsuya Higami

“…Idiopathic pulmonary fibrosis (IPF) is characterized by slowly progressive respiratory dysfunction. Nevertheless, some IPF patients experience acute exacerbations generally characterized by suddenly worsening and fatal respiratory failure with new lung opacities and pathological lesions of diffuse alveolar damage. …”
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Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient by Nu T. Lu, Jeffrey Raizer, Erwin P. Gabor, Natalie M. Liu, James Q. Vu, Dennis J. Slamon, John L. Barstis

“…We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of stable disease on combination therapy with intravenous (IV) trastuzumab. Due to progressive CNS disease, intrathecal (IT) trastuzumab was introduced to enhance HER-2+ therapy into the CSF space. …”
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Cholangiocyte organoids for disease, cancer, and regenerative medicine by Munemasa Nagao, Akihisa Fukuda, Hirotaka Kashima, Sho Matsuyama, Kei Iimori, Shinnosuke Nakayama, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mayuki Omatsu, Mio Namikawa, Tomonori Masuda, Yukiko Hiramatsu, Yu Muta, Takahisa Maruno, Yuki Nakanishi, Tatsuaki Tsuruyama, Hiroshi Seno

“…This review also discusses the use of organoids in genetically engineered mouse models to provide mechanistic insights into tumorigenesis and cancer progression. Continued innovation and standardization of organoid technology are crucial for advancing precision medicine for biliary diseases and cancer.…”
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Mold Strength Analysis of Press Machine Composite Brake Using FEM Method on Train Brakes by Andhika Muhammad Kasyafa, Muhamad Juan Raffindo, Nuha Desi Anggraeni

“…Therefore, the mold of the press must have sturdy characteristics and can withstand a lot of loads so that the structure will not deform while the process is in progress. The conclusion is that the maximum voltage amount in the mold is 33,596,928 N/m² (using ASTM A36 as the reference material) which does not cause major deformation of the mold and is still considered safe.…”
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Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention by Liang Chen, Meng Shi, Chenghao Lv, Ying Song, Yuanjie Wu, Suifei Liu, Zhibing Zheng, Xiangyang Lu, Si Qin

“…Continuous oxidative stress caused by intracellular redox imbalance can lead to chronic inflammation, which is intimately associated with the initiation, promotion, and progression of cancer. DHM is considered a potential redox regulator for chronic disease prevention, and its biological activities are abundantly evaluated by using diverse cell and animal models. …”
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Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma by Bibek Aryal, Munekazu Yamakuchi, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Kentaro Gejima, Teruo Komokata, Teruto Hashiguchi, Yutaka Imoto

“…This narrative review summarizes the progress made on implicating platelet as a diagnostic and prognostic tool for HCC; the review also dissects the contradictory results from earlier studies and reflects how combining platelet-based information may enable more reliable test for diagnostic and prognostic evaluation of HCC.…”
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Ultrasound Radiogenomics-based Prediction Models for Gene Mutation Status in Breast Cancer by Zhai Yue, Tan Dianhuan, Lin Xiaona, Lv Heng, Chen Yan, Li Yongbin, Luo Haiyu, Dan Qing, Zhao Chenyang, Xiang Hongjin, Zheng Tingting, Sun Desheng

“…These features, including shape, texture, and intensity variations, are correlated with specific genetic mutations such as TP53 and PIK3CA, critical for cancer progression and treatment response. By integrating clinical data with ultrasonic features, predictive models are developed using machine learning techniques, aiming to refine the capability to diagnose and personalize treatment plans for breast cancer patients. …”
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Principal Approaches to Understanding Occupation and Occupational Science Found in the Chilean Journal of Occupational Therapy (2001–2012) by Rodolfo Morrison, Silvia Gómez, Enrique Henny, María Jesús Tapia, Laura Rueda

“…Background. The progression of occupational science in Chile is documented in the main scientific publication of the field, the Chilean Journal of Occupational Therapy (RChTO). …”
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Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases by Vitor Arantes, Pina Michieletti, Ross Cameron, Jenny Heathcote, Morris Sherman

“…Despite surgical debridement the lesion progressed and contributed to her death. Treatment of alcoholic hepatitis with steroids is not innocuous, and physicians should be aware of the potential for life-threatening complications.…”
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A standardized image processing and data quality platform for rodent fMRI by Gabriel Desrosiers-Grégoire, Gabriel A. Devenyi, Joanes Grandjean, M. Mallar Chakravarty

“…Taken together, this software platform will allow the emerging community to adopt reproducible practices and foster progress in translational neuroscience.…”
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Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP by Xiaoqi Zhao, Yuzhou Liu, Yucheng Zhong, Bo Liu, Kunwu Yu, Huairui Shi, Ruirui Zhu, Kai Meng, Wei Zhang, Bangwei Wu, Qiutang Zeng

“…Regulatory T cells play an important role in the progression of atherosclerosis. GARP is a newly biological membrane molecule existed on activated Tregs, which is related to the release of TGF-β. …”
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Role of macrophage in intervertebral disc degeneration by Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang

“…Macrophages construct the inflammatory microenvironment of the intervertebral disc and are involved in regulating intervertebral disc cell activities, extracellular matrix metabolism, intervertebral disc vascularization, and innervation, profoundly influencing the progression of disc degeneration. To gain a deeper understanding of the inflammatory microenvironment of intervertebral disc degeneration, this review will summarize the role of macrophages in the pathological process of intervertebral disc degeneration, analyze the regulatory mechanisms involving macrophages, and review therapeutic strategies targeting macrophage modulation for the treatment of intervertebral disc degeneration. …”
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Effects of the FR 4 Substrate Realized in a Circularly Polarized UHF-RFID Reader Antenna with Fractal Geometry for Enhancing Parameters by Chitra Varadhan, S. Arulselvi, Fekadu Ashine Chamatu

“…The proposed RFID reader antenna progressed with perfect electric conductor (PEC) as the radiating element and FR 4 as the substrate to achieve circular polarization, enhancement in bandwidth, and read range. …”
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The Problem of Malaria and Its Eradication System in Tanjungpinang During The Dutch Colonial Era by Zulfa Saumia, Erniwati Erniwati, Yelda Syafrina

“…There has been significant progress in malaria eradication, and the understanding of the causes of malaria and the selected eradication methods reflect scientific advances and economic considerations.…”
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