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2441
Chagas Disease Cardiomyopathy: Immunopathology and Genetics
Published 2014-01-01“…In this paper, we will review the immunopathogenesis and genetics of Chagas disease, highlighting studies that shed light on the differential progression of Chagas disease patients to CCC.…”
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2442
Aging-associated sensory decline and Alzheimer’s disease
Published 2024-12-01“…Hearing impairment is significantly associated with AD, but its causal impact on AD progression remains unclear. The review also discusses visual and tactile deficits in AD, including retinal thinning and changes in tactile perception, highlighting their links to disease progression. …”
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2443
Advances in Energy Conservation of China Steel Industry
Published 2013-01-01“…The course, technical progresses, and achievements of energy conservation of China steel industry (CSI) during 1980–2010 were summarized. …”
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2444
Spontaneous Rupture of Renal Metastasis from Hepatocellular Carcinoma
Published 2017-01-01“…Unfortunately, two months after the TAE, the tumor locally progressed within the retroperitoneal space. Tumors were controlled by repeated TAE as the patient did not want to undergo a nephrectomy. …”
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2445
Physiology-informed use of Cupriavidus necator in biomanufacturing: a review of advances and challenges
Published 2025-01-01“…Additionally, C. necator natively fixes carbon in the form of poly-3-hydroxybutyrate, which can be processed to make biodegradable plastic. Recent progress in development of modelling and synthetic biology tools have made C. necator much more usable as a biomanufacturing chassis. …”
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2446
Homonymous Superior Quadrantanopia due to Erdheim-Chester Disease with Asymptomatic Pituitary Involvement
Published 2017-01-01“…Here we describe a case of ECD in a 45-year-old female who presented initially with bilateral knee pain and homonymous superior quadrantanopia progressed to ophthalmoplegia and complete visual loss of the left eye over a period of one year. …”
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2447
Case report: Guillain-Barré syndrome and possible association with Lyme disease
Published 2019-12-01“…This is a life-threatening condition that urges patients to seek emergency treatment for progressive pain, paralysis and/or respiratory distress that can cause death in the absence of timely treatment. …”
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2448
The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation
Published 2025-01-01“…This review systematically discusses the role of human pluripotent stem cell (hPSC)-derived glia and supporting cells within the CNS, including astrocytes, microglia, oligodendrocyte precursor cells, pericytes, and endothelial cells, to describe the state of the field and hope for future discoveries. hPSC-derived cells offer an expanded potential to study the pathobiology of neuroinflammation and immunomodulatory cascades that impact disease progression. While much progress has been made in the development of models, there is much left to explore in the application of these models to understand the complex inflammatory response in the CNS.…”
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2449
PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer
Published 2009-01-01“…It is now well established that the development and progression of a variety of human malignancies are associated with dysregulated activity of the insulin-like growth factor (IGF) system. …”
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2450
Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals
Published 2014-01-01“…Despite the important progress obtained in the treatment of some pets’ malignancies, new treatments need to be developed. …”
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2451
Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis
Published 2014-01-01“…Conventional treatments have little effects on the progression of the condition often leaving surgery as the last option. …”
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2452
Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease
Published 2015-01-01“…Randomized, placebo-controlled clinical trials have demonstrated that xanthophyll supplementation increases macular pigment levels, improves visual function, and decreases the risk of progression to late AMD, especially neovascular AMD. …”
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2453
Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation
Published 2025-01-01“…Abstract Wnt signaling is essential for cell growth and tumor formation and is abnormally activated in colorectal cancer (CRC), contributing to tumor progression; however, the specific role and regulatory mechanisms involved in tumor development remain unclear. …”
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2454
Diet at intestinal diseases: traditional bases and new discoverings
Published 2011-06-01“…In the last years essential progress was achieved for diet at diabetes mellitus, peptic ulcer and liver failure. …”
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2455
Risk Factors for Foot Amputation in Patients Hospitalized for Diabetic Foot Infection
Published 2016-01-01“…Regarding patient outcome, 61% progressed to amputation, 14% to debridement, and 9% to revascularization. …”
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2456
A Small Beautiful Example of Sustainability in the Heart of Zimbabwe
Published 2023-03-01“… Zimbabwe has diligently started pursuing the Sustainable Development Goals (SDGs) defined by the United Nations in 2015. While making progress and being aware of it, will be a shot in the arm, with success breeding more success, the journey may seem daunting at times. …”
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2457
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy.
Published 2025-02-01“…Myeloid VANGL2 deficiency exacerbates the progression of DSS-induced colitis in mice and specifically enhances the activation of NLRP3 inflammasome in macrophages. …”
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2458
Promoting Articular Cartilage Regeneration through Microenvironmental Regulation
Published 2024-01-01“…Therefore, there is an urgent need to identify effective treatment methods that can delay the pathological progression of this condition. The changes in the articular cartilage microenvironment, which are complex and diverse, can aggravate the pathological progression into a vicious cycle, inhibiting the repair and regeneration of articular cartilage. …”
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2459
Comparison of Presumed PDF Models of Turbulent Flames
Published 2012-01-01“…Over the past years, the use of a presumed probability density function (PDF) for combustion progress variable or/and mixture fraction has been becoming more and more popular approach to average reaction rates in premixed and partially premixed turbulent flames. …”
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2460
Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients?
Published 2014-01-01“…High MMP-3 levels are associated with joint progression in RA patients, but there is no data about their utility in clinical remission. …”
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