The trajectory of changes in cognitive frailty and factors influencing it in elderly patients with cerebral infarction by Shengnan Xu, Qin Liang, Li Zhang, Shihua Liu

“…[Objective] The trajectory of cognitive frailty in elderly patients with cerebral infarction was analyzed, and the influencing factors were discussed. [ Methods] A total of 100 elderly patients with cerebral infarction hospitalized in Suzhou Hospital of Anhui Medical University from January to September in 2023 were selected for the study.Clinical data were collected on the patients, and cognitive frailty was assessed using the Frailty Screening Scale and the Montreal Cognitive Assessment Questionnaire (MoCA) at the time of admission and 1, 3, 6 months after treatment.Failty score ≥3 scores and MoCA <26 scores were defined as cognitive fraily.Potential categories of cognitive frailty change trajectories were identified by latent category growth modeling, and multifactorial logistic regression analyzed the factors influencing patients' cognitive frailty change trajectories. [ Results] The trajectory of cognitive frailty change in elderly patients with cerebral infarction identified by model fitting can be categorized into a group with a persistently low level of frailty (30 cases), a group with a slow rise in frailty (52 cases), and a group with a persistently high level of frailty (18 cases).Multifactorial logistic regression analysis showed that older age, poor sleep quality, and the number of comorbid chronic diseases > 4 were all risk factors for the development of persistent low levels of cognitive frailty into a slow rise in cognitive decline in elderly patients with cerebral infarction (P<0.05), Higher body mass index and high self-care ability were both protective factors for the development of persistent low levels of cognitive decline into a slow rise in cognitive decline in elderly patients with cerebral infarction (P<0.05).Older age, poor sleep quality and the number of comorbid chronic diseases >4 were risk factors for the progression of persistent low levels of cognitive decline to persistent high levels of cognitive decline in elderly patients with cerebral infarction (P < 0.05), and higher self-care ability were protective factors for the progression of persistent low levels of cognitive decline to persistent high levels of cognitive decline in elderly patients with cerebral infarction (P < 0.05). …”
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Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src by Xieyi Guo, Liu Yang, Xiaoning An, Maofang Hu, Yilan Shen, Niansong Wang, Youhua Xu, Dingkun Gui

“…Abstract Background The treatment options to delay the progression of diabetic nephropathy (DN), a key contributor to chronic kidney disease (CKD), are urgently needed. …”
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Payment Reforms for Prehospital Care Services in a Middle Income Country: Assessing Implementation and Patient Outcomes Using a Mixed-Methods Approach by Paibul Suriyawongpaisal, Samrit Srithamrongsawad, Pongsakorn Atiksawedparit, Khanisthar Phooseemungkun, Krongkan Bunchaiyai, Thanita Thongtan

“…Conclusion. It is evident that progress has been made in terms of mobilising more financial inputs and improving financial information flow. …”
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Research of <i>PNPLA3</i> I148M Gene Polymorphism in Patients with Non-Alcoholic Fatty Liver Disease, with Liver Cirrhosis and with Hepatocellular Carcinoma by V. V. Petkau, G. A. Tsaur, E. N. Bessonova, A. A. Karimova

“…The PNPLA3 I148M polymorphism increases the incidence of NAFLD progression to cirrhosis and HCC, but only with concomitant cirrhosis.…”
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Development and validation of an EHR-based risk prediction model for geriatric patients undergoing urgent and emergency surgery by Edward N. Yap, Jie Huang, Joshua Chiu, Robert W. Chang, Bradley Cohn, Judith C. F. Hwang, Mary Reed

“…XGBoost AUCROC was 0.823, 0.781, and 0.839 in predicting outcomes of sepsis, progressive renal insufficiency or renal failure, and mortality, respectively. …”
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Integration of Umbilical Cord Mesenchymal Stem Cell Application in Hydroxyapatite-Based Scaffolds in the Treatment of Vertebral Bone Defect due to Spondylitis Tuberculosis: A Trans... by Ahmad Jabir Rahyussalim, Ahmad Nugroho, Muhammad Luqman Labib Zufar, Irfan Fathurrahman, Tri Kurniawati

“…Vertebral bone defect represents one of the most commonly found skeletal problems in the spine. Progressive increase of vertebral involvement of skeletal tuberculosis (TB) is reported as the main cause, especially in developed countries. …”
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Egfr Amplification Specific Gene Expression in Phyllodes Tumours of the Breast by Konstantin Agelopoulos, Christian Kersting, Eberhard Korsching, Hartmut Schmidt, Arno Kuijper, Christian August, Pia Wülfing, Joke Tio, Werner Boecker, Paul J. van Diest, Burkhard Brandt, Horst Buerger

“…The interplay between EGFR and caveolin-1, eps15, pAkt, mdm2 and pERK therefore seems to present a major molecular pathway in carcinogenesis and progression of breast phyllodes tumours.…”
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Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the l... by Cinzia Marchica, Faisal Zawawi, Dania Basodan, Rosie Scuccimarri, Sam J. Daniel

“…With further escalation of the Anakinra dose, there was also complete resolution of the aseptic meningitis. Conclusions Progressive hearing loss is a significant finding in patients with MWS. …”
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Efficacy and safety of pembrolizumab in patients with advanced endometrial cancer: a systematic review and meta-analysis by Biqiong Pan, Xiaojun Lai, Jiefang Lu, Xiaoyan Bao, Zengke Fan, Jie Sun

“…Eight studies with 2,742 patients were included. Outcomes were progression-free survival (PFS), overall survival (OS), objective response rate (ORR), complete remission (CR), and adverse events (AEs); a subgroup analysis was carried out based on combination treatment regimens. …”
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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

“…Furthermore, data also indicate that both poor glycemic control and dyslipidemia are associated with disease progression. Consequently, this rat model of T2D seems to fit well with progression of DPN in humans and could be a relevant preclinical model to use in relation to research investigating treatment opportunities for DPN.…”
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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…The analysis further revealed PAQR11's involvement in immunological and epigenetic processes, underscoring its critical role in cancer progression and treatment response. Notably, a strong correlation between PAQR11 expression and drug sensitivity was identified, suggesting its potential influence on the initiation and progression of various cancers and highlighting its promise as a therapeutic target. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…Conclusions Two patients with Townes-Brocks syndrome (TBS) harboring novel variants presented atypical phenotypes, characterized primarily by significant and rapidly progressing renal involvement. Rare renal biopsy pathology revealed the presence of focal segmental glomerulosclerosis (FSGS) in both cases. …”
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The Women in ORTHopaedics Program Offers Early Exposure to Orthopaedic Surgery for Young Women. A Pre- and Post-Event Survey Comparison by Marianna Hsu, BSc candidate, Hayley Spurr, MB, BCh, BAO, FRCSC, Anthony P. Cooper, MBChB, FRCSC, Emily K. Schaeffer, PhD

“…Background: In recent years, the medical field has made significant progress toward promoting gender equality. Despite this progress, orthopaaedic surgery remains the least diverse specialty among other surgical specialties. …”
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CircBAZ1B stimulates myocardial ischemia/reperfusion injury (MI/RI) by modulating miR-1252-5p/ATF3-mediated ferroptosis by Ruili Wei, Tianxiao Yang, Weihong Li, Xiqian Wang

“…In vivo experimental data further revealed that circBAZ1B suppressed cardiomyocyte activity and promoted ferroptosis, thereby facilitating MI/RI progression. Conclusions The circBAZ1B/miR-1252-5p/ATF3 axis is crucial in MI/RI pathogenesis through ferroptosis regulation, offering a potential therapeutic target. …”
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Neutrophil-to-lymphocyte ratio as a prognostic indicator in COVID-19: Evidence from a northern tanzanian cohort. by Norman Jonas Kyala, Innocent Mboya, Elichilia Shao, Francis Sakita, Kajiru Gadiel Kilonzo, Laura Shirima, Abid Sadiq, Elifuraha Mkwizu, Nyasatu Chamba, Annette Marandu, Sophia Muhali, Faryal Raza, Eliasa Ndale, Damas Bayo, Daniel Mujuni, Furaha Lyamuya

“…Early identification of the subclinical progression is crucial for timely intervention and improved patient outcomes. …”
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Non-Alcoholic Fatty Liver Disease in Cardiac Patients with Overweight and Obesity by I. V. Logacheva, T. A. Ryazanova, V. R. Makarova, O. V. Surnina

“…It is demonstrated that the correlation coefficients grow with the progression of fatty infiltration and liver fibrosis signs.Conclusions. …”
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Case report: Chemotherapy plus sintilimab for the treatment of gastroesophageal junction hepatoid adenocarcinoma with liver metastasis: a case study with literature review by Genlin Lu, Jiarui Tu, Jinming Tu, Renya Jiang

“…The patient achieved a major pathological response (MPR) and remains in a progression-free stage.ConclusionsSintilimab-based chemotherapy has proven efficacy in achieving a MPR and maintaining a progression-free state for a patient with GEJ HAC that has metastasized to the liver.…”
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Effectiveness of the ARTHE-e app for exercise adherence in people with knee osteoarthritis: protocol for a randomised controlled trial by Bruno Pereira, Charlotte Lanhers, Emmanuel Coudeyre, Lech Dobija, Mathilde Pelletier-Visa, Alexis Bonhomme

“…Introduction Osteoarthritis, the most prevalent joint disease, poses a significant challenge due to its progressive nature and impact on the whole joint and periarticular structures. …”
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Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets by Xin Wang, Xin Wang, Shuang Zhang, Shuang Zhang, Shuyi Wang, Tao Cao, Tao Cao, Hong Fan, Hong Fan

“…Notably, most of these hub genes such as NEK2, NDC80, NUF2, PLK1, SMAD2, TP53, TPX2, TTK, UBE2C, WDHD1, WTAP, YWHAZ are directly or indirectly associated with cell cycle progression, underscoring the role of DEmiRs in driving tumor proliferation and survival in OC via dysregulating cell cycle. …”
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Using Health Information Resources for People With Cognitive Impairment (digiDEM Bayern): Registry-Based Cohort Study by Florian Weidinger, Nikolas Dietzel, Elmar Graessel, Hans-Ulrich Prokosch, Peter Kolominsky-Rabas

“…Slight changes in valuation should be considered as the medical condition progresses, along with variations by age and gender. …”
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