Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications by Haiming Wang, Zifan Liu, Junjie Shao, Lejian Lin, Min Jiang, Lin Wang, Xuechun Lu, Haomin Zhang, Yundai Chen, Ran Zhang

“…Both innate and adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus formation. …”
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RTEL1 is upregulated in gastric cancer and promotes tumor growth by Chunyu Yang, Suzeng Wang, Ge Gao, Peiwen Xu, Mengyuan Qian, Yuan Yin, Surui Yao, Zhaohui Huang, Zehua Bian

“…GC is a highly heterogeneous disease and its progression is associated with complex interplay between genetic and environmental factors. …”
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A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens by Ralf Baumann, Susanne Kaempfer, Novel N. Chegou, Wulf Oehlmann, Ralf Spallek, André G. Loxton, Paul D. van Helden, Gillian F. Black, Mahavir Singh, Gerhard Walzl

“…Elevated antibody responses to Mycobacterium tuberculosis antigens in individuals with latent infection (LTBI) have previously been linked to an increased risk for progression to active disease. Studies in the field focussed mainly on IgG antibodies. …”
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Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury by Cheng-Chia Tsai, Kung-Shing Lee, Sheng-Hsien Chen, Li-Jen Chen, Keng-Fan Liu, Juei-Tang Cheng

“…However, the relationship between the progress of diabetes and PPARδ in SCI remains unknown. …”
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Fibrinogen: A Marker in Predicting Diabetic Foot Ulcer Severity by X. H. Li, L. Y. Guan, H. Y. Lin, S. H. Wang, Y. Q. Cao, X. Y. Jiang, Y. B. Wang

“…To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). …”
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N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential by Qihui Wu, Xiaodan Fu, Guoqian Liu, Xiaoyun He, Yimin Li, Chunlin Ou

“…Their influence on the synthesis and processing of messenger RNA, ribosomal RNA, and transfer RNA allows m7G modifications to affect diverse cellular, physiological, and pathological processes. m7G modifications are pivotal in human diseases, particularly cancer progression. On one hand, m7G modification-associated modulate tumour progression and affect malignant biological characteristics, including sustained proliferation signalling, resistance to cell death, activation of invasion and metastasis, reprogramming of energy metabolism, genome instability, and immune evasion. …”
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Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases by Jiao Lv, Honghai Yu, Sasa Du, Pengyu Xu, Yunyun Zhao, Wenxiu Qi, Xiuge Wang

“…Previous studies have shown that ERS in podocytes can contribute to the development of diseases such as glomerulonephritis, hereditary nephropathy, and diabetic kidney disease, potentially progressing to end-stage renal disease and causing patient mortality. …”
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Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer by Carlos Eduardo Salazar-Mejía, María Elena García-Gutiérrez, María Inés Contreras-Salcido, Carlos Javier Rodríguez-Álvarez, Blanca Otilia Wimer-Castillo, Jackeline Grace Lara-Campos, Edio Llerena-Hernández, José Luis González-Vela, David Hernández-Barajas

“…It is characterized by the abrupt establishment of rapidly progressive and hemorrhagic tumors associated with very high levels of the beta fraction of human chorionic gonadotropin (β-hCG) and with a very poor prognosis, particularly in patients with β-hCG values above 50,000 IU/L. …”
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CD4+CD25highCD127low/-FoxP3+ Regulatory T-Cell Population in Acute Leukemias: A Review of the Literature by M. Niedźwiecki, O. Budziło, E. Adamkiewicz-Drożyńska, D. Pawlik-Gwozdecka, M. Zieliński, L. Maciejka-Kembłowska, T. Szczepański, P. Trzonkowski

“…On the other hand, Tregs could be responsible for the progression of acute and chronic leukemias. In our study, we review publications available in the PUMED database concerning acute leukemia, with a particular emphasis on child’s leukemias. …”
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Human Calmodulin-Like Protein CALML3: A Novel Marker for Normal Oral Squamous Mucosa That Is Downregulated in Malignant Transformation by Michael D. Brooks, Richard D. Bennett, Amy L. Weaver, Thomas J. Sebo, Steven E. Eckert, Emanuel E. Strehler, Alan B. Carr

“…The purpose of this study was to determine if the epithelial-specific human calmodulin-like protein (CALML3) could be used as marker for the various phases of oral tumor progression. Immunohistochemical analysis using an affinity-purified CALML3 antibody was performed on biopsy-confirmed oral tissue samples representing these phases. …”
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CO2 Laser and Topical Fluoride Therapy in the Control of Caries Lesions on Demineralized Primary Enamel by R. A. Valério, C. T. Rocha, R. Galo, M. C. Borsatto, M. C. P. Saraiva, S. A. M. Corona

“…It was concluded that CO2 laser can be an additional resource in caries control progression on primary teeth enamel.…”
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Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells by Bin Han, Naohiro Fujimoto, Mizuki Kobayashi, Tetsuro Matsumoto

“…Most advanced prostate cancers progress to castration resistant prostate cancer (CRPC) after a few years of androgen deprivation therapy and the prognosis of patients with CRPC is poor. …”
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System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment by Joyce Bonaccorsi, Simona Cintoli, Rosa Mastrogiacomo, Sigrid Baldanzi, Chiara Braschi, Tommaso Pizzorusso, Maria Cristina Cenni, Nicoletta Berardi

“…We characterized the time course of hippocampal and cortical activation following recall of progressively more remote spatial memories. Wild-type mice either exposed to EE for 40 days or left in standard environment were subjected to spatial learning in the Morris water maze and to the probe test 1, 10, 20, 30, and 50 days after learning. …”
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Tuberculosis vaccines and therapeutic drug: challenges and future directions by Yajing An, Ruizi Ni, Li Zhuang, Ling Yang, Zhaoyang Ye, Linsheng Li, Seppo Parkkila, Ashok Aspatwar, Wenping Gong

“…This review meticulously maps out the contemporary landscape of TB vaccine development, with a focus on antigen identification, clinical trial progress, and the obstacles and future trajectories in vaccine research. …”
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Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy: An In Vivo Study Using Spectral Domain OCT by Stela Vujosevic, Silvia Bini, Giulia Midena, Marianna Berton, Elisabetta Pilotto, Edoardo Midena

“…With progressing retinopathy, HRS reach the outer retinal layer. …”
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Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apo... by Ah Young Yang, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyun Hee Kwon, Jaechan Leem, Eon-Ju Jeon

“…Chronic kidney disease (CKD) progresses through mechanisms involving inflammation, fibrosis, and oxidative stress, leading to the gradual structural and functional deterioration of the kidneys. …”
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The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background by Jinsheng Yu, Sharon Marsh, Junbo Hu, Wenke Feng, Chaodong Wu

“…Although a high-fat diet and inactive lifestyles are typical risk factors for NAFLD, the interplay between diet, gut microbiota, and genetic background is believed to be more important in the development and progression of NAFLD. This review summarizes the common pathogenic mechanisms, the gut microbiota relevant mechanisms, and the major genetic variants leading to NAFLD and its progression.…”
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Early Diagnosis of Alzheimer’s Disease Using Adaptive Neuro K-Means Clustering Technique by Karan Kumar, Shweta Agrawal, Isha Suwalka, Celestine Iwendi, Cresantus N. Biamba

“…Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, behavioral changes, and impaired self-care, often preceded by Mild Cognitive Impairment (MCI). …”
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Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis by Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu

“…Abstract Background Extracellular vesicles (EVs) derived from endothelial cells (ECs) are increasingly recognized for their role in the initiation and progression of atherosclerosis. ECs experience varying degrees and types of blood flow depending on their specific arterial locations. …”
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Valve dysfunction in patients with cardiac myxomas: mechanism of damage and methods of correction by R.M. Vitovskyi, V.V. Isaienko, D.M. Dyadyun, I.V. Martyshchenko, O.A. Pishchurin, O.V. Kupchinsky

“…The features of the long-term postoperative period in such patients include progressive valve dysfunction manifested by the progression of insufficiency due to further deformation of the valve apparatus. …”
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