Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma by Hideo Suzuki, Motoyuki Kohjima, Masatake Tanaka, Takeshi Goya, Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori, Mariko Tsuda, Motoi Takahashi, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Akifumi Kuwano, Masaki Kato, Seiji Okada, Makoto Nakamuta, Yoshihiro Ogawa

“…Same metabolic alterations were observed in noncancer tissue as the liver disease progresses from healthy liver to chronic hepatitis, cirrhosis, and HCC. …”
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Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC by Chenxuan Li, En-di Zhang, Rui Yu, Bo Yuan, Yunxin Yang, Zhong Zeng, Hanfei Huang

“…Conclusions: CDC6 is associated with the occurrence and progression of multiple cancer types by regulating the cell cycle. …”
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RETRACTED: LncRNA CCAT2 promotes the proliferation and metastasis of colorectal cancer through activation of the ERK and Wnt signaling pathways by regulating GNB2 expression by Jinhai Tian, Xu Cao, Zongying Jiang, Jia Wang, Wan Fan, Shaoting Zhang, Sien Zhao, Jianmin Sun

“…Conclusion CCAT2 plays a crucial role in CRC progression by modulating the ERK and Wnt signaling pathways through its interaction with GNB2. …”
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Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with ApcMin/+ Mutation by Michele Barone, Maria Principia Scavo, Raffaele Licinio, Michele Piombino, Nicola De Tullio, Rosanna Mallamaci, Alfredo Di Leo

“…At 4 and 7 weeks after transplantation, a progressive significant reduction of polyp number and volume was observed in WT-Tx-Apc mice. …”
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Comparison of Two Creatinine-Based Equations for Predicting Decline in Renal Function in Type 2 Diabetic Patients with Nephropathy in a Korean Population by Eun Young Lee, Young-Mi Lee, Kyu Hun Choi, Hyun Chul Lee, Byung-Wan Lee, Beom Seok Kim

“…To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. …”
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Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides by Serkan Yazıcı, Emel Bülbül Başkan, Ferah Budak, Barbaros Oral, Şaduman Balaban Adim, Zübeyde Ceylan Kalin, Güven Özkaya, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali

“…Flow cytometric analysis of peripheral blood cell surface antigens in patients with mycosis fungoides may contribute to predicting disease stage and progression.…”
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Clinical round: 27 year old patient with initially diagnosed Crohn's disease and severe protein and energy deficiency by V. S. Scherbakha, O. Z. Okhlobystina, A. V. Korolev, O. S. Shifrin, A. V. Stepanov, A. S. Tertychny, A. V. Okhlobystin, V. T. Ivashkin

“…The diagnosis of Crohn’s disease in our clinic was established on the basis of careful study of clinical course of disease (late postprandial pain, diarrhea, fever and progressive weight loss). The diagnostic concept was confirmed by modern laboratory and instrumental methods of investigation (CT enterocolonography, endoscopic and histological study). …”
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Multi-Task Learning for Alzheimer’s Disease Diagnosis and Mini-Mental State Examination Score Prediction by Jin Liu, Xu Tian, Hanhe Lin, Hong-Dong Li, Yi Pan

“…Therefore, it can be used as a reference for the clinical diagnosis of Alzheimer’s disease, and can also help doctors and patients track disease progression in a timely manner.…”
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Anti-Tumor Effect of Rutin on Human Neuroblastoma Cell Lines through Inducing G2/M Cell Cycle Arrest and Promoting Apoptosis by Hongyan Chen, Qing Miao, Miao Geng, Jing Liu, Yazhuo Hu, Lei Tian, Jingkun Pan, Yi Yang

“…Flow cytometric analysis revealed that rutin induced G2/M arrest in the cell cycle progression and induced cell apoptosis. The RT-PCR showed that rutin could decrease BCL2 expression and BCL2/BAX ratio. …”
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Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients by Susan Woolley, Ray Goetz, Pam Factor-Litvak, Jennifer Murphy, Jonathan Hupf, Catherine Lomen-Hoerth, Howard Andrews, Daragh Heitzman, Richard Bedlack, Jonathan Katz, Richard Barohn, Eric Sorenson, Bjorn Oskarsson, Americo Fernandes Filho, Edward Kasarskis, Tahseen Mozaffar, Sharon Nations, Andrea Swenson, Agnes Koczon-Jaremko, Georgia Christodoulou, Hiroshi Mitsumoto

“…Disinhibition changes did not correlate with disease duration or progression. Baseline behavioral problems were associated with advanced, rapidly progressive disease and study attrition.…”
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Cervical Spinal Osteomyelitis with Epidural Abscess following an Escherichia coli Urinary Tract Infection in an Immunocompetent Host by Abdelmoniem Moustafa, Rowida Kheireldine, Zubair Khan, Hussam Alim, Mohammad Saud Khan, Mohd Amer Alsamman, Eslam Youssef

“…A diagnosis of SEA should be considered in patients presenting with progressive weakness and neurological deficits following UTI and is to be confirmed by MRI. …”
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Eight-element flexible MIMO antenna based on characteristics mode theory with enhanced channel capacity for sub 6 GHz 5G communications by Deepthi Mariam John, Shweta Vincent, Sameena Pathan, Kunjan D Shinde, B S Supreetha, Tanweer Ali

“…The rapid progress in wireless technology introduces a suite of furtherance designed to fulfil the ever-growing data consumption, expansion of smart devices, and rise of the Internet of Things (IoT). …”
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Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis by Zuojie Peng, Jia Song, Wenzhong Zhu, Haijun Bao, Yuan Hu, Yongping Shi, Xukai Cheng, Mi Jiang, Feifei Fang, Jinhuang Chen, Xiaogang Shu

“…Objective: There is growing evidence that sleep deprivation promotes cancer progression. In addition, colon cancer patients often experience sleep deprivation due to factors such as cancer pain and side effects of treatment. …”
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Promoter Methylation Precedes Chromosomal Alterations in Colorectal Cancer Development by Sarah Derks, Cindy Postma, Peter T. M. Moerkerk, Sandra M. van den Bosch, Beatriz Carvalho, Mario A. J. A. Hermsen, Walter Giaretti, James G. Herman, Matty P. Weijenberg, Adriaan P. de Bruïne, Gerrit A. Meijer, Manon van Engeland

“…Results: Our data demonstrate that nonprogressed adenomas, progressed adenomas and carcinomas show similar frequencies of promoter methylation for the majority of the genes. …”
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Auditory Phenotype of a Novel Missense Variant in the CEACAM16 Gene in a Large Russian Family With Autosomal Dominant Nonsyndromic Hearing Loss by Tatiana G. Markova, Natalia N. Alekseeva, Oxana P. Ryzhkova, Olga L. Shatokhina, Anna A. Orlova, Viktoriia V. Zabnenkova, Olga S. Groznova, Olesya V. Sagaydak, Svetlana S. Chibisova, Alexander V. Polyakov, George A. Tavartkiladze

“…Hearing loss slowly progresses with age in each person and is similar to age-related hearing loss. …”
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Evaluation of compliance and accuracy in Parkinson’s disease motor symptom tracking: a comparative study of digital and traditional paper diaries using a smartphone application (My... by Nazli Durmaz Celik, Nazli Durmaz Celik, Asli Yaman Kula, Naci Murat, Müge Kuzu Kumcu, Aydan Topal, Serhat Özkan

“…Parkinson’s disease (PD) is a neurodegenerative disorder with progressive motor symptoms. Treatment becomes more challenging as PD progresses, motor complications in the form of wearing-off phenomenon and levodopa-induced dyskinesia develop. …”
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Low seismic shaking induced densification of large spoil heap composed with low-density particle material by Jian Lv, Tao Jiang, Shuangcheng Wang, Wei Huang, Shenghua Cui, Lihu Duan, Zhenfu Huang

“…This vibration-induced densification leads to a progressively more significant elevation amplification effect.DiscussionDuring the vibration-induced densification process, the medium undergoes self-organization in three phases, including settlement, dynamic equilibrium, and expansion. …”
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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…We demonstrate that TMEM45A is highly expressed in palbociclib-resistant breast cancer (BRCA) cells, correlating with enhanced tumor progression. Silencing TMEM45A enhances sensitivity to palbociclib, promotes cell cycle arrest and apoptosis, and inhibits the proliferation of BRCA cells. …”
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Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals by J Sardell, S Das, K Taylor, C Stubberfield, A Malinowski, M Strivens, S Gardner

“…They also illustrate the potential for development of precision medicine approaches that can increase healthspan by reducing the progression of disease.…”
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Percutaneous Radiofrequency Ablation of Small (1–2 cm) Hepatocellular Carcinomas Inconspicuous on B-Mode Ultrasonographic Imaging: Usefulness of Combined Fusion Imaging with MRI an... by Min Woo Lee, Hyo Keun Lim, Hyunchul Rhim, Dong Ik Cha, Tae Wook Kang, Kyoung Doo Song, Ji Hye Min, Geum-Youn Gwak, Seonwoo Kim, David S. K. Lu

“…Cumulative local tumor progression rates after RFA were estimated to be 5.3%, 10.8%, and 10.8% at 1, 2, and 3 years, respectively. …”
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